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A comparison of live and inactivated influenza A (H1N1) virus vaccines

Identifieur interne : 002737 ( Main/Merge ); précédent : 002736; suivant : 002738

A comparison of live and inactivated influenza A (H1N1) virus vaccines

Auteurs : A. Clark ; C. W. Potter ; R. Jennings ; J. P. Nicholl ; A. F. Langrick [Royaume-Uni] ; G. C. Schild ; J. M. Wood ; D. A. J. Tyrrell

Source :

Journal of Hygiene [ 0022-1724 ] ; 1983-06.

RBID : ISTEX:C6311DC19692F1A134E73B897CFE23C5583EC119

Abstract

Groups of volunteers were immunized with one of three influenza virus vaccines, and the resistance to challenge infection with attenuated influenza A (H1N1) virus was measured 8 months later. The vaccines were aqueous subunit influenza A/USSR/77 (H1N1) vaccine, aqueous subunit influenza B/Hong Kong/73 vaccine, or attenuated influenza virus A (H1N1) vaccine. The B virus vaccine was included as a control to assess the incidence of natural A virus infection during the study period. A proportion of the B virus vaccinees had pre-existing A (H1N1) virus antibody and were used to study the immunity conferred by natural infection to the live virus challenge. The serum antibody responses were measured at 1 and 8 months after immunization. The results showed that all the vaccines induced serum HI antibody in a proportion of the volunteers; however, after 1 month, higher titres of serum antibody were found in volunteers given inactivated A vaccine than in those given live attenuated A virus vaccine. Eight months post-immunization the titres of serum antibody in volunteers given inactivated vaccine had declined significantly, but there were no changes in the antibody titres of those given live virus vaccine. The incidence of infection by the challenge virus at 8 months post-immunization was directly related to the serum antibody titres 1 month post-immunization; no evidence was obtained to suggest that those given live virus vaccine had a more solid immunity than those given inactivated vaccine.

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https://api.istex.fr/ark:/67375/6GQ-S4Z2CXGR-4/fulltext.pdf

DOI: 10.1017/S0022172400028990

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ISTEX:C6311DC19692F1A134E73B897CFE23C5583EC119

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<front><div type="abstract">Groups of volunteers were immunized with one of three influenza virus vaccines, and the resistance to challenge infection with attenuated influenza A (H1N1) virus was measured 8 months later. The vaccines were aqueous subunit influenza A/USSR/77 (H1N1) vaccine, aqueous subunit influenza B/Hong Kong/73 vaccine, or attenuated influenza virus A (H1N1) vaccine. The B virus vaccine was included as a control to assess the incidence of natural A virus infection during the study period. A proportion of the B virus vaccinees had pre-existing A (H1N1) virus antibody and were used to study the immunity conferred by natural infection to the live virus challenge. The serum antibody responses were measured at 1 and 8 months after immunization. The results showed that all the vaccines induced serum HI antibody in a proportion of the volunteers; however, after 1 month, higher titres of serum antibody were found in volunteers given inactivated A vaccine than in those given live attenuated A virus vaccine. Eight months post-immunization the titres of serum antibody in volunteers given inactivated vaccine had declined significantly, but there were no changes in the antibody titres of those given live virus vaccine. The incidence of infection by the challenge virus at 8 months post-immunization was directly related to the serum antibody titres 1 month post-immunization; no evidence was obtained to suggest that those given live virus vaccine had a more solid immunity than those given inactivated vaccine.</div>
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A comparison of live and inactivated influenza A (H1N1) virus vaccines

A comparison of live and inactivated influenza A (H1N1) virus vaccines

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Abstract

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