Subtype cross-reactive, infection-enhancing antibody responses to influenza A viruses.
Identifieur interne : 001E54 ( Main/Merge ); précédent : 001E53; suivant : 001E55Subtype cross-reactive, infection-enhancing antibody responses to influenza A viruses.
Auteurs : M. Tamura ; R G Webster ; F A EnnisSource :
- Journal of virology [ 0022-538X ] ; 1994.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (biosynthèse), Anticorps monoclonaux, Antigènes viraux, Cellules présentatrices d'antigène (immunologie), Cellules présentatrices d'antigène (microbiologie), Grippe humaine (enzymologie), Grippe humaine (immunologie), Grippe humaine (microbiologie), Humains, Lignée cellulaire, Mâle, Réactions croisées, Récepteur Fc (métabolisme), Sialidase (immunologie), Souris, Souris de lignée BALB C, Tests de neutralisation, Virus de la grippe A (), Virus de la grippe A (immunologie).
- MESH :
- biosynthèse : Anticorps antiviraux.
- enzymologie : Grippe humaine.
- immunologie : Cellules présentatrices d'antigène, Grippe humaine, Sialidase, Virus de la grippe A.
- microbiologie : Cellules présentatrices d'antigène, Grippe humaine.
- métabolisme : Récepteur Fc.
- Animaux, Anticorps monoclonaux, Antigènes viraux, Humains, Lignée cellulaire, Mâle, Réactions croisées, Souris, Souris de lignée BALB C, Tests de neutralisation, Virus de la grippe A.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal, Antibodies, Viral (biosynthesis), Antigen-Presenting Cells (immunology), Antigen-Presenting Cells (microbiology), Antigens, Viral, Cell Line, Cross Reactions, Humans, Influenza A virus (classification), Influenza A virus (immunology), Influenza, Human (enzymology), Influenza, Human (immunology), Influenza, Human (microbiology), Male, Mice, Mice, Inbred BALB C, Neuraminidase (immunology), Neutralization Tests, Receptors, Fc (metabolism).
- MESH :
- chemical , biosynthesis : Antibodies, Viral.
- chemical , immunology : Neuraminidase.
- chemical , metabolism : Receptors, Fc.
- chemical : Antibodies, Monoclonal, Antigens, Viral.
- classification : Influenza A virus.
- enzymology : Influenza, Human.
- immunology : Antigen-Presenting Cells, Influenza A virus, Influenza, Human.
- microbiology : Antigen-Presenting Cells, Influenza, Human.
- Animals, Cell Line, Cross Reactions, Humans, Male, Mice, Mice, Inbred BALB C, Neutralization Tests.
Abstract
Antibody-dependent enhancement of the uptake of influenza A virus by Fc receptor-bearing cells was analyzed by using virus strains of the three human influenza A virus subtypes, A/PR/8/34 (H1N1), A/Japan/305/57 (H2N2), and A/Port Chalmers/1/73 (H3N2). Immune sera obtained from mice following primary infection with an H1N1, H2N2, or H3N2 subtype virus neutralized only virus of the same subtype; however, immune sera augmented the uptake of virus across subtypes. Immune sera from H1N1-infected mice augmented uptake of the homologous (H1N1) and H2N2 viruses. Antisera to the H2N2 virus augmented the uptake of virus of all subtypes (H1N1, H2N2, or H3N2). Antisera to the H3N2 virus augmented the uptake of the homologous (H3N2) and H2N2 viruses. These results show that subtype cross-reactive, nonneutralizing antibodies augment the uptake of influenza A virus strains of different subtypes. Antibodies to neuraminidase may contribute to the enhanced uptake of viruses of a different subtype, because N2-specific monoclonal antibodies augmented the uptake of both A/Japan/305/57 (H2N2) and A/Port Chalmers/1/73 (H3N2) viruses.
PubMed: 8189489
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Immune sera obtained from mice following primary infection with an H1N1, H2N2, or H3N2 subtype virus neutralized only virus of the same subtype; however, immune sera augmented the uptake of virus across subtypes. Immune sera from H1N1-infected mice augmented uptake of the homologous (H1N1) and H2N2 viruses. Antisera to the H2N2 virus augmented the uptake of virus of all subtypes (H1N1, H2N2, or H3N2). Antisera to the H3N2 virus augmented the uptake of the homologous (H3N2) and H2N2 viruses. These results show that subtype cross-reactive, nonneutralizing antibodies augment the uptake of influenza A virus strains of different subtypes. Antibodies to neuraminidase may contribute to the enhanced uptake of viruses of a different subtype, because N2-specific monoclonal antibodies augmented the uptake of both A/Japan/305/57 (H2N2) and A/Port Chalmers/1/73 (H3N2) viruses.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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