Viral induction of co-stimulatory activity on antigen-presenting cells bypasses the need for CD4+ T-cell help in CD8+ T-cell responses.
Identifieur interne : 001E51 ( Main/Merge ); précédent : 001E50; suivant : 001E52Viral induction of co-stimulatory activity on antigen-presenting cells bypasses the need for CD4+ T-cell help in CD8+ T-cell responses.
Auteurs : Y. Wu [États-Unis] ; Y. LiuSource :
- Current biology : CB [ 0960-9822 ] ; 1994.
Descripteurs français
- KwdFr :
- Activation des lymphocytes, Animaux, Cellules présentatrices d'antigène (immunologie), Coopération des lymphocytes, Lymphocytes T CD4+ (immunologie), Lymphocytes T CD8+ (immunologie), Modèles biologiques, Souris, Souris de lignée BALB C, Souris de lignée CBA, Techniques in vitro, Virus de la grippe A (), Virus de la grippe A (immunologie).
- MESH :
English descriptors
- KwdEn :
- Animals, Antigen-Presenting Cells (immunology), CD4-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (immunology), In Vitro Techniques, Influenza A virus (classification), Influenza A virus (immunology), Lymphocyte Activation, Lymphocyte Cooperation, Mice, Mice, Inbred BALB C, Mice, Inbred CBA, Models, Biological.
- MESH :
Abstract
CD4+ T-cell help is critical for cytotoxic (CD8+) T-lymphocyte responses to many antigens, such as viruses, minor histocompatibility antigens and allogeneic major histocompatibility antigens. However, the nature of such help is still a mystery: cytokines such as interleukin-2 may be involved but cell-cell contact may also be necessary. As some viruses can induce CD8+ T-cell responses in the absence of CD4+ T cells, we asked whether these viruses and CD4+ cells share a pathway for helping the CD8+ T-cell response.
DOI: 10.1016/s0960-9822(00)00110-x
PubMed: 7922370
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pubmed:7922370Le document en format XML
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Wu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, New York University Medical Center, New York 10016.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pathology, New York University Medical Center</wicri:cityArea></affiliation></author><author><name sortKey="Liu, Y" sort="Liu, Y" uniqKey="Liu Y" first="Y" last="Liu">Y. Liu</name></author></analytic><series><title level="j">Current biology : CB</title><idno type="ISSN">0960-9822</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigen-Presenting Cells (immunology)</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>CD8-Positive T-Lymphocytes (immunology)</term><term>In Vitro Techniques</term><term>Influenza A virus (classification)</term><term>Influenza A virus (immunology)</term><term>Lymphocyte Activation</term><term>Lymphocyte Cooperation</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred CBA</term><term>Models, Biological</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term><term>Animaux</term><term>Cellules présentatrices d'antigène (immunologie)</term><term>Coopération des lymphocytes</term><term>Lymphocytes T CD4+ (immunologie)</term><term>Lymphocytes T CD8+ (immunologie)</term><term>Modèles biologiques</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris de lignée CBA</term><term>Techniques in vitro</term><term>Virus de la grippe A ()</term><term>Virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules présentatrices d'antigène</term><term>Lymphocytes T CD4+</term><term>Lymphocytes T CD8+</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Antigen-Presenting Cells</term><term>CD4-Positive T-Lymphocytes</term><term>CD8-Positive T-Lymphocytes</term><term>Influenza A virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>In Vitro Techniques</term><term>Lymphocyte Activation</term><term>Lymphocyte Cooperation</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred CBA</term><term>Models, Biological</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term><term>Animaux</term><term>Coopération des lymphocytes</term><term>Modèles biologiques</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris de lignée CBA</term><term>Techniques in vitro</term><term>Virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">CD4+ T-cell help is critical for cytotoxic (CD8+) T-lymphocyte responses to many antigens, such as viruses, minor histocompatibility antigens and allogeneic major histocompatibility antigens. However, the nature of such help is still a mystery: cytokines such as interleukin-2 may be involved but cell-cell contact may also be necessary. As some viruses can induce CD8+ T-cell responses in the absence of CD4+ T cells, we asked whether these viruses and CD4+ cells share a pathway for helping the CD8+ T-cell response.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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