Does prenatal exposure to influenza in mice induce pyramidal cell disarray in the dorsal hippocampus?
Identifieur interne : 001D67 ( Main/Merge ); précédent : 001D66; suivant : 001D68Does prenatal exposure to influenza in mice induce pyramidal cell disarray in the dorsal hippocampus?
Auteurs : D. Cotter [Irlande (pays)] ; N. Takei ; M. Farrell ; P. Sham ; P. Quinn ; C. Larkin ; J. Oxford ; R M Murray ; E. O'CallaghanSource :
- Schizophrenia research [ 0920-9964 ] ; 1995.
Descripteurs français
- KwdFr :
- Animaux, Cellules pyramidales (anatomopathologie), Effets différés de l'exposition prénatale aux facteurs de risque, Femelle, Grossesse, Hippocampe (anatomopathologie), Infections à Orthomyxoviridae (anatomopathologie), Modèles animaux de maladie humaine, Mâle, Souris, Souris de lignée BALB C, Virus de la grippe A.
- MESH :
English descriptors
- KwdEn :
- MESH :
Abstract
Epidemiological studies point to an association between prenatal exposure to influenza and later schizophrenia. Such studies are consistent with neuropathologic reports demonstrating cytoarchitectural abnormalities in the hippocampus and parahippocampal gyrus suggestive of second trimester developmental anomalies. The hypothesis that prenatal exposure to influenza in the second trimester may induce hippocampal pyramidal cell disarray in mice was investigated. Between days 9-16 of pregnancy, 35 Balb/c mice were intranasally inoculated with either a mouse-adapted or non mouse-adapted pool of Influenza A/Singapore/1/57 (H2N2), and 10 controls were inoculated with normal saline. Offspring were sacrificed on day 21 postpartum. Microscopic examination of the CA1-CA2 junctional areas in the offspring of mice exposed to influenza failed to demonstrate excess pyramidal cell disarray when compared with influenza-free, age matched controls. There was evidence that disarray was greater among those exposed on day 13 of pregnancy. Analyses of the data by sex and severity of maternal infection failed to reveal any significant effects.
DOI: 10.1016/0920-9964(94)e0082-i
PubMed: 7488569
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Sham</name></author><author><name sortKey="Quinn, P" sort="Quinn, P" uniqKey="Quinn P" first="P" last="Quinn">P. Quinn</name></author><author><name sortKey="Larkin, C" sort="Larkin, C" uniqKey="Larkin C" first="C" last="Larkin">C. Larkin</name></author><author><name sortKey="Oxford, J" sort="Oxford, J" uniqKey="Oxford J" first="J" last="Oxford">J. Oxford</name></author><author><name sortKey="Murray, R M" sort="Murray, R M" uniqKey="Murray R" first="R M" last="Murray">R M Murray</name></author><author><name sortKey="O Callaghan, E" sort="O Callaghan, E" uniqKey="O Callaghan E" first="E" last="O'Callaghan">E. 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Cotter</name><affiliation wicri:level="1"><nlm:affiliation>Cluain Mhuire Family Centre, Blackrock, Co Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Cluain Mhuire Family Centre, Blackrock, Co Dublin</wicri:regionArea><wicri:noRegion>Co Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Takei, N" sort="Takei, N" uniqKey="Takei N" first="N" last="Takei">N. Takei</name></author><author><name sortKey="Farrell, M" sort="Farrell, M" uniqKey="Farrell M" first="M" last="Farrell">M. Farrell</name></author><author><name sortKey="Sham, P" sort="Sham, P" uniqKey="Sham P" first="P" last="Sham">P. Sham</name></author><author><name sortKey="Quinn, P" sort="Quinn, P" uniqKey="Quinn P" first="P" last="Quinn">P. Quinn</name></author><author><name sortKey="Larkin, C" sort="Larkin, C" uniqKey="Larkin C" first="C" last="Larkin">C. Larkin</name></author><author><name sortKey="Oxford, J" sort="Oxford, J" uniqKey="Oxford J" first="J" last="Oxford">J. Oxford</name></author><author><name sortKey="Murray, R M" sort="Murray, R M" uniqKey="Murray R" first="R M" last="Murray">R M Murray</name></author><author><name sortKey="O Callaghan, E" sort="O Callaghan, E" uniqKey="O Callaghan E" first="E" last="O'Callaghan">E. O'Callaghan</name></author></analytic><series><title level="j">Schizophrenia research</title><idno type="ISSN">0920-9964</idno><imprint><date when="1995" type="published">1995</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Hippocampus (pathology)</term><term>Influenza A virus</term><term>Male</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Orthomyxoviridae Infections (pathology)</term><term>Pregnancy</term><term>Prenatal Exposure Delayed Effects</term><term>Pyramidal Cells (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules pyramidales (anatomopathologie)</term><term>Effets différés de l'exposition prénatale aux facteurs de risque</term><term>Femelle</term><term>Grossesse</term><term>Hippocampe (anatomopathologie)</term><term>Infections à Orthomyxoviridae (anatomopathologie)</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules pyramidales</term><term>Hippocampe</term><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Hippocampus</term><term>Orthomyxoviridae Infections</term><term>Pyramidal Cells</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Influenza A virus</term><term>Male</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Pregnancy</term><term>Prenatal Exposure Delayed Effects</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Effets différés de l'exposition prénatale aux facteurs de risque</term><term>Femelle</term><term>Grossesse</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Epidemiological studies point to an association between prenatal exposure to influenza and later schizophrenia. Such studies are consistent with neuropathologic reports demonstrating cytoarchitectural abnormalities in the hippocampus and parahippocampal gyrus suggestive of second trimester developmental anomalies. The hypothesis that prenatal exposure to influenza in the second trimester may induce hippocampal pyramidal cell disarray in mice was investigated. Between days 9-16 of pregnancy, 35 Balb/c mice were intranasally inoculated with either a mouse-adapted or non mouse-adapted pool of Influenza A/Singapore/1/57 (H2N2), and 10 controls were inoculated with normal saline. Offspring were sacrificed on day 21 postpartum. Microscopic examination of the CA1-CA2 junctional areas in the offspring of mice exposed to influenza failed to demonstrate excess pyramidal cell disarray when compared with influenza-free, age matched controls. There was evidence that disarray was greater among those exposed on day 13 of pregnancy. Analyses of the data by sex and severity of maternal infection failed to reveal any significant effects.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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