Natural and 'in vitro' selected antigenic variants of influenza A virus (H2N2).
Identifieur interne : 001A93 ( Main/Merge ); précédent : 001A92; suivant : 001A94Natural and 'in vitro' selected antigenic variants of influenza A virus (H2N2).
Auteurs : A. Natali [Italie] ; E. Pilotti ; P P Valcavi ; C. Chezzi ; J S OxfordSource :
- The Journal of infection [ 0163-4453 ] ; 1998.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Anticorps monoclonaux, Antigènes viraux (immunologie), Femelle, Glycoprotéine hémagglutinine du virus influenza (immunologie), Grippe humaine (épidémiologie), Humains, Mâle, Répartition par âge, Sous-type H2N2 du virus de la grippe A, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests d'inhibition de l'hémagglutination, Variation des antigènes, Virus de la grippe A (), Virus de la grippe A (immunologie), Études séroépidémiologiques.
- MESH :
- immunologie : Antigènes viraux, Glycoprotéine hémagglutinine du virus influenza, Virus de la grippe A.
- sang : Anticorps antiviraux.
- épidémiologie : Grippe humaine.
- Adulte, Adulte d'âge moyen, Anticorps monoclonaux, Femelle, Humains, Mâle, Répartition par âge, Sous-type H2N2 du virus de la grippe A, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests d'inhibition de l'hémagglutination, Variation des antigènes, Virus de la grippe A, Études séroépidémiologiques.
English descriptors
- KwdEn :
- Adult, Age Distribution, Aged, Aged, 80 and over, Antibodies, Monoclonal, Antibodies, Viral (blood), Antigenic Variation, Antigens, Viral (immunology), Female, Hemagglutination Inhibition Tests, Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Influenza A Virus, H2N2 Subtype, Influenza A virus (classification), Influenza A virus (immunology), Influenza, Human (epidemiology), Male, Middle Aged, Seroepidemiologic Studies.
- MESH :
- chemical , blood : Antibodies, Viral.
- chemical , immunology : Antigens, Viral, Hemagglutinin Glycoproteins, Influenza Virus.
- chemical : Antibodies, Monoclonal.
- classification : Influenza A virus.
- epidemiology : Influenza, Human.
- immunology : Influenza A virus.
- Adult, Age Distribution, Aged, Aged, 80 and over, Antigenic Variation, Female, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H2N2 Subtype, Male, Middle Aged, Seroepidemiologic Studies.
Abstract
We provide data on the prevalence of SRH antibody to influenza A/Singapore/1/57 (H2N2). Approximately 10.3% of sera had antibody to the influenza A (H2N2) subtype virus in comparison to the 36.9% of positive sera to a representative influenza A (H3N2) and 31.5% to influenza A (H1N1) viruses. The percentage of subjects with antibody constantly decreased from the older to the younger age groups. Persons born after 1968 were essentially seronegative, whereas subjects born before 1900, and in the decade 1950-1959, showed the highest antibody levels to influenza A (H2N2) viruses. These age groups also appeared to have 'protective' levels of anti-HA antibody to influenza A (H2N2) virus. An antigenic variant of A/Singapore/1/57 virus was selected in the laboratory using a monoclonal antibody to HA. Serological comparison of the new in vitro variant with the parental virus and two naturally occurring viruses, namely A/England/12/64 and Tokyo/3/67, showed that certain human sera were able to distinguish the variant, indicating a restricted antibody repertoire in these adult and children's sera, providing an explanation of how such variants could actually arise in nature.
DOI: 10.1016/s0163-4453(98)90260-2
PubMed: 9733372
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pubmed:9733372Le document en format XML
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<term>Age Distribution</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antibodies, Monoclonal</term>
<term>Antibodies, Viral (blood)</term>
<term>Antigenic Variation</term>
<term>Antigens, Viral (immunology)</term>
<term>Female</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term>
<term>Humans</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A virus (classification)</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Seroepidemiologic Studies</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Anticorps antiviraux (sang)</term>
<term>Anticorps monoclonaux</term>
<term>Antigènes viraux (immunologie)</term>
<term>Femelle</term>
<term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains</term>
<term>Mâle</term>
<term>Répartition par âge</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Variation des antigènes</term>
<term>Virus de la grippe A ()</term>
<term>Virus de la grippe A (immunologie)</term>
<term>Études séroépidémiologiques</term>
</keywords>
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<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
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</keywords>
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<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Virus de la grippe A</term>
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<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term>
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<term>Age Distribution</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antigenic Variation</term>
<term>Female</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Seroepidemiologic Studies</term>
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<term>Adulte d'âge moyen</term>
<term>Anticorps monoclonaux</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Répartition par âge</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Variation des antigènes</term>
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<front><div type="abstract" xml:lang="en">We provide data on the prevalence of SRH antibody to influenza A/Singapore/1/57 (H2N2). Approximately 10.3% of sera had antibody to the influenza A (H2N2) subtype virus in comparison to the 36.9% of positive sera to a representative influenza A (H3N2) and 31.5% to influenza A (H1N1) viruses. The percentage of subjects with antibody constantly decreased from the older to the younger age groups. Persons born after 1968 were essentially seronegative, whereas subjects born before 1900, and in the decade 1950-1959, showed the highest antibody levels to influenza A (H2N2) viruses. These age groups also appeared to have 'protective' levels of anti-HA antibody to influenza A (H2N2) virus. An antigenic variant of A/Singapore/1/57 virus was selected in the laboratory using a monoclonal antibody to HA. Serological comparison of the new in vitro variant with the parental virus and two naturally occurring viruses, namely A/England/12/64 and Tokyo/3/67, showed that certain human sera were able to distinguish the variant, indicating a restricted antibody repertoire in these adult and children's sera, providing an explanation of how such variants could actually arise in nature.</div>
</front>
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