Natural and 'in vitro' selected antigenic variants of influenza A virus (H2N2).
Identifieur interne : 000347 ( PubMed/Checkpoint ); précédent : 000346; suivant : 000348Natural and 'in vitro' selected antigenic variants of influenza A virus (H2N2).
Auteurs : A. Natali [Italie] ; E. Pilotti ; P P Valcavi ; C. Chezzi ; J S OxfordSource :
- The Journal of infection [ 0163-4453 ] ; 1998.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Anticorps monoclonaux, Antigènes viraux (immunologie), Femelle, Glycoprotéine hémagglutinine du virus influenza (immunologie), Grippe humaine (épidémiologie), Humains, Mâle, Répartition par âge, Sous-type H2N2 du virus de la grippe A, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests d'inhibition de l'hémagglutination, Variation des antigènes, Virus de la grippe A (), Virus de la grippe A (immunologie), Études séroépidémiologiques.
- MESH :
- immunologie : Antigènes viraux, Glycoprotéine hémagglutinine du virus influenza, Virus de la grippe A.
- sang : Anticorps antiviraux.
- épidémiologie : Grippe humaine.
- Adulte, Adulte d'âge moyen, Anticorps monoclonaux, Femelle, Humains, Mâle, Répartition par âge, Sous-type H2N2 du virus de la grippe A, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests d'inhibition de l'hémagglutination, Variation des antigènes, Virus de la grippe A, Études séroépidémiologiques.
English descriptors
- KwdEn :
- Adult, Age Distribution, Aged, Aged, 80 and over, Antibodies, Monoclonal, Antibodies, Viral (blood), Antigenic Variation, Antigens, Viral (immunology), Female, Hemagglutination Inhibition Tests, Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Influenza A Virus, H2N2 Subtype, Influenza A virus (classification), Influenza A virus (immunology), Influenza, Human (epidemiology), Male, Middle Aged, Seroepidemiologic Studies.
- MESH :
- chemical , blood : Antibodies, Viral.
- chemical , immunology : Antigens, Viral, Hemagglutinin Glycoproteins, Influenza Virus.
- chemical : Antibodies, Monoclonal.
- classification : Influenza A virus.
- epidemiology : Influenza, Human.
- immunology : Influenza A virus.
- Adult, Age Distribution, Aged, Aged, 80 and over, Antigenic Variation, Female, Hemagglutination Inhibition Tests, Humans, Influenza A Virus, H2N2 Subtype, Male, Middle Aged, Seroepidemiologic Studies.
Abstract
We provide data on the prevalence of SRH antibody to influenza A/Singapore/1/57 (H2N2). Approximately 10.3% of sera had antibody to the influenza A (H2N2) subtype virus in comparison to the 36.9% of positive sera to a representative influenza A (H3N2) and 31.5% to influenza A (H1N1) viruses. The percentage of subjects with antibody constantly decreased from the older to the younger age groups. Persons born after 1968 were essentially seronegative, whereas subjects born before 1900, and in the decade 1950-1959, showed the highest antibody levels to influenza A (H2N2) viruses. These age groups also appeared to have 'protective' levels of anti-HA antibody to influenza A (H2N2) virus. An antigenic variant of A/Singapore/1/57 virus was selected in the laboratory using a monoclonal antibody to HA. Serological comparison of the new in vitro variant with the parental virus and two naturally occurring viruses, namely A/England/12/64 and Tokyo/3/67, showed that certain human sera were able to distinguish the variant, indicating a restricted antibody repertoire in these adult and children's sera, providing an explanation of how such variants could actually arise in nature.
DOI: 10.1016/s0163-4453(98)90260-2
PubMed: 9733372
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:9733372Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Natural and 'in vitro' selected antigenic variants of influenza A virus (H2N2).</title><author><name sortKey="Natali, A" sort="Natali, A" uniqKey="Natali A" first="A" last="Natali">A. Natali</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, University of Parma, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Microbiology, University of Parma</wicri:regionArea><wicri:noRegion>University of Parma</wicri:noRegion></affiliation></author><author><name sortKey="Pilotti, E" sort="Pilotti, E" uniqKey="Pilotti E" first="E" last="Pilotti">E. Pilotti</name></author><author><name sortKey="Valcavi, P P" sort="Valcavi, P P" uniqKey="Valcavi P" first="P P" last="Valcavi">P P Valcavi</name></author><author><name sortKey="Chezzi, C" sort="Chezzi, C" uniqKey="Chezzi C" first="C" last="Chezzi">C. Chezzi</name></author><author><name sortKey="Oxford, J S" sort="Oxford, J S" uniqKey="Oxford J" first="J S" last="Oxford">J S Oxford</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9733372</idno><idno type="pmid">9733372</idno><idno type="doi">10.1016/s0163-4453(98)90260-2</idno><idno type="wicri:Area/PubMed/Corpus">000378</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000378</idno><idno type="wicri:Area/PubMed/Curation">000378</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000378</idno><idno type="wicri:Area/PubMed/Checkpoint">000347</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000347</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Natural and 'in vitro' selected antigenic variants of influenza A virus (H2N2).</title><author><name sortKey="Natali, A" sort="Natali, A" uniqKey="Natali A" first="A" last="Natali">A. Natali</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology, University of Parma, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Microbiology, University of Parma</wicri:regionArea><wicri:noRegion>University of Parma</wicri:noRegion></affiliation></author><author><name sortKey="Pilotti, E" sort="Pilotti, E" uniqKey="Pilotti E" first="E" last="Pilotti">E. Pilotti</name></author><author><name sortKey="Valcavi, P P" sort="Valcavi, P P" uniqKey="Valcavi P" first="P P" last="Valcavi">P P Valcavi</name></author><author><name sortKey="Chezzi, C" sort="Chezzi, C" uniqKey="Chezzi C" first="C" last="Chezzi">C. Chezzi</name></author><author><name sortKey="Oxford, J S" sort="Oxford, J S" uniqKey="Oxford J" first="J S" last="Oxford">J S Oxford</name></author></analytic><series><title level="j">The Journal of infection</title><idno type="ISSN">0163-4453</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Distribution</term><term>Aged</term><term>Aged, 80 and over</term><term>Antibodies, Monoclonal</term><term>Antibodies, Viral (blood)</term><term>Antigenic Variation</term><term>Antigens, Viral (immunology)</term><term>Female</term><term>Hemagglutination Inhibition Tests</term><term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term><term>Humans</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A virus (classification)</term><term>Influenza A virus (immunology)</term><term>Influenza, Human (epidemiology)</term><term>Male</term><term>Middle Aged</term><term>Seroepidemiologic Studies</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps antiviraux (sang)</term><term>Anticorps monoclonaux</term><term>Antigènes viraux (immunologie)</term><term>Femelle</term><term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Mâle</term><term>Répartition par âge</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tests d'inhibition de l'hémagglutination</term><term>Variation des antigènes</term><term>Virus de la grippe A ()</term><term>Virus de la grippe A (immunologie)</term><term>Études séroépidémiologiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Monoclonal</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes viraux</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Distribution</term><term>Aged</term><term>Aged, 80 and over</term><term>Antigenic Variation</term><term>Female</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Influenza A Virus, H2N2 Subtype</term><term>Male</term><term>Middle Aged</term><term>Seroepidemiologic Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps monoclonaux</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Répartition par âge</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tests d'inhibition de l'hémagglutination</term><term>Variation des antigènes</term><term>Virus de la grippe A</term><term>Études séroépidémiologiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We provide data on the prevalence of SRH antibody to influenza A/Singapore/1/57 (H2N2). Approximately 10.3% of sera had antibody to the influenza A (H2N2) subtype virus in comparison to the 36.9% of positive sera to a representative influenza A (H3N2) and 31.5% to influenza A (H1N1) viruses. The percentage of subjects with antibody constantly decreased from the older to the younger age groups. Persons born after 1968 were essentially seronegative, whereas subjects born before 1900, and in the decade 1950-1959, showed the highest antibody levels to influenza A (H2N2) viruses. These age groups also appeared to have 'protective' levels of anti-HA antibody to influenza A (H2N2) virus. An antigenic variant of A/Singapore/1/57 virus was selected in the laboratory using a monoclonal antibody to HA. Serological comparison of the new in vitro variant with the parental virus and two naturally occurring viruses, namely A/England/12/64 and Tokyo/3/67, showed that certain human sera were able to distinguish the variant, indicating a restricted antibody repertoire in these adult and children's sera, providing an explanation of how such variants could actually arise in nature.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9733372</PMID><DateCompleted><Year>1998</Year><Month>12</Month><Day>10</Day></DateCompleted><DateRevised><Year>2019</Year><Month>09</Month><Day>05</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0163-4453</ISSN><JournalIssue CitedMedium="Print"><Volume>37</Volume><Issue>1</Issue><PubDate><Year>1998</Year><Month>Jul</Month></PubDate></JournalIssue><Title>The Journal of infection</Title><ISOAbbreviation>J. Infect.</ISOAbbreviation></Journal><ArticleTitle>Natural and 'in vitro' selected antigenic variants of influenza A virus (H2N2).</ArticleTitle><Pagination><MedlinePgn>19-23</MedlinePgn></Pagination><Abstract><AbstractText>We provide data on the prevalence of SRH antibody to influenza A/Singapore/1/57 (H2N2). Approximately 10.3% of sera had antibody to the influenza A (H2N2) subtype virus in comparison to the 36.9% of positive sera to a representative influenza A (H3N2) and 31.5% to influenza A (H1N1) viruses. The percentage of subjects with antibody constantly decreased from the older to the younger age groups. Persons born after 1968 were essentially seronegative, whereas subjects born before 1900, and in the decade 1950-1959, showed the highest antibody levels to influenza A (H2N2) viruses. These age groups also appeared to have 'protective' levels of anti-HA antibody to influenza A (H2N2) virus. An antigenic variant of A/Singapore/1/57 virus was selected in the laboratory using a monoclonal antibody to HA. Serological comparison of the new in vitro variant with the parental virus and two naturally occurring viruses, namely A/England/12/64 and Tokyo/3/67, showed that certain human sera were able to distinguish the variant, indicating a restricted antibody repertoire in these adult and children's sera, providing an explanation of how such variants could actually arise in nature.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Natali</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Microbiology, University of Parma, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pilotti</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Valcavi</LastName><ForeName>P P</ForeName><Initials>PP</Initials></Author><Author ValidYN="Y"><LastName>Chezzi</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Oxford</LastName><ForeName>J S</ForeName><Initials>JS</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Infect</MedlineTA><NlmUniqueID>7908424</NlmUniqueID><ISSNLinking>0163-4453</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000956">Antigens, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019267">Hemagglutinin Glycoproteins, Influenza Virus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017677" MajorTopicYN="N">Age Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000911" MajorTopicYN="N">Antibodies, Monoclonal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000940" MajorTopicYN="Y">Antigenic Variation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000956" MajorTopicYN="N">Antigens, Viral</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006385" MajorTopicYN="N">Hemagglutination Inhibition Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019267" MajorTopicYN="N">Hemagglutinin Glycoproteins, Influenza Virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053121" MajorTopicYN="Y">Influenza A Virus, H2N2 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="Y">classification</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016036" MajorTopicYN="N">Seroepidemiologic Studies</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1998</Year><Month>11</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1998</Year><Month>11</Month><Day>20</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1998</Year><Month>11</Month><Day>20</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9733372</ArticleId><ArticleId IdType="pii">S0163-4453(98)90260-2</ArticleId><ArticleId IdType="doi">10.1016/s0163-4453(98)90260-2</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Chezzi, C" sort="Chezzi, C" uniqKey="Chezzi C" first="C" last="Chezzi">C. Chezzi</name><name sortKey="Oxford, J S" sort="Oxford, J S" uniqKey="Oxford J" first="J S" last="Oxford">J S Oxford</name><name sortKey="Pilotti, E" sort="Pilotti, E" uniqKey="Pilotti E" first="E" last="Pilotti">E. Pilotti</name><name sortKey="Valcavi, P P" sort="Valcavi, P P" uniqKey="Valcavi P" first="P P" last="Valcavi">P P Valcavi</name></noCountry><country name="Italie"><noRegion><name sortKey="Natali, A" sort="Natali, A" uniqKey="Natali A" first="A" last="Natali">A. Natali</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000347 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000347 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:9733372
|texte= Natural and 'in vitro' selected antigenic variants of influenza A virus (H2N2).
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:9733372" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |