Animal models in influenza vaccine testing.
Identifieur interne : 001292 ( Main/Merge ); précédent : 001291; suivant : 001293Animal models in influenza vaccine testing.
Auteurs : Jan Willem Van Der Laan [Pays-Bas] ; Carla Herberts ; Robert Lambkin-Williams ; Alison Boyers ; Alexander J. Mann ; John OxfordSource :
- Expert review of vaccines [ 1744-8395 ] ; 2008.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Influenza Vaccines.
- prevention & control : Orthomyxoviridae Infections.
- Animals, Ferrets, Humans, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H5N1 Subtype, Macaca, Mice, Models, Animal.
Abstract
The threat of a pandemic outbreak of influenza A H5N1 and H2N2 has brought attention to the development of new vaccines. Regulatory authorities require companies to provide data proving the effectiveness of vaccines, which cannot, however, be based on real efficacy data in humans. A weight-of-evidence approach may be used, based on evidence of protection in an appropriate animal model and the satisfaction of the surrogate end points in the clinical situation. In this review, we will discuss various animal species that can be infected with influenza. The main animals used for testing vaccines destined for human use are laboratory mice and ferrets and, to a lesser extent, macaques. We will focus particularly on these species.
DOI: 10.1586/14760584.7.6.783
PubMed: 18665776
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<term>Ferrets</term>
<term>Humans</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A Virus, H5N1 Subtype</term>
<term>Influenza Vaccines (immunology)</term>
<term>Macaca</term>
<term>Mice</term>
<term>Models, Animal</term>
<term>Orthomyxoviridae Infections (prevention & control)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Furets</term>
<term>Humains</term>
<term>Infections à Orthomyxoviridae ()</term>
<term>Macaca</term>
<term>Modèles animaux</term>
<term>Souris</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Sous-type H5N1 du virus de la grippe A</term>
<term>Vaccins antigrippaux (immunologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term>
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<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A Virus, H5N1 Subtype</term>
<term>Macaca</term>
<term>Mice</term>
<term>Models, Animal</term>
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<term>Infections à Orthomyxoviridae</term>
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<term>Modèles animaux</term>
<term>Souris</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
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<front><div type="abstract" xml:lang="en">The threat of a pandemic outbreak of influenza A H5N1 and H2N2 has brought attention to the development of new vaccines. Regulatory authorities require companies to provide data proving the effectiveness of vaccines, which cannot, however, be based on real efficacy data in humans. A weight-of-evidence approach may be used, based on evidence of protection in an appropriate animal model and the satisfaction of the surrogate end points in the clinical situation. In this review, we will discuss various animal species that can be infected with influenza. The main animals used for testing vaccines destined for human use are laboratory mice and ferrets and, to a lesser extent, macaques. We will focus particularly on these species.</div>
</front>
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