Animal models in influenza vaccine testing.
Identifieur interne : 000309 ( Ncbi/Merge ); précédent : 000308; suivant : 000310Animal models in influenza vaccine testing.
Auteurs : Jan Willem Van Der Laan [Pays-Bas] ; Carla Herberts ; Robert Lambkin-Williams ; Alison Boyers ; Alexander J. Mann ; John OxfordSource :
- Expert review of vaccines [ 1744-8395 ] ; 2008.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Influenza Vaccines.
- prevention & control : Orthomyxoviridae Infections.
- Animals, Ferrets, Humans, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H5N1 Subtype, Macaca, Mice, Models, Animal.
Abstract
The threat of a pandemic outbreak of influenza A H5N1 and H2N2 has brought attention to the development of new vaccines. Regulatory authorities require companies to provide data proving the effectiveness of vaccines, which cannot, however, be based on real efficacy data in humans. A weight-of-evidence approach may be used, based on evidence of protection in an appropriate animal model and the satisfaction of the surrogate end points in the clinical situation. In this review, we will discuss various animal species that can be infected with influenza. The main animals used for testing vaccines destined for human use are laboratory mice and ferrets and, to a lesser extent, macaques. We will focus particularly on these species.
DOI: 10.1586/14760584.7.6.783
PubMed: 18665776
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Mann</name></author><author><name sortKey="Oxford, John" sort="Oxford, John" uniqKey="Oxford J" first="John" last="Oxford">John Oxford</name></author></analytic><series><title level="j">Expert review of vaccines</title><idno type="eISSN">1744-8395</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Ferrets</term><term>Humans</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza Vaccines (immunology)</term><term>Macaca</term><term>Mice</term><term>Models, Animal</term><term>Orthomyxoviridae Infections (prevention & control)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Furets</term><term>Humains</term><term>Infections à Orthomyxoviridae ()</term><term>Macaca</term><term>Modèles animaux</term><term>Souris</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H5N1 du virus de la grippe A</term><term>Vaccins antigrippaux (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Ferrets</term><term>Humans</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H5N1 Subtype</term><term>Macaca</term><term>Mice</term><term>Models, Animal</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Furets</term><term>Humains</term><term>Infections à Orthomyxoviridae</term><term>Macaca</term><term>Modèles animaux</term><term>Souris</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H5N1 du virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The threat of a pandemic outbreak of influenza A H5N1 and H2N2 has brought attention to the development of new vaccines. Regulatory authorities require companies to provide data proving the effectiveness of vaccines, which cannot, however, be based on real efficacy data in humans. A weight-of-evidence approach may be used, based on evidence of protection in an appropriate animal model and the satisfaction of the surrogate end points in the clinical situation. In this review, we will discuss various animal species that can be infected with influenza. The main animals used for testing vaccines destined for human use are laboratory mice and ferrets and, to a lesser extent, macaques. We will focus particularly on these species.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18665776</PMID><DateCompleted><Year>2008</Year><Month>09</Month><Day>08</Day></DateCompleted><DateRevised><Year>2008</Year><Month>10</Month><Day>06</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1744-8395</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>6</Issue><PubDate><Year>2008</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Expert review of vaccines</Title><ISOAbbreviation>Expert Rev Vaccines</ISOAbbreviation></Journal><ArticleTitle>Animal models in influenza vaccine testing.</ArticleTitle><Pagination><MedlinePgn>783-93</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1586/14760584.7.6.783</ELocationID><Abstract><AbstractText>The threat of a pandemic outbreak of influenza A H5N1 and H2N2 has brought attention to the development of new vaccines. Regulatory authorities require companies to provide data proving the effectiveness of vaccines, which cannot, however, be based on real efficacy data in humans. A weight-of-evidence approach may be used, based on evidence of protection in an appropriate animal model and the satisfaction of the surrogate end points in the clinical situation. In this review, we will discuss various animal species that can be infected with influenza. The main animals used for testing vaccines destined for human use are laboratory mice and ferrets and, to a lesser extent, macaques. We will focus particularly on these species.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>van der Laan</LastName><ForeName>Jan Willem</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>Section on Safety of Medicines and Teratology, Centre for Biological Medicines and Medical Technology, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands. jan-willem.van.der.laan@rivm.nl</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herberts</LastName><ForeName>Carla</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Lambkin-Williams</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Boyers</LastName><ForeName>Alison</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Mann</LastName><ForeName>Alexander J</ForeName><Initials>AJ</Initials></Author><Author ValidYN="Y"><LastName>Oxford</LastName><ForeName>John</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Expert Rev Vaccines</MedlineTA><NlmUniqueID>101155475</NlmUniqueID><ISSNLinking>1476-0584</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005289" MajorTopicYN="N">Ferrets</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053121" MajorTopicYN="N">Influenza A Virus, H2N2 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053124" MajorTopicYN="N">Influenza A Virus, H5N1 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008251" MajorTopicYN="N">Macaca</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D023421" MajorTopicYN="Y">Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading></MeshHeadingList><NumberOfReferences>105</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>7</Month><Day>31</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>9</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>7</Month><Day>31</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18665776</ArticleId><ArticleId IdType="doi">10.1586/14760584.7.6.783</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="Boyers, Alison" sort="Boyers, Alison" uniqKey="Boyers A" first="Alison" last="Boyers">Alison Boyers</name><name sortKey="Herberts, Carla" sort="Herberts, Carla" uniqKey="Herberts C" first="Carla" last="Herberts">Carla Herberts</name><name sortKey="Lambkin Williams, Robert" sort="Lambkin Williams, Robert" uniqKey="Lambkin Williams R" first="Robert" last="Lambkin-Williams">Robert Lambkin-Williams</name><name sortKey="Mann, Alexander J" sort="Mann, Alexander J" uniqKey="Mann A" first="Alexander J" last="Mann">Alexander J. Mann</name><name sortKey="Oxford, John" sort="Oxford, John" uniqKey="Oxford J" first="John" last="Oxford">John Oxford</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Van Der Laan, Jan Willem" sort="Van Der Laan, Jan Willem" uniqKey="Van Der Laan J" first="Jan Willem" last="Van Der Laan">Jan Willem Van Der Laan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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