Serveur d'exploration H2N2

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells.

Identifieur interne : 000E46 ( Main/Merge ); précédent : 000E45; suivant : 000E47

Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells.

Auteurs : Ryan A. Langlois [États-Unis] ; Kevin L. Legge

Source :

RBID : pubmed:20220091

Descripteurs français

English descriptors

Abstract

Previous studies have shown that the reduction in CD8 T cell immunity observed during high-dose influenza A virus (IAV) infection is mediated via lymph node (LN) dendritic cells (DCs) that express Fas ligand (FasL) and drive FasL-Fas (DC-T)-induced apoptosis. However, the specific DC subset(s) within the LN and the additional factors required for DC-mediated elimination of IAV-specific CD8 T cells remain unknown. In this paper, we demonstrate that plasmacytoid DCs (pDCs), which downregulate FasL during sublethal, but not lethal, IAV infection, accumulate to greater numbers within the LNs of lethal dose-infected mice. Further our findings show that pDCs from lethal, but not sublethal, dose IAV infections drive elimination of Fas(+) CD8 T cells and that this elimination occurs only in the absence of TCR recognition of IAV peptide-MHC class I complexes. Together, these results suggest that pDCs play a heretofore unknown deleterious role during lethal dose IAV infections by limiting the CD8 T cell response.

DOI: 10.4049/jimmunol.0902984
PubMed: 20220091

Links toward previous steps (curation, corpus...)


Links to Exploration step

pubmed:20220091

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells.</title>
<author>
<name sortKey="Langlois, Ryan A" sort="Langlois, Ryan A" uniqKey="Langlois R" first="Ryan A" last="Langlois">Ryan A. Langlois</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Pathology, University of Iowa, Iowa City, IA 52242, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, University of Iowa, Iowa City, IA 52242</wicri:regionArea>
<orgName type="university">Université de l'Iowa</orgName>
<placeName>
<settlement type="city">Iowa City</settlement>
<region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Legge, Kevin L" sort="Legge, Kevin L" uniqKey="Legge K" first="Kevin L" last="Legge">Kevin L. Legge</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PubMed</idno>
<date when="2010">2010</date>
<idno type="RBID">pubmed:20220091</idno>
<idno type="pmid">20220091</idno>
<idno type="doi">10.4049/jimmunol.0902984</idno>
<idno type="wicri:Area/PubMed/Corpus">000207</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000207</idno>
<idno type="wicri:Area/PubMed/Curation">000207</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000207</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000177</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000177</idno>
<idno type="wicri:Area/Ncbi/Merge">000500</idno>
<idno type="wicri:Area/Ncbi/Curation">000500</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000500</idno>
<idno type="wicri:Area/Main/Merge">000E46</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells.</title>
<author>
<name sortKey="Langlois, Ryan A" sort="Langlois, Ryan A" uniqKey="Langlois R" first="Ryan A" last="Langlois">Ryan A. Langlois</name>
<affiliation wicri:level="4">
<nlm:affiliation>Department of Pathology, University of Iowa, Iowa City, IA 52242, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, University of Iowa, Iowa City, IA 52242</wicri:regionArea>
<orgName type="university">Université de l'Iowa</orgName>
<placeName>
<settlement type="city">Iowa City</settlement>
<region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Legge, Kevin L" sort="Legge, Kevin L" uniqKey="Legge K" first="Kevin L" last="Legge">Kevin L. Legge</name>
</author>
</analytic>
<series>
<title level="j">Journal of immunology (Baltimore, Md. : 1950)</title>
<idno type="eISSN">1550-6606</idno>
<imprint>
<date when="2010" type="published">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Adoptive Transfer</term>
<term>Animals</term>
<term>Apoptosis (immunology)</term>
<term>CD8 Antigens (biosynthesis)</term>
<term>CD8-Positive T-Lymphocytes (immunology)</term>
<term>CD8-Positive T-Lymphocytes (metabolism)</term>
<term>CD8-Positive T-Lymphocytes (pathology)</term>
<term>Cell Movement (immunology)</term>
<term>Dendritic Cells (immunology)</term>
<term>Dendritic Cells (metabolism)</term>
<term>Dendritic Cells (transplantation)</term>
<term>Down-Regulation (immunology)</term>
<term>Fas Ligand Protein (antagonists & inhibitors)</term>
<term>Fas Ligand Protein (biosynthesis)</term>
<term>Fas Ligand Protein (physiology)</term>
<term>Immunophenotyping</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza A Virus, H2N2 Subtype (immunology)</term>
<term>Lymph Nodes (immunology)</term>
<term>Lymph Nodes (pathology)</term>
<term>Lymph Nodes (virology)</term>
<term>Lymphocyte Activation (immunology)</term>
<term>Lymphocyte Count</term>
<term>Lymphocyte Depletion (methods)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Mice, Transgenic</term>
<term>Orthomyxoviridae Infections (immunology)</term>
<term>Orthomyxoviridae Infections (mortality)</term>
<term>Orthomyxoviridae Infections (pathology)</term>
<term>fas Receptor (biosynthesis)</term>
<term>fas Receptor (physiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Activation des lymphocytes (immunologie)</term>
<term>Animaux</term>
<term>Apoptose (immunologie)</term>
<term>Cellules dendritiques (immunologie)</term>
<term>Cellules dendritiques (métabolisme)</term>
<term>Cellules dendritiques (transplantation)</term>
<term>Déplétion lymphocytaire ()</term>
<term>Immunophénotypage</term>
<term>Infections à Orthomyxoviridae (anatomopathologie)</term>
<term>Infections à Orthomyxoviridae (immunologie)</term>
<term>Infections à Orthomyxoviridae (mortalité)</term>
<term>Ligand de Fas (antagonistes et inhibiteurs)</term>
<term>Ligand de Fas (biosynthèse)</term>
<term>Ligand de Fas (physiologie)</term>
<term>Lymphocytes T CD8+ (anatomopathologie)</term>
<term>Lymphocytes T CD8+ (immunologie)</term>
<term>Lymphocytes T CD8+ (métabolisme)</term>
<term>Mouvement cellulaire (immunologie)</term>
<term>Noeuds lymphatiques (anatomopathologie)</term>
<term>Noeuds lymphatiques (immunologie)</term>
<term>Noeuds lymphatiques (virologie)</term>
<term>Numération des lymphocytes</term>
<term>Régulation négative (immunologie)</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Souris transgéniques</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
<term>Sous-type H2N2 du virus de la grippe A (immunologie)</term>
<term>Transfert adoptif</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en">
<term>Fas Ligand Protein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en">
<term>CD8 Antigens</term>
<term>Fas Ligand Protein</term>
<term>fas Receptor</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr">
<term>Infections à Orthomyxoviridae</term>
<term>Lymphocytes T CD8+</term>
<term>Noeuds lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr">
<term>Ligand de Fas</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr">
<term>Ligand de Fas</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr">
<term>Activation des lymphocytes</term>
<term>Apoptose</term>
<term>Cellules dendritiques</term>
<term>Infections à Orthomyxoviridae</term>
<term>Lymphocytes T CD8+</term>
<term>Mouvement cellulaire</term>
<term>Noeuds lymphatiques</term>
<term>Régulation négative</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en">
<term>Apoptosis</term>
<term>CD8-Positive T-Lymphocytes</term>
<term>Cell Movement</term>
<term>Dendritic Cells</term>
<term>Down-Regulation</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Lymph Nodes</term>
<term>Lymphocyte Activation</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en">
<term>CD8-Positive T-Lymphocytes</term>
<term>Dendritic Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en">
<term>Lymphocyte Depletion</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en">
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr">
<term>Infections à Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr">
<term>Cellules dendritiques</term>
<term>Lymphocytes T CD8+</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>CD8-Positive T-Lymphocytes</term>
<term>Lymph Nodes</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr">
<term>Ligand de Fas</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en">
<term>Fas Ligand Protein</term>
<term>fas Receptor</term>
</keywords>
<keywords scheme="MESH" qualifier="transplantation" xml:lang="en">
<term>Dendritic Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr">
<term>Noeuds lymphatiques</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en">
<term>Lymph Nodes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adoptive Transfer</term>
<term>Animals</term>
<term>Immunophenotyping</term>
<term>Lymphocyte Count</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Mice, Transgenic</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr">
<term>Animaux</term>
<term>Cellules dendritiques</term>
<term>Déplétion lymphocytaire</term>
<term>Immunophénotypage</term>
<term>Numération des lymphocytes</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Souris transgéniques</term>
<term>Transfert adoptif</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Previous studies have shown that the reduction in CD8 T cell immunity observed during high-dose influenza A virus (IAV) infection is mediated via lymph node (LN) dendritic cells (DCs) that express Fas ligand (FasL) and drive FasL-Fas (DC-T)-induced apoptosis. However, the specific DC subset(s) within the LN and the additional factors required for DC-mediated elimination of IAV-specific CD8 T cells remain unknown. In this paper, we demonstrate that plasmacytoid DCs (pDCs), which downregulate FasL during sublethal, but not lethal, IAV infection, accumulate to greater numbers within the LNs of lethal dose-infected mice. Further our findings show that pDCs from lethal, but not sublethal, dose IAV infections drive elimination of Fas(+) CD8 T cells and that this elimination occurs only in the absence of TCR recognition of IAV peptide-MHC class I complexes. Together, these results suggest that pDCs play a heretofore unknown deleterious role during lethal dose IAV infections by limiting the CD8 T cell response.</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E46 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000E46 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     pubmed:20220091
   |texte=   Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i   -Sk "pubmed:20220091" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a H2N2V1 

Wicri

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021