Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells.
Identifieur interne : 000500 ( Ncbi/Curation ); précédent : 000499; suivant : 000501Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells.
Auteurs : Ryan A. Langlois [États-Unis] ; Kevin L. LeggeSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 1550-6606 ] ; 2010.
Descripteurs français
- KwdFr :
- Activation des lymphocytes (immunologie), Animaux, Apoptose (immunologie), Cellules dendritiques (immunologie), Cellules dendritiques (métabolisme), Cellules dendritiques (transplantation), Déplétion lymphocytaire (), Immunophénotypage, Infections à Orthomyxoviridae (anatomopathologie), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (mortalité), Ligand de Fas (antagonistes et inhibiteurs), Ligand de Fas (biosynthèse), Ligand de Fas (physiologie), Lymphocytes T CD8+ (anatomopathologie), Lymphocytes T CD8+ (immunologie), Lymphocytes T CD8+ (métabolisme), Mouvement cellulaire (immunologie), Noeuds lymphatiques (anatomopathologie), Noeuds lymphatiques (immunologie), Noeuds lymphatiques (virologie), Numération des lymphocytes, Régulation négative (immunologie), Souris, Souris de lignée BALB C, Souris transgéniques, Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H2N2 du virus de la grippe A (immunologie), Transfert adoptif.
- MESH :
- anatomopathologie : Infections à Orthomyxoviridae, Lymphocytes T CD8+, Noeuds lymphatiques.
- antagonistes et inhibiteurs : Ligand de Fas.
- biosynthèse : Ligand de Fas.
- immunologie : Activation des lymphocytes, Apoptose, Cellules dendritiques, Infections à Orthomyxoviridae, Lymphocytes T CD8+, Mouvement cellulaire, Noeuds lymphatiques, Régulation négative, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A.
- mortalité : Infections à Orthomyxoviridae.
- métabolisme : Cellules dendritiques, Lymphocytes T CD8+.
- physiologie : Ligand de Fas.
- virologie : Noeuds lymphatiques.
- Animaux, Cellules dendritiques, Déplétion lymphocytaire, Immunophénotypage, Numération des lymphocytes, Souris, Souris de lignée BALB C, Souris transgéniques, Transfert adoptif.
English descriptors
- KwdEn :
- Adoptive Transfer, Animals, Apoptosis (immunology), CD8 Antigens (biosynthesis), CD8-Positive T-Lymphocytes (immunology), CD8-Positive T-Lymphocytes (metabolism), CD8-Positive T-Lymphocytes (pathology), Cell Movement (immunology), Dendritic Cells (immunology), Dendritic Cells (metabolism), Dendritic Cells (transplantation), Down-Regulation (immunology), Fas Ligand Protein (antagonists & inhibitors), Fas Ligand Protein (biosynthesis), Fas Ligand Protein (physiology), Immunophenotyping, Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H2N2 Subtype (immunology), Lymph Nodes (immunology), Lymph Nodes (pathology), Lymph Nodes (virology), Lymphocyte Activation (immunology), Lymphocyte Count, Lymphocyte Depletion (methods), Mice, Mice, Inbred BALB C, Mice, Transgenic, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (mortality), Orthomyxoviridae Infections (pathology), fas Receptor (biosynthesis), fas Receptor (physiology).
- MESH :
- chemical , antagonists & inhibitors : Fas Ligand Protein.
- chemical , biosynthesis : CD8 Antigens, Fas Ligand Protein, fas Receptor.
- immunology : Apoptosis, CD8-Positive T-Lymphocytes, Cell Movement, Dendritic Cells, Down-Regulation, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Lymph Nodes, Lymphocyte Activation, Orthomyxoviridae Infections.
- metabolism : CD8-Positive T-Lymphocytes, Dendritic Cells.
- methods : Lymphocyte Depletion.
- mortality : Orthomyxoviridae Infections.
- pathology : CD8-Positive T-Lymphocytes, Lymph Nodes, Orthomyxoviridae Infections.
- chemical , physiology : Fas Ligand Protein, fas Receptor.
- transplantation : Dendritic Cells.
- virology : Lymph Nodes.
- Adoptive Transfer, Animals, Immunophenotyping, Lymphocyte Count, Mice, Mice, Inbred BALB C, Mice, Transgenic.
Abstract
Previous studies have shown that the reduction in CD8 T cell immunity observed during high-dose influenza A virus (IAV) infection is mediated via lymph node (LN) dendritic cells (DCs) that express Fas ligand (FasL) and drive FasL-Fas (DC-T)-induced apoptosis. However, the specific DC subset(s) within the LN and the additional factors required for DC-mediated elimination of IAV-specific CD8 T cells remain unknown. In this paper, we demonstrate that plasmacytoid DCs (pDCs), which downregulate FasL during sublethal, but not lethal, IAV infection, accumulate to greater numbers within the LNs of lethal dose-infected mice. Further our findings show that pDCs from lethal, but not sublethal, dose IAV infections drive elimination of Fas(+) CD8 T cells and that this elimination occurs only in the absence of TCR recognition of IAV peptide-MHC class I complexes. Together, these results suggest that pDCs play a heretofore unknown deleterious role during lethal dose IAV infections by limiting the CD8 T cell response.
DOI: 10.4049/jimmunol.0902984
PubMed: 20220091
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<term>Animals</term>
<term>Apoptosis (immunology)</term>
<term>CD8 Antigens (biosynthesis)</term>
<term>CD8-Positive T-Lymphocytes (immunology)</term>
<term>CD8-Positive T-Lymphocytes (metabolism)</term>
<term>CD8-Positive T-Lymphocytes (pathology)</term>
<term>Cell Movement (immunology)</term>
<term>Dendritic Cells (immunology)</term>
<term>Dendritic Cells (metabolism)</term>
<term>Dendritic Cells (transplantation)</term>
<term>Down-Regulation (immunology)</term>
<term>Fas Ligand Protein (antagonists & inhibitors)</term>
<term>Fas Ligand Protein (biosynthesis)</term>
<term>Fas Ligand Protein (physiology)</term>
<term>Immunophenotyping</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza A Virus, H2N2 Subtype (immunology)</term>
<term>Lymph Nodes (immunology)</term>
<term>Lymph Nodes (pathology)</term>
<term>Lymph Nodes (virology)</term>
<term>Lymphocyte Activation (immunology)</term>
<term>Lymphocyte Count</term>
<term>Lymphocyte Depletion (methods)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Mice, Transgenic</term>
<term>Orthomyxoviridae Infections (immunology)</term>
<term>Orthomyxoviridae Infections (mortality)</term>
<term>Orthomyxoviridae Infections (pathology)</term>
<term>fas Receptor (biosynthesis)</term>
<term>fas Receptor (physiology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes (immunologie)</term>
<term>Animaux</term>
<term>Apoptose (immunologie)</term>
<term>Cellules dendritiques (immunologie)</term>
<term>Cellules dendritiques (métabolisme)</term>
<term>Cellules dendritiques (transplantation)</term>
<term>Déplétion lymphocytaire ()</term>
<term>Immunophénotypage</term>
<term>Infections à Orthomyxoviridae (anatomopathologie)</term>
<term>Infections à Orthomyxoviridae (immunologie)</term>
<term>Infections à Orthomyxoviridae (mortalité)</term>
<term>Ligand de Fas (antagonistes et inhibiteurs)</term>
<term>Ligand de Fas (biosynthèse)</term>
<term>Ligand de Fas (physiologie)</term>
<term>Lymphocytes T CD8+ (anatomopathologie)</term>
<term>Lymphocytes T CD8+ (immunologie)</term>
<term>Lymphocytes T CD8+ (métabolisme)</term>
<term>Mouvement cellulaire (immunologie)</term>
<term>Noeuds lymphatiques (anatomopathologie)</term>
<term>Noeuds lymphatiques (immunologie)</term>
<term>Noeuds lymphatiques (virologie)</term>
<term>Numération des lymphocytes</term>
<term>Régulation négative (immunologie)</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Souris transgéniques</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
<term>Sous-type H2N2 du virus de la grippe A (immunologie)</term>
<term>Transfert adoptif</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Fas Ligand Protein</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>CD8 Antigens</term>
<term>Fas Ligand Protein</term>
<term>fas Receptor</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term>
<term>Lymphocytes T CD8+</term>
<term>Noeuds lymphatiques</term>
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<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Ligand de Fas</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Ligand de Fas</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Activation des lymphocytes</term>
<term>Apoptose</term>
<term>Cellules dendritiques</term>
<term>Infections à Orthomyxoviridae</term>
<term>Lymphocytes T CD8+</term>
<term>Mouvement cellulaire</term>
<term>Noeuds lymphatiques</term>
<term>Régulation négative</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Apoptosis</term>
<term>CD8-Positive T-Lymphocytes</term>
<term>Cell Movement</term>
<term>Dendritic Cells</term>
<term>Down-Regulation</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Lymph Nodes</term>
<term>Lymphocyte Activation</term>
<term>Orthomyxoviridae Infections</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term>
<term>Dendritic Cells</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Lymphocyte Depletion</term>
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<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Orthomyxoviridae Infections</term>
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<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à Orthomyxoviridae</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules dendritiques</term>
<term>Lymphocytes T CD8+</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term>
<term>Lymph Nodes</term>
<term>Orthomyxoviridae Infections</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Ligand de Fas</term>
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<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Fas Ligand Protein</term>
<term>fas Receptor</term>
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<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Noeuds lymphatiques</term>
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<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lymph Nodes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adoptive Transfer</term>
<term>Animals</term>
<term>Immunophenotyping</term>
<term>Lymphocyte Count</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Mice, Transgenic</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules dendritiques</term>
<term>Déplétion lymphocytaire</term>
<term>Immunophénotypage</term>
<term>Numération des lymphocytes</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Souris transgéniques</term>
<term>Transfert adoptif</term>
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<front><div type="abstract" xml:lang="en">Previous studies have shown that the reduction in CD8 T cell immunity observed during high-dose influenza A virus (IAV) infection is mediated via lymph node (LN) dendritic cells (DCs) that express Fas ligand (FasL) and drive FasL-Fas (DC-T)-induced apoptosis. However, the specific DC subset(s) within the LN and the additional factors required for DC-mediated elimination of IAV-specific CD8 T cells remain unknown. In this paper, we demonstrate that plasmacytoid DCs (pDCs), which downregulate FasL during sublethal, but not lethal, IAV infection, accumulate to greater numbers within the LNs of lethal dose-infected mice. Further our findings show that pDCs from lethal, but not sublethal, dose IAV infections drive elimination of Fas(+) CD8 T cells and that this elimination occurs only in the absence of TCR recognition of IAV peptide-MHC class I complexes. Together, these results suggest that pDCs play a heretofore unknown deleterious role during lethal dose IAV infections by limiting the CD8 T cell response.</div>
</front>
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