Assessing Antigenic Drift of Seasonal Influenza A(H3N2) and A(H1N1)pdm09 Viruses
Identifieur interne : 000591 ( Main/Merge ); précédent : 000590; suivant : 000592Assessing Antigenic Drift of Seasonal Influenza A(H3N2) and A(H1N1)pdm09 Viruses
Auteurs : Nipaporn Tewawong ; Slinporn Prachayangprecha ; Preeyaporn Vichiwattana ; Sumeth Korkong ; Sirapa Klinfueng ; Sompong Vongpunsawad ; Thanunrat Thongmee ; Apiradee Theamboonlers ; Yong PoovorawanSource :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
Under selective pressure from the host immune system, antigenic epitopes of influenza virus hemagglutinin (HA) have continually evolved to escape antibody recognition, termed antigenic drift. We analyzed the genomes of influenza A(H3N2) and A(H1N1)pdm09 virus strains circulating in Thailand between 2010 and 2014 and assessed how well the yearly vaccine strains recommended for the southern hemisphere matched them. We amplified and sequenced the HA gene of 120 A(H3N2) and 81 A(H1N1)pdm09 influenza virus samples obtained from respiratory specimens and calculated the perfect-match vaccine efficacy using the
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DOI: 10.1371/journal.pone.0139958
PubMed: 26440103
PubMed Central: 4594909
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Korkong</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Klinfueng, Sirapa" sort="Klinfueng, Sirapa" uniqKey="Klinfueng S" first="Sirapa" last="Klinfueng">Sirapa Klinfueng</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Vongpunsawad, Sompong" sort="Vongpunsawad, Sompong" uniqKey="Vongpunsawad S" first="Sompong" last="Vongpunsawad">Sompong Vongpunsawad</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Thongmee, Thanunrat" sort="Thongmee, Thanunrat" uniqKey="Thongmee T" first="Thanunrat" last="Thongmee">Thanunrat Thongmee</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Theamboonlers, Apiradee" sort="Theamboonlers, Apiradee" uniqKey="Theamboonlers A" first="Apiradee" last="Theamboonlers">Apiradee Theamboonlers</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Poovorawan, Yong" sort="Poovorawan, Yong" uniqKey="Poovorawan Y" first="Yong" last="Poovorawan">Yong Poovorawan</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26440103</idno><idno type="pmc">4594909</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594909</idno><idno type="RBID">PMC:4594909</idno><idno type="doi">10.1371/journal.pone.0139958</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000A65</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A65</idno><idno type="wicri:Area/Pmc/Curation">000A65</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A65</idno><idno type="wicri:Area/Pmc/Checkpoint">000421</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000421</idno><idno type="wicri:Area/Ncbi/Merge">000C30</idno><idno type="wicri:Area/Ncbi/Curation">000C30</idno><idno type="wicri:Area/Ncbi/Checkpoint">000C30</idno><idno type="wicri:Area/Main/Merge">000591</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Assessing Antigenic Drift of Seasonal Influenza A(H3N2) and A(H1N1)pdm09 Viruses</title><author><name sortKey="Tewawong, Nipaporn" sort="Tewawong, Nipaporn" uniqKey="Tewawong N" first="Nipaporn" last="Tewawong">Nipaporn Tewawong</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Prachayangprecha, Slinporn" sort="Prachayangprecha, Slinporn" uniqKey="Prachayangprecha S" first="Slinporn" last="Prachayangprecha">Slinporn Prachayangprecha</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Vichiwattana, Preeyaporn" sort="Vichiwattana, Preeyaporn" uniqKey="Vichiwattana P" first="Preeyaporn" last="Vichiwattana">Preeyaporn Vichiwattana</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Korkong, Sumeth" sort="Korkong, Sumeth" uniqKey="Korkong S" first="Sumeth" last="Korkong">Sumeth Korkong</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Klinfueng, Sirapa" sort="Klinfueng, Sirapa" uniqKey="Klinfueng S" first="Sirapa" last="Klinfueng">Sirapa Klinfueng</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Vongpunsawad, Sompong" sort="Vongpunsawad, Sompong" uniqKey="Vongpunsawad S" first="Sompong" last="Vongpunsawad">Sompong Vongpunsawad</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Thongmee, Thanunrat" sort="Thongmee, Thanunrat" uniqKey="Thongmee T" first="Thanunrat" last="Thongmee">Thanunrat Thongmee</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Theamboonlers, Apiradee" sort="Theamboonlers, Apiradee" uniqKey="Theamboonlers A" first="Apiradee" last="Theamboonlers">Apiradee Theamboonlers</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Poovorawan, Yong" sort="Poovorawan, Yong" uniqKey="Poovorawan Y" first="Yong" last="Poovorawan">Yong Poovorawan</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Under selective pressure from the host immune system, antigenic epitopes of influenza virus hemagglutinin (HA) have continually evolved to escape antibody recognition, termed antigenic drift. We analyzed the genomes of influenza A(H3N2) and A(H1N1)pdm09 virus strains circulating in Thailand between 2010 and 2014 and assessed how well the yearly vaccine strains recommended for the southern hemisphere matched them. We amplified and sequenced the HA gene of 120 A(H3N2) and 81 A(H1N1)pdm09 influenza virus samples obtained from respiratory specimens and calculated the perfect-match vaccine efficacy using the <italic>p</italic><sub>epitope</sub> model, which quantitated the antigenic drift in the dominant epitope of HA. Phylogenetic analysis of the A(H3N2) HA1 genes classified most strains into genetic clades 1, 3A, 3B, and 3C. The A(H3N2) strains from the 2013 and 2014 seasons showed very low to moderate vaccine efficacy and demonstrated antigenic drift from epitopes C and A to epitope B. Meanwhile, most A(H1N1)pdm09 strains from the 2012–2014 seasons belonged to genetic clades 6A, 6B, and 6C and displayed the dominant epitope mutations at epitopes B and E. Finally, the vaccine efficacy for A(H1N1)pdm09 (79.6–93.4%) was generally higher than that of A(H3N2). 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