Assessing Antigenic Drift of Seasonal Influenza A(H3N2) and A(H1N1)pdm09 Viruses
Identifieur interne : 000C30 ( Ncbi/Merge ); précédent : 000C29; suivant : 000C31Assessing Antigenic Drift of Seasonal Influenza A(H3N2) and A(H1N1)pdm09 Viruses
Auteurs : Nipaporn Tewawong ; Slinporn Prachayangprecha ; Preeyaporn Vichiwattana ; Sumeth Korkong ; Sirapa Klinfueng ; Sompong Vongpunsawad ; Thanunrat Thongmee ; Apiradee Theamboonlers ; Yong PoovorawanSource :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
Under selective pressure from the host immune system, antigenic epitopes of influenza virus hemagglutinin (HA) have continually evolved to escape antibody recognition, termed antigenic drift. We analyzed the genomes of influenza A(H3N2) and A(H1N1)pdm09 virus strains circulating in Thailand between 2010 and 2014 and assessed how well the yearly vaccine strains recommended for the southern hemisphere matched them. We amplified and sequenced the HA gene of 120 A(H3N2) and 81 A(H1N1)pdm09 influenza virus samples obtained from respiratory specimens and calculated the perfect-match vaccine efficacy using the
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DOI: 10.1371/journal.pone.0139958
PubMed: 26440103
PubMed Central: 4594909
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<front><div type="abstract" xml:lang="en"><p>Under selective pressure from the host immune system, antigenic epitopes of influenza virus hemagglutinin (HA) have continually evolved to escape antibody recognition, termed antigenic drift. We analyzed the genomes of influenza A(H3N2) and A(H1N1)pdm09 virus strains circulating in Thailand between 2010 and 2014 and assessed how well the yearly vaccine strains recommended for the southern hemisphere matched them. We amplified and sequenced the HA gene of 120 A(H3N2) and 81 A(H1N1)pdm09 influenza virus samples obtained from respiratory specimens and calculated the perfect-match vaccine efficacy using the <italic>p</italic>
<sub>epitope</sub>
model, which quantitated the antigenic drift in the dominant epitope of HA. Phylogenetic analysis of the A(H3N2) HA1 genes classified most strains into genetic clades 1, 3A, 3B, and 3C. The A(H3N2) strains from the 2013 and 2014 seasons showed very low to moderate vaccine efficacy and demonstrated antigenic drift from epitopes C and A to epitope B. Meanwhile, most A(H1N1)pdm09 strains from the 2012–2014 seasons belonged to genetic clades 6A, 6B, and 6C and displayed the dominant epitope mutations at epitopes B and E. Finally, the vaccine efficacy for A(H1N1)pdm09 (79.6–93.4%) was generally higher than that of A(H3N2). These findings further confirmed the accelerating antigenic drift of the circulating influenza A(H3N2) in recent years.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Thompson, Ww" uniqKey="Thompson W">WW Thompson</name>
</author>
<author><name sortKey="Shay, Dk" uniqKey="Shay D">DK Shay</name>
</author>
<author><name sortKey="Weintraub, E" uniqKey="Weintraub E">E Weintraub</name>
</author>
<author><name sortKey="Brammer, L" uniqKey="Brammer L">L Brammer</name>
</author>
<author><name sortKey="Cox, N" uniqKey="Cox N">N Cox</name>
</author>
<author><name sortKey="Anderson, Lj" uniqKey="Anderson L">LJ Anderson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pariani, E" uniqKey="Pariani E">E Pariani</name>
</author>
<author><name sortKey="Amendola, A" uniqKey="Amendola A">A Amendola</name>
</author>
<author><name sortKey="Ebranati, E" uniqKey="Ebranati E">E Ebranati</name>
</author>
<author><name sortKey="Ranghiero, A" uniqKey="Ranghiero A">A Ranghiero</name>
</author>
<author><name sortKey="Lai, A" uniqKey="Lai A">A Lai</name>
</author>
<author><name sortKey="Anselmi, G" uniqKey="Anselmi G">G Anselmi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nicholson, Kg" uniqKey="Nicholson K">KG Nicholson</name>
</author>
<author><name sortKey="Wood, Jm" uniqKey="Wood J">JM Wood</name>
</author>
<author><name sortKey="Zambon, M" uniqKey="Zambon M">M Zambon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krystal, M" uniqKey="Krystal M">M Krystal</name>
</author>
<author><name sortKey="Elliott, Rm" uniqKey="Elliott R">RM Elliott</name>
</author>
<author><name sortKey="Benz, Ew" uniqKey="Benz E">EW Benz</name>
</author>
<author><name sortKey="Young, Jf" uniqKey="Young J">JF Young</name>
</author>
<author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Jong, Jc" uniqKey="De Jong J">JC De Jong</name>
</author>
<author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name>
</author>
<author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name>
</author>
<author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bush, Rm" uniqKey="Bush R">RM Bush</name>
</author>
<author><name sortKey="Bender, Ca" uniqKey="Bender C">CA Bender</name>
</author>
<author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name>
</author>
<author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name>
</author>
<author><name sortKey="Fitch, Wm" uniqKey="Fitch W">WM Fitch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fantoni, A" uniqKey="Fantoni A">A Fantoni</name>
</author>
<author><name sortKey="Arena, C" uniqKey="Arena C">C Arena</name>
</author>
<author><name sortKey="Corrias, L" uniqKey="Corrias L">L Corrias</name>
</author>
<author><name sortKey="Salez, N" uniqKey="Salez N">N Salez</name>
</author>
<author><name sortKey="De Lamballerie, Xn" uniqKey="De Lamballerie X">XN de Lamballerie</name>
</author>
<author><name sortKey="Amoros, Jp" uniqKey="Amoros J">JP Amoros</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, Jw" uniqKey="Huang J">JW Huang</name>
</author>
<author><name sortKey="Yang, Jm" uniqKey="Yang J">JM Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kittikraisak, W" uniqKey="Kittikraisak W">W Kittikraisak</name>
</author>
<author><name sortKey="Suntarattiwong, P" uniqKey="Suntarattiwong P">P Suntarattiwong</name>
</author>
<author><name sortKey="Levy, J" uniqKey="Levy J">J Levy</name>
</author>
<author><name sortKey="Fernandez, S" uniqKey="Fernandez S">S Fernandez</name>
</author>
<author><name sortKey="Dawood, Fs" uniqKey="Dawood F">FS Dawood</name>
</author>
<author><name sortKey="Olsen, Sj" uniqKey="Olsen S">SJ Olsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gupta, V" uniqKey="Gupta V">V Gupta</name>
</author>
<author><name sortKey="Earl, Dj" uniqKey="Earl D">DJ Earl</name>
</author>
<author><name sortKey="Deem, Mw" uniqKey="Deem M">MW Deem</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hoffmann, E" uniqKey="Hoffmann E">E Hoffmann</name>
</author>
<author><name sortKey="Stech, J" uniqKey="Stech J">J Stech</name>
</author>
<author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
<author><name sortKey="Perez, Dr" uniqKey="Perez D">DR Perez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Suwannakarn, K" uniqKey="Suwannakarn K">K Suwannakarn</name>
</author>
<author><name sortKey="Payungporn, S" uniqKey="Payungporn S">S Payungporn</name>
</author>
<author><name sortKey="Chieochansin, T" uniqKey="Chieochansin T">T Chieochansin</name>
</author>
<author><name sortKey="Samransamruajkit, R" uniqKey="Samransamruajkit R">R Samransamruajkit</name>
</author>
<author><name sortKey="Amonsin, A" uniqKey="Amonsin A">A Amonsin</name>
</author>
<author><name sortKey="Songserm, T" uniqKey="Songserm T">T Songserm</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Prachayangprecha, S" uniqKey="Prachayangprecha S">S Prachayangprecha</name>
</author>
<author><name sortKey="Makkoch, J" uniqKey="Makkoch J">J Makkoch</name>
</author>
<author><name sortKey="Suwannakarn, K" uniqKey="Suwannakarn K">K Suwannakarn</name>
</author>
<author><name sortKey="Vichaiwattana, P" uniqKey="Vichaiwattana P">P Vichaiwattana</name>
</author>
<author><name sortKey="Korkong, S" uniqKey="Korkong S">S Korkong</name>
</author>
<author><name sortKey="Theamboonlers, A" uniqKey="Theamboonlers A">A Theamboonlers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tewawong, N" uniqKey="Tewawong N">N Tewawong</name>
</author>
<author><name sortKey="Suwannakarn, K" uniqKey="Suwannakarn K">K Suwannakarn</name>
</author>
<author><name sortKey="Prachayangprecha, S" uniqKey="Prachayangprecha S">S Prachayangprecha</name>
</author>
<author><name sortKey="Korkong, S" uniqKey="Korkong S">S Korkong</name>
</author>
<author><name sortKey="Vichiwattana, P" uniqKey="Vichiwattana P">P Vichiwattana</name>
</author>
<author><name sortKey="Vongpunsawad, S" uniqKey="Vongpunsawad S">S Vongpunsawad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Larkin, Ma" uniqKey="Larkin M">MA Larkin</name>
</author>
<author><name sortKey="Blackshields, G" uniqKey="Blackshields G">G Blackshields</name>
</author>
<author><name sortKey="Brown, Np" uniqKey="Brown N">NP Brown</name>
</author>
<author><name sortKey="Chenna, R" uniqKey="Chenna R">R Chenna</name>
</author>
<author><name sortKey="Mcgettigan, Pa" uniqKey="Mcgettigan P">PA McGettigan</name>
</author>
<author><name sortKey="Mcwilliam, H" uniqKey="Mcwilliam H">H McWilliam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hasegawa, M" uniqKey="Hasegawa M">M Hasegawa</name>
</author>
<author><name sortKey="Kishino, H" uniqKey="Kishino H">H Kishino</name>
</author>
<author><name sortKey="Yano, T" uniqKey="Yano T">T Yano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tamura, K" uniqKey="Tamura K">K Tamura</name>
</author>
<author><name sortKey="Stecher, G" uniqKey="Stecher G">G Stecher</name>
</author>
<author><name sortKey="Peterson, D" uniqKey="Peterson D">D Peterson</name>
</author>
<author><name sortKey="Filipski, A" uniqKey="Filipski A">A Filipski</name>
</author>
<author><name sortKey="Kumar, S" uniqKey="Kumar S">S Kumar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Macken, C" uniqKey="Macken C">C Macken</name>
</author>
<author><name sortKey="Lu, H" uniqKey="Lu H">H Lu</name>
</author>
<author><name sortKey="Goodman, J" uniqKey="Goodman J">J Goodman</name>
</author>
<author><name sortKey="Boykin, L" uniqKey="Boykin L">L Boykin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Deem, Mw" uniqKey="Deem M">MW Deem</name>
</author>
<author><name sortKey="Pan, K" uniqKey="Pan K">K Pan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Crooks, Ge" uniqKey="Crooks G">GE Crooks</name>
</author>
<author><name sortKey="Hon, G" uniqKey="Hon G">G Hon</name>
</author>
<author><name sortKey="Chandonia, Jm" uniqKey="Chandonia J">JM Chandonia</name>
</author>
<author><name sortKey="Brenner, Se" uniqKey="Brenner S">SE Brenner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Delport, W" uniqKey="Delport W">W Delport</name>
</author>
<author><name sortKey="Poon, Af" uniqKey="Poon A">AF Poon</name>
</author>
<author><name sortKey="Frost, Sd" uniqKey="Frost S">SD Frost</name>
</author>
<author><name sortKey="Kosakovsky Pond, Sl" uniqKey="Kosakovsky Pond S">SL Kosakovsky Pond</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Pan, K" uniqKey="Pan K">K Pan</name>
</author>
<author><name sortKey="Subieta, Kc" uniqKey="Subieta K">KC Subieta</name>
</author>
<author><name sortKey="Deem, Mw" uniqKey="Deem M">MW Deem</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Falchi, A" uniqKey="Falchi A">A Falchi</name>
</author>
<author><name sortKey="Amoros, Jp" uniqKey="Amoros J">JP Amoros</name>
</author>
<author><name sortKey="Arena, C" uniqKey="Arena C">C Arena</name>
</author>
<author><name sortKey="Arrighi, J" uniqKey="Arrighi J">J Arrighi</name>
</author>
<author><name sortKey="Casabianca, F" uniqKey="Casabianca F">F Casabianca</name>
</author>
<author><name sortKey="Andreoletti, L" uniqKey="Andreoletti L">L Andreoletti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shao, Tj" uniqKey="Shao T">TJ Shao</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Yu, Xf" uniqKey="Yu X">XF Yu</name>
</author>
<author><name sortKey="Kou, Y" uniqKey="Kou Y">Y Kou</name>
</author>
<author><name sortKey="Zhou, Yy" uniqKey="Zhou Y">YY Zhou</name>
</author>
<author><name sortKey="Qian, X" uniqKey="Qian X">X Qian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stevens, J" uniqKey="Stevens J">J Stevens</name>
</author>
<author><name sortKey="Blixt, O" uniqKey="Blixt O">O Blixt</name>
</author>
<author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
</author>
<author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name>
</author>
<author><name sortKey="Paulson, Jc" uniqKey="Paulson J">JC Paulson</name>
</author>
<author><name sortKey="Wilson, Ia" uniqKey="Wilson I">IA Wilson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kryazhimskiy, S" uniqKey="Kryazhimskiy S">S Kryazhimskiy</name>
</author>
<author><name sortKey="Plotkin, Jb" uniqKey="Plotkin J">JB Plotkin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kilbourne, Ed" uniqKey="Kilbourne E">ED Kilbourne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Melidou, A" uniqKey="Melidou A">A Melidou</name>
</author>
<author><name sortKey="Gioula, G" uniqKey="Gioula G">G Gioula</name>
</author>
<author><name sortKey="Exindari, M" uniqKey="Exindari M">M Exindari</name>
</author>
<author><name sortKey="Chatzidimitriou, D" uniqKey="Chatzidimitriou D">D Chatzidimitriou</name>
</author>
<author><name sortKey="Malisiovas, N" uniqKey="Malisiovas N">N Malisiovas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Widgren, K" uniqKey="Widgren K">K Widgren</name>
</author>
<author><name sortKey="Magnusson, M" uniqKey="Magnusson M">M Magnusson</name>
</author>
<author><name sortKey="Hagstam, P" uniqKey="Hagstam P">P Hagstam</name>
</author>
<author><name sortKey="Widerstrom, M" uniqKey="Widerstrom M">M Widerstrom</name>
</author>
<author><name sortKey="Ortqvist, A" uniqKey="Ortqvist A">A Ortqvist</name>
</author>
<author><name sortKey="Einemo, Im" uniqKey="Einemo I">IM Einemo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rondy, M" uniqKey="Rondy M">M Rondy</name>
</author>
<author><name sortKey="Launay, O" uniqKey="Launay O">O Launay</name>
</author>
<author><name sortKey="Puig Barbera, J" uniqKey="Puig Barbera J">J Puig-Barbera</name>
</author>
<author><name sortKey="Gefenaite, G" uniqKey="Gefenaite G">G Gefenaite</name>
</author>
<author><name sortKey="Castilla, J" uniqKey="Castilla J">J Castilla</name>
</author>
<author><name sortKey="De Gaetano Donati, K" uniqKey="De Gaetano Donati K">K de Gaetano Donati</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, Dj" uniqKey="Smith D">DJ Smith</name>
</author>
<author><name sortKey="Lapedes, As" uniqKey="Lapedes A">AS Lapedes</name>
</author>
<author><name sortKey="De Jong, Jc" uniqKey="De Jong J">JC de Jong</name>
</author>
<author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name>
</author>
<author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name>
</author>
<author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name>
</author>
<author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Klein, Ey" uniqKey="Klein E">EY Klein</name>
</author>
<author><name sortKey="Serohijos, Aw" uniqKey="Serohijos A">AW Serohijos</name>
</author>
<author><name sortKey="Choi, Jm" uniqKey="Choi J">JM Choi</name>
</author>
<author><name sortKey="Shakhnovich, Ei" uniqKey="Shakhnovich E">EI Shakhnovich</name>
</author>
<author><name sortKey="Pekosz, A" uniqKey="Pekosz A">A Pekosz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wilson, Ia" uniqKey="Wilson I">IA Wilson</name>
</author>
<author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shih, Ac" uniqKey="Shih A">AC Shih</name>
</author>
<author><name sortKey="Hsiao, Tc" uniqKey="Hsiao T">TC Hsiao</name>
</author>
<author><name sortKey="Ho, Ms" uniqKey="Ho M">MS Ho</name>
</author>
<author><name sortKey="Li, Wh" uniqKey="Li W">WH Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bragstad, K" uniqKey="Bragstad K">K Bragstad</name>
</author>
<author><name sortKey="Nielsen, Lp" uniqKey="Nielsen L">LP Nielsen</name>
</author>
<author><name sortKey="Fomsgaard, A" uniqKey="Fomsgaard A">A Fomsgaard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eshaghi, A" uniqKey="Eshaghi A">A Eshaghi</name>
</author>
<author><name sortKey="Duvvuri, Vr" uniqKey="Duvvuri V">VR Duvvuri</name>
</author>
<author><name sortKey="Li, A" uniqKey="Li A">A Li</name>
</author>
<author><name sortKey="Patel, Sn" uniqKey="Patel S">SN Patel</name>
</author>
<author><name sortKey="Bastien, N" uniqKey="Bastien N">N Bastien</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nakajima, K" uniqKey="Nakajima K">K Nakajima</name>
</author>
<author><name sortKey="Nobusawa, E" uniqKey="Nobusawa E">E Nobusawa</name>
</author>
<author><name sortKey="Nagy, A" uniqKey="Nagy A">A Nagy</name>
</author>
<author><name sortKey="Nakajima, S" uniqKey="Nakajima S">S Nakajima</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, S" uniqKey="Sun S">S Sun</name>
</author>
<author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name>
</author>
<author><name sortKey="Zhao, F" uniqKey="Zhao F">F Zhao</name>
</author>
<author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name>
</author>
<author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Suzuki, Y" uniqKey="Suzuki Y">Y Suzuki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dawood, Fs" uniqKey="Dawood F">FS Dawood</name>
</author>
<author><name sortKey="Prapasiri, P" uniqKey="Prapasiri P">P Prapasiri</name>
</author>
<author><name sortKey="Areerat, P" uniqKey="Areerat P">P Areerat</name>
</author>
<author><name sortKey="Ruayajin, A" uniqKey="Ruayajin A">A Ruayajin</name>
</author>
<author><name sortKey="Chittaganpitch, M" uniqKey="Chittaganpitch M">M Chittaganpitch</name>
</author>
<author><name sortKey="Muangchana, C" uniqKey="Muangchana C">C Muangchana</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eick Cost, Aa" uniqKey="Eick Cost A">AA Eick-Cost</name>
</author>
<author><name sortKey="Tastad, Kj" uniqKey="Tastad K">KJ Tastad</name>
</author>
<author><name sortKey="Guerrero, Ac" uniqKey="Guerrero A">AC Guerrero</name>
</author>
<author><name sortKey="Johns, Mc" uniqKey="Johns M">MC Johns</name>
</author>
<author><name sortKey="Lee, Se" uniqKey="Lee S">SE Lee</name>
</author>
<author><name sortKey="Macintosh, Vh" uniqKey="Macintosh V">VH Macintosh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bridges, Cb" uniqKey="Bridges C">CB Bridges</name>
</author>
<author><name sortKey="Thompson, Ww" uniqKey="Thompson W">WW Thompson</name>
</author>
<author><name sortKey="Meltzer, Mi" uniqKey="Meltzer M">MI Meltzer</name>
</author>
<author><name sortKey="Reeve, Gr" uniqKey="Reeve G">GR Reeve</name>
</author>
<author><name sortKey="Talamonti, Wj" uniqKey="Talamonti W">WJ Talamonti</name>
</author>
<author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, Jw" uniqKey="Huang J">JW Huang</name>
</author>
<author><name sortKey="Lin, Wf" uniqKey="Lin W">WF Lin</name>
</author>
<author><name sortKey="Yang, Jm" uniqKey="Yang J">JM Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Caton, Aj" uniqKey="Caton A">AJ Caton</name>
</author>
<author><name sortKey="Brownlee, Gg" uniqKey="Brownlee G">GG Brownlee</name>
</author>
<author><name sortKey="Yewdell, Jw" uniqKey="Yewdell J">JW Yewdell</name>
</author>
<author><name sortKey="Gerhard, W" uniqKey="Gerhard W">W Gerhard</name>
</author>
</analytic>
</biblStruct>
</listBibl>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group><journal-title>PLoS ONE</journal-title>
</journal-title-group>
<issn pub-type="epub">1932-6203</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, CA USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26440103</article-id>
<article-id pub-id-type="pmc">4594909</article-id>
<article-id pub-id-type="doi">10.1371/journal.pone.0139958</article-id>
<article-id pub-id-type="publisher-id">PONE-D-15-30993</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Assessing Antigenic Drift of Seasonal Influenza A(H3N2) and A(H1N1)pdm09 Viruses</article-title>
<alt-title alt-title-type="running-head">Antigenic Drift of Seasonal Influenza A Virus</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Tewawong</surname>
<given-names>Nipaporn</given-names>
</name>
<xref ref-type="aff" rid="aff001"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Prachayangprecha</surname>
<given-names>Slinporn</given-names>
</name>
<xref ref-type="aff" rid="aff001"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vichiwattana</surname>
<given-names>Preeyaporn</given-names>
</name>
<xref ref-type="aff" rid="aff001"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Korkong</surname>
<given-names>Sumeth</given-names>
</name>
<xref ref-type="aff" rid="aff001"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Klinfueng</surname>
<given-names>Sirapa</given-names>
</name>
<xref ref-type="aff" rid="aff001"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vongpunsawad</surname>
<given-names>Sompong</given-names>
</name>
<xref ref-type="aff" rid="aff001"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thongmee</surname>
<given-names>Thanunrat</given-names>
</name>
<xref ref-type="aff" rid="aff001"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Theamboonlers</surname>
<given-names>Apiradee</given-names>
</name>
<xref ref-type="aff" rid="aff001"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Poovorawan</surname>
<given-names>Yong</given-names>
</name>
<xref rid="cor001" ref-type="corresp">*</xref>
<xref ref-type="aff" rid="aff001"></xref>
</contrib>
</contrib-group>
<aff id="aff001"><addr-line>Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Krammer</surname>
<given-names>Florian</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>Icahn School of Medicine at Mount Sinai, UNITED STATES</addr-line>
</aff>
<author-notes><fn fn-type="COI-statement" id="coi001"><p><bold>Competing Interests: </bold>
The authors received funding from commercial sources, Siam Cement Group and MK Restaurant Company Limited. However, this does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. The authors also declare that no competing interests exist.</p>
</fn>
<fn fn-type="con" id="contrib001"><p>Conceived and designed the experiments: NT TT YP. Performed the experiments: NT SP PV S. Klinfueng S. Korkong. Analyzed the data: NT SV. Contributed reagents/materials/analysis tools: NT TT AT. Wrote the paper: NT SV YP.</p>
</fn>
<corresp id="cor001">* E-mail: <email>Yong.P@chula.ac.th</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>6</day>
<month>10</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<volume>10</volume>
<issue>10</issue>
<elocation-id>e0139958</elocation-id>
<history><date date-type="received"><day>15</day>
<month>7</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>18</day>
<month>9</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>© 2015 Tewawong et al</copyright-statement>
<copyright-year>2015</copyright-year>
<copyright-holder>Tewawong et al</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="pone.0139958.pdf"></self-uri>
<abstract><p>Under selective pressure from the host immune system, antigenic epitopes of influenza virus hemagglutinin (HA) have continually evolved to escape antibody recognition, termed antigenic drift. We analyzed the genomes of influenza A(H3N2) and A(H1N1)pdm09 virus strains circulating in Thailand between 2010 and 2014 and assessed how well the yearly vaccine strains recommended for the southern hemisphere matched them. We amplified and sequenced the HA gene of 120 A(H3N2) and 81 A(H1N1)pdm09 influenza virus samples obtained from respiratory specimens and calculated the perfect-match vaccine efficacy using the <italic>p</italic>
<sub>epitope</sub>
model, which quantitated the antigenic drift in the dominant epitope of HA. Phylogenetic analysis of the A(H3N2) HA1 genes classified most strains into genetic clades 1, 3A, 3B, and 3C. The A(H3N2) strains from the 2013 and 2014 seasons showed very low to moderate vaccine efficacy and demonstrated antigenic drift from epitopes C and A to epitope B. Meanwhile, most A(H1N1)pdm09 strains from the 2012–2014 seasons belonged to genetic clades 6A, 6B, and 6C and displayed the dominant epitope mutations at epitopes B and E. Finally, the vaccine efficacy for A(H1N1)pdm09 (79.6–93.4%) was generally higher than that of A(H3N2). These findings further confirmed the accelerating antigenic drift of the circulating influenza A(H3N2) in recent years.</p>
</abstract>
<funding-group><funding-statement>This work was supported by The National Research University Project, Office of Higher Education Commission (WCU001-HR-57, WCU007-HR-57, and WCU-58-006-HR), The National Research Council of Thailand (NRCT), The Research Chair Grant from the National Science and Technology Development Agency, Chulalongkorn University Centenary Academic Development Project (CU56-HR01), Ratchadaphiseksomphot Endowment Fund of Chulalongkorn University (RES560530093), The Outstanding Professor of Thailand Research Fund (DPG5480002), Siam Cement Group, and MK Restaurant Company Limited. The authors thank the 100th anniversary Chulalongkorn University Fund for doctoral scholarship awarded to Nipaporn Tewawong. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement>
</funding-group>
<counts><fig-count count="3"></fig-count>
<table-count count="4"></table-count>
<page-count count="15"></page-count>
</counts>
<custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name>
<meta-value>All relevant data are within the paper and its Supporting Information files.</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
<notes><title>Data Availability</title>
<p>All relevant data are within the paper and its Supporting Information files.</p>
</notes>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Klinfueng, Sirapa" sort="Klinfueng, Sirapa" uniqKey="Klinfueng S" first="Sirapa" last="Klinfueng">Sirapa Klinfueng</name>
<name sortKey="Korkong, Sumeth" sort="Korkong, Sumeth" uniqKey="Korkong S" first="Sumeth" last="Korkong">Sumeth Korkong</name>
<name sortKey="Poovorawan, Yong" sort="Poovorawan, Yong" uniqKey="Poovorawan Y" first="Yong" last="Poovorawan">Yong Poovorawan</name>
<name sortKey="Prachayangprecha, Slinporn" sort="Prachayangprecha, Slinporn" uniqKey="Prachayangprecha S" first="Slinporn" last="Prachayangprecha">Slinporn Prachayangprecha</name>
<name sortKey="Tewawong, Nipaporn" sort="Tewawong, Nipaporn" uniqKey="Tewawong N" first="Nipaporn" last="Tewawong">Nipaporn Tewawong</name>
<name sortKey="Theamboonlers, Apiradee" sort="Theamboonlers, Apiradee" uniqKey="Theamboonlers A" first="Apiradee" last="Theamboonlers">Apiradee Theamboonlers</name>
<name sortKey="Thongmee, Thanunrat" sort="Thongmee, Thanunrat" uniqKey="Thongmee T" first="Thanunrat" last="Thongmee">Thanunrat Thongmee</name>
<name sortKey="Vichiwattana, Preeyaporn" sort="Vichiwattana, Preeyaporn" uniqKey="Vichiwattana P" first="Preeyaporn" last="Vichiwattana">Preeyaporn Vichiwattana</name>
<name sortKey="Vongpunsawad, Sompong" sort="Vongpunsawad, Sompong" uniqKey="Vongpunsawad S" first="Sompong" last="Vongpunsawad">Sompong Vongpunsawad</name>
</noCountry>
</tree>
</affiliations>
</record>
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