Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein
Identifieur interne : 002118 ( Main/Exploration ); précédent : 002117; suivant : 002119Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein
Auteurs : H. P. Wei [Allemagne] ; L. Stitz [Allemagne] ; H. Becht [Allemagne]Source :
- Archives of Virology [ 0304-8608 ] ; 1990-03-01.
English descriptors
- Teeft :
- Anal biochem, Antibody production, Antibody titers, Asia virus, Bacterial lipopolysaccharide, Blood samples, Body weight, Booster injections, Carbohydrate, Carbonate buffer, Challenge infections, Chorioallantoic membranes, Cytotoxic, Cytotoxicity assays, Effector cells, Electron micrograph, Electron microscope, Elisa, Embryonated eggs, Envelope glycoproteins, Federal republic, Further control group, Glycan detection, High antibody titers, Immune system, Immunization, Immunol, Immunol today, Influenza, Influenza hemagglutinin, Influenza viruses, Intranasal instillation, Iscom, Iscom particles, Iscom preparation, Iscom preparations, Iscom suspension, Isoelectric point, Lipid, Micellar structures, Microbiol immunol, Morein, Mouse, Native antigen, Nucleoprotein, Periodate oxidation method, Reaction mixture, Reproducible results, Retroorbital plexus, Room temperature, Spleen cells, Surplus concentration, Survival rates, Target cells, Virus nucleoprotein.
Abstract
Summary: After covalent attachment of bacterial lipopolysaccharide to the nucleoprotein of influenza A virus, this water-soluble antigen could be incorporated firmly into ISCOM. This potent “immunostimulating complex” induced the production of high antibody titers in mice and could partially protect the animals from a lethal challenge infection. After immunization with ISCOM preparations NP-specific cytotoxic T cell activity could not be demonstrated.
Url:
DOI: 10.1007/BF01311015
Affiliations:
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