Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein
Identifieur interne : 000839 ( Istex/Corpus ); précédent : 000838; suivant : 000840Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein
Auteurs : H. P. Wei ; L. Stitz ; H. BechtSource :
- Archives of Virology [ 0304-8608 ] ; 1990-03-01.
English descriptors
- Teeft :
- Anal biochem, Antibody production, Antibody titers, Asia virus, Bacterial lipopolysaccharide, Blood samples, Body weight, Booster injections, Carbohydrate, Carbonate buffer, Challenge infections, Chorioallantoic membranes, Cytotoxic, Cytotoxicity assays, Effector cells, Electron micrograph, Electron microscope, Elisa, Embryonated eggs, Envelope glycoproteins, Federal republic, Further control group, Glycan detection, High antibody titers, Immune system, Immunization, Immunol, Immunol today, Influenza, Influenza hemagglutinin, Influenza viruses, Intranasal instillation, Iscom, Iscom particles, Iscom preparation, Iscom preparations, Iscom suspension, Isoelectric point, Lipid, Micellar structures, Microbiol immunol, Morein, Mouse, Native antigen, Nucleoprotein, Periodate oxidation method, Reaction mixture, Reproducible results, Retroorbital plexus, Room temperature, Spleen cells, Surplus concentration, Survival rates, Target cells, Virus nucleoprotein.
Abstract
Summary: After covalent attachment of bacterial lipopolysaccharide to the nucleoprotein of influenza A virus, this water-soluble antigen could be incorporated firmly into ISCOM. This potent “immunostimulating complex” induced the production of high antibody titers in mice and could partially protect the animals from a lethal challenge infection. After immunization with ISCOM preparations NP-specific cytotoxic T cell activity could not be demonstrated.
Url:
DOI: 10.1007/BF01311015
Links to Exploration step
ISTEX:B2723298C45D7DF8115F98D53360C136FD5537A5Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein</title><author><name sortKey="Wei, H P" sort="Wei, H P" uniqKey="Wei H" first="H. P." last="Wei">H. P. Wei</name><affiliation><mods:affiliation>Institut für Virologie, Justus-Liebig-Universität Giessen, Giessen, Federal Republic of Germany</mods:affiliation></affiliation></author><author><name sortKey="Stitz, L" sort="Stitz, L" uniqKey="Stitz L" first="L." last="Stitz">L. Stitz</name><affiliation><mods:affiliation>Institut für Virologie, Justus-Liebig-Universität Giessen, Giessen, Federal Republic of Germany</mods:affiliation></affiliation></author><author><name sortKey="Becht, H" sort="Becht, H" uniqKey="Becht H" first="H." last="Becht">H. Becht</name><affiliation><mods:affiliation>Institut für Virologie, Justus-Liebig-Universität Giessen, Giessen, Federal Republic of Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B2723298C45D7DF8115F98D53360C136FD5537A5</idno><date when="1990" year="1990">1990</date><idno type="doi">10.1007/BF01311015</idno><idno type="url">https://api.istex.fr/ark:/67375/1BB-NVFZTWRW-9/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000839</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000839</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein</title><author><name sortKey="Wei, H P" sort="Wei, H P" uniqKey="Wei H" first="H. P." last="Wei">H. P. Wei</name><affiliation><mods:affiliation>Institut für Virologie, Justus-Liebig-Universität Giessen, Giessen, Federal Republic of Germany</mods:affiliation></affiliation></author><author><name sortKey="Stitz, L" sort="Stitz, L" uniqKey="Stitz L" first="L." last="Stitz">L. Stitz</name><affiliation><mods:affiliation>Institut für Virologie, Justus-Liebig-Universität Giessen, Giessen, Federal Republic of Germany</mods:affiliation></affiliation></author><author><name sortKey="Becht, H" sort="Becht, H" uniqKey="Becht H" first="H." last="Becht">H. Becht</name><affiliation><mods:affiliation>Institut für Virologie, Justus-Liebig-Universität Giessen, Giessen, Federal Republic of Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Archives of Virology</title><title level="j" type="abbrev">Archives of Virology</title><idno type="ISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1990-03-01">1990-03-01</date><biblScope unit="volume">114</biblScope><biblScope unit="issue">1-2</biblScope><biblScope unit="page" from="109">109</biblScope><biblScope unit="page" to="120">120</biblScope></imprint><idno type="ISSN">0304-8608</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-8608</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Anal biochem</term><term>Antibody production</term><term>Antibody titers</term><term>Asia virus</term><term>Bacterial lipopolysaccharide</term><term>Blood samples</term><term>Body weight</term><term>Booster injections</term><term>Carbohydrate</term><term>Carbonate buffer</term><term>Challenge infections</term><term>Chorioallantoic membranes</term><term>Cytotoxic</term><term>Cytotoxicity assays</term><term>Effector cells</term><term>Electron micrograph</term><term>Electron microscope</term><term>Elisa</term><term>Embryonated eggs</term><term>Envelope glycoproteins</term><term>Federal republic</term><term>Further control group</term><term>Glycan detection</term><term>High antibody titers</term><term>Immune system</term><term>Immunization</term><term>Immunol</term><term>Immunol today</term><term>Influenza</term><term>Influenza hemagglutinin</term><term>Influenza viruses</term><term>Intranasal instillation</term><term>Iscom</term><term>Iscom particles</term><term>Iscom preparation</term><term>Iscom preparations</term><term>Iscom suspension</term><term>Isoelectric point</term><term>Lipid</term><term>Micellar structures</term><term>Microbiol immunol</term><term>Morein</term><term>Mouse</term><term>Native antigen</term><term>Nucleoprotein</term><term>Periodate oxidation method</term><term>Reaction mixture</term><term>Reproducible results</term><term>Retroorbital plexus</term><term>Room temperature</term><term>Spleen cells</term><term>Surplus concentration</term><term>Survival rates</term><term>Target cells</term><term>Virus nucleoprotein</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: After covalent attachment of bacterial lipopolysaccharide to the nucleoprotein of influenza A virus, this water-soluble antigen could be incorporated firmly into ISCOM. This potent “immunostimulating complex” induced the production of high antibody titers in mice and could partially protect the animals from a lethal challenge infection. After immunization with ISCOM preparations NP-specific cytotoxic T cell activity could not be demonstrated.</div></front></TEI><istex><corpusName>springer-journals</corpusName><keywords><teeft><json:string>iscom</json:string><json:string>cytotoxic</json:string><json:string>morein</json:string><json:string>lipid</json:string><json:string>nucleoprotein</json:string><json:string>immunol</json:string><json:string>elisa</json:string><json:string>influenza</json:string><json:string>reaction mixture</json:string><json:string>room temperature</json:string><json:string>immunization</json:string><json:string>asia virus</json:string><json:string>carbohydrate</json:string><json:string>high antibody titers</json:string><json:string>iscom particles</json:string><json:string>federal republic</json:string><json:string>immune system</json:string><json:string>immunol today</json:string><json:string>influenza viruses</json:string><json:string>carbonate buffer</json:string><json:string>anal biochem</json:string><json:string>isoelectric point</json:string><json:string>embryonated eggs</json:string><json:string>surplus concentration</json:string><json:string>iscom suspension</json:string><json:string>glycan detection</json:string><json:string>spleen cells</json:string><json:string>cytotoxicity assays</json:string><json:string>intranasal instillation</json:string><json:string>further control group</json:string><json:string>booster injections</json:string><json:string>body weight</json:string><json:string>virus nucleoprotein</json:string><json:string>micellar structures</json:string><json:string>reproducible results</json:string><json:string>electron microscope</json:string><json:string>envelope glycoproteins</json:string><json:string>native antigen</json:string><json:string>iscom preparation</json:string><json:string>electron micrograph</json:string><json:string>antibody production</json:string><json:string>antibody titers</json:string><json:string>blood samples</json:string><json:string>retroorbital plexus</json:string><json:string>survival rates</json:string><json:string>chorioallantoic membranes</json:string><json:string>challenge infections</json:string><json:string>effector cells</json:string><json:string>target cells</json:string><json:string>bacterial lipopolysaccharide</json:string><json:string>influenza hemagglutinin</json:string><json:string>periodate oxidation method</json:string><json:string>microbiol immunol</json:string><json:string>iscom preparations</json:string><json:string>mouse</json:string></teeft></keywords><author><json:item><name>H. -P. Weiß</name><affiliations><json:string>Institut für Virologie, Justus-Liebig-Universität Giessen, Giessen, Federal Republic of Germany</json:string></affiliations></json:item><json:item><name>L. Stitz</name><affiliations><json:string>Institut für Virologie, Justus-Liebig-Universität Giessen, Giessen, Federal Republic of Germany</json:string></affiliations></json:item><json:item><name>H. Becht</name><affiliations><json:string>Institut für Virologie, Justus-Liebig-Universität Giessen, Giessen, Federal Republic of Germany</json:string></affiliations></json:item></author><articleId><json:string>BF01311015</json:string><json:string>Art8</json:string></articleId><arkIstex>ark:/67375/1BB-NVFZTWRW-9</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Summary: After covalent attachment of bacterial lipopolysaccharide to the nucleoprotein of influenza A virus, this water-soluble antigen could be incorporated firmly into ISCOM. This potent “immunostimulating complex” induced the production of high antibody titers in mice and could partially protect the animals from a lethal challenge infection. After immunization with ISCOM preparations NP-specific cytotoxic T cell activity could not be demonstrated.</abstract><qualityIndicators><score>7.138</score><pdfWordCount>4406</pdfWordCount><pdfCharCount>24428</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>12</pdfPageCount><pdfPageSize>562 x 774 pts</pdfPageSize><refBibsNative>false</refBibsNative><abstractWordCount>61</abstractWordCount><abstractCharCount>455</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein</title><pmid><json:string>2222187</json:string></pmid><genre><json:string>research-article</json:string></genre><host><title>Archives of Virology</title><language><json:string>unknown</json:string></language><publicationDate>1990</publicationDate><copyrightDate>1990</copyrightDate><issn><json:string>0304-8608</json:string></issn><eissn><json:string>1432-8798</json:string></eissn><journalId><json:string>705</json:string></journalId><volume>114</volume><issue>1-2</issue><pages><first>109</first><last>120</last></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Medical Microbiology</value></json:item><json:item><value>Virology</value></json:item><json:item><value>Infectious Diseases</value></json:item></subject></host><namedEntities><unitex><date></date><geogName></geogName><orgName></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName></persName><placeName></placeName><ref_url></ref_url><ref_bibl></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/1BB-NVFZTWRW-9</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - virology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - virology</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Virology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - General Medicine</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences biologiques fondamentales et appliquees. psychologie</json:string><json:string>4 - microbiologie</json:string></inist></categories><publicationDate>1990</publicationDate><copyrightDate>1990</copyrightDate><doi><json:string>10.1007/BF01311015</json:string></doi><id>B2723298C45D7DF8115F98D53360C136FD5537A5</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-NVFZTWRW-9/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-NVFZTWRW-9/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/1BB-NVFZTWRW-9/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><availability><licence><p>Springer-Verlag, 1990</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</p></availability><date>1990-01-16</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>Original Papers</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein</title><author xml:id="author-0000"><persName><forename type="first">H.</forename><surname>Weiß</surname></persName><affiliation>Institut für Virologie, Justus-Liebig-Universität Giessen, Giessen, Federal Republic of Germany</affiliation></author><author xml:id="author-0001"><persName><forename type="first">L.</forename><surname>Stitz</surname></persName><affiliation>Institut für Virologie, Justus-Liebig-Universität Giessen, Giessen, Federal Republic of Germany</affiliation></author><author xml:id="author-0002"><persName><forename type="first">H.</forename><surname>Becht</surname></persName><affiliation>Institut für Virologie, Justus-Liebig-Universität Giessen, Giessen, Federal Republic of Germany</affiliation></author><idno type="istex">B2723298C45D7DF8115F98D53360C136FD5537A5</idno><idno type="ark">ark:/67375/1BB-NVFZTWRW-9</idno><idno type="DOI">10.1007/BF01311015</idno><idno type="article-id">BF01311015</idno><idno type="article-id">Art8</idno></analytic><monogr><title level="j">Archives of Virology</title><title level="j" type="abbrev">Archives of Virology</title><idno type="pISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><idno type="journal-ID">true</idno><idno type="issue-article-count">10</idno><idno type="volume-issue-count">4</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1990-03-01"></date><biblScope unit="volume">114</biblScope><biblScope unit="issue">1-2</biblScope><biblScope unit="page" from="109">109</biblScope><biblScope unit="page" to="120">120</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1990-01-16</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Summary: After covalent attachment of bacterial lipopolysaccharide to the nucleoprotein of influenza A virus, this water-soluble antigen could be incorporated firmly into ISCOM. This potent “immunostimulating complex” induced the production of high antibody titers in mice and could partially protect the animals from a lethal challenge infection. After immunization with ISCOM preparations NP-specific cytotoxic T cell activity could not be demonstrated.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Biomedicine</head><item><term>Medical Microbiology</term></item><item><term>Virology</term></item><item><term>Infectious Diseases</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1990-01-16">Created</change><change when="1990-03-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-NVFZTWRW-9/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Vienna</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>705</JournalID><JournalPrintISSN>0304-8608</JournalPrintISSN><JournalElectronicISSN>1432-8798</JournalElectronicISSN><JournalTitle>Archives of Virology</JournalTitle><JournalAbbreviatedTitle>Archives of Virology</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Biomedicine</JournalSubject><JournalSubject Type="Secondary">Medical Microbiology</JournalSubject><JournalSubject Type="Secondary">Virology</JournalSubject><JournalSubject Type="Secondary">Infectious Diseases</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>114</VolumeIDStart><VolumeIDEnd>114</VolumeIDEnd><VolumeIssueCount>4</VolumeIssueCount></VolumeInfo><Issue IssueType="Combined"><IssueInfo TocLevels="0"><IssueIDStart>1</IssueIDStart><IssueIDEnd>2</IssueIDEnd><IssueArticleCount>10</IssueArticleCount><IssueHistory><CoverDate><DateString>1990</DateString><Year>1990</Year><Month>3</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1990</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art8"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF01311015</ArticleID><ArticleDOI>10.1007/BF01311015</ArticleDOI><ArticleSequenceNumber>8</ArticleSequenceNumber><ArticleTitle Language="En">Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein</ArticleTitle><ArticleCategory>Original Papers</ArticleCategory><ArticleFirstPage>109</ArticleFirstPage><ArticleLastPage>120</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2005</Year><Month>2</Month><Day>28</Day></RegistrationDate><Received><Year>1990</Year><Month>1</Month><Day>16</Day></Received><Accepted><Year>1990</Year><Month>4</Month><Day>18</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1990</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>705</JournalID><VolumeIDStart>114</VolumeIDStart><VolumeIDEnd>114</VolumeIDEnd><IssueIDStart>1</IssueIDStart><IssueIDEnd>2</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>H.</GivenName><GivenName>-P.</GivenName><FamilyName>Weiß</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>L.</GivenName><FamilyName>Stitz</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>H.</GivenName><FamilyName>Becht</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Institut für Virologie</OrgDivision><OrgName>Justus-Liebig-Universität Giessen</OrgName><OrgAddress><City>Giessen</City><Country>Federal Republic of Germany</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>After covalent attachment of bacterial lipopolysaccharide to the nucleoprotein of influenza A virus, this water-soluble antigen could be incorporated firmly into ISCOM. This potent “immunostimulating complex” induced the production of high antibody titers in mice and could partially protect the animals from a lethal challenge infection. After immunization with ISCOM preparations NP-specific cytotoxic T cell activity could not be demonstrated.</Para></Abstract></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein</title></titleInfo><name type="personal"><namePart type="given">H.</namePart><namePart type="given">-P.</namePart><namePart type="family">Weiß</namePart><affiliation>Institut für Virologie, Justus-Liebig-Universität Giessen, Giessen, Federal Republic of Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Stitz</namePart><affiliation>Institut für Virologie, Justus-Liebig-Universität Giessen, Giessen, Federal Republic of Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Becht</namePart><affiliation>Institut für Virologie, Justus-Liebig-Universität Giessen, Giessen, Federal Republic of Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Vienna</placeTerm></place><dateCreated encoding="w3cdtf">1990-01-16</dateCreated><dateIssued encoding="w3cdtf">1990-03-01</dateIssued><copyrightDate encoding="w3cdtf">1990</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Summary: After covalent attachment of bacterial lipopolysaccharide to the nucleoprotein of influenza A virus, this water-soluble antigen could be incorporated firmly into ISCOM. This potent “immunostimulating complex” induced the production of high antibody titers in mice and could partially protect the animals from a lethal challenge infection. After immunization with ISCOM preparations NP-specific cytotoxic T cell activity could not be demonstrated.</abstract><note>Original Papers</note><relatedItem type="host"><titleInfo><title>Archives of Virology</title></titleInfo><titleInfo type="abbreviated"><title>Archives of Virology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">1990-03-01</dateIssued><copyrightDate encoding="w3cdtf">1990</copyrightDate></originInfo><subject><genre>Biomedicine</genre><topic>Medical Microbiology</topic><topic>Virology</topic><topic>Infectious Diseases</topic></subject><identifier type="ISSN">0304-8608</identifier><identifier type="eISSN">1432-8798</identifier><identifier type="JournalID">705</identifier><identifier type="IssueArticleCount">10</identifier><identifier type="VolumeIssueCount">4</identifier><part><date>1990</date><detail type="volume"><number>114</number><caption>vol.</caption></detail><detail type="issue"><number>1-2</number><caption>no.</caption></detail><extent unit="pages"><start>109</start><end>120</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1990</recordOrigin></recordInfo></relatedItem><identifier type="istex">B2723298C45D7DF8115F98D53360C136FD5537A5</identifier><identifier type="ark">ark:/67375/1BB-NVFZTWRW-9</identifier><identifier type="DOI">10.1007/BF01311015</identifier><identifier type="ArticleID">BF01311015</identifier><identifier type="ArticleID">Art8</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1990</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag, 1990</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-NVFZTWRW-9/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000839 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000839 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:B2723298C45D7DF8115F98D53360C136FD5537A5
|texte= Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein
}}
| This area was generated with Dilib version V0.6.33. |  |