H2N2V1, Main, Exploration, bibRecord, 002448

Cytotoxic T cells recognize fragments of the influenza nucleoprotein

Identifieur interne : 002448 ( Main/Exploration ); précédent : 002447; suivant : 002449

Cytotoxic T cells recognize fragments of the influenza nucleoprotein

Auteurs : Alain R. M. Townsend [Royaume-Uni] ; Frances M. Gotch [Royaume-Uni] ; John Davey [Allemagne]

Source :

Cell [ 0092-8674 ] ; 1985.

RBID : ISTEX:6DCE60103C67668B5E977706D5788E8B1D7E3683

English descriptors

Teeft :
- Amino, Amino acids, Assay, Cell lines, Cell recognition, Cell surface, Cells cotransfected, Cells transfected, Clone, Cotransfected, Cytotoxic, Davey, Determinant, Epitope, First panel, Fragment, Gene, High expression, Histocompatibility, Immunol, Influenza, Influenza virus, Lymphocyte, Mcmichael, Mmole, Molecular weight, Monoclonal, Monoclonal antibodies, Monoclonal antibody, Mrna, Mrna transcripts, Murine, Nuclear accumulation, Nucleoprotein, Plasma membrane, Plasmid, Polyclonal, Polyclonal cells, Recombinant, Release assay, Same results, Short peptides, Sigma, Skehel, Soluble proteins, Southern analysis, Spleen cells, Townsend, Transfected, Transfected cells, Viral, Viral proteins, Virus, Virus nucleoprotein, Xenopus oocytes, Yewdell.

Abstract

Abstract: Recent work has shown that a major population of murine influenza A specific cytotoxic T lymphocytes (CTL) recognize the viral nucleoprotein. In order to investigate the mechanism by which this nonglycoprotein component of the virus is recognized by CTL, a series of deletion mutants of an A virus NP gene were studied. The results showed that CTL recognize three distinct epitopes of the NP molecule. Both N- and C-terminal fragments of the protein are transported, independently of each other, to the site of recognition by CTL. These findings imply that a mechanism may exist for transport to the cell surface and presentation to CTL, of viral proteins and protein fragments that lack defined signal sequences.

Url:

https://api.istex.fr/ark:/67375/6H6-QM17956C-7/fulltext.pdf

DOI: 10.1016/0092-8674(85)90103-5

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: Recent work has shown that a major population of murine influenza A specific cytotoxic T lymphocytes (CTL) recognize the viral nucleoprotein. In order to investigate the mechanism by which this nonglycoprotein component of the virus is recognized by CTL, a series of deletion mutants of an A virus NP gene were studied. The results showed that CTL recognize three distinct epitopes of the NP molecule. Both N- and C-terminal fragments of the protein are transported, independently of each other, to the site of recognition by CTL. These findings imply that a mechanism may exist for transport to the cell surface and presentation to CTL, of viral proteins and protein fragments that lack defined signal sequences.</div>
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Cytotoxic T cells recognize fragments of the influenza nucleoprotein

Cytotoxic T cells recognize fragments of the influenza nucleoprotein

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri