H2N2V1, Main, Exploration, bibRecord, 002150

Nucleotide sequence of the avian influenza A/Mallard/NY/6750/78 virus polymerase genes

Identifieur interne : 002150 ( Main/Exploration ); précédent : 002149; suivant : 002151

Nucleotide sequence of the avian influenza A/Mallard/NY/6750/78 virus polymerase genes

Auteurs : John Treanor ; Kawaoka Yoshihiro [États-Unis] ; Roger Miller ; Robert G. Webster [États-Unis] ; Brian Murphy

Source :

Virus Research [ 0168-1702 ] ; 1989.

RBID : ISTEX:5174CC987A39013BB6ADFFBCD08CABDFC01216C1

Descripteurs français

KwdFr :
- ADN viral (génétique), Animaux, Données de séquences moléculaires, Gènes viraux, Humains, RNA-directed DNA polymerase (génétique), Similitude de séquences d'acides nucléiques, Séquence d'acides aminés, Séquence nucléotidique, Virus de la grippe A (enzymologie), Virus de la grippe A (génétique).
MESH :
- enzymologie : Virus de la grippe A.
- génétique : ADN viral, RNA-directed DNA polymerase, Virus de la grippe A.
- Animaux, Données de séquences moléculaires, Gènes viraux, Humains, Similitude de séquences d'acides nucléiques, Séquence d'acides aminés, Séquence nucléotidique.

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Base Sequence, DNA, Viral (genetics), Genes, Viral, Humans, Influenza A virus (enzymology), Influenza A virus (genetics), Molecular Sequence Data, RNA-Directed DNA Polymerase (genetics), Sequence Homology, Nucleic Acid.
MESH :
- chemical , genetics : DNA, Viral, RNA-Directed DNA Polymerase.
- enzymology : Influenza A virus.
- genetics : Influenza A virus.
Teeft :
- Amino, Amino Acid Sequence, Amino acid sequence, Amino acid sequences, Amino acids, Animal influenza, Animals, Attenuated, Avian, Avian influenza, Avian influenza virus, Avian virus, Base Sequence, Embryonated eggs, Encoding, Gene, Gene segment, Gene segments, Genes, Viral, Hlnl, Homology, Human influenza, Human influenza virus, Human virus, Human viruses, Humans, Influenza, Influenza virus, Internal genes, Location signals, Molecular Sequence Data, Nuclear location signal, Nucleoprotein, Nucleotide, Nucleotide sequence, Nucleotide sequences, Polymerase, Polymerase gene segments, Polymerase genes, Polymerase proteins, Reassortant, Reassortant virus, Reassortant viruses, Replication, Sequence Homology, Nucleic Acid, Sequencing, Squirrel monkeys, Vaccine, Virology, Virus.

Abstract

Abstract: The avian influenza A/Mallard/NY/6750/78 virus is currently being evaluated as a donor of attenuating genes in the construction of live avian-human influenza A reassortant virus vaccines for use in humans. We determined the nucleotide sequences of the three polymerase gene segments of this virus. This completes the nucleotide sequence of the six transferrable genes of the avian donor virus. Comparison of the nucleotide and deduced amino acid sequences of the non-glycoprotein genes of the avian A/Mallard/78 virus with representative avian and human influenza A viruses suggests that the PB1 gene of H2N2 subtype human influenza A viruses may have been derived from a non-human, possibly avian influenza A virus by genetic reassortment. In addition, several regions of conserved amino acids with potential functional significance were identified in the deduced amino acid sequences of the polymerase proteins.

Url:

https://api.istex.fr/ark:/67375/6H6-VVKR89MJ-M/fulltext.pdf

DOI: 10.1016/0168-1702(89)90006-3

Affiliations:

États-Unis

Le document en format XML

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<term>Genes, Viral</term>
<term>Humans</term>
<term>Influenza A virus (enzymology)</term>
<term>Influenza A virus (genetics)</term>
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<term>RNA-Directed DNA Polymerase (genetics)</term>
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<term>Gènes viraux</term>
<term>Humains</term>
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<term>Séquence d'acides aminés</term>
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<term>Virus de la grippe A (génétique)</term>
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<term>Gene segments</term>
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<term>Human influenza virus</term>
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<term>Influenza virus</term>
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<term>Location signals</term>
<term>Molecular Sequence Data</term>
<term>Nuclear location signal</term>
<term>Nucleoprotein</term>
<term>Nucleotide</term>
<term>Nucleotide sequence</term>
<term>Nucleotide sequences</term>
<term>Polymerase</term>
<term>Polymerase gene segments</term>
<term>Polymerase genes</term>
<term>Polymerase proteins</term>
<term>Reassortant</term>
<term>Reassortant virus</term>
<term>Reassortant viruses</term>
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<term>Virology</term>
<term>Virus</term>
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<front><div type="abstract" xml:lang="en">Abstract: The avian influenza A/Mallard/NY/6750/78 virus is currently being evaluated as a donor of attenuating genes in the construction of live avian-human influenza A reassortant virus vaccines for use in humans. We determined the nucleotide sequences of the three polymerase gene segments of this virus. This completes the nucleotide sequence of the six transferrable genes of the avian donor virus. Comparison of the nucleotide and deduced amino acid sequences of the non-glycoprotein genes of the avian A/Mallard/78 virus with representative avian and human influenza A viruses suggests that the PB1 gene of H2N2 subtype human influenza A viruses may have been derived from a non-human, possibly avian influenza A virus by genetic reassortment. In addition, several regions of conserved amino acids with potential functional significance were identified in the deduced amino acid sequences of the polymerase proteins.</div>
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Nucleotide sequence of the avian influenza A/Mallard/NY/6750/78 virus polymerase genes

Nucleotide sequence of the avian influenza A/Mallard/NY/6750/78 virus polymerase genes

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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