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Nucleotide sequence of the avian influenza A/Mallard/NY/6750/78 virus polymerase genes

Identifieur interne : 000189 ( Istex/Corpus ); précédent : 000188; suivant : 000190

Nucleotide sequence of the avian influenza A/Mallard/NY/6750/78 virus polymerase genes

Auteurs : John Treanor ; Kawaoka Yoshihiro ; Roger Miller ; Robert G. Webster ; Brian Murphy

Source :

RBID : ISTEX:5174CC987A39013BB6ADFFBCD08CABDFC01216C1

English descriptors

Abstract

Abstract: The avian influenza A/Mallard/NY/6750/78 virus is currently being evaluated as a donor of attenuating genes in the construction of live avian-human influenza A reassortant virus vaccines for use in humans. We determined the nucleotide sequences of the three polymerase gene segments of this virus. This completes the nucleotide sequence of the six transferrable genes of the avian donor virus. Comparison of the nucleotide and deduced amino acid sequences of the non-glycoprotein genes of the avian A/Mallard/78 virus with representative avian and human influenza A viruses suggests that the PB1 gene of H2N2 subtype human influenza A viruses may have been derived from a non-human, possibly avian influenza A virus by genetic reassortment. In addition, several regions of conserved amino acids with potential functional significance were identified in the deduced amino acid sequences of the polymerase proteins.

Url:
DOI: 10.1016/0168-1702(89)90006-3

Links to Exploration step

ISTEX:5174CC987A39013BB6ADFFBCD08CABDFC01216C1

Le document en format XML

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<p>Abstract: The avian influenza A/Mallard/NY/6750/78 virus is currently being evaluated as a donor of attenuating genes in the construction of live avian-human influenza A reassortant virus vaccines for use in humans. We determined the nucleotide sequences of the three polymerase gene segments of this virus. This completes the nucleotide sequence of the six transferrable genes of the avian donor virus. Comparison of the nucleotide and deduced amino acid sequences of the non-glycoprotein genes of the avian A/Mallard/78 virus with representative avian and human influenza A viruses suggests that the PB1 gene of H2N2 subtype human influenza A viruses may have been derived from a non-human, possibly avian influenza A virus by genetic reassortment. In addition, several regions of conserved amino acids with potential functional significance were identified in the deduced amino acid sequences of the polymerase proteins.</p>
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