Molecular mechanisms of transcription and replication of the influenza A virus genome
Identifieur interne : 000D30 ( Main/Exploration ); précédent : 000D29; suivant : 000D31Molecular mechanisms of transcription and replication of the influenza A virus genome
Auteurs : Shijian Zhang [République populaire de Chine] ; Tetsuya Toyoda [Japon]Source :
- Frontiers in Biology [ 1674-7984 ] ; 2011-12-01.
English descriptors
Abstract
Abstract: Influenza Avirus is one of the major pathogens that pose a large threat to human health worldwide and has caused pandemics. Influenza A virus is the Orthomyxoviridae prototype, and has 8 segmented negative-sense single-stranded RNA (vRNA) as its genome. Influenza virus RNA polymerase (RdRp) consists of three subunits PB2, PB1 and PA, and catalyzes both transcription and replication. Recently, intensive biochemical and structural analysis of its RdRp has been performed. In this paper, we review the details from the biochemical analysis of the purified influenza virus RdRp and the classical ribonucleoprotein complex, as well as piece together their structures to form an overall picture.
Url:
DOI: 10.1007/s11515-011-1151-5
Affiliations:
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Biol. </title><idno type="ISSN">1674-7984</idno><idno type="eISSN">1674-7992</idno><imprint><publisher>SP Higher Education Press</publisher><pubPlace>Heidelberg</pubPlace><date type="published" when="2011-12-01">2011-12-01</date><biblScope unit="volume">6</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="446">446</biblScope><biblScope unit="page" to="461">461</biblScope></imprint><idno type="ISSN">1674-7984</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1674-7984</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>RNA polymerase</term><term>influenza virus</term><term>replication</term><term>ribonucleoprotein complex</term><term>transcription</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Influenza Avirus is one of the major pathogens that pose a large threat to human health worldwide and has caused pandemics. Influenza A virus is the Orthomyxoviridae prototype, and has 8 segmented negative-sense single-stranded RNA (vRNA) as its genome. Influenza virus RNA polymerase (RdRp) consists of three subunits PB2, PB1 and PA, and catalyzes both transcription and replication. Recently, intensive biochemical and structural analysis of its RdRp has been performed. In this paper, we review the details from the biochemical analysis of the purified influenza virus RdRp and the classical ribonucleoprotein complex, as well as piece together their structures to form an overall picture.</div></front></TEI><affiliations><list><country><li>Japon</li><li>République populaire de Chine</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Shijian" sort="Zhang, Shijian" uniqKey="Zhang S" first="Shijian" last="Zhang">Shijian Zhang</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Toyoda, Tetsuya" sort="Toyoda, Tetsuya" uniqKey="Toyoda T" first="Tetsuya" last="Toyoda">Tetsuya Toyoda</name></noRegion><name sortKey="Toyoda, Tetsuya" sort="Toyoda, Tetsuya" uniqKey="Toyoda T" first="Tetsuya" last="Toyoda">Tetsuya Toyoda</name><name sortKey="Toyoda, Tetsuya" sort="Toyoda, Tetsuya" uniqKey="Toyoda T" first="Tetsuya" last="Toyoda">Tetsuya Toyoda</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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