Molecular mechanisms of transcription and replication of the influenza A virus genome
Identifieur interne : 001745 ( Istex/Corpus ); précédent : 001744; suivant : 001746Molecular mechanisms of transcription and replication of the influenza A virus genome
Auteurs : Shijian Zhang ; Tetsuya ToyodaSource :
- Frontiers in Biology [ 1674-7984 ] ; 2011-12-01.
English descriptors
Abstract
Abstract: Influenza Avirus is one of the major pathogens that pose a large threat to human health worldwide and has caused pandemics. Influenza A virus is the Orthomyxoviridae prototype, and has 8 segmented negative-sense single-stranded RNA (vRNA) as its genome. Influenza virus RNA polymerase (RdRp) consists of three subunits PB2, PB1 and PA, and catalyzes both transcription and replication. Recently, intensive biochemical and structural analysis of its RdRp has been performed. In this paper, we review the details from the biochemical analysis of the purified influenza virus RdRp and the classical ribonucleoprotein complex, as well as piece together their structures to form an overall picture.
Url:
DOI: 10.1007/s11515-011-1151-5
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ISTEX:FD4EA4FA3627D45AE570D9B32DD98F0109E313EFLe document en format XML
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Influenza A virus is the Orthomyxoviridae prototype, and has 8 segmented negative-sense single-stranded RNA (vRNA) as its genome. Influenza virus RNA polymerase (RdRp) consists of three subunits PB2, PB1 and PA, and catalyzes both transcription and replication. Recently, intensive biochemical and structural analysis of its RdRp has been performed. 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Influenza A virus is the <Emphasis Type="Italic">Orthomyxoviridae</Emphasis> prototype, and has 8 segmented negative-sense single-stranded RNA (vRNA) as its genome. Influenza virus RNA polymerase (RdRp) consists of three subunits PB2, PB1 and PA, and catalyzes both transcription and replication. Recently, intensive biochemical and structural analysis of its RdRp has been performed. In this paper, we review the details from the biochemical analysis of the purified influenza virus RdRp and the classical ribonucleoprotein complex, as well as piece together their structures to form an overall picture.</Para></Abstract><KeywordGroup Language="En"><Heading>Keywords</Heading><Keyword>influenza virus</Keyword><Keyword>RNA polymerase</Keyword><Keyword>ribonucleoprotein complex</Keyword><Keyword>transcription</Keyword><Keyword>replication</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Molecular mechanisms of transcription and replication of the influenza A virus genome</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Molecular mechanisms of transcription and replication of the influenza A virus genome</title></titleInfo><name type="personal"><namePart type="given">Shijian</namePart><namePart type="family">Zhang</namePart><affiliation>Shanghai Medical College of Fudan University, 200032, Shanghai, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Tetsuya</namePart><namePart type="family">Toyoda</namePart><affiliation>Choju Medical Institute, Fukushimura Hospital, 19-14 Azanakayama, Noyori-cho, 441-8124, Toyohashi, Aichi, Japan</affiliation><affiliation>Infectious Disease Regulation Project, Tokyo Metropolitan Institute of Medical Sciences, 1-6, Kamikitazawa 2-chome, Setagaya-ku, 156-8506, Tokyo, Japan</affiliation><affiliation>E-mail: toyoda_tetsuya@yahoo.co.jp</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="ReviewPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>SP Higher Education Press</publisher><place><placeTerm type="text">Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">2011-03-18</dateCreated><dateIssued encoding="w3cdtf">2011-12-01</dateIssued><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Influenza Avirus is one of the major pathogens that pose a large threat to human health worldwide and has caused pandemics. Influenza A virus is the Orthomyxoviridae prototype, and has 8 segmented negative-sense single-stranded RNA (vRNA) as its genome. Influenza virus RNA polymerase (RdRp) consists of three subunits PB2, PB1 and PA, and catalyzes both transcription and replication. Recently, intensive biochemical and structural analysis of its RdRp has been performed. In this paper, we review the details from the biochemical analysis of the purified influenza virus RdRp and the classical ribonucleoprotein complex, as well as piece together their structures to form an overall picture.</abstract><note>Review</note><subject lang="en"><genre>Keywords</genre><topic>influenza virus</topic><topic>RNA polymerase</topic><topic>ribonucleoprotein complex</topic><topic>transcription</topic><topic>replication</topic></subject><relatedItem type="host"><titleInfo><title>Frontiers in Biology</title><subTitle>Selected Publications from Chinese Universities</subTitle></titleInfo><titleInfo type="abbreviated"><title>Front. 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