H2N2V1, Main, Exploration, bibRecord, 000C98

N-Glycans from Porcine Trachea and Lung: Predominant NeuAcα2-6Gal Could Be a Selective Pressure for Influenza Variants in Favor of Human-Type Receptor

Identifieur interne : 000C98 ( Main/Exploration ); précédent : 000C97; suivant : 000C99

N-Glycans from Porcine Trachea and Lung: Predominant NeuAcα2-6Gal Could Be a Selective Pressure for Influenza Variants in Favor of Human-Type Receptor

Auteurs : Nongluk Sriwilaijaroen [Thaïlande, Japon] ; Sachiko Kondo [Japon] ; Hirokazu Yagi [Japon] ; Nobuhiro Takemae [Thaïlande, Japon] ; Takehiko Saito [Thaïlande, Japon] ; Hiroaki Hiramatsu [Japon] ; Koichi Kato [Japon] ; Yasuo Suzuki [Japon]

Source :

PLoS ONE [ 1932-6203 ] ; 2011.

RBID : PMC:3036579

Abstract

It is known that pigs acted as “mixing vessels” for genesis of a new reassortant influenza strain responsible for pandemic H1N1 2009. However, the host factors driving the evolution of a reassorted virus in pigs to ‘jump species’ resulting in a human outbreak remain unclear. N-glycans derived from the porcine respiratory tract were enzymatically released, fluorescent labeled with 2-aminopyridine, separated according to charge, size and hydrophobicity, and structurally identified by a two-dimensional (size and hydrophobicity) HPLC mapping technique and MALDI-TOF mass spectrometry before and after exo-glycosidase digestion. We found a 3-, 5-, and 13-fold increases in NeuAcα2-6, a preferable human influenza receptor, over NeuAcα2-3, an avian influenza receptor, from upper and lower parts of the porcine trachea towards the porcine lung, a major target organ for swine virus replication. The large proportion of NeuAcα2-6 may exert selective pressure for selection of influenza variants with altered receptor preference for this human-type α2-6 receptor, a crucial first step for generating a human pandemic.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036579

DOI: 10.1371/journal.pone.0016302
PubMed: 21347401
PubMed Central: 3036579

Affiliations:

Le document en format XML

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-Glycans from Porcine Trachea and Lung: Predominant NeuAcα2-6Gal Could Be a Selective Pressure for Influenza Variants in Favor of Human-Type Receptor</title>
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-Glycans from Porcine Trachea and Lung: Predominant NeuAcα2-6Gal Could Be a Selective Pressure for Influenza Variants in Favor of Human-Type Receptor</title>
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<front><div type="abstract" xml:lang="en"><p>It is known that pigs acted as “mixing vessels” for genesis of a new reassortant influenza strain responsible for pandemic H1N1 2009. However, the host factors driving the evolution of a reassorted virus in pigs to ‘jump species’ resulting in a human outbreak remain unclear. <italic>N</italic>
-glycans derived from the porcine respiratory tract were enzymatically released, fluorescent labeled with 2-aminopyridine, separated according to charge, size and hydrophobicity, and structurally identified by a two-dimensional (size and hydrophobicity) HPLC mapping technique and MALDI-TOF mass spectrometry before and after exo-glycosidase digestion. We found a 3-, 5-, and 13-fold increases in NeuAcα2-6, a preferable human influenza receptor, over NeuAcα2-3, an avian influenza receptor, from upper and lower parts of the porcine trachea towards the porcine lung, a major target organ for swine virus replication. The large proportion of NeuAcα2-6 may exert selective pressure for selection of influenza variants with altered receptor preference for this human-type α2-6 receptor, a crucial first step for generating a human pandemic.</p>
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</analytic>
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</author>
<author><name sortKey="Kawamura, Y" uniqKey="Kawamura Y">Y Kawamura</name>
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</analytic>
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</author>
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<author><name sortKey="Kato, K" uniqKey="Kato K">K Kato</name>
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</author>
<author><name sortKey="Khoo, Kh" uniqKey="Khoo K">KH Khoo</name>
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</author>
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<author><name sortKey="Lee, Yc" uniqKey="Lee Y">YC Lee</name>
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<author><name sortKey="Suzuki, T" uniqKey="Suzuki T">T Suzuki</name>
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<author><name sortKey="Chambers, Tm" uniqKey="Chambers T">TM Chambers</name>
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<author><name sortKey="Suzuki, T" uniqKey="Suzuki T">T Suzuki</name>
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<author><name sortKey="Nguyen, Td" uniqKey="Nguyen T">TD Nguyen</name>
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<author><name sortKey="Puthavathana, P" uniqKey="Puthavathana P">P Puthavathana</name>
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</TEI>
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<li>Thaïlande</li>
</country>
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</region>
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</settlement>
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<name sortKey="Saito, Takehiko" sort="Saito, Takehiko" uniqKey="Saito T" first="Takehiko" last="Saito">Takehiko Saito</name>
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<name sortKey="Hiramatsu, Hiroaki" sort="Hiramatsu, Hiroaki" uniqKey="Hiramatsu H" first="Hiroaki" last="Hiramatsu">Hiroaki Hiramatsu</name>
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<name sortKey="Kato, Koichi" sort="Kato, Koichi" uniqKey="Kato K" first="Koichi" last="Kato">Koichi Kato</name>
<name sortKey="Kato, Koichi" sort="Kato, Koichi" uniqKey="Kato K" first="Koichi" last="Kato">Koichi Kato</name>
<name sortKey="Kato, Koichi" sort="Kato, Koichi" uniqKey="Kato K" first="Koichi" last="Kato">Koichi Kato</name>
<name sortKey="Kondo, Sachiko" sort="Kondo, Sachiko" uniqKey="Kondo S" first="Sachiko" last="Kondo">Sachiko Kondo</name>
<name sortKey="Kondo, Sachiko" sort="Kondo, Sachiko" uniqKey="Kondo S" first="Sachiko" last="Kondo">Sachiko Kondo</name>
<name sortKey="Saito, Takehiko" sort="Saito, Takehiko" uniqKey="Saito T" first="Takehiko" last="Saito">Takehiko Saito</name>
<name sortKey="Suzuki, Yasuo" sort="Suzuki, Yasuo" uniqKey="Suzuki Y" first="Yasuo" last="Suzuki">Yasuo Suzuki</name>
<name sortKey="Suzuki, Yasuo" sort="Suzuki, Yasuo" uniqKey="Suzuki Y" first="Yasuo" last="Suzuki">Yasuo Suzuki</name>
<name sortKey="Takemae, Nobuhiro" sort="Takemae, Nobuhiro" uniqKey="Takemae N" first="Nobuhiro" last="Takemae">Nobuhiro Takemae</name>
<name sortKey="Yagi, Hirokazu" sort="Yagi, Hirokazu" uniqKey="Yagi H" first="Hirokazu" last="Yagi">Hirokazu Yagi</name>
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</tree>
</affiliations>
</record>

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N-Glycans from Porcine Trachea and Lung: Predominant NeuAcα2-6Gal Could Be a Selective Pressure for Influenza Variants in Favor of Human-Type Receptor

N-Glycans from Porcine Trachea and Lung: Predominant NeuAcα2-6Gal Could Be a Selective Pressure for Influenza Variants in Favor of Human-Type Receptor

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