Immune Dysfunction and Bacterial Co-Infections following Influenza
Identifieur interne : 000883 ( Main/Exploration ); précédent : 000882; suivant : 000884Immune Dysfunction and Bacterial Co-Infections following Influenza
Auteurs : Dennis W. Metzger ; Keer SunSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 0022-1767 ] ; 2013.
Abstract
Secondary pulmonary infections by encapsulated bacteria including
Url:
DOI: 10.4049/jimmunol.1301152
PubMed: 23964104
PubMed Central: 3760235
Affiliations:
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immune Dysfunction and Bacterial Co-Infections following Influenza</title><author><name sortKey="Metzger, Dennis W" sort="Metzger, Dennis W" uniqKey="Metzger D" first="Dennis W." last="Metzger">Dennis W. Metzger</name></author><author><name sortKey="Sun, Keer" sort="Sun, Keer" uniqKey="Sun K" first="Keer" last="Sun">Keer Sun</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23964104</idno><idno type="pmc">3760235</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760235</idno><idno type="RBID">PMC:3760235</idno><idno type="doi">10.4049/jimmunol.1301152</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000842</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000842</idno><idno type="wicri:Area/Pmc/Curation">000842</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000842</idno><idno type="wicri:Area/Pmc/Checkpoint">000617</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000617</idno><idno type="wicri:Area/Ncbi/Merge">000941</idno><idno type="wicri:Area/Ncbi/Curation">000941</idno><idno type="wicri:Area/Ncbi/Checkpoint">000941</idno><idno type="wicri:doubleKey">0022-1767:2013:Metzger D:immune:dysfunction:and</idno><idno type="wicri:Area/Main/Merge">000884</idno><idno type="wicri:Area/Main/Curation">000883</idno><idno type="wicri:Area/Main/Exploration">000883</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Immune Dysfunction and Bacterial Co-Infections following Influenza</title><author><name sortKey="Metzger, Dennis W" sort="Metzger, Dennis W" uniqKey="Metzger D" first="Dennis W." last="Metzger">Dennis W. Metzger</name></author><author><name sortKey="Sun, Keer" sort="Sun, Keer" uniqKey="Sun K" first="Keer" last="Sun">Keer Sun</name></author></analytic><series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title><idno type="ISSN">0022-1767</idno><idno type="eISSN">1550-6606</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Secondary pulmonary infections by encapsulated bacteria including <italic>Streptococcus pneumoniae</italic> and <italic>Staphylococcus aureus</italic> following influenza represent a common and challenging clinical problem. The reasons for this polymicrobial synergy are still not completely understood, hampering development of effective prophylactic and therapeutic interventions. While it has been commonly thought that viral-induced epithelial cell damage allows bacterial invasiveness, recent studies by several groups have now implicated dysfunctional innate immune defenses following influenza as the primary culprit for enhanced susceptibility to secondary bacterial infections. Understanding the immunological imbalances that are responsible for virus-bacteria synergy will ultimately allow the design of effective, broad-spectrum therapeutic approaches for prevention of enhanced susceptibility to these pathogens.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Metzger, Dennis W" sort="Metzger, Dennis W" uniqKey="Metzger D" first="Dennis W." last="Metzger">Dennis W. Metzger</name><name sortKey="Sun, Keer" sort="Sun, Keer" uniqKey="Sun K" first="Keer" last="Sun">Keer Sun</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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