Immune Dysfunction and Bacterial Co-Infections following Influenza
Identifieur interne : 000941 ( Ncbi/Merge ); précédent : 000940; suivant : 000942Immune Dysfunction and Bacterial Co-Infections following Influenza
Auteurs : Dennis W. Metzger ; Keer SunSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 0022-1767 ] ; 2013.
Abstract
Secondary pulmonary infections by encapsulated bacteria including
Url:
DOI: 10.4049/jimmunol.1301152
PubMed: 23964104
PubMed Central: 3760235
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PMC:3760235Le document en format XML
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<author><name sortKey="Sun, Keer" sort="Sun, Keer" uniqKey="Sun K" first="Keer" last="Sun">Keer Sun</name>
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<series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">Secondary pulmonary infections by encapsulated bacteria including <italic>Streptococcus pneumoniae</italic>
and <italic>Staphylococcus aureus</italic>
following influenza represent a common and challenging clinical problem. The reasons for this polymicrobial synergy are still not completely understood, hampering development of effective prophylactic and therapeutic interventions. While it has been commonly thought that viral-induced epithelial cell damage allows bacterial invasiveness, recent studies by several groups have now implicated dysfunctional innate immune defenses following influenza as the primary culprit for enhanced susceptibility to secondary bacterial infections. Understanding the immunological imbalances that are responsible for virus-bacteria synergy will ultimately allow the design of effective, broad-spectrum therapeutic approaches for prevention of enhanced susceptibility to these pathogens.</p>
</div>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">2985117R</journal-id>
<journal-id journal-id-type="pubmed-jr-id">4816</journal-id>
<journal-id journal-id-type="nlm-ta">J Immunol</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Immunol.</journal-id>
<journal-title-group><journal-title>Journal of immunology (Baltimore, Md. : 1950)</journal-title>
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<article-id pub-id-type="doi">10.4049/jimmunol.1301152</article-id>
<article-id pub-id-type="manuscript">NIHMS500323</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Immune Dysfunction and Bacterial Co-Infections following Influenza</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Metzger</surname>
<given-names>Dennis W.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Sun</surname>
<given-names>Keer</given-names>
</name>
</contrib>
<aff id="A1">Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York 12208</aff>
</contrib-group>
<author-notes><corresp id="FN1">Corresponding Author: Dennis W. Metzger, Ph.D., Center for Immunology and Microbial Disease, Albany Medical College, MC-151, 47 New Scotland Avenue, Albany, NY 12208, Phone: (518) 262-6750, Fax: (518) 262-6053, <email>metzged@mail.amc.edu</email>
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<pub-date pub-type="nihms-submitted"><day>7</day>
<month>8</month>
<year>2013</year>
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<pub-date pub-type="ppub"><day>1</day>
<month>9</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>9</month>
<year>2014</year>
</pub-date>
<volume>191</volume>
<issue>5</issue>
<fpage>2047</fpage>
<lpage>2052</lpage>
<abstract><p id="P1">Secondary pulmonary infections by encapsulated bacteria including <italic>Streptococcus pneumoniae</italic>
and <italic>Staphylococcus aureus</italic>
following influenza represent a common and challenging clinical problem. The reasons for this polymicrobial synergy are still not completely understood, hampering development of effective prophylactic and therapeutic interventions. While it has been commonly thought that viral-induced epithelial cell damage allows bacterial invasiveness, recent studies by several groups have now implicated dysfunctional innate immune defenses following influenza as the primary culprit for enhanced susceptibility to secondary bacterial infections. Understanding the immunological imbalances that are responsible for virus-bacteria synergy will ultimately allow the design of effective, broad-spectrum therapeutic approaches for prevention of enhanced susceptibility to these pathogens.</p>
</abstract>
<funding-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source>
<award-id>R01 AI075312 || AI</award-id>
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<name sortKey="Sun, Keer" sort="Sun, Keer" uniqKey="Sun K" first="Keer" last="Sun">Keer Sun</name>
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