Availability, Pharmaceutics, Security, Pharmacokinetics, and Pharmacological Activities of Patchouli Alcohol
Identifieur interne : 000340 ( Main/Exploration ); précédent : 000339; suivant : 000341Availability, Pharmaceutics, Security, Pharmacokinetics, and Pharmacological Activities of Patchouli Alcohol
Auteurs : Guanying Hu [République populaire de Chine] ; Cheng Peng [République populaire de Chine] ; Xiaofang Xie [République populaire de Chine] ; Sanyin Zhang [République populaire de Chine] ; Xiaoyu Cao [République populaire de Chine]Source :
- Evidence-based Complementary and Alternative Medicine : eCAM [ 1741-427X ] ; 2017.
Abstract
Patchouli alcohol (PA), a tricyclic sesquiterpene, is one of the critical bioactive ingredients and is mainly isolated from aerial part of
Url:
DOI: 10.1155/2017/4850612
PubMed: 28421121
PubMed Central: 5379095
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Patchouli alcohol (PA), a tricyclic sesquiterpene, is one of the critical bioactive ingredients and is mainly isolated from aerial part of<italic> Pogostemon cablin</italic>
(known as guanghuoxiang in China) belonging to Labiatae. So far, PA has been widely applied in perfume industries. This review was written with the use of reliable information published between 1974 and 2016 from libraries and electronic researches including NCKI, PubMed, Reaxys, ACS, ScienceDirect, Springer, and Wiley-Blackwell, aiming at presenting comprehensive outline of security, pharmacokinetics, and bioactivities of PA and at further providing a potential guide in exploring the PA and its use in various medical fields. We found that PA maybe was a low toxic drug that was acquired numerously through vegetable oil isolation and chemical synthesis and its stability and low water dissolution were improved in pharmaceutics. It also possessed specific pharmacokinetic characteristics, such as two-compartment open model, first-order kinetic elimination, and certain biometabolism and biotransformation process, and was shown to have multiple biological activities, that is, immunomodulatory, anti-inflammatory, antioxidative, antitumor, antimicrobial, insecticidal, antiatherogenic, antiemetic, whitening, and sedative activity. However, the systematic evaluations of preparation, pharmaceutics, toxicology, pharmacokinetics, and bioactivities underlying molecular mechanisms of action also required further investigation prior to practices of PA in clinic.</p>
</div>
</front>
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<affiliations><list><country><li>République populaire de Chine</li>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Hu, Guanying" sort="Hu, Guanying" uniqKey="Hu G" first="Guanying" last="Hu">Guanying Hu</name>
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<name sortKey="Peng, Cheng" sort="Peng, Cheng" uniqKey="Peng C" first="Cheng" last="Peng">Cheng Peng</name>
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