Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies
Identifieur interne : 000287 ( Main/Exploration ); précédent : 000286; suivant : 000288Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies
Auteurs : Irene Sanjuan Nandin ; Carol Fong ; Cecilia Deantonio ; Juan A. Torreno-Pina ; Simone Pecetta ; Paula Maldonado ; Francesca Gasparrini ; Jose Ordovas-Montanes ; Samuel W. Kazer ; Svend Kjaer ; Daryl W. Borley ; Usha Nair ; Julia A. Coleman ; Daniel Lingwood ; Alex K. Shalek ; Eric Meffre ; Pascal Poignard ; Dennis R. Burton ; Facundo D. BatistaSource :
- The Journal of Experimental Medicine [ 0022-1007 ] ; 2017.
Abstract
Sanjuan Nandin et al. describe an innovative approach based on antigen-dependent activation of human memory B cells in culture. It results in the rapid generation of human antibodies against infectious agents and offers the potential for therapeutic antibody production and vaccine development.
Url:
DOI: 10.1084/jem.20170633
PubMed: 28739603
PubMed Central: 5551578
Affiliations:
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Torreno-Pina</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation></author><author><name sortKey="Pecetta, Simone" sort="Pecetta, Simone" uniqKey="Pecetta S" first="Simone" last="Pecetta">Simone Pecetta</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation></author><author><name sortKey="Maldonado, Paula" sort="Maldonado, Paula" uniqKey="Maldonado P" first="Paula" last="Maldonado">Paula Maldonado</name><affiliation><nlm:aff id="aff1"><institution>Lymphocyte Interaction Laboratory, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Gasparrini, Francesca" sort="Gasparrini, Francesca" uniqKey="Gasparrini F" first="Francesca" last="Gasparrini">Francesca Gasparrini</name><affiliation><nlm:aff id="aff1"><institution>Lymphocyte Interaction Laboratory, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Ordovas Montanes, Jose" sort="Ordovas Montanes, Jose" uniqKey="Ordovas Montanes J" first="Jose" last="Ordovas-Montanes">Jose Ordovas-Montanes</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><institution>Broad Institute of MIT and Harvard, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Institute for Medical Engineering and Science, MIT, Cambridge, MA</institution></nlm:aff></affiliation></author><author><name sortKey="Kazer, Samuel W" sort="Kazer, Samuel W" uniqKey="Kazer S" first="Samuel W." last="Kazer">Samuel W. Kazer</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><institution>Broad Institute of MIT and Harvard, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Institute for Medical Engineering and Science, MIT, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Department of Chemistry, MIT, Cambridge, MA</institution></nlm:aff></affiliation></author><author><name sortKey="Kjaer, Svend" sort="Kjaer, Svend" uniqKey="Kjaer S" first="Svend" last="Kjaer">Svend Kjaer</name><affiliation><nlm:aff id="aff2"><institution>Protein Purification and Structural Biology, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Borley, Daryl W" sort="Borley, Daryl W" uniqKey="Borley D" first="Daryl W." last="Borley">Daryl W. 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Coleman</name><affiliation><nlm:aff id="aff1"><institution>Lymphocyte Interaction Laboratory, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Lingwood, Daniel" sort="Lingwood, Daniel" uniqKey="Lingwood D" first="Daniel" last="Lingwood">Daniel Lingwood</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation></author><author><name sortKey="Shalek, Alex K" sort="Shalek, Alex K" uniqKey="Shalek A" first="Alex K." last="Shalek">Alex K. Shalek</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><institution>Broad Institute of MIT and Harvard, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Institute for Medical Engineering and Science, MIT, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Department of Chemistry, MIT, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff8"><institution>Division of Health Sciences and Technology, Harvard Medical School, Boston, MA</institution></nlm:aff></affiliation></author><author><name sortKey="Meffre, Eric" sort="Meffre, Eric" uniqKey="Meffre E" first="Eric" last="Meffre">Eric Meffre</name><affiliation><nlm:aff id="aff9"><institution>Department of Immunobiology, Yale University School of Medicine, New Haven, CT</institution></nlm:aff></affiliation></author><author><name sortKey="Poignard, Pascal" sort="Poignard, Pascal" uniqKey="Poignard P" first="Pascal" last="Poignard">Pascal Poignard</name><affiliation><nlm:aff id="aff10"><institution>International AIDS Vaccine Initiative Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, CA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff11"><institution>Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA</institution></nlm:aff></affiliation></author><author><name sortKey="Burton, Dennis R" sort="Burton, Dennis R" uniqKey="Burton D" first="Dennis R." last="Burton">Dennis R. Burton</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff10"><institution>International AIDS Vaccine Initiative Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, CA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff11"><institution>Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA</institution></nlm:aff></affiliation></author><author><name sortKey="Batista, Facundo D" sort="Batista, Facundo D" uniqKey="Batista F" first="Facundo D." last="Batista">Facundo D. Batista</name><affiliation><nlm:aff id="aff1"><institution>Lymphocyte Interaction Laboratory, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Experimental Medicine</title><idno type="ISSN">0022-1007</idno><idno type="eISSN">1540-9538</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Sanjuan Nandin et al. describe an innovative approach based on antigen-dependent activation of human memory B cells in culture. 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Borley</name><name sortKey="Burton, Dennis R" sort="Burton, Dennis R" uniqKey="Burton D" first="Dennis R." last="Burton">Dennis R. Burton</name><name sortKey="Coleman, Julia A" sort="Coleman, Julia A" uniqKey="Coleman J" first="Julia A." last="Coleman">Julia A. Coleman</name><name sortKey="Deantonio, Cecilia" sort="Deantonio, Cecilia" uniqKey="Deantonio C" first="Cecilia" last="Deantonio">Cecilia Deantonio</name><name sortKey="Fong, Carol" sort="Fong, Carol" uniqKey="Fong C" first="Carol" last="Fong">Carol Fong</name><name sortKey="Gasparrini, Francesca" sort="Gasparrini, Francesca" uniqKey="Gasparrini F" first="Francesca" last="Gasparrini">Francesca Gasparrini</name><name sortKey="Kazer, Samuel W" sort="Kazer, Samuel W" uniqKey="Kazer S" first="Samuel W." last="Kazer">Samuel W. 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Shalek</name><name sortKey="Torreno Pina, Juan A" sort="Torreno Pina, Juan A" uniqKey="Torreno Pina J" first="Juan A." last="Torreno-Pina">Juan A. Torreno-Pina</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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