Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies
Identifieur interne : 000A02 ( Pmc/Curation ); précédent : 000A01; suivant : 000A03Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies
Auteurs : Irene Sanjuan Nandin ; Carol Fong ; Cecilia Deantonio ; Juan A. Torreno-Pina ; Simone Pecetta ; Paula Maldonado ; Francesca Gasparrini ; Jose Ordovas-Montanes ; Samuel W. Kazer ; Svend Kjaer ; Daryl W. Borley ; Usha Nair ; Julia A. Coleman ; Daniel Lingwood ; Alex K. Shalek ; Eric Meffre ; Pascal Poignard ; Dennis R. Burton ; Facundo D. BatistaSource :
- The Journal of Experimental Medicine [ 0022-1007 ] ; 2017.
Abstract
Sanjuan Nandin et al. describe an innovative approach based on antigen-dependent activation of human memory B cells in culture. It results in the rapid generation of human antibodies against infectious agents and offers the potential for therapeutic antibody production and vaccine development.
Url:
DOI: 10.1084/jem.20170633
PubMed: 28739603
PubMed Central: 5551578
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies</title><author><name sortKey="Sanjuan Nandin, Irene" sort="Sanjuan Nandin, Irene" uniqKey="Sanjuan Nandin I" first="Irene" last="Sanjuan Nandin">Irene Sanjuan Nandin</name><affiliation><nlm:aff id="aff1"><institution>Lymphocyte Interaction Laboratory, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Fong, Carol" sort="Fong, Carol" uniqKey="Fong C" first="Carol" last="Fong">Carol Fong</name><affiliation><nlm:aff id="aff1"><institution>Lymphocyte Interaction Laboratory, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Deantonio, Cecilia" sort="Deantonio, Cecilia" uniqKey="Deantonio C" first="Cecilia" last="Deantonio">Cecilia Deantonio</name><affiliation><nlm:aff id="aff1"><institution>Lymphocyte Interaction Laboratory, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Torreno Pina, Juan A" sort="Torreno Pina, Juan A" uniqKey="Torreno Pina J" first="Juan A." last="Torreno-Pina">Juan A. Torreno-Pina</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation></author><author><name sortKey="Pecetta, Simone" sort="Pecetta, Simone" uniqKey="Pecetta S" first="Simone" last="Pecetta">Simone Pecetta</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation></author><author><name sortKey="Maldonado, Paula" sort="Maldonado, Paula" uniqKey="Maldonado P" first="Paula" last="Maldonado">Paula Maldonado</name><affiliation><nlm:aff id="aff1"><institution>Lymphocyte Interaction Laboratory, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Gasparrini, Francesca" sort="Gasparrini, Francesca" uniqKey="Gasparrini F" first="Francesca" last="Gasparrini">Francesca Gasparrini</name><affiliation><nlm:aff id="aff1"><institution>Lymphocyte Interaction Laboratory, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Ordovas Montanes, Jose" sort="Ordovas Montanes, Jose" uniqKey="Ordovas Montanes J" first="Jose" last="Ordovas-Montanes">Jose Ordovas-Montanes</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><institution>Broad Institute of MIT and Harvard, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Institute for Medical Engineering and Science, MIT, Cambridge, MA</institution></nlm:aff></affiliation></author><author><name sortKey="Kazer, Samuel W" sort="Kazer, Samuel W" uniqKey="Kazer S" first="Samuel W." last="Kazer">Samuel W. 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Coleman</name><affiliation><nlm:aff id="aff1"><institution>Lymphocyte Interaction Laboratory, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Lingwood, Daniel" sort="Lingwood, Daniel" uniqKey="Lingwood D" first="Daniel" last="Lingwood">Daniel Lingwood</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation></author><author><name sortKey="Shalek, Alex K" sort="Shalek, Alex K" uniqKey="Shalek A" first="Alex K." last="Shalek">Alex K. Shalek</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><institution>Broad Institute of MIT and Harvard, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Institute for Medical Engineering and Science, MIT, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Department of Chemistry, MIT, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff8"><institution>Division of Health Sciences and Technology, Harvard Medical School, Boston, MA</institution></nlm:aff></affiliation></author><author><name sortKey="Meffre, Eric" sort="Meffre, Eric" uniqKey="Meffre E" first="Eric" last="Meffre">Eric Meffre</name><affiliation><nlm:aff id="aff9"><institution>Department of Immunobiology, Yale University School of Medicine, New Haven, CT</institution></nlm:aff></affiliation></author><author><name sortKey="Poignard, Pascal" sort="Poignard, Pascal" uniqKey="Poignard P" first="Pascal" last="Poignard">Pascal Poignard</name><affiliation><nlm:aff id="aff10"><institution>International AIDS Vaccine Initiative Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, CA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff11"><institution>Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA</institution></nlm:aff></affiliation></author><author><name sortKey="Burton, Dennis R" sort="Burton, Dennis R" uniqKey="Burton D" first="Dennis R." last="Burton">Dennis R. 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Batista</name><affiliation><nlm:aff id="aff1"><institution>Lymphocyte Interaction Laboratory, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28739603</idno><idno type="pmc">5551578</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551578</idno><idno type="RBID">PMC:5551578</idno><idno type="doi">10.1084/jem.20170633</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000A02</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A02</idno><idno type="wicri:Area/Pmc/Curation">000A02</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A02</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies</title><author><name sortKey="Sanjuan Nandin, Irene" sort="Sanjuan Nandin, Irene" uniqKey="Sanjuan Nandin I" first="Irene" last="Sanjuan Nandin">Irene Sanjuan Nandin</name><affiliation><nlm:aff id="aff1"><institution>Lymphocyte Interaction Laboratory, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Fong, Carol" sort="Fong, Carol" uniqKey="Fong C" first="Carol" last="Fong">Carol Fong</name><affiliation><nlm:aff id="aff1"><institution>Lymphocyte Interaction Laboratory, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Deantonio, Cecilia" sort="Deantonio, Cecilia" uniqKey="Deantonio C" first="Cecilia" last="Deantonio">Cecilia Deantonio</name><affiliation><nlm:aff id="aff1"><institution>Lymphocyte Interaction Laboratory, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Torreno Pina, Juan A" sort="Torreno Pina, Juan A" uniqKey="Torreno Pina J" first="Juan A." last="Torreno-Pina">Juan A. Torreno-Pina</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation></author><author><name sortKey="Pecetta, Simone" sort="Pecetta, Simone" uniqKey="Pecetta S" first="Simone" last="Pecetta">Simone Pecetta</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation></author><author><name sortKey="Maldonado, Paula" sort="Maldonado, Paula" uniqKey="Maldonado P" first="Paula" last="Maldonado">Paula Maldonado</name><affiliation><nlm:aff id="aff1"><institution>Lymphocyte Interaction Laboratory, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Gasparrini, Francesca" sort="Gasparrini, Francesca" uniqKey="Gasparrini F" first="Francesca" last="Gasparrini">Francesca Gasparrini</name><affiliation><nlm:aff id="aff1"><institution>Lymphocyte Interaction Laboratory, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Ordovas Montanes, Jose" sort="Ordovas Montanes, Jose" uniqKey="Ordovas Montanes J" first="Jose" last="Ordovas-Montanes">Jose Ordovas-Montanes</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><institution>Broad Institute of MIT and Harvard, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Institute for Medical Engineering and Science, MIT, Cambridge, MA</institution></nlm:aff></affiliation></author><author><name sortKey="Kazer, Samuel W" sort="Kazer, Samuel W" uniqKey="Kazer S" first="Samuel W." last="Kazer">Samuel W. Kazer</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><institution>Broad Institute of MIT and Harvard, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Institute for Medical Engineering and Science, MIT, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Department of Chemistry, MIT, Cambridge, MA</institution></nlm:aff></affiliation></author><author><name sortKey="Kjaer, Svend" sort="Kjaer, Svend" uniqKey="Kjaer S" first="Svend" last="Kjaer">Svend Kjaer</name><affiliation><nlm:aff id="aff2"><institution>Protein Purification and Structural Biology, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Borley, Daryl W" sort="Borley, Daryl W" uniqKey="Borley D" first="Daryl W." last="Borley">Daryl W. Borley</name><affiliation><nlm:aff id="aff7"><institution>Diagnostic and Molecular Development, hLAB Division, hVIVO PLC, Queen Mary BioEnterprises Innovation Centre, London, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Nair, Usha" sort="Nair, Usha" uniqKey="Nair U" first="Usha" last="Nair">Usha Nair</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation></author><author><name sortKey="Coleman, Julia A" sort="Coleman, Julia A" uniqKey="Coleman J" first="Julia A." last="Coleman">Julia A. Coleman</name><affiliation><nlm:aff id="aff1"><institution>Lymphocyte Interaction Laboratory, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation></author><author><name sortKey="Lingwood, Daniel" sort="Lingwood, Daniel" uniqKey="Lingwood D" first="Daniel" last="Lingwood">Daniel Lingwood</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation></author><author><name sortKey="Shalek, Alex K" sort="Shalek, Alex K" uniqKey="Shalek A" first="Alex K." last="Shalek">Alex K. Shalek</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><institution>Broad Institute of MIT and Harvard, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff5"><institution>Institute for Medical Engineering and Science, MIT, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff6"><institution>Department of Chemistry, MIT, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff8"><institution>Division of Health Sciences and Technology, Harvard Medical School, Boston, MA</institution></nlm:aff></affiliation></author><author><name sortKey="Meffre, Eric" sort="Meffre, Eric" uniqKey="Meffre E" first="Eric" last="Meffre">Eric Meffre</name><affiliation><nlm:aff id="aff9"><institution>Department of Immunobiology, Yale University School of Medicine, New Haven, CT</institution></nlm:aff></affiliation></author><author><name sortKey="Poignard, Pascal" sort="Poignard, Pascal" uniqKey="Poignard P" first="Pascal" last="Poignard">Pascal Poignard</name><affiliation><nlm:aff id="aff10"><institution>International AIDS Vaccine Initiative Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, CA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff11"><institution>Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA</institution></nlm:aff></affiliation></author><author><name sortKey="Burton, Dennis R" sort="Burton, Dennis R" uniqKey="Burton D" first="Dennis R." last="Burton">Dennis R. Burton</name><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff10"><institution>International AIDS Vaccine Initiative Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, CA</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff11"><institution>Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA</institution></nlm:aff></affiliation></author><author><name sortKey="Batista, Facundo D" sort="Batista, Facundo D" uniqKey="Batista F" first="Facundo D." last="Batista">Facundo D. Batista</name><affiliation><nlm:aff id="aff1"><institution>Lymphocyte Interaction Laboratory, Francis Crick Institute, London, England, UK</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Experimental Medicine</title><idno type="ISSN">0022-1007</idno><idno type="eISSN">1540-9538</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Sanjuan Nandin et al. describe an innovative approach based on antigen-dependent activation of human memory B cells in culture. It results in the rapid generation of human antibodies against infectious agents and offers the potential for therapeutic antibody production and vaccine development.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Arpin, C" uniqKey="Arpin C">C. Arpin</name></author><author><name sortKey="Dechanet, J" uniqKey="Dechanet J">J. Déchanet</name></author><author><name sortKey="Van Kooten, C" uniqKey="Van Kooten C">C. Van Kooten</name></author><author><name sortKey="Merville, P" uniqKey="Merville P">P. Merville</name></author><author><name sortKey="Grouard, G" uniqKey="Grouard G">G. Grouard</name></author><author><name sortKey="Briere, F" uniqKey="Briere F">F. Brière</name></author><author><name sortKey="Banchereau, J" uniqKey="Banchereau J">J. Banchereau</name></author><author><name sortKey="Liu, Y J" uniqKey="Liu Y">Y.J. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Exp Med</journal-id><journal-id journal-id-type="iso-abbrev">J. Exp. Med</journal-id><journal-id journal-id-type="publisher-id">jem</journal-id><journal-id journal-id-type="hwp">jem</journal-id><journal-title-group><journal-title>The Journal of Experimental Medicine</journal-title></journal-title-group><issn pub-type="ppub">0022-1007</issn><issn pub-type="epub">1540-9538</issn><publisher><publisher-name>The Rockefeller University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28739603</article-id><article-id pub-id-type="pmc">5551578</article-id><article-id pub-id-type="publisher-id">20170633</article-id><article-id pub-id-type="doi">10.1084/jem.20170633</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Articles</subject><subj-group><subject>Technical Advances</subject></subj-group></subj-group></article-categories><title-group><article-title>Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies</article-title><alt-title alt-title-type="short">In vitro boost strategy to produce human antibodies</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sanjuan Nandin</surname><given-names>Irene</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="author-notes" rid="afn13">*</xref></contrib><contrib contrib-type="author"><name><surname>Fong</surname><given-names>Carol</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="author-notes" rid="afn13">*</xref></contrib><contrib contrib-type="author"><name><surname>Deantonio</surname><given-names>Cecilia</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Torreno-Pina</surname><given-names>Juan A.</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Pecetta</surname><given-names>Simone</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Maldonado</surname><given-names>Paula</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Gasparrini</surname><given-names>Francesca</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ordovas-Montanes</surname><given-names>Jose</given-names></name><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Kazer</surname><given-names>Samuel W.</given-names></name><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="aff" rid="aff5">5</xref><xref ref-type="aff" rid="aff6">6</xref></contrib><contrib contrib-type="author"><name><surname>Kjaer</surname><given-names>Svend</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Borley</surname><given-names>Daryl W.</given-names></name><xref ref-type="aff" rid="aff7">7</xref></contrib><contrib contrib-type="author"><name><surname>Nair</surname><given-names>Usha</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-0605-3459</contrib-id><name><surname>Coleman</surname><given-names>Julia A.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0003-0374-1982</contrib-id><name><surname>Lingwood</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0001-5670-8778</contrib-id><name><surname>Shalek</surname><given-names>Alex K.</given-names></name><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="aff" rid="aff5">5</xref><xref ref-type="aff" rid="aff6">6</xref><xref ref-type="aff" rid="aff8">8</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0003-4326-0171</contrib-id><name><surname>Meffre</surname><given-names>Eric</given-names></name><xref ref-type="aff" rid="aff9">9</xref></contrib><contrib contrib-type="author"><name><surname>Poignard</surname><given-names>Pascal</given-names></name><xref ref-type="aff" rid="aff10">10</xref><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib contrib-type="author"><name><surname>Burton</surname><given-names>Dennis R.</given-names></name><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="aff" rid="aff10">10</xref><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0002-6317-293X</contrib-id><name><surname>Batista</surname><given-names>Facundo D.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="corresp" rid="cor12"></xref></contrib></contrib-group><aff id="aff1"><label>1</label><institution>Lymphocyte Interaction Laboratory, Francis Crick Institute, London, England, UK</institution></aff><aff id="aff2"><label>2</label><institution>Protein Purification and Structural Biology, Francis Crick Institute, London, England, UK</institution></aff><aff id="aff3"><label>3</label><institution>Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Cambridge, MA</institution></aff><aff id="aff4"><label>4</label><institution>Broad Institute of MIT and Harvard, Cambridge, MA</institution></aff><aff id="aff5"><label>5</label><institution>Institute for Medical Engineering and Science, MIT, Cambridge, MA</institution></aff><aff id="aff6"><label>6</label><institution>Department of Chemistry, MIT, Cambridge, MA</institution></aff><aff id="aff7"><label>7</label><institution>Diagnostic and Molecular Development, hLAB Division, hVIVO PLC, Queen Mary BioEnterprises Innovation Centre, London, England, UK</institution></aff><aff id="aff8"><label>8</label><institution>Division of Health Sciences and Technology, Harvard Medical School, Boston, MA</institution></aff><aff id="aff9"><label>9</label><institution>Department of Immunobiology, Yale University School of Medicine, New Haven, CT</institution></aff><aff id="aff10"><label>10</label><institution>International AIDS Vaccine Initiative Neutralizing Antibody Center and the Collaboration for AIDS Vaccine Discovery, The Scripps Research Institute, La Jolla, CA</institution></aff><aff id="aff11"><label>11</label><institution>Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA</institution></aff><author-notes><corresp id="cor12">Correspondence to Facundo D. Batista: <email>fbatista1@mgh.harvard.edu</email></corresp><fn fn-type="equal" specific-use="equal" id="afn13"><label>*</label><p>I. Sanjuan Nandin and C. Fong contributed equally to this paper.</p></fn></author-notes><pub-date pub-type="ppub"><day>07</day><month>8</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>07</day><month>8</month><year>2017</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>214</volume><issue>8</issue><fpage>2471</fpage><lpage>2490</lpage><history><date date-type="received"><day>05</day><month>4</month><year>2017</year></date><date date-type="rev-recd"><day>01</day><month>6</month><year>2017</year></date><date date-type="accepted"><day>26</day><month>6</month><year>2017</year></date></history><permissions><copyright-statement>© 2017 Sanjuan Nandin et al.</copyright-statement><copyright-year>2017</copyright-year><ali:free_to_read></ali:free_to_read><license license-type="openaccess"><ali:license_ref specific-use="vor">https://creativecommons.org/licenses/by/4.0/</ali:license_ref><license-p>This article is available under a Creative Commons License (Attribution 4.0 International, as described at <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>).</license-p></license></permissions><self-uri xlink:role="icon" xlink:href="JEM_20170633_thumb.gif"></self-uri><abstract abstract-type="precis"><p>Sanjuan Nandin et al. describe an innovative approach based on antigen-dependent activation of human memory B cells in culture. It results in the rapid generation of human antibodies against infectious agents and offers the potential for therapeutic antibody production and vaccine development.</p></abstract><abstract><p>Vaccines remain the most effective tool to prevent infectious diseases. Here, we introduce an in vitro booster vaccination approach that relies on antigen-dependent activation of human memory B cells in culture. This stimulation induces antigen-specific B cell proliferation, differentiation of B cells into plasma cells, and robust antibody secretion after a few days of culture. We validated this strategy using cells from healthy donors to retrieve human antibodies against tetanus toxoid and influenza hemagglutinin (HA) from H1N1 and newly emergent subtypes such as H5N1 and H7N9. Anti-HA antibodies were cross-reactive against multiple subtypes, and some showed neutralizing activity. Although these antibodies may have arisen as a result of previous influenza infection, we also obtained gp120-reactive antibodies from non–HIV-infected donors, indicating that we can generate antibodies without prior antigenic exposure. Overall, our novel approach can be used to rapidly produce therapeutic antibodies and has the potential to assess the immunogenicity of candidate antigens, which could be exploited in future vaccine development.</p></abstract><funding-group><award-group id="sp1"><funding-source><institution-wrap><institution>Francis Crick Institute</institution><institution-id institution-id-type="DOI">http://dx.doi.org/10.13039/100010438</institution-id></institution-wrap></funding-source></award-group><award-group id="sp2"><funding-source><institution-wrap><institution>Cancer Research UK</institution><institution-id institution-id-type="DOI">http://dx.doi.org/10.13039/501100000289</institution-id></institution-wrap></funding-source><award-id rid="sp2">FC001035</award-id></award-group><award-group id="sp3"><funding-source><institution-wrap><institution>Medical Research Council</institution><institution-id institution-id-type="DOI">http://dx.doi.org/10.13039/501100000265</institution-id></institution-wrap></funding-source><award-id rid="sp3">FC001035</award-id></award-group><award-group id="sp4"><funding-source><institution-wrap><institution>Wellcome Trust</institution><institution-id institution-id-type="DOI">http://dx.doi.org/10.13039/100004440</institution-id></institution-wrap></funding-source><award-id rid="sp4">FC001035</award-id></award-group><award-group id="sp5"><funding-source>Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery</funding-source></award-group><award-group id="sp6"><funding-source><institution-wrap><institution>National Institutes of Health</institution><institution-id institution-id-type="DOI">http://dx.doi.org/10.13039/100000002</institution-id></institution-wrap></funding-source><award-id rid="sp6">UM1AI100663</award-id></award-group><award-group id="sp7"><funding-source>Phillip T. and Susan M. Ragon Institute Foundation</funding-source></award-group><award-group id="sp8"><funding-source><institution-wrap><institution>Bill and Melinda Gates Foundation</institution><institution-id institution-id-type="DOI">http://dx.doi.org/10.13039/100000865</institution-id></institution-wrap></funding-source><award-id rid="sp8">228966</award-id></award-group><award-group id="sp9"><funding-source>BLiNK Therapeutics Ltd</funding-source></award-group><award-group id="sp10"><funding-source>Searle</funding-source></award-group><award-group id="sp11"><funding-source>Beckman</funding-source></award-group><award-group id="sp12"><funding-source><institution-wrap><institution>NIH</institution><institution-id institution-id-type="DOI">http://dx.doi.org/10.13039/100000002</institution-id></institution-wrap></funding-source><award-id rid="sp12">DP2 OD020839</award-id><award-id rid="sp12">U24 AI11862-01</award-id><award-id rid="sp12">P50 HG006193</award-id></award-group><award-group id="sp13"><funding-source><institution-wrap><institution>Bill and Melinda Gates Foundation</institution><institution-id institution-id-type="DOI">http://dx.doi.org/10.13039/100000865</institution-id></institution-wrap></funding-source><award-id rid="sp13">03629000189</award-id></award-group><award-group id="sp14"><funding-source>Ragon Institute</funding-source></award-group><award-group id="sp15"><funding-source><institution-wrap><institution>Gilead</institution><institution-id institution-id-type="DOI">http://dx.doi.org/10.13039/100005564</institution-id></institution-wrap></funding-source></award-group><award-group id="sp16"><funding-source><institution-wrap><institution>NIH</institution><institution-id institution-id-type="DOI">http://dx.doi.org/10.13039/100000002</institution-id></institution-wrap></funding-source><award-id rid="sp16">DP2DA042422</award-id><award-id rid="sp16">2P30AI060354-11</award-id></award-group><award-group id="sp17"><funding-source><institution-wrap><institution>European Molecular Biology Organization</institution><institution-id institution-id-type="DOI">http://dx.doi.org/10.13039/100004410</institution-id></institution-wrap></funding-source><award-id rid="sp17">ALTF 345-2016</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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