Personal historical chronicle of six decades of basic and applied research in virology, immunology, and vaccinology
Identifieur interne : 001771 ( Istex/Corpus ); précédent : 001770; suivant : 001772Personal historical chronicle of six decades of basic and applied research in virology, immunology, and vaccinology
Auteurs : Maurice R. HillemanSource :
- Immunological Reviews [ 0105-2896 ] ; 1999-08.
English descriptors
- Teeft :
- Adenovirus, Adenovirus vaccine, Adjuvant, Antigenic, Attenuated, Attenuated measles virus vaccine, Attenuated mumps virus vaccine, Attenuation, Bioi, Biol, Bull world health organ, Buynak, Cell culture, Cell cultures, Clinical studies, Costa rica, Cytopathic changes, Duck cells, Embryo, Enders, Epidemic occurrence, Experimental vaccines, Healthy children, Hepatitis, Hiileman, Hilieman, Hilleman, Hillenian, Hong kong, Human hepatitis, Immune, Immunologic, Immunology, Influenza, Influenza virus, Interferon, Jama, Kmcc virus, Laboratory studies, Licensure, Marmoset, Mcaleer, Measles, Measles vaccine, Measles virus, Meningococcai, Meningococcai vaccines, Merck, Molecular biology, Mumps, Ofthe, Pandemic, Pandemic influenza, Plotkin, Pneumococcal, Polysaccharide, Proc, Protective efficacy, Provost, Public health, Respiratory virus vaccines, Rhinovirus, Rubella, Rubella vaccines, Serotypes, Simian virus, Stokes, Surface antigen, Tytell, Vaccine, Vaccine development, Vaccine developments, Vaccinology, Varicella, Viral, Viral hepatitis, Virology, Virus, Virus vaccine, Virus vaccines, Walter reed, Weibel, Young children.
Url:
DOI: 10.1111/j.1600-065X.1999.tb01325.x
Links to Exploration step
ISTEX:6CE08202E62D5DF0F5A6CB1858A342EF4753B8AALe document en format XML
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<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><p><hi rend="bold">Summary: </hi> The sciences of vaccinology and of immunology were created just two centuries ago by Jenner's studies of prevention of smallpox by inoculation with cowpox virus. Tins rudimentary beginning was expanded greatly by the giants of late 19th and early 10th centuries, bio‐medical sciences. The period from 1930 to 1950 was a transitional era with the introduction of chick embryos and minced tissues for propagating viruses and rickettsiae in vitro for vaccines. Modern era vaccinology began about i950 as a continuum of notable advances made during the 1940s and World War II. Present vaccinology is based largely on breakthroughs in cell culture, bacterial polysaccharide chemistry, molecular biology, and immunology By invitation, the author, who is a microbe hunter in fact, was asked to chronicle his six decades of pioneering achievements in basic and applied virology, bacteriology, immunology, molecular biology, epidemiology, and cancer, with special reference to the pioneering creation of most of the present day vaccines. Knowledge of the past may guide the present and future. This chronicle will have achieved its legacy if it helps others to understand the why and how of the past that may help to create the substance of the future.</p></abstract><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-MZQ1HHLQ-L/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-065X</doi><issn type="print">0105-2896</issn><issn type="electronic">1600-065X</issn><idGroup><id type="product" value="IMR"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="IMMUNOLOGICAL REVIEWS">Immunological Reviews</title></titleGroup></publicationMeta><publicationMeta level="part" position="08001"><doi origin="wiley">10.1111/imr.1999.170.issue-1</doi><numberingGroup><numbering type="journalVolume" number="170">170</numbering><numbering type="journalIssue" number="1">1</numbering></numberingGroup><coverDate startDate="1999-08">August 1999</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0000700" status="forIssue"><doi origin="wiley">10.1111/j.1600-065X.1999.tb01325.x</doi><idGroup><id type="unit" value="IMR7"></id></idGroup><countGroup><count type="pageTotal" number="21"></count></countGroup><eventGroup><event type="firstOnline" date="2006-04-28"></event><event type="publishedOnlineFinalForm" date="2006-04-28"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.5 mode:FullText source:HeaderRef result:HeaderRef" date="2010-04-07"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-13"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-23"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="7">7</numbering><numbering type="pageLast" number="27">27</numbering></numberingGroup><correspondenceTo>Maurice R. Hilleman, Merck Institute for Therapeutic Research Merck Research Laboratories (WP53C‐350) 770 Sumneytown Pike West Point PA 19486 USA Fax: 1 215 652 2154 e‐mail: <email>konarske@merck.com</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:IMR.IMR7.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="referenceTotal" number="179"></count><count type="linksCrossRef" number="2"></count></countGroup><titleGroup><title type="main">Personal historical chronicle of six decades of basic and applied research in virology, immunology, and vaccinology</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>Maurice R.</givenNames><familyName>Hilleman</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="US"><unparsedAffiliation>Merck Institute for Therapeutic Research, Merck Research Laboratories, West Point, Pennsylvania, USA.</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Summary: </b> The sciences of vaccinology and of immunology were created just two centuries ago by Jenner's studies of prevention of smallpox by inoculation with cowpox virus. Tins rudimentary beginning was expanded greatly by the giants of late 19th and early 10th centuries, bio‐medical sciences. The period from 1930 to 1950 was a transitional era with the introduction of chick embryos and minced tissues for propagating viruses and rickettsiae in vitro for vaccines. Modern era vaccinology began about i950 as a continuum of notable advances made during the 1940s and World War II. Present vaccinology is based largely on breakthroughs in cell culture, bacterial polysaccharide chemistry, molecular biology, and immunology By invitation, the author, who is a microbe hunter in fact, was asked to chronicle his six decades of pioneering achievements in basic and applied virology, bacteriology, immunology, molecular biology, epidemiology, and cancer, with special reference to the pioneering creation of most of the present day vaccines. Knowledge of the past may guide the present and future. This chronicle will have achieved its legacy if it helps others to understand the why and how of the past that may help to create the substance of the future.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Personal historical chronicle of six decades of basic and applied research in virology, immunology, and vaccinology</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Personal historical chronicle of six decades of basic and applied research in virology, immunology, and vaccinology</title></titleInfo><name type="personal"><namePart type="given">Maurice R.</namePart><namePart type="family">Hilleman</namePart><affiliation>Merck Institute for Therapeutic Research, Merck Research Laboratories, West Point, Pennsylvania, USA.</affiliation><affiliation>E-mail: konarske@merck.com</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1999-08</dateIssued><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="references">179</extent><extent unit="linksCrossRef">2</extent></physicalDescription>Summary: The sciences of vaccinology and of immunology were created just two centuries ago by Jenner's studies of prevention of smallpox by inoculation with cowpox virus. Tins rudimentary beginning was expanded greatly by the giants of late 19th and early 10th centuries, bio‐medical sciences. The period from 1930 to 1950 was a transitional era with the introduction of chick embryos and minced tissues for propagating viruses and rickettsiae in vitro for vaccines. Modern era vaccinology began about i950 as a continuum of notable advances made during the 1940s and World War II. Present vaccinology is based largely on breakthroughs in cell culture, bacterial polysaccharide chemistry, molecular biology, and immunology By invitation, the author, who is a microbe hunter in fact, was asked to chronicle his six decades of pioneering achievements in basic and applied virology, bacteriology, immunology, molecular biology, epidemiology, and cancer, with special reference to the pioneering creation of most of the present day vaccines. Knowledge of the past may guide the present and future. 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