H2N2V1, Istex, Corpus, bibRecord, 001699

Lessons for Human Influenza from Pathogenicity Studies with Ferrets

Identifieur interne : 001699 ( Istex/Corpus ); précédent : 001698; suivant : 001700

Lessons for Human Influenza from Pathogenicity Studies with Ferrets

Source :

Reviews of Infectious Diseases [ 1058-4838 ] ; 1988.

RBID : ISTEX:4B388BEB26913D3EFE1A274DACBDAE328CDCFFB0

Abstract

In research on influenza, little attention has been given to factors that determine the patterns of infection in human adults or infants and the severity of disease. Ferret influenza has been used to elucidate the following facets of pathogenicity that bear on these questions about human disease: the differential infectivity of virus strains for the upper respiratory tract (URT); the reasons for less severe infection of the lower respiratory tract (LRT) than of the URT; why pneumonia is rare; and why strains differ in the production of LRT infection. The origin of fever has been defined; viruses have been shown to differ in fever-producing components. Poor spread of virus from the respiratory tract to other susceptible tissues and rarity of fetal infection have been explained. Death in neonatal ferrets due to influenza with either a syndrome akin to cot death or viral pneumonia have been elucidated, and protection of the young by immunized mothers has been demonstrated.

Url:

https://api.istex.fr/ark:/67375/HXZ-WS25ZW1D-W/fulltext.pdf

DOI: 10.1093/clinids/10.1.56

Links to Exploration step

ISTEX:4B388BEB26913D3EFE1A274DACBDAE328CDCFFB0

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Lessons for Human Influenza from Pathogenicity Studies with Ferrets</title>
<author><name sortKey="Smith, Harry" sort="Smith, Harry" uniqKey="Smith H" first="Harry" last="Smith">Harry Smith</name>
<affiliation><mods:affiliation>Department of Microbiology, University of Birmingham, Birmingham, England</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Sweet, Clive" sort="Sweet, Clive" uniqKey="Sweet C" first="Clive" last="Sweet">Clive Sweet</name>
<affiliation><mods:affiliation>Department of Microbiology, University of Birmingham, Birmingham, England</mods:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:4B388BEB26913D3EFE1A274DACBDAE328CDCFFB0</idno>
<date when="1988" year="1988">1988</date>
<idno type="doi">10.1093/clinids/10.1.56</idno>
<idno type="url">https://api.istex.fr/ark:/67375/HXZ-WS25ZW1D-W/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001699</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001699</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Lessons for Human Influenza from Pathogenicity Studies with Ferrets</title>
<author><name sortKey="Smith, Harry" sort="Smith, Harry" uniqKey="Smith H" first="Harry" last="Smith">Harry Smith</name>
<affiliation><mods:affiliation>Department of Microbiology, University of Birmingham, Birmingham, England</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Sweet, Clive" sort="Sweet, Clive" uniqKey="Sweet C" first="Clive" last="Sweet">Clive Sweet</name>
<affiliation><mods:affiliation>Department of Microbiology, University of Birmingham, Birmingham, England</mods:affiliation>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Reviews of Infectious Diseases</title>
<title level="j" type="abbrev">Reviews of Infectious Diseases</title>
<idno type="ISSN">1058-4838</idno>
<idno type="eISSN">1537-6591</idno>
<imprint><publisher>The University of Chicago Press</publisher>
<date when="1988-01">1988</date>
<biblScope unit="vol">10</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="56">56</biblScope>
<biblScope unit="page" to="75">75</biblScope>
</imprint>
<idno type="ISSN">1058-4838</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1058-4838</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">In research on influenza, little attention has been given to factors that determine the patterns of infection in human adults or infants and the severity of disease. Ferret influenza has been used to elucidate the following facets of pathogenicity that bear on these questions about human disease: the differential infectivity of virus strains for the upper respiratory tract (URT); the reasons for less severe infection of the lower respiratory tract (LRT) than of the URT; why pneumonia is rare; and why strains differ in the production of LRT infection. The origin of fever has been defined; viruses have been shown to differ in fever-producing components. Poor spread of virus from the respiratory tract to other susceptible tissues and rarity of fetal infection have been explained. Death in neonatal ferrets due to influenza with either a syndrome akin to cot death or viral pneumonia have been elucidated, and protection of the young by immunized mothers has been demonstrated.</div>
</front>
</TEI>
<istex><corpusName>oup</corpusName>
<keywords><teeft><json:string>clone</json:string>
<json:string>influenza virus</json:string>
<json:string>influenza</json:string>
<json:string>epithelium</json:string>
<json:string>phagocyte</json:string>
<json:string>attenuated</json:string>
<json:string>pyrogen</json:string>
<json:string>pathogenicity</json:string>
<json:string>neonate</json:string>
<json:string>virol</json:string>
<json:string>respiratory tract</json:string>
<json:string>viral</json:string>
<json:string>turbinate</json:string>
<json:string>virulent</json:string>
<json:string>hini</json:string>
<json:string>organ culture</json:string>
<json:string>inflammatory</json:string>
<json:string>endogenous pyrogen</json:string>
<json:string>fetal</json:string>
<json:string>airway</json:string>
<json:string>replication</json:string>
<json:string>pathol</json:string>
<json:string>interferon</json:string>
<json:string>attenuated strain</json:string>
<json:string>pyrexial</json:string>
<json:string>nasal</json:string>
<json:string>bronchial epithelium</json:string>
<json:string>pyrexial temperature</json:string>
<json:string>macrophage</json:string>
<json:string>ebid</json:string>
<json:string>neonatal</json:string>
<json:string>alveolar cell</json:string>
<json:string>immunofluorescence</json:string>
<json:string>husseini</json:string>
<json:string>suckling</json:string>
<json:string>hemagglutinin</json:string>
<json:string>pyrexia</json:string>
<json:string>endogenous</json:string>
<json:string>virus</json:string>
<json:string>immune</json:string>
<json:string>inflammatory response</json:string>
<json:string>urogenital</json:string>
<json:string>infection</json:string>
<json:string>intranasal</json:string>
<json:string>reticuloendothelial</json:string>
<json:string>intranasal inoculation</json:string>
<json:string>vrna</json:string>
<json:string>virus titer</json:string>
<json:string>nonspecific inhibitor</json:string>
<json:string>bloodstream inoculation</json:string>
<json:string>neuraminidase</json:string>
<json:string>alveolar tissue</json:string>
<json:string>viremia</json:string>
<json:string>out zone</json:string>
<json:string>nasal turbinate</json:string>
<json:string>inoculation</json:string>
<json:string>vaccine</json:string>
<json:string>bioi</json:string>
<json:string>epithelial</json:string>
<json:string>virology</json:string>
<json:string>fetus</json:string>
<json:string>virulent strain</json:string>
<json:string>syncytial</json:string>
<json:string>infectious virus</json:string>
<json:string>alveolar infection</json:string>
<json:string>alveolar macrophage</json:string>
<json:string>extrarespiratory</json:string>
<json:string>recombinant</json:string>
<json:string>virion</json:string>
<json:string>human influenza</json:string>
<json:string>nasal turbinate tissue</json:string>
<json:string>strain difference</json:string>
<json:string>virulent clone</json:string>
<json:string>poor inflammatory response</json:string>
<json:string>large quantity</json:string>
<json:string>lower respiratory tract</json:string>
<json:string>syndrome</json:string>
<json:string>virulence</json:string>
<json:string>influenza virus infection</json:string>
<json:string>intermediate zone</json:string>
<json:string>genetic constitution</json:string>
<json:string>virus infection</json:string>
<json:string>nasal wash</json:string>
<json:string>inflammatory cell</json:string>
<json:string>less severe</json:string>
<json:string>nasal epithelium</json:string>
<json:string>constitutional effect</json:string>
<json:string>bronchial tissue</json:string>
<json:string>fetal tissue</json:string>
<json:string>fetal membrane</json:string>
<json:string>respiratory infection</json:string>
<json:string>maternal immunity</json:string>
<json:string>intranasal infection</json:string>
<json:string>human infant</json:string>
<json:string>greater proportion</json:string>
<json:string>tissue specificity</json:string>
<json:string>fetal infection</json:string>
<json:string>influenza infection</json:string>
<json:string>attenuated clone</json:string>
<json:string>reticuloendothelial system</json:string>
<json:string>virulent influenza virus</json:string>
<json:string>academic press</json:string>
<json:string>lung lobe</json:string>
<json:string>inflammatory phagocyte</json:string>
<json:string>arch virol</json:string>
<json:string>more virus</json:string>
<json:string>recent hini</json:string>
<json:string>influenza virus pathogenicity</json:string>
<json:string>bronchial organ culture</json:string>
<json:string>virus strain</json:string>
<json:string>superior ability</json:string>
<json:string>up respiratory tract</json:string>
<json:string>suckling animal</json:string>
<json:string>bronchiolar</json:string>
<json:string>alveolus</json:string>
<json:string>inflammation</json:string>
<json:string>susceptibility</json:string>
<json:string>collie</json:string>
<json:string>determinant</json:string>
<json:string>interferon production</json:string>
<json:string>virus antigen</json:string>
<json:string>differential production</json:string>
<json:string>lung zone</json:string>
<json:string>differential pyrogenicity</json:string>
<json:string>local interaction</json:string>
<json:string>extrarespiratory tissue</json:string>
<json:string>alveolar involvement</json:string>
<json:string>total virus</json:string>
<json:string>hilar zone</json:string>
<json:string>greater susceptibility</json:string>
<json:string>different level</json:string>
<json:string>molecular basis</json:string>
<json:string>second barrier</json:string>
<json:string>third barrier</json:string>
<json:string>organ culture experiment</json:string>
<json:string>intracardial inoculation</json:string>
<json:string>greater ability</json:string>
<json:string>newborn animal</json:string>
<json:string>sudden infant death syndrome</json:string>
<json:string>much less</json:string>
<json:string>modern hini strain</json:string>
<json:string>infectious dose</json:string>
<json:string>immune mother</json:string>
<json:string>neonatal protection</json:string>
<json:string>other factor</json:string>
<json:string>respiratory syncytial virus</json:string>
<json:string>local origin</json:string>
<json:string>avian influenza virus</json:string>
<json:string>viral replication</json:string>
<json:string>edward arnold</json:string>
<json:string>reticuloendothelial phagocyte</json:string>
<json:string>virus vaccine</json:string>
<json:string>human disease</json:string>
<json:string>philos trans</json:string>
<json:string>airway epithelium</json:string>
<json:string>inhibitor</json:string>
<json:string>vivo</json:string>
<json:string>coates</json:string>
<json:string>titer</json:string>
<json:string>alveolar</json:string>
</teeft>
</keywords>
<author><json:item><name>Harry Smith</name>
<affiliations><json:string>Department of Microbiology, University of Birmingham, Birmingham, England</json:string>
</affiliations>
</json:item>
<json:item><name>Clive Sweet</name>
<affiliations><json:string>Department of Microbiology, University of Birmingham, Birmingham, England</json:string>
</affiliations>
</json:item>
</author>
<arkIstex>ark:/67375/HXZ-WS25ZW1D-W</arkIstex>
<language><json:string>unknown</json:string>
</language>
<originalGenre><json:string>review-article</json:string>
</originalGenre>
<abstract>In research on influenza, little attention has been given to factors that determine the patterns of infection in human adults or infants and the severity of disease. Ferret influenza has been used to elucidate the following facets of pathogenicity that bear on these questions about human disease: the differential infectivity of virus strains for the upper respiratory tract (URT); the reasons for less severe infection of the lower respiratory tract (LRT) than of the URT; why pneumonia is rare; and why strains differ in the production of LRT infection. The origin of fever has been defined; viruses have been shown to differ in fever-producing components. Poor spread of virus from the respiratory tract to other susceptible tissues and rarity of fetal infection have been explained. Death in neonatal ferrets due to influenza with either a syndrome akin to cot death or viral pneumonia have been elucidated, and protection of the young by immunized mothers has been demonstrated.</abstract>
<qualityIndicators><score>7.551</score>
<pdfWordCount>12914</pdfWordCount>
<pdfCharCount>78964</pdfCharCount>
<pdfVersion>1.4</pdfVersion>
<pdfPageCount>20</pdfPageCount>
<pdfPageSize>598.32 x 768.96 pts</pdfPageSize>
<pdfWordsPerPage>646</pdfWordsPerPage>
<pdfText>true</pdfText>
<refBibsNative>false</refBibsNative>
<abstractWordCount>157</abstractWordCount>
<abstractCharCount>984</abstractCharCount>
<keywordCount>0</keywordCount>
</qualityIndicators>
<title>Lessons for Human Influenza from Pathogenicity Studies with Ferrets</title>
<genre><json:string>review-article</json:string>
</genre>
<host><title>Reviews of Infectious Diseases</title>
<language><json:string>unknown</json:string>
</language>
<issn><json:string>1058-4838</json:string>
</issn>
<eissn><json:string>1537-6591</json:string>
</eissn>
<publisherId><json:string>cid</json:string>
</publisherId>
<volume>10</volume>
<issue>1</issue>
<pages><first>56</first>
<last>75</last>
</pages>
<genre><json:string>journal</json:string>
</genre>
</host>
<namedEntities><unitex><date><json:string>10S</json:string>
<json:string>JANUARY-FEBRUARY 1988</json:string>
<json:string>1988</json:string>
</date>
<geogName></geogName>
<orgName><json:string>Department of Microbiology, University of Birmingham</json:string>
<json:string>Department of Microbiology, University of Birmingham, Birmingham, England In</json:string>
<json:string>Medical Research Council</json:string>
<json:string>Wellcome Trust</json:string>
<json:string>Cancer Research Campaign</json:string>
<json:string>Foundation for the Study of Infant Deaths</json:string>
</orgName>
<orgName_funder><json:string>Medical Research Council</json:string>
<json:string>Wellcome Trust</json:string>
<json:string>Cancer Research Campaign</json:string>
<json:string>Foundation for the Study of Infant Deaths</json:string>
</orgName_funder>
<orgName_provider></orgName_provider>
<persName><json:string>Viral Interaction</json:string>
<json:string>H. Smith</json:string>
<json:string>R. A. Bird</json:string>
<json:string>D. M. Coates</json:string>
<json:string>The</json:string>
<json:string>C. W. Penn</json:string>
<json:string>Immunofluorescence</json:string>
<json:string>Clive</json:string>
<json:string>Harry Smith</json:string>
</persName>
<placeName><json:string>Birmingham</json:string>
<json:string>Finland</json:string>
<json:string>Pathogenicity</json:string>
<json:string>Puerto Rico</json:string>
<json:string>Fiji</json:string>
</placeName>
<ref_url></ref_url>
<ref_bibl><json:string>[94]</json:string>
<json:string>[4]</json:string>
<json:string>[35,45]</json:string>
<json:string>[89]</json:string>
<json:string>[102]</json:string>
<json:string>[78, 79]</json:string>
<json:string>[110]</json:string>
<json:string>[93]</json:string>
<json:string>[36,45]</json:string>
<json:string>[80, 81]</json:string>
<json:string>[88]</json:string>
<json:string>[62, 69]</json:string>
<json:string>[13, 34-37]</json:string>
<json:string>[8]</json:string>
<json:string>[115]</json:string>
<json:string>[39]</json:string>
<json:string>[113, 114]</json:string>
<json:string>[1]</json:string>
<json:string>[10]</json:string>
<json:string>[112]</json:string>
<json:string>[35, 88]</json:string>
<json:string>[49]</json:string>
<json:string>[22, 101]</json:string>
<json:string>[109]</json:string>
<json:string>[91]</json:string>
<json:string>[74, 82]</json:string>
<json:string>[97]</json:string>
<json:string>[35, 47]</json:string>
<json:string>[5]</json:string>
<json:string>[72, 104-106]</json:string>
<json:string>[15]</json:string>
<json:string>[92, 93]</json:string>
<json:string>[94, 98]</json:string>
<json:string>[85]</json:string>
<json:string>[14, 103]</json:string>
<json:string>[36]</json:string>
<json:string>[111]</json:string>
<json:string>[10,27,28]</json:string>
<json:string>[47, 99, 100]</json:string>
<json:string>[10, 31]</json:string>
<json:string>[108]</json:string>
<json:string>[73]</json:string>
<json:string>[35]</json:string>
<json:string>[36-42]</json:string>
<json:string>[95, 96]</json:string>
<json:string>[64, 68]</json:string>
</ref_bibl>
<bibl></bibl>
</unitex>
</namedEntities>
<ark><json:string>ark:/67375/HXZ-WS25ZW1D-W</json:string>
</ark>
<categories><wos><json:string>1 - science</json:string>
<json:string>2 - microbiology</json:string>
<json:string>2 - infectious diseases</json:string>
<json:string>2 - immunology</json:string>
</wos>
<scienceMetrix><json:string>1 - health sciences</json:string>
<json:string>2 - biomedical research</json:string>
<json:string>3 - microbiology</json:string>
</scienceMetrix>
<scopus><json:string>1 - Health Sciences</json:string>
<json:string>2 - Medicine</json:string>
<json:string>3 - Infectious Diseases</json:string>
<json:string>1 - Health Sciences</json:string>
<json:string>2 - Medicine</json:string>
<json:string>3 - Microbiology (medical)</json:string>
</scopus>
<inist><json:string>1 - sciences appliquees, technologies et medecines</json:string>
<json:string>2 - sciences biologiques et medicales</json:string>
<json:string>3 - sciences medicales</json:string>
</inist>
</categories>
<publicationDate>1988</publicationDate>
<copyrightDate>1988</copyrightDate>
<doi><json:string>10.1093/clinids/10.1.56</json:string>
</doi>
<id>4B388BEB26913D3EFE1A274DACBDAE328CDCFFB0</id>
<score>1</score>
<fulltext><json:item><extension>pdf</extension>
<original>true</original>
<mimetype>application/pdf</mimetype>
<uri>https://api.istex.fr/ark:/67375/HXZ-WS25ZW1D-W/fulltext.pdf</uri>
</json:item>
<json:item><extension>zip</extension>
<original>false</original>
<mimetype>application/zip</mimetype>
<uri>https://api.istex.fr/ark:/67375/HXZ-WS25ZW1D-W/bundle.zip</uri>
</json:item>
<istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/HXZ-WS25ZW1D-W/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Lessons for Human Influenza from Pathogenicity Studies with Ferrets</title>
<respStmt><resp>Références bibliographiques récupérées via GROBID</resp>
<name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name>
</respStmt>
</titleStmt>
<publicationStmt><authority>ISTEX</authority>
<publisher>The University of Chicago Press</publisher>
<availability><licence>© 1988 by The University of Chicago</licence>
</availability>
<date type="Copyright" when="1988">1988</date>
<date when="1988-01">1988</date>
</publicationStmt>
<notesStmt><note type="content-type" source="review-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</note>
<note type="publication-type" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note>
</notesStmt>
<sourceDesc><biblStruct type="article"><analytic><title level="a" type="main" xml:lang="en">Lessons for Human Influenza from Pathogenicity Studies with Ferrets</title>
<author xml:id="author-0000"><persName><surname>Smith</surname>
<forename type="first">Harry</forename>
</persName>
<affiliation><orgName type="institution">Department of Microbiology, University of Birmingham</orgName>
<address><addrLine>Birmingham, England</addrLine>
</address>
</affiliation>
<affiliation><orgName type="department">Department of Microbiology</orgName>
<orgName type="institution">University of Birmingham</orgName>
<address><addrLine>Birmingham, England</addrLine>
</address>
</affiliation>
</author>
<author xml:id="author-0001"><persName><surname>Sweet</surname>
<forename type="first">Clive</forename>
</persName>
<affiliation><orgName type="institution">Department of Microbiology, University of Birmingham</orgName>
<address><addrLine>Birmingham, England</addrLine>
</address>
</affiliation>
<affiliation><orgName type="department">Department of Microbiology</orgName>
<orgName type="institution">University of Birmingham</orgName>
<address><addrLine>Birmingham, England</addrLine>
</address>
</affiliation>
</author>
<idno type="istex">4B388BEB26913D3EFE1A274DACBDAE328CDCFFB0</idno>
<idno type="ark">ark:/67375/HXZ-WS25ZW1D-W</idno>
<idno type="DOI">10.1093/clinids/10.1.56</idno>
</analytic>
<monogr><title level="j" type="main">Reviews of Infectious Diseases</title>
<title level="j" type="abbrev">Reviews of Infectious Diseases</title>
<idno type="hwp">cid</idno>
<idno type="publisher-id">cid</idno>
<idno type="pISSN">1058-4838</idno>
<idno type="eISSN">1537-6591</idno>
<imprint><publisher>The University of Chicago Press</publisher>
<date when="1988-01">1988</date>
<biblScope unit="vol">10</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="56">56</biblScope>
<biblScope unit="page" to="75">75</biblScope>
</imprint>
</monogr>
</biblStruct>
</sourceDesc>
</fileDesc>
<encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef>
<appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-09"><label>pub2TEI-ISTEX</label>
<desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
                        <ref target="http://www.tei-c.org/">We use TEI</ref>
</desc>
</application>
</appInfo>
</encodingDesc>
<profileDesc><abstract><p>In research on influenza, little attention has been given to factors that determine the patterns of infection in human adults or infants and the severity of disease. Ferret influenza has been used to elucidate the following facets of pathogenicity that bear on these questions about human disease: the differential infectivity of virus strains for the upper respiratory tract (URT); the reasons for less severe infection of the lower respiratory tract (LRT) than of the URT; why pneumonia is rare; and why strains differ in the production of LRT infection. The origin of fever has been defined; viruses have been shown to differ in fever-producing components. Poor spread of virus from the respiratory tract to other susceptible tissues and rarity of fetal infection have been explained. Death in neonatal ferrets due to influenza with either a syndrome akin to cot death or viral pneumonia have been elucidated, and protection of the young by immunized mothers has been demonstrated.</p>
</abstract>
<textClass ana="subject"><keywords scheme="heading"><term>Review Articles</term>
</keywords>
</textClass>
<langUsage><language ident="EN"></language>
</langUsage>
</profileDesc>
<revisionDesc><change when="2019-12-09" who="#istex" xml:id="pub2tei">formatting</change>
<change xml:id="refBibs-istex" who="#ISTEX-API" when="2019-12-10">References added</change>
</revisionDesc>
</teiHeader>
</istex:fulltextTEI>
<json:item><extension>txt</extension>
<original>false</original>
<mimetype>text/plain</mimetype>
<uri>https://api.istex.fr/ark:/67375/HXZ-WS25ZW1D-W/fulltext.txt</uri>
</json:item>
</fulltext>
<metadata><istex:metadataXml wicri:clean="corpus oup, element #text not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0"</istex:xmlDeclaration>
<istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType>
<istex:document><article article-type="review-article">

<front>

<journal-meta>

<journal-id journal-id-type="hwp">cid</journal-id>

<journal-id journal-id-type="publisher-id">cid</journal-id>

<journal-title>Reviews of Infectious Diseases</journal-title>

<abbrev-journal-title>Reviews of Infectious Diseases</abbrev-journal-title>

<issn pub-type="ppub">1058-4838</issn>

<issn pub-type="epub">1537-6591</issn>

<publisher>

<publisher-name>The University of Chicago Press</publisher-name>

</publisher>

</journal-meta>

<article-meta>

<article-id pub-id-type="doi">10.1093/clinids/10.1.56</article-id>

<article-categories>

<subj-group subj-group-type="heading">

<subject>Review Articles</subject>

</subj-group>

</article-categories>

<title-group>

<article-title>Lessons for Human Influenza from Pathogenicity Studies with Ferrets</article-title>

</title-group>

<contrib-group>

<contrib contrib-type="author">

<name>

<surname>Smith</surname>

<given-names>Harry</given-names>

</name>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Sweet</surname>

<given-names>Clive</given-names>

</name>

</contrib>

<aff>From the <institution>Department of Microbiology, University of Birmingham</institution>
, <addr-line>Birmingham, England</addr-line>
</aff>

</contrib-group>

<author-notes>

<fn fn-type="other">

<p>The work described in this review was supported by grants from the Medical Research Council, the Wellcome Trust, the Cancer Research Campaign, and the Foundation for the Study of Infant Deaths.</p>

</fn>

<fn fn-type="other">

<p>The authors are indebted to their colleagues, Drs. D. M. Coates and C. W. Penn, for their critical review of this manuscript.</p>

</fn>

<fn fn-type="other">

<p>Please address requests for reprints to Professor Harry Smith, Department of Microbiology, University of Birmingham, p.o. Box 363, Birmingham B15 2TT, England.</p>

</fn>

</author-notes>

<pub-date pub-type="ppub">

<month>1</month>

<year>1988</year>

</pub-date>

<volume>10</volume>

<issue>1</issue>

<fpage>56</fpage>

<lpage>75</lpage>

<history>

<date date-type="received">

<day>21</day>

<month>1</month>

<year>1987</year>

</date>

<date date-type="rev-recd">

<day>8</day>

<month>5</month>

<year>1987</year>

</date>

</history>

<copyright-statement>© 1988 by The University of Chicago</copyright-statement>

<copyright-year>1988</copyright-year>

<abstract>

<p>In research on influenza, little attention has been given to factors that determine the patterns of infection in human adults or infants and the severity of disease. Ferret influenza has been used to elucidate the following facets of pathogenicity that bear on these questions about human disease: the differential infectivity of virus strains for the upper respiratory tract (URT); the reasons for less severe infection of the lower respiratory tract (LRT) than of the URT; why pneumonia is rare; and why strains differ in the production of LRT infection. The origin of fever has been defined; viruses have been shown to differ in fever-producing components. Poor spread of virus from the respiratory tract to other susceptible tissues and rarity of fetal infection have been explained. Death in neonatal ferrets due to influenza with either a syndrome akin to cot death or viral pneumonia have been elucidated, and protection of the young by immunized mothers has been demonstrated.</p>

</abstract>

</article-meta>

</front>

</article>
</istex:document>
</istex:metadataXml>
<mods version="3.6"><titleInfo><title>Lessons for Human Influenza from Pathogenicity Studies with Ferrets</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA"><title>Lessons for Human Influenza from Pathogenicity Studies with Ferrets</title>
</titleInfo>
<name type="personal"><namePart type="given">Harry</namePart>
<namePart type="family">Smith</namePart>
<affiliation>Department of Microbiology, University of Birmingham, Birmingham, England</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Clive</namePart>
<namePart type="family">Sweet</namePart>
<affiliation>Department of Microbiology, University of Birmingham, Birmingham, England</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre type="review-article" displayLabel="review-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre>
<originInfo><publisher>The University of Chicago Press</publisher>
<dateIssued encoding="w3cdtf">1988-01</dateIssued>
<copyrightDate encoding="w3cdtf">1988</copyrightDate>
</originInfo>
<abstract>In research on influenza, little attention has been given to factors that determine the patterns of infection in human adults or infants and the severity of disease. Ferret influenza has been used to elucidate the following facets of pathogenicity that bear on these questions about human disease: the differential infectivity of virus strains for the upper respiratory tract (URT); the reasons for less severe infection of the lower respiratory tract (LRT) than of the URT; why pneumonia is rare; and why strains differ in the production of LRT infection. The origin of fever has been defined; viruses have been shown to differ in fever-producing components. Poor spread of virus from the respiratory tract to other susceptible tissues and rarity of fetal infection have been explained. Death in neonatal ferrets due to influenza with either a syndrome akin to cot death or viral pneumonia have been elucidated, and protection of the young by immunized mothers has been demonstrated.</abstract>
<note type="footnotes">The work described in this review was supported by grants from the Medical Research Council, the Wellcome Trust, the Cancer Research Campaign, and the Foundation for the Study of Infant Deaths.</note>
<relatedItem type="host"><titleInfo><title>Reviews of Infectious Diseases</title>
</titleInfo>
<titleInfo type="abbreviated"><title>Reviews of Infectious Diseases</title>
</titleInfo>
<genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre>
<identifier type="ISSN">1058-4838</identifier>
<identifier type="eISSN">1537-6591</identifier>
<identifier type="PublisherID">cid</identifier>
<identifier type="PublisherID-hwp">cid</identifier>
<part><date>1988</date>
<detail type="volume"><caption>vol.</caption>
<number>10</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>1</number>
</detail>
<extent unit="pages"><start>56</start>
<end>75</end>
</extent>
</part>
</relatedItem>
<identifier type="istex">4B388BEB26913D3EFE1A274DACBDAE328CDCFFB0</identifier>
<identifier type="ark">ark:/67375/HXZ-WS25ZW1D-W</identifier>
<identifier type="DOI">10.1093/clinids/10.1.56</identifier>
<accessCondition type="use and reproduction" contentType="copyright">© 1988 by The University of Chicago</accessCondition>
<recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-GTWS0RDP-M">oup</recordContentSource>
<recordOrigin>Converted from  (version 1.2.0) to MODS version 3.6.</recordOrigin>
<recordCreationDate encoding="w3cdtf">2019-12-09</recordCreationDate>
</recordInfo>
</mods>
<json:item><extension>json</extension>
<original>false</original>
<mimetype>application/json</mimetype>
<uri>https://api.istex.fr/ark:/67375/HXZ-WS25ZW1D-W/record.json</uri>
</json:item>
</metadata>
<covers><json:item><extension>tiff</extension>
<original>true</original>
<mimetype>image/tiff</mimetype>
<uri>https://api.istex.fr/document/4B388BEB26913D3EFE1A274DACBDAE328CDCFFB0/covers/tiff</uri>
</json:item>
</covers>
<annexes><json:item><extension>pdf</extension>
<original>true</original>
<mimetype>application/pdf</mimetype>
<uri>https://api.istex.fr/ark:/67375/HXZ-WS25ZW1D-W/annexes.pdf</uri>
</json:item>
</annexes>
<serie></serie>
</istex>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Istex/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001699 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001699 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Istex
   |étape=   Corpus
   |type=    RBID
   |clé=     ISTEX:4B388BEB26913D3EFE1A274DACBDAE328CDCFFB0
   |texte=   Lessons for Human Influenza from Pathogenicity Studies with Ferrets
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration H2N2

Lessons for Human Influenza from Pathogenicity Studies with Ferrets

Lessons for Human Influenza from Pathogenicity Studies with Ferrets

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri