H2N2V1, Istex, Corpus, bibRecord, 001265

A Prospective Double-Blind Study of Side Effects Associated with the Administration of Amantadine for Influenza A Virus Prophylaxis

Identifieur interne : 001265 ( Istex/Corpus ); précédent : 001264; suivant : 001266

A Prospective Double-Blind Study of Side Effects Associated with the Administration of Amantadine for Influenza A Virus Prophylaxis

Auteurs : Yvonne J. Bryson ; Carolyn Monahan ; Melanie Pollack ; W. Donald Shields

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 1980.

RBID : ISTEX:5F5AB0CC442677121780DF6AEE8987AAC4D3CD1C

Abstract

During a study of efficacy of amantadine prophylaxis of influenza A virus infection in young adults, gross and subtle side effects were monitored. Eighty-eight students were randomly selected to receive either amantadine or placebo for four weeks or both in a sequential crossover design of two weeks each. Side effects (i.e., dizziness, nervousness, and insomnia) occurred in 33% of those receiving amantadine and in 10% of those receiving placebo (P < 0.005). Although side effects were well tolerated by most subjects, six volunteers discontinued amantadine because of marked complaints. Cessation of side effects occurred in more than half of those continuing amantadine. Sixteen students receiving amantadine had decreased performance on sustained attention tasks as compared with ones receiving placebo (P < 0.05). Gross and subtle side effects of amantadine observed in this study on currently recommended dosage are higher than previously reported, which may be an important factor in consideration of mass prophylaxis.

Url:

https://api.istex.fr/ark:/67375/HXZ-6FBJCLBG-T/fulltext.pdf

DOI: 10.1093/infdis/141.5.543

Links to Exploration step

ISTEX:5F5AB0CC442677121780DF6AEE8987AAC4D3CD1C

Le document en format XML

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<surname>Shields</surname>

<given-names>W. Donald</given-names>

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<institution>Department of Pediatrics, Center for the Health Sciences, University of California, Los Angeles, School of Medicine</institution>
, <addr-line>Los Angeles, California</addr-line>

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<corresp id="cor1">Please address requests for reprints to Dr. Yvonne J. Bryson, Department of Pediatrics, Division of Infectious Diseases, Center for the Health Sciences, University of California, Los Angeles, School of Medicine, Los Angeles, California 90024.</corresp>

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<pub-date pub-type="ppub">

<month>5</month>

<year>1980</year>

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<volume>141</volume>

<issue>5</issue>

<fpage>543</fpage>

<lpage>547</lpage>

<history>

<date date-type="received">

<day>10</day>

<month>1</month>

<year>1979</year>

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<date date-type="rev-recd">

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<month>12</month>

<year>1979</year>

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<copyright-statement>© 1980 by The University of Chicago</copyright-statement>

<copyright-year>1980</copyright-year>

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<p>During a study of efficacy of amantadine prophylaxis of influenza A virus infection in young adults, gross and subtle side effects were monitored. Eighty-eight students were randomly selected to receive either amantadine or placebo for four weeks or both in a sequential crossover design of two weeks each. Side effects (i.e., dizziness, nervousness, and insomnia) occurred in 33% of those receiving amantadine and in 10% of those receiving placebo (<italic>P</italic>
 < 0.005). Although side effects were well tolerated by most subjects, six volunteers discontinued amantadine because of marked complaints. Cessation of side effects occurred in more than half of those continuing amantadine. Sixteen students receiving amantadine had decreased performance on sustained attention tasks as compared with ones receiving placebo (<italic>P</italic>
 < 0.05). Gross and subtle side effects of amantadine observed in this study on currently recommended dosage are higher than previously reported, which may be an important factor in consideration of mass prophylaxis.</p>

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A Prospective Double-Blind Study of Side Effects Associated with the Administration of Amantadine for Influenza A Virus Prophylaxis

A Prospective Double-Blind Study of Side Effects Associated with the Administration of Amantadine for Influenza A Virus Prophylaxis

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