Role of Natural Killer Cells in the Generation of Influenza Virus-Specific Cytotoxic T Cells
Identifieur interne : 001140 ( Istex/Corpus ); précédent : 001139; suivant : 001141Role of Natural Killer Cells in the Generation of Influenza Virus-Specific Cytotoxic T Cells
Auteurs : Ferdynand J. Kos ; Edgar G. EnglemanSource :
- Cellular Immunology [ 0008-8749 ] ; 1996.
English descriptors
- Teeft :
- Academic press, Accessory signals, Adherent pbmc, Assay, Autologous pbmc, Cell activation, Cell activity, Cell immuno, Cell immuno interactions, Cell responses, Critical accessory cells, Culture conditions, Cytolytic, Cytolytic activity, Cytometric analysis, Cytotoxicity assay, Days cytolytic activity, Early studies, Effector, Effector cells, Engleman, Gradient centrifugation, Human pbmc, Immunol, Immunomagnetic separation, Lysis, Melanoma cells, Mouse splenocytes, Natural killer, Palo alto, Pbmc, Previous studies, Responder, Responder cell numbers, Secondary responses, Splenocytes, Target cells, Triplicate cultures, Virus infection, Vivo, Vivo depletion.
Abstract
Abstract: Recently we reported that natural killer (NK) cells are critical accessory cells required for the differentiation of alloantigen-stimulated CD8+T cells into effector cytotoxic T lymphocytes (CTL)in vitro.In this study we provide evidence that NK cells are also required for the generation of influenza virus-specific CTL. Depletion of NK cells from responder human peripheral blood mononuclear cells or mouse splenocytes abolished the induction of influenza A virus-specific CTL under culture conditions. Treatment of C57BL/6 mice with the NK cell-depleting NK1.1 monoclonal antibody (mAb) before primary or secondary immunization with influenza A virus abrogated the capacity of CTL precursors to differentiate into influenza virus-specific CTL effectorsin vivo.These results extend our previous findings and demonstrate that NK cells critically influence the induction of antigen-specific CTL, bothin vitroandin vivo.
Url:
DOI: 10.1006/cimm.1996.0245
Links to Exploration step
ISTEX:C5576EE2BE4A33D5D5ECDAE56B0E81956AE3C04FLe document en format XML
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Depletion of NK cells from responder human peripheral blood mononuclear cells or mouse splenocytes abolished the induction of influenza A virus-specific CTL under culture conditions. Treatment of C57BL/6 mice with the NK cell-depleting NK1.1 monoclonal antibody (mAb) before primary or secondary immunization with influenza A virus abrogated the capacity of CTL precursors to differentiate into influenza virus-specific CTL effectorsin vivo.These results extend our previous findings and demonstrate that NK cells critically influence the induction of antigen-specific CTL, bothin vitroandin vivo.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>pbmc</json:string><json:string>immunol</json:string><json:string>effector</json:string><json:string>splenocytes</json:string><json:string>responder</json:string><json:string>target cells</json:string><json:string>cytolytic</json:string><json:string>lysis</json:string><json:string>engleman</json:string><json:string>cytotoxicity assay</json:string><json:string>human pbmc</json:string><json:string>assay</json:string><json:string>mouse splenocytes</json:string><json:string>cytolytic activity</json:string><json:string>cell immuno</json:string><json:string>palo alto</json:string><json:string>adherent pbmc</json:string><json:string>cell responses</json:string><json:string>culture conditions</json:string><json:string>gradient centrifugation</json:string><json:string>academic press</json:string><json:string>cytometric analysis</json:string><json:string>triplicate cultures</json:string><json:string>melanoma cells</json:string><json:string>effector cells</json:string><json:string>natural killer</json:string><json:string>critical accessory cells</json:string><json:string>cell activity</json:string><json:string>secondary responses</json:string><json:string>previous studies</json:string><json:string>cell immuno interactions</json:string><json:string>autologous pbmc</json:string><json:string>vivo depletion</json:string><json:string>responder cell numbers</json:string><json:string>cell activation</json:string><json:string>accessory signals</json:string><json:string>days cytolytic activity</json:string><json:string>early studies</json:string><json:string>virus infection</json:string><json:string>immunomagnetic separation</json:string><json:string>vivo</json:string></teeft></keywords><author><json:item><name>Ferdynand J. Kos</name><affiliations><json:string>Department of Pathology, Stanford University School of Medicine, 800 Welch Road, Palo Alto, California, 94304</json:string></affiliations></json:item><json:item><name>Edgar G. Engleman</name><affiliations><json:string>Department of Pathology, Stanford University School of Medicine, 800 Welch Road, Palo Alto, California, 94304</json:string></affiliations></json:item></author><articleId><json:string>90245</json:string></articleId><arkIstex>ark:/67375/6H6-VW3LPW23-F</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: Recently we reported that natural killer (NK) cells are critical accessory cells required for the differentiation of alloantigen-stimulated CD8+T cells into effector cytotoxic T lymphocytes (CTL)in vitro.In this study we provide evidence that NK cells are also required for the generation of influenza virus-specific CTL. Depletion of NK cells from responder human peripheral blood mononuclear cells or mouse splenocytes abolished the induction of influenza A virus-specific CTL under culture conditions. Treatment of C57BL/6 mice with the NK cell-depleting NK1.1 monoclonal antibody (mAb) before primary or secondary immunization with influenza A virus abrogated the capacity of CTL precursors to differentiate into influenza virus-specific CTL effectorsin vivo.These results extend our previous findings and demonstrate that NK cells critically influence the induction of antigen-specific CTL, bothin vitroandin vivo.</abstract><qualityIndicators><score>6.939</score><pdfWordCount>3427</pdfWordCount><pdfCharCount>20659</pdfCharCount><pdfVersion>1.1</pdfVersion><pdfPageCount>6</pdfPageCount><pdfPageSize>550 x 732 pts</pdfPageSize><refBibsNative>false</refBibsNative><abstractWordCount>126</abstractWordCount><abstractCharCount>929</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Role of Natural Killer Cells in the Generation of Influenza Virus-Specific Cytotoxic T Cells</title><pmid><json:string>8871595</json:string></pmid><pii><json:string>S0008-8749(96)90245-2</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Cellular Immunology</title><language><json:string>unknown</json:string></language><publicationDate>1996</publicationDate><issn><json:string>0008-8749</json:string></issn><pii><json:string>S0008-8749(00)X0085-8</json:string></pii><volume>173</volume><issue>1</issue><pages><first>1</first><last>6</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>5</json:string><json:string>13 and 5-38</json:string><json:string>13</json:string><json:string>09-12-96</json:string><json:string>38</json:string><json:string>1996</json:string></date><geogName></geogName><orgName><json:string>Zymed Laboratories, San Francisco</json:string><json:string>Academic Press, Inc</json:string><json:string>Stanford University</json:string><json:string>Life Technologies</json:string><json:string>Virginia Commonwealth University</json:string><json:string>Simonsen Laboratories</json:string><json:string>Massey Cancer Center</json:string><json:string>Sigma Chemical Co.</json:string><json:string>Academic Press, Inc.</json:string><json:string>Blood Center</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>L. 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Box 980037, Richmond, VA 23298-0037.</affiliation><affiliation>Department of Pathology, Stanford University School of Medicine, 800 Welch Road, Palo Alto, California, 94304</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Edgar G.</forename><surname>Engleman</surname></persName><affiliation>Department of Pathology, Stanford University School of Medicine, 800 Welch Road, Palo Alto, California, 94304</affiliation></author><idno type="istex">C5576EE2BE4A33D5D5ECDAE56B0E81956AE3C04F</idno><idno type="ark">ark:/67375/6H6-VW3LPW23-F</idno><idno type="DOI">10.1006/cimm.1996.0245</idno><idno type="PII">S0008-8749(96)90245-2</idno><idno type="article-id">90245</idno></analytic><monogr><title level="j">Cellular Immunology</title><title level="j" type="abbrev">YCIMM</title><idno type="pISSN">0008-8749</idno><idno type="PII">S0008-8749(00)X0085-8</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996"></date><biblScope unit="volume">173</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="1">1</biblScope><biblScope unit="page" to="6">6</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1996</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Recently we reported that natural killer (NK) cells are critical accessory cells required for the differentiation of alloantigen-stimulated CD8+T cells into effector cytotoxic T lymphocytes (CTL)in vitro.In this study we provide evidence that NK cells are also required for the generation of influenza virus-specific CTL. Depletion of NK cells from responder human peripheral blood mononuclear cells or mouse splenocytes abolished the induction of influenza A virus-specific CTL under culture conditions. Treatment of C57BL/6 mice with the NK cell-depleting NK1.1 monoclonal antibody (mAb) before primary or secondary immunization with influenza A virus abrogated the capacity of CTL precursors to differentiate into influenza virus-specific CTL effectorsin vivo.These results extend our previous findings and demonstrate that NK cells critically influence the induction of antigen-specific CTL, bothin vitroandin vivo.</p></abstract></profileDesc><revisionDesc><change when="1996">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-VW3LPW23-F/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier converted-article found"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>YCIMM</jid><aid>90245</aid><ce:pii>S0008-8749(96)90245-2</ce:pii><ce:doi>10.1006/cimm.1996.0245</ce:doi><ce:copyright type="full-transfer" year="1996">Academic Press</ce:copyright></item-info><head><ce:dochead><ce:textfn>Regular Article</ce:textfn></ce:dochead><ce:title>Role of Natural Killer Cells in the Generation of Influenza Virus-Specific Cytotoxic T Cells</ce:title><ce:author-group><ce:author><ce:given-name>Ferdynand J.</ce:given-name><ce:surname>Kos</ce:surname><ce:cross-ref refid="FN1">1</ce:cross-ref></ce:author><ce:author><ce:given-name>Edgar G.</ce:given-name><ce:surname>Engleman</ce:surname></ce:author><ce:affiliation><ce:textfn>Department of Pathology, Stanford University School of Medicine, 800 Welch Road, Palo Alto, California, 94304</ce:textfn></ce:affiliation><ce:footnote id="FN1"><ce:label>1</ce:label><ce:note-para>To whom correspondence should be addressed at present address: Massey Cancer Center, Virginia Commonwealth University/MCV, 401 N. College St., P.O. Box 980037, Richmond, VA 23298-0037.</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="15" month="3" year="1996"></ce:date-received><ce:date-accepted day="11" month="6" year="1996"></ce:date-accepted><ce:abstract class="author"><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para view="all" id="simple-para.0010">Recently we reported that natural killer (NK) cells are critical accessory cells required for the differentiation of alloantigen-stimulated CD8<ce:sup loc="post">+</ce:sup>T cells into effector cytotoxic T lymphocytes (CTL)<ce:italic>in vitro.</ce:italic>In this study we provide evidence that NK cells are also required for the generation of influenza virus-specific CTL. Depletion of NK cells from responder human peripheral blood mononuclear cells or mouse splenocytes abolished the induction of influenza A virus-specific CTL under culture conditions. Treatment of C57BL/6 mice with the NK cell-depleting NK1.1 monoclonal antibody (mAb) before primary or secondary immunization with influenza A virus abrogated the capacity of CTL precursors to differentiate into influenza virus-specific CTL effectors<ce:italic>in vivo.</ce:italic>These results extend our previous findings and demonstrate that NK cells critically influence the induction of antigen-specific CTL, both<ce:italic>in vitro</ce:italic>and<ce:italic>in vivo.</ce:italic></ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Role of Natural Killer Cells in the Generation of Influenza Virus-Specific Cytotoxic T Cells</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Role of Natural Killer Cells in the Generation of Influenza Virus-Specific Cytotoxic T Cells</title></titleInfo><name type="personal"><namePart type="given">Ferdynand J.</namePart><namePart type="family">Kos</namePart><affiliation>Department of Pathology, Stanford University School of Medicine, 800 Welch Road, Palo Alto, California, 94304</affiliation><description>To whom correspondence should be addressed at present address: Massey Cancer Center, Virginia Commonwealth University/MCV, 401 N. 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Box 980037, Richmond, VA 23298-0037.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Edgar G.</namePart><namePart type="family">Engleman</namePart><affiliation>Department of Pathology, Stanford University School of Medicine, 800 Welch Road, Palo Alto, California, 94304</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1996</dateIssued><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Recently we reported that natural killer (NK) cells are critical accessory cells required for the differentiation of alloantigen-stimulated CD8+T cells into effector cytotoxic T lymphocytes (CTL)in vitro.In this study we provide evidence that NK cells are also required for the generation of influenza virus-specific CTL. 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