Alkaloids from the antarctic sponge Kirkpatrickia varialosa . Part 2: Variolin A and N (3′)-methyl tetrahydrovariolin B
Identifieur interne : 001139 ( Istex/Corpus ); précédent : 001138; suivant : 001140Alkaloids from the antarctic sponge Kirkpatrickia varialosa . Part 2: Variolin A and N (3′)-methyl tetrahydrovariolin B
Auteurs : Golakoti Trimurtulu ; D. John Faulkner ; Nigel B. Perry ; Laurent Ettouati ; Marc Litaudon ; John W. Blunt ; Murray H. G. Munro ; Geoffrey B. JamesonSource :
- Tetrahedron [ 0040-4020 ] ; 1994.
English descriptors
- Teeft :
- Baker bond, Bond lengths, Cape armitage, Carbon signal, Carbon signals, Cell line, Cosy spectrum, Enhancement, Hydrogen atoms, Mcmurdo sound, Meoh, Moiety, Molecular formula, Noeds experiment, Organic layer, Pyridine ring, Reaction mixture, Room temperature, Screening data, Sephadex, Silver oxide, Sponge kirkpatrickia variufosa, Tetrahydrovariolin, Variolin.
Abstract
Abstract: Two pyridopyrrolopyrimidine alkaloids, variolin A (2) and N(3′)-methyl tetrahydrovariolin B (3), have been isolated from the Antarctic sponge Kirkpatrickia varialosa, and their structures determined by X-ray crystallography and interpretation of spectral data respectively. N(3′)-Methyl tetrahydrovariolin B (3) is moderately cytotoxic and showed antifungal activity, while variolin A (2) is weakly cytotoxic.
The title compounds, which are both cytotoxic, have been characterised by X-ray crystallography and interpretation of spectral data.gr1
Url:
DOI: 10.1016/S0040-4020(01)89674-5
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Abstract: Two pyridopyrrolopyrimidine alkaloids, variolin A (2) and N(3′)-methyl tetrahydrovariolin B (3), have been isolated from the Antarctic sponge Kirkpatrickia varialosa, and their structures determined by X-ray crystallography and interpretation of spectral data respectively. N(3′)-Methyl tetrahydrovariolin B (3) is moderately cytotoxic and showed antifungal activity, while variolin A (2) is weakly cytotoxic.</div>
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<ce:author><ce:given-name>D.John</ce:given-name>
<ce:surname>Faulkner</ce:surname>
</ce:author>
<ce:affiliation><ce:textfn>Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0212, U.S.A.</ce:textfn>
</ce:affiliation>
</ce:author-group>
<ce:author-group><ce:author><ce:given-name>Nigel B.</ce:given-name>
<ce:surname>Perry</ce:surname>
</ce:author>
<ce:author><ce:given-name>Laurent</ce:given-name>
<ce:surname>Ettouati</ce:surname>
</ce:author>
<ce:author><ce:given-name>Marc</ce:given-name>
<ce:surname>Litaudon</ce:surname>
</ce:author>
<ce:author><ce:given-name>John W.</ce:given-name>
<ce:surname>Blunt</ce:surname>
<ce:ranking><ce:sup>∗</ce:sup>
</ce:ranking>
</ce:author>
<ce:author><ce:given-name>Murray H.G.</ce:given-name>
<ce:surname>Munro</ce:surname>
<ce:ranking><ce:sup>∗</ce:sup>
</ce:ranking>
</ce:author>
<ce:affiliation><ce:textfn>Department of Chemistry, University of Canterbury, Christchurch, New Zealand</ce:textfn>
</ce:affiliation>
</ce:author-group>
<ce:author-group><ce:author><ce:given-name>Geoffrey B</ce:given-name>
<ce:surname>Jameson</ce:surname>
</ce:author>
<ce:affiliation><ce:textfn>Department of Chemistry, Georgetown University, Washington, DC 20057, U.S.A.</ce:textfn>
</ce:affiliation>
</ce:author-group>
<ce:date-received day="23" month="12" year="1993"></ce:date-received>
<ce:date-accepted day="21" month="1" year="1994"></ce:date-accepted>
<ce:abstract><ce:section-title>Abstract</ce:section-title>
<ce:abstract-sec><ce:simple-para>Two pyridopyrrolopyrimidine alkaloids, variolin A (<ce:bold>2</ce:bold>
) and <ce:italic>N</ce:italic>
(3′)-methyl tetrahydrovariolin B (<ce:bold>3</ce:bold>
), have been isolated from the Antarctic sponge <ce:italic>Kirkpatrickia varialosa</ce:italic>
, and their structures determined by X-ray crystallography and interpretation of spectral data respectively. <ce:italic>N</ce:italic>
(3′)-Methyl tetrahydrovariolin B (<ce:bold>3</ce:bold>
) is moderately cytotoxic and showed antifungal activity, while variolin A (<ce:bold>2</ce:bold>
) is weakly cytotoxic.</ce:simple-para>
</ce:abstract-sec>
</ce:abstract>
<ce:abstract class="graphical"><ce:abstract-sec><ce:simple-para>The title compounds, which are both cytotoxic, have been characterised by X-ray crystallography and interpretation of spectral data. </ce:simple-para>
</ce:abstract-sec>
<ce:figure><ce:link locator="gr1"></ce:link>
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<name type="personal"><namePart type="given">Golakoti</namePart>
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<affiliation>Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0212, U.S.A.</affiliation>
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<name type="personal"><namePart type="given">Laurent</namePart>
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<name type="personal"><namePart type="given">Geoffrey B</namePart>
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<abstract lang="en">Abstract: Two pyridopyrrolopyrimidine alkaloids, variolin A (2) and N(3′)-methyl tetrahydrovariolin B (3), have been isolated from the Antarctic sponge Kirkpatrickia varialosa, and their structures determined by X-ray crystallography and interpretation of spectral data respectively. N(3′)-Methyl tetrahydrovariolin B (3) is moderately cytotoxic and showed antifungal activity, while variolin A (2) is weakly cytotoxic.</abstract>
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