Alkaloids from the antarctic sponge Kirkpatrickia varialosa . Part 2: Variolin A and N (3′)-methyl tetrahydrovariolin B
Identifieur interne : 001139 ( Istex/Corpus ); précédent : 001138; suivant : 001140Alkaloids from the antarctic sponge Kirkpatrickia varialosa . Part 2: Variolin A and N (3′)-methyl tetrahydrovariolin B
Auteurs : Golakoti Trimurtulu ; D. John Faulkner ; Nigel B. Perry ; Laurent Ettouati ; Marc Litaudon ; John W. Blunt ; Murray H. G. Munro ; Geoffrey B. JamesonSource :
- Tetrahedron [ 0040-4020 ] ; 1994.
English descriptors
- Teeft :
- Baker bond, Bond lengths, Cape armitage, Carbon signal, Carbon signals, Cell line, Cosy spectrum, Enhancement, Hydrogen atoms, Mcmurdo sound, Meoh, Moiety, Molecular formula, Noeds experiment, Organic layer, Pyridine ring, Reaction mixture, Room temperature, Screening data, Sephadex, Silver oxide, Sponge kirkpatrickia variufosa, Tetrahydrovariolin, Variolin.
Abstract
Abstract: Two pyridopyrrolopyrimidine alkaloids, variolin A (2) and N(3′)-methyl tetrahydrovariolin B (3), have been isolated from the Antarctic sponge Kirkpatrickia varialosa, and their structures determined by X-ray crystallography and interpretation of spectral data respectively. N(3′)-Methyl tetrahydrovariolin B (3) is moderately cytotoxic and showed antifungal activity, while variolin A (2) is weakly cytotoxic.
The title compounds, which are both cytotoxic, have been characterised by X-ray crystallography and interpretation of spectral data.gr1
Url:
DOI: 10.1016/S0040-4020(01)89674-5
Links to Exploration step
ISTEX:A667DE5F612088F97600241C5ABEF90B0DCACB12Le document en format XML
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Part 2: Variolin A and N (3′)-methyl tetrahydrovariolin B</title><author><name sortKey="Trimurtulu, Golakoti" sort="Trimurtulu, Golakoti" uniqKey="Trimurtulu G" first="Golakoti" last="Trimurtulu">Golakoti Trimurtulu</name><affiliation><mods:affiliation>Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0212, U.S.A.</mods:affiliation></affiliation></author><author><name sortKey="Faulkner, D John" sort="Faulkner, D John" uniqKey="Faulkner D" first="D. John" last="Faulkner">D. John Faulkner</name><affiliation><mods:affiliation>Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0212, U.S.A.</mods:affiliation></affiliation></author><author><name sortKey="Perry, Nigel B" sort="Perry, Nigel B" uniqKey="Perry N" first="Nigel B." last="Perry">Nigel B. 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Part 2: Variolin A and N (3′)-methyl tetrahydrovariolin B</title><author xml:id="author-0000"><persName><forename type="first">Golakoti</forename><surname>Trimurtulu</surname></persName><affiliation>Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0212, U.S.A.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">D.John</forename><surname>Faulkner</surname></persName><affiliation>Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0212, U.S.A.</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Nigel B.</forename><surname>Perry</surname></persName><affiliation>Department of Chemistry, University of Canterbury, Christchurch, New Zealand</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Laurent</forename><surname>Ettouati</surname></persName><affiliation>Department of Chemistry, University of Canterbury, Christchurch, New Zealand</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Marc</forename><surname>Litaudon</surname></persName><affiliation>Department of Chemistry, University of Canterbury, Christchurch, New Zealand</affiliation></author><author xml:id="author-0005"><persName><forename type="first">John W.</forename><surname>Blunt</surname></persName><affiliation>Department of Chemistry, University of Canterbury, Christchurch, New Zealand</affiliation></author><author xml:id="author-0006"><persName><forename type="first">Murray H.G.</forename><surname>Munro</surname></persName><affiliation>Department of Chemistry, University of Canterbury, Christchurch, New Zealand</affiliation></author><author xml:id="author-0007"><persName><forename type="first">Geoffrey B</forename><surname>Jameson</surname></persName><affiliation>Department of Chemistry, Georgetown University, Washington, DC 20057, U.S.A.</affiliation></author><idno type="istex">A667DE5F612088F97600241C5ABEF90B0DCACB12</idno><idno type="ark">ark:/67375/6H6-CKSGFX5G-2</idno><idno type="DOI">10.1016/S0040-4020(01)89674-5</idno><idno type="PII">S0040-4020(01)89674-5</idno></analytic><monogr><title level="j">Tetrahedron</title><title level="j" type="abbrev">TET</title><idno type="pISSN">0040-4020</idno><idno type="PII">S0040-4020(00)X0347-X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994"></date><biblScope unit="volume">50</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="3993">3993</biblScope><biblScope unit="page" to="4000">4000</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1994</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Two pyridopyrrolopyrimidine alkaloids, variolin A (2) and N(3′)-methyl tetrahydrovariolin B (3), have been isolated from the Antarctic sponge Kirkpatrickia varialosa, and their structures determined by X-ray crystallography and interpretation of spectral data respectively. N(3′)-Methyl tetrahydrovariolin B (3) is moderately cytotoxic and showed antifungal activity, while variolin A (2) is weakly cytotoxic.</p></abstract><abstract style="graphical"><p>The title compounds, which are both cytotoxic, have been characterised by X-ray crystallography and interpretation of spectral data.gr1</p></abstract></profileDesc><revisionDesc><change when="1994">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-CKSGFX5G-2/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"><istex:entity SYSTEM="gr1" NDATA="IMAGE" name="gr1"></istex:entity></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>TET</jid><aid>01896745</aid><ce:pii>S0040-4020(01)89674-5</ce:pii><ce:doi>10.1016/S0040-4020(01)89674-5</ce:doi><ce:copyright type="unknown" year="1994"></ce:copyright></item-info><head><ce:title>Alkaloids from the antarctic sponge <ce:italic>Kirkpatrickia varialosa</ce:italic>. Part 2: Variolin A and <ce:italic>N</ce:italic>(3′)-methyl tetrahydrovariolin B</ce:title><ce:author-group><ce:author><ce:given-name>Golakoti</ce:given-name><ce:surname>Trimurtulu</ce:surname></ce:author><ce:author><ce:given-name>D.John</ce:given-name><ce:surname>Faulkner</ce:surname></ce:author><ce:affiliation><ce:textfn>Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0212, U.S.A.</ce:textfn></ce:affiliation></ce:author-group><ce:author-group><ce:author><ce:given-name>Nigel B.</ce:given-name><ce:surname>Perry</ce:surname></ce:author><ce:author><ce:given-name>Laurent</ce:given-name><ce:surname>Ettouati</ce:surname></ce:author><ce:author><ce:given-name>Marc</ce:given-name><ce:surname>Litaudon</ce:surname></ce:author><ce:author><ce:given-name>John W.</ce:given-name><ce:surname>Blunt</ce:surname><ce:ranking><ce:sup>∗</ce:sup></ce:ranking></ce:author><ce:author><ce:given-name>Murray H.G.</ce:given-name><ce:surname>Munro</ce:surname><ce:ranking><ce:sup>∗</ce:sup></ce:ranking></ce:author><ce:affiliation><ce:textfn>Department of Chemistry, University of Canterbury, Christchurch, New Zealand</ce:textfn></ce:affiliation></ce:author-group><ce:author-group><ce:author><ce:given-name>Geoffrey B</ce:given-name><ce:surname>Jameson</ce:surname></ce:author><ce:affiliation><ce:textfn>Department of Chemistry, Georgetown University, Washington, DC 20057, U.S.A.</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="23" month="12" year="1993"></ce:date-received><ce:date-accepted day="21" month="1" year="1994"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Two pyridopyrrolopyrimidine alkaloids, variolin A (<ce:bold>2</ce:bold>) and <ce:italic>N</ce:italic>(3′)-methyl tetrahydrovariolin B (<ce:bold>3</ce:bold>), have been isolated from the Antarctic sponge <ce:italic>Kirkpatrickia varialosa</ce:italic>, and their structures determined by X-ray crystallography and interpretation of spectral data respectively. <ce:italic>N</ce:italic>(3′)-Methyl tetrahydrovariolin B (<ce:bold>3</ce:bold>) is moderately cytotoxic and showed antifungal activity, while variolin A (<ce:bold>2</ce:bold>) is weakly cytotoxic.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:abstract class="graphical"><ce:abstract-sec><ce:simple-para>The title compounds, which are both cytotoxic, have been characterised by X-ray crystallography and interpretation of spectral data. </ce:simple-para></ce:abstract-sec><ce:figure><ce:link locator="gr1"></ce:link></ce:figure></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Alkaloids from the antarctic sponge Kirkpatrickia varialosa . Part 2: Variolin A and N (3′)-methyl tetrahydrovariolin B</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Alkaloids from the antarctic sponge</title></titleInfo><name type="personal"><namePart type="given">Golakoti</namePart><namePart type="family">Trimurtulu</namePart><affiliation>Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0212, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.John</namePart><namePart type="family">Faulkner</namePart><affiliation>Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0212, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nigel B.</namePart><namePart type="family">Perry</namePart><affiliation>Department of Chemistry, University of Canterbury, Christchurch, New Zealand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laurent</namePart><namePart type="family">Ettouati</namePart><affiliation>Department of Chemistry, University of Canterbury, Christchurch, New Zealand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marc</namePart><namePart type="family">Litaudon</namePart><affiliation>Department of Chemistry, University of Canterbury, Christchurch, New Zealand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John W.</namePart><namePart type="family">Blunt</namePart><affiliation>Department of Chemistry, University of Canterbury, Christchurch, New Zealand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Murray H.G.</namePart><namePart type="family">Munro</namePart><affiliation>Department of Chemistry, University of Canterbury, Christchurch, New Zealand</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Geoffrey B</namePart><namePart type="family">Jameson</namePart><affiliation>Department of Chemistry, Georgetown University, Washington, DC 20057, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1994</dateIssued><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Two pyridopyrrolopyrimidine alkaloids, variolin A (2) and N(3′)-methyl tetrahydrovariolin B (3), have been isolated from the Antarctic sponge Kirkpatrickia varialosa, and their structures determined by X-ray crystallography and interpretation of spectral data respectively. N(3′)-Methyl tetrahydrovariolin B (3) is moderately cytotoxic and showed antifungal activity, while variolin A (2) is weakly cytotoxic.</abstract><abstract type="graphical">The title compounds, which are both cytotoxic, have been characterised by X-ray crystallography and interpretation of spectral data.gr1 </abstract><relatedItem type="host"><titleInfo><title>Tetrahedron</title></titleInfo><titleInfo type="abbreviated"><title>TET</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1994</dateIssued></originInfo><identifier type="ISSN">0040-4020</identifier><identifier type="PII">S0040-4020(00)X0347-X</identifier><part><date>1994</date><detail type="issue"><title>The International Journal for the Rapid Publication of Critical</title></detail><detail type="volume"><number>50</number><caption>vol.</caption></detail><detail type="issue"><number>13</number><caption>no.</caption></detail><extent unit="issue-pages"><start>3849</start><end>4036</end></extent><extent unit="pages"><start>3993</start><end>4000</end></extent></part></relatedItem><identifier type="istex">A667DE5F612088F97600241C5ABEF90B0DCACB12</identifier><identifier type="ark">ark:/67375/6H6-CKSGFX5G-2</identifier><identifier type="DOI">10.1016/S0040-4020(01)89674-5</identifier><identifier type="PII">S0040-4020(01)89674-5</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-CKSGFX5G-2/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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