Genetic changes in influenza A(H3N2) viruses circulating during 2011 to 2013 in northern India (Lucknow)
Identifieur interne : 001104 ( Istex/Corpus ); précédent : 001103; suivant : 001105Genetic changes in influenza A(H3N2) viruses circulating during 2011 to 2013 in northern India (Lucknow)
Auteurs : Amita Jain ; Tanushree Dangi ; Bhawana Jain ; Ajay Kumar Singh ; J. V. Singh ; Rashmi KumarSource :
- Journal of Medical Virology [ 0146-6615 ] ; 2015-08.
Abstract
Genetic variability in the hemagglutinin (HA1) and the neuraminidase (NA) genes of influenza viruses results in the emergence of new strains which differ in pathogenicity and severity. The present study was undertaken for genotypic characterization of the HA1 and NA genes of the influenza A(H3N2) strains, detected during the 2011–2013. A total of fifty five influenza A(H3N2) positive samples [2011 (n = 20), 2012 (n = 4) and 2013 (n = 31)] were studied. The 824 bp segment of HA1 gene and 931 bp segment of NA gene were amplified and sequenced by Big‐Dye terminator kit on ABI3130, Genetic analyzer. Molecular and phylogenetic analysis was done by MEGA 5.05 software and PhyML program (v3.0). Mutations were determined by comparing the deduced amino acid sequences of study strains with that of 2009–2013 vaccine strains. The studied influenza A(H3N2) strains showed 98.1–99.6% similarity in HA1 and NA amino acid sequences with the influenza A/Victoria/361/2011 vaccine strain. Four mutations in the HA1 amino acid sequences (T128A, R142G, L157S and N278K) and three unique mutations in the NA amino acid sequences [D251V, S315G and V313A] were found. These mutations were observed only in strains from the year 2013 (cluster II). None of the strains showed the presence of mutations, N294S and R292K, markers of oseltamivir resistance. In conclusion, Lucknow strains have accumulated the significant number of mutations in the antigenic sites of the HA and the NA coding sequences and continue to be evolving from the 2013 vaccine strain [A/Victoria/361/2011], however, mutations specific for oseltamivir resistance were not detected. J. Med. Virol. 87:1268–1275, 2015. © 2015 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/jmv.24096
Links to Exploration step
ISTEX:C8872BDC2688E93C2EFAA7BD623432F7AF8722BDLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic changes in influenza A(H3N2) viruses circulating during 2011 to 2013 in northern India (Lucknow)</title><author><name sortKey="Jain, Amita" sort="Jain, Amita" uniqKey="Jain A" first="Amita" last="Jain">Amita Jain</name><affiliation><mods:affiliation>Department of Microbiology, King George's Medical University, Lucknow, India</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence to: Prof. Amita Jain, MD, Department of Microbiology, King George Medical University, Lucknow‐226003, India.E‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: amita602002@yahoo.com</mods:affiliation></affiliation></author><author><name sortKey="Dangi, Tanushree" sort="Dangi, Tanushree" uniqKey="Dangi T" first="Tanushree" last="Dangi">Tanushree Dangi</name><affiliation><mods:affiliation>Department of Microbiology, King George's Medical University, Lucknow, India</mods:affiliation></affiliation></author><author><name sortKey="Jain, Bhawana" sort="Jain, Bhawana" uniqKey="Jain B" first="Bhawana" last="Jain">Bhawana Jain</name><affiliation><mods:affiliation>Department of Microbiology, King George's Medical University, Lucknow, India</mods:affiliation></affiliation></author><author><name sortKey="Singh, Ajay Kumar" sort="Singh, Ajay Kumar" uniqKey="Singh A" first="Ajay Kumar" last="Singh">Ajay Kumar Singh</name><affiliation><mods:affiliation>Department of Microbiology, King George's Medical University, Lucknow, India</mods:affiliation></affiliation></author><author><name sortKey="Singh, J V" sort="Singh, J V" uniqKey="Singh J" first="J. V." last="Singh">J. V. Singh</name><affiliation><mods:affiliation>Department of Community, Medicine King George's Medical University, Lucknow, India</mods:affiliation></affiliation></author><author><name sortKey="Kumar, Rashmi" sort="Kumar, Rashmi" uniqKey="Kumar R" first="Rashmi" last="Kumar">Rashmi Kumar</name><affiliation><mods:affiliation>Department of Paediatrics, King George's Medical University, Lucknow, India</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C8872BDC2688E93C2EFAA7BD623432F7AF8722BD</idno><date when="2015" year="2015">2015</date><idno type="doi">10.1002/jmv.24096</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-QR1JJF8F-H/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001104</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001104</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Genetic changes in influenza A(H3N2) viruses circulating during 2011 to 2013 in northern India (Lucknow)</title><author><name sortKey="Jain, Amita" sort="Jain, Amita" uniqKey="Jain A" first="Amita" last="Jain">Amita Jain</name><affiliation><mods:affiliation>Department of Microbiology, King George's Medical University, Lucknow, India</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence to: Prof. Amita Jain, MD, Department of Microbiology, King George Medical University, Lucknow‐226003, India.E‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: amita602002@yahoo.com</mods:affiliation></affiliation></author><author><name sortKey="Dangi, Tanushree" sort="Dangi, Tanushree" uniqKey="Dangi T" first="Tanushree" last="Dangi">Tanushree Dangi</name><affiliation><mods:affiliation>Department of Microbiology, King George's Medical University, Lucknow, India</mods:affiliation></affiliation></author><author><name sortKey="Jain, Bhawana" sort="Jain, Bhawana" uniqKey="Jain B" first="Bhawana" last="Jain">Bhawana Jain</name><affiliation><mods:affiliation>Department of Microbiology, King George's Medical University, Lucknow, India</mods:affiliation></affiliation></author><author><name sortKey="Singh, Ajay Kumar" sort="Singh, Ajay Kumar" uniqKey="Singh A" first="Ajay Kumar" last="Singh">Ajay Kumar Singh</name><affiliation><mods:affiliation>Department of Microbiology, King George's Medical University, Lucknow, India</mods:affiliation></affiliation></author><author><name sortKey="Singh, J V" sort="Singh, J V" uniqKey="Singh J" first="J. V." last="Singh">J. V. Singh</name><affiliation><mods:affiliation>Department of Community, Medicine King George's Medical University, Lucknow, India</mods:affiliation></affiliation></author><author><name sortKey="Kumar, Rashmi" sort="Kumar, Rashmi" uniqKey="Kumar R" first="Rashmi" last="Kumar">Rashmi Kumar</name><affiliation><mods:affiliation>Department of Paediatrics, King George's Medical University, Lucknow, India</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">87</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1268">1268</biblScope><biblScope unit="page" to="1275">1275</biblScope><biblScope unit="page-count">8</biblScope><date type="published" when="2015-08">2015-08</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genetic variability in the hemagglutinin (HA1) and the neuraminidase (NA) genes of influenza viruses results in the emergence of new strains which differ in pathogenicity and severity. The present study was undertaken for genotypic characterization of the HA1 and NA genes of the influenza A(H3N2) strains, detected during the 2011–2013. A total of fifty five influenza A(H3N2) positive samples [2011 (n = 20), 2012 (n = 4) and 2013 (n = 31)] were studied. The 824 bp segment of HA1 gene and 931 bp segment of NA gene were amplified and sequenced by Big‐Dye terminator kit on ABI3130, Genetic analyzer. Molecular and phylogenetic analysis was done by MEGA 5.05 software and PhyML program (v3.0). Mutations were determined by comparing the deduced amino acid sequences of study strains with that of 2009–2013 vaccine strains. The studied influenza A(H3N2) strains showed 98.1–99.6% similarity in HA1 and NA amino acid sequences with the influenza A/Victoria/361/2011 vaccine strain. Four mutations in the HA1 amino acid sequences (T128A, R142G, L157S and N278K) and three unique mutations in the NA amino acid sequences [D251V, S315G and V313A] were found. These mutations were observed only in strains from the year 2013 (cluster II). None of the strains showed the presence of mutations, N294S and R292K, markers of oseltamivir resistance. In conclusion, Lucknow strains have accumulated the significant number of mutations in the antigenic sites of the HA and the NA coding sequences and continue to be evolving from the 2013 vaccine strain [A/Victoria/361/2011], however, mutations specific for oseltamivir resistance were not detected. J. Med. Virol. 87:1268–1275, 2015. © 2015 Wiley Periodicals, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Amita Jain</name><affiliations><json:string>Department of Microbiology, King George's Medical University, Lucknow, India</json:string><json:string>Correspondence to: Prof. Amita Jain, MD, Department of Microbiology, King George Medical University, Lucknow‐226003, India.E‐mail:</json:string><json:string>E-mail: amita602002@yahoo.com</json:string></affiliations></json:item><json:item><name>Tanushree Dangi</name><affiliations><json:string>Department of Microbiology, King George's Medical University, Lucknow, India</json:string></affiliations></json:item><json:item><name>Bhawana Jain</name><affiliations><json:string>Department of Microbiology, King George's Medical University, Lucknow, India</json:string></affiliations></json:item><json:item><name>Ajay Kumar Singh</name><affiliations><json:string>Department of Microbiology, King George's Medical University, Lucknow, India</json:string></affiliations></json:item><json:item><name>J. V. Singh</name><affiliations><json:string>Department of Community, Medicine King George's Medical University, Lucknow, India</json:string></affiliations></json:item><json:item><name>Rashmi Kumar</name><affiliations><json:string>Department of Paediatrics, King George's Medical University, Lucknow, India</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>influenza A(H3N2) virus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>epidemic; HA1 gene</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>NA gene</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>phylogenetic</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mutations</value></json:item></subject><articleId><json:string>JMV24096</json:string></articleId><arkIstex>ark:/67375/WNG-QR1JJF8F-H</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Genetic variability in the hemagglutinin (HA1) and the neuraminidase (NA) genes of influenza viruses results in the emergence of new strains which differ in pathogenicity and severity. The present study was undertaken for genotypic characterization of the HA1 and NA genes of the influenza A(H3N2) strains, detected during the 2011–2013. A total of fifty five influenza A(H3N2) positive samples [2011 (n = 20), 2012 (n = 4) and 2013 (n = 31)] were studied. The 824 bp segment of HA1 gene and 931 bp segment of NA gene were amplified and sequenced by Big‐Dye terminator kit on ABI3130, Genetic analyzer. Molecular and phylogenetic analysis was done by MEGA 5.05 software and PhyML program (v3.0). Mutations were determined by comparing the deduced amino acid sequences of study strains with that of 2009–2013 vaccine strains. The studied influenza A(H3N2) strains showed 98.1–99.6% similarity in HA1 and NA amino acid sequences with the influenza A/Victoria/361/2011 vaccine strain. Four mutations in the HA1 amino acid sequences (T128A, R142G, L157S and N278K) and three unique mutations in the NA amino acid sequences [D251V, S315G and V313A] were found. These mutations were observed only in strains from the year 2013 (cluster II). None of the strains showed the presence of mutations, N294S and R292K, markers of oseltamivir resistance. In conclusion, Lucknow strains have accumulated the significant number of mutations in the antigenic sites of the HA and the NA coding sequences and continue to be evolving from the 2013 vaccine strain [A/Victoria/361/2011], however, mutations specific for oseltamivir resistance were not detected. J. Med. Virol. 87:1268–1275, 2015. © 2015 Wiley Periodicals, Inc.</abstract><qualityIndicators><score>9.004</score><pdfWordCount>4004</pdfWordCount><pdfCharCount>28960</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>8</pdfPageCount><pdfPageSize>593.972 x 792 pts</pdfPageSize><pdfWordsPerPage>501</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>257</abstractWordCount><abstractCharCount>1705</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Genetic changes in influenza A(H3N2) viruses circulating during 2011 to 2013 in northern India (Lucknow)</title><genre><json:string>article</json:string></genre><host><title>Journal of Medical Virology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1096-9071</json:string></doi><issn><json:string>0146-6615</json:string></issn><eissn><json:string>1096-9071</json:string></eissn><publisherId><json:string>JMV</json:string></publisherId><volume>87</volume><issue>8</issue><pages><first>1268</first><last>1275</last><total>8</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Research Article</value></json:item><json:item><value>Research Articles</value></json:item></subject></host><ark><json:string>ark:/67375/WNG-QR1JJF8F-H</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - virology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - virology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Infectious Diseases</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Virology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string><json:string>4 - nephrologie. maladies des voies urinaires</json:string></inist></categories><publicationDate>2015</publicationDate><copyrightDate>2015</copyrightDate><doi><json:string>10.1002/jmv.24096</json:string></doi><id>C8872BDC2688E93C2EFAA7BD623432F7AF8722BD</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-QR1JJF8F-H/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-QR1JJF8F-H/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-QR1JJF8F-H/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Genetic changes in influenza A(H3N2) viruses circulating during 2011 to 2013 in northern India (Lucknow)</title><title level="a" type="short">Genetic Changes in Influenza A(H3N2) Viruses Circulating</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher ref="https://scientific-publisher.data.istex.fr/ark:/67375/H02-QW5Q88H5-V">Wiley Publishing Ltd</publisher><availability><licence>© 2015 Wiley Periodicals, Inc.</licence></availability><date type="published" when="2015-08"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Genetic changes in influenza A(H3N2) viruses circulating during 2011 to 2013 in northern India (Lucknow)</title><title level="a" type="short">Genetic Changes in Influenza A(H3N2) Viruses Circulating</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Amita</forename><surname>Jain</surname></persName><affiliation><orgName type="division">Department of Microbiology</orgName><orgName type="institution">King George's Medical University</orgName><address><settlement>Lucknow</settlement><country key="IN" xml:lang="en">INDIA</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Tanushree</forename><surname>Dangi</surname></persName><affiliation><orgName type="division">Department of Microbiology</orgName><orgName type="institution">King George's Medical University</orgName><address><settlement>Lucknow</settlement><country key="IN" xml:lang="en">INDIA</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Bhawana</forename><surname>Jain</surname></persName><affiliation><orgName type="division">Department of Microbiology</orgName><orgName type="institution">King George's Medical University</orgName><address><settlement>Lucknow</settlement><country key="IN" xml:lang="en">INDIA</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Ajay Kumar</forename><surname>Singh</surname></persName><affiliation><orgName type="division">Department of Microbiology</orgName><orgName type="institution">King George's Medical University</orgName><address><settlement>Lucknow</settlement><country key="IN" xml:lang="en">INDIA</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">J. V.</forename><surname>Singh</surname></persName><affiliation><orgName type="division">Department of Community</orgName><orgName type="institution">Medicine King George's Medical University</orgName><address><settlement>Lucknow</settlement><country key="IN" xml:lang="en">INDIA</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Rashmi</forename><surname>Kumar</surname></persName><affiliation><orgName type="division">Department of Paediatrics</orgName><orgName type="institution">King George's Medical University</orgName><address><settlement>Lucknow</settlement><country key="IN" xml:lang="en">INDIA</country></address></affiliation></author><idno type="istex">C8872BDC2688E93C2EFAA7BD623432F7AF8722BD</idno><idno type="ark">ark:/67375/WNG-QR1JJF8F-H</idno><idno type="DOI">10.1002/jmv.24096</idno><idno type="unit">JMV24096</idno><idno type="toTypesetVersion">file:JMV.JMV24096.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="pISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><idno type="book-DOI">10.1002/(ISSN)1096-9071</idno><idno type="book-part-DOI">10.1002/jmv.v87.8</idno><idno type="product">JMV</idno><imprint><biblScope unit="vol">87</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1268">1268</biblScope><biblScope unit="page" to="1275">1275</biblScope><biblScope unit="page-count">8</biblScope><date type="published" when="2015-08"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><p>Genetic variability in the hemagglutinin (HA1) and the neuraminidase (NA) genes of influenza viruses results in the emergence of new strains which differ in pathogenicity and severity. The present study was undertaken for genotypic characterization of the HA1 and NA genes of the influenza A(H3N2) strains, detected during the 2011–2013. A total of fifty five influenza A(H3N2) positive samples [2011 (n = 20), 2012 (n = 4) and 2013 (n = 31)] were studied. The 824 bp segment of HA1 gene and 931 bp segment of NA gene were amplified and sequenced by Big‐Dye terminator kit on ABI3130, Genetic analyzer. Molecular and phylogenetic analysis was done by MEGA 5.05 software and PhyML program (v3.0). Mutations were determined by comparing the deduced amino acid sequences of study strains with that of 2009–2013 vaccine strains. The studied influenza A(H3N2) strains showed 98.1–99.6% similarity in HA1 and NA amino acid sequences with the influenza A/Victoria/361/2011 vaccine strain. Four mutations in the HA1 amino acid sequences (T128A, R142G, L157S and N278K) and three unique mutations in the NA amino acid sequences [D251V, S315G and V313A] were found. These mutations were observed only in strains from the year 2013 (cluster II). None of the strains showed the presence of mutations, N294S and R292K, markers of oseltamivir resistance. In conclusion, Lucknow strains have accumulated the significant number of mutations in the antigenic sites of the HA and the NA coding sequences and continue to be evolving from the 2013 vaccine strain [A/Victoria/361/2011], however, mutations specific for oseltamivir resistance were not detected. <hi rend="bold"><hi rend="italic">J. Med. Virol. 87:1268–1275, 2015</hi>.</hi> © 2015 Wiley Periodicals, Inc.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="jmv24096-kwd-0001">influenza A(H3N2) virus</term><term xml:id="jmv24096-kwd-0002">epidemic; HA1 gene</term><term xml:id="jmv24096-kwd-0003">NA gene</term><term xml:id="jmv24096-kwd-0004">phylogenetic</term><term xml:id="jmv24096-kwd-0005">mutations</term></keywords><keywords rend="articleCategory"><term>Research Article</term></keywords><keywords rend="tocHeading1"><term>Research Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-QR1JJF8F-H/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" xml:lang="en" type="serialArticle" xml:id="jmv24096"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1002/(ISSN)1096-9071</doi><issn type="print">0146-6615</issn><issn type="electronic">1096-9071</issn><idGroup><id type="product" value="JMV"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF MEDICAL VIROLOGY">Journal of Medical Virology</title><title type="short">J. Med. Virol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="80"><doi registered="yes">10.1002/jmv.v87.8</doi><copyright ownership="publisher">© 2015 Wiley Periodicals, Inc.</copyright><numberingGroup><numbering type="journalVolume" number="87">87</numbering><numbering type="journalIssue">8</numbering></numberingGroup><coverDate startDate="2015-08">August 2015</coverDate></publicationMeta><publicationMeta level="unit" position="40" type="article" status="forIssue"><doi>10.1002/jmv.24096</doi><idGroup><id type="unit" value="JMV24096"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="publisher">© 2015 Wiley Periodicals, Inc.</copyright><eventGroup><event type="manuscriptAccepted" date="2014-10-15"></event><event type="xmlCreated" agent="Thomson Digital" date="2015-04-16"></event><event type="publishedOnlineEarlyUnpaginated" date="2015-04-24"></event><event type="firstOnline" date="2015-04-24"></event><event type="publishedOnlineFinalForm" date="2015-06-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.7.5 mode:FullText" date="2016-01-23"></event></eventGroup><numberingGroup><numbering type="pageFirst">1268</numbering><numbering type="pageLast">1275</numbering></numberingGroup><correspondenceTo><lineatedText><line>Correspondence to: Prof. Amita Jain, MD, Department of Microbiology, King George Medical University, Lucknow‐226003, India.</line><line>E‐mail:
<email>amita602002@yahoo.com</email></line></lineatedText></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JMV.JMV24096.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Genetic changes in influenza A(H3N2) viruses circulating during 2011 to 2013 in northern India (Lucknow)</title><title type="short">Genetic Changes in Influenza A(H3N2) Viruses Circulating</title><title type="shortAuthors">Jain et al</title></titleGroup><creators><creator xml:id="jmv24096-cr-0001" creatorRole="author" affiliationRef="#jmv24096-aff-0001" corresponding="yes"><personName><givenNames>Amita</givenNames> <familyName>Jain</familyName></personName></creator><creator xml:id="jmv24096-cr-0002" creatorRole="author" affiliationRef="#jmv24096-aff-0001"><personName><givenNames>Tanushree</givenNames> <familyName>Dangi</familyName></personName></creator><creator xml:id="jmv24096-cr-0003" creatorRole="author" affiliationRef="#jmv24096-aff-0001"><personName><givenNames>Bhawana</givenNames> <familyName>Jain</familyName></personName></creator><creator xml:id="jmv24096-cr-0004" creatorRole="author" affiliationRef="#jmv24096-aff-0001"><personName><givenNames>Ajay Kumar</givenNames> <familyName>Singh</familyName></personName></creator><creator xml:id="jmv24096-cr-0005" creatorRole="author" affiliationRef="#jmv24096-aff-0002"><personName><givenNames>J. V.</givenNames> <familyName>Singh</familyName></personName></creator><creator xml:id="jmv24096-cr-0006" creatorRole="author" affiliationRef="#jmv24096-aff-0003"><personName><givenNames>Rashmi</givenNames> <familyName>Kumar</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="jmv24096-aff-0001" countryCode="IN"><orgDiv>Department of Microbiology</orgDiv><orgName>King George's Medical University</orgName><address><city>Lucknow</city><country>India</country></address></affiliation><affiliation xml:id="jmv24096-aff-0002" countryCode="IN"><orgDiv>Department of Community</orgDiv><orgName>Medicine King George's Medical University</orgName><address><city>Lucknow</city><country>India</country></address></affiliation><affiliation xml:id="jmv24096-aff-0003" countryCode="IN"><orgDiv>Department of Paediatrics</orgDiv><orgName>King George's Medical University</orgName><address><city>Lucknow</city><country>India</country></address></affiliation></affiliationGroup><keywordGroup type="author" xml:lang="en"><keyword xml:id="jmv24096-kwd-0001">influenza A(H3N2) virus</keyword><keyword xml:id="jmv24096-kwd-0002">epidemic; HA1 gene</keyword><keyword xml:id="jmv24096-kwd-0003">NA gene</keyword><keyword xml:id="jmv24096-kwd-0004">phylogenetic</keyword><keyword xml:id="jmv24096-kwd-0005">mutations</keyword></keywordGroup><fundingInfo><fundingAgency>Influenza surveillance network</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Indian Council of Medical Research</fundingAgency><fundingNumber>5/8/7/14/2009‐ECD‐1(Vol.II)</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><section xml:id="jmv24096-sec-0001"><p>Genetic variability in the hemagglutinin (HA1) and the neuraminidase (NA) genes of influenza viruses results in the emergence of new strains which differ in pathogenicity and severity. The present study was undertaken for genotypic characterization of the HA1 and NA genes of the influenza A(H3N2) strains, detected during the 2011–2013. A total of fifty five influenza A(H3N2) positive samples [2011 (n = 20), 2012 (n = 4) and 2013 (n = 31)] were studied. The 824 bp segment of HA1 gene and 931 bp segment of NA gene were amplified and sequenced by Big‐Dye terminator kit on ABI3130, Genetic analyzer. Molecular and phylogenetic analysis was done by MEGA 5.05 software and PhyML program (v3.0). Mutations were determined by comparing the deduced amino acid sequences of study strains with that of 2009–2013 vaccine strains. The studied influenza A(H3N2) strains showed 98.1–99.6% similarity in HA1 and NA amino acid sequences with the influenza A/Victoria/361/2011 vaccine strain. Four mutations in the HA1 amino acid sequences (T128A, R142G, L157S and N278K) and three unique mutations in the NA amino acid sequences [D251V, S315G and V313A] were found. These mutations were observed only in strains from the year 2013 (cluster II). None of the strains showed the presence of mutations, N294S and R292K, markers of oseltamivir resistance. In conclusion, Lucknow strains have accumulated the significant number of mutations in the antigenic sites of the HA and the NA coding sequences and continue to be evolving from the 2013 vaccine strain [A/Victoria/361/2011], however, mutations specific for oseltamivir resistance were not detected. <b><i>J. Med. Virol. 87:1268–1275, 2015</i>.</b> © 2015 Wiley Periodicals, Inc.</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="jmv24096-note-0002" numbered="no">Conflict of Interest: None</note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Genetic changes in influenza A(H3N2) viruses circulating during 2011 to 2013 in northern India (Lucknow)</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Genetic Changes in Influenza A(H3N2) Viruses Circulating</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Genetic changes in influenza A(H3N2) viruses circulating during 2011 to 2013 in northern India (Lucknow)</title></titleInfo><name type="personal"><namePart type="given">Amita</namePart><namePart type="family">Jain</namePart><affiliation>Department of Microbiology, King George's Medical University, Lucknow, India</affiliation><affiliation>Correspondence to: Prof. Amita Jain, MD, Department of Microbiology, King George Medical University, Lucknow‐226003, India.E‐mail:</affiliation><affiliation>E-mail: amita602002@yahoo.com</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tanushree</namePart><namePart type="family">Dangi</namePart><affiliation>Department of Microbiology, King George's Medical University, Lucknow, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bhawana</namePart><namePart type="family">Jain</namePart><affiliation>Department of Microbiology, King George's Medical University, Lucknow, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ajay Kumar</namePart><namePart type="family">Singh</namePart><affiliation>Department of Microbiology, King George's Medical University, Lucknow, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. V.</namePart><namePart type="family">Singh</namePart><affiliation>Department of Community, Medicine King George's Medical University, Lucknow, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rashmi</namePart><namePart type="family">Kumar</namePart><affiliation>Department of Paediatrics, King George's Medical University, Lucknow, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2015-08</dateIssued><dateCreated encoding="w3cdtf">2015-04-16</dateCreated><dateValid encoding="w3cdtf">2014-10-15</dateValid><copyrightDate encoding="w3cdtf">2015</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Genetic variability in the hemagglutinin (HA1) and the neuraminidase (NA) genes of influenza viruses results in the emergence of new strains which differ in pathogenicity and severity. The present study was undertaken for genotypic characterization of the HA1 and NA genes of the influenza A(H3N2) strains, detected during the 2011–2013. A total of fifty five influenza A(H3N2) positive samples [2011 (n = 20), 2012 (n = 4) and 2013 (n = 31)] were studied. The 824 bp segment of HA1 gene and 931 bp segment of NA gene were amplified and sequenced by Big‐Dye terminator kit on ABI3130, Genetic analyzer. Molecular and phylogenetic analysis was done by MEGA 5.05 software and PhyML program (v3.0). Mutations were determined by comparing the deduced amino acid sequences of study strains with that of 2009–2013 vaccine strains. The studied influenza A(H3N2) strains showed 98.1–99.6% similarity in HA1 and NA amino acid sequences with the influenza A/Victoria/361/2011 vaccine strain. Four mutations in the HA1 amino acid sequences (T128A, R142G, L157S and N278K) and three unique mutations in the NA amino acid sequences [D251V, S315G and V313A] were found. These mutations were observed only in strains from the year 2013 (cluster II). None of the strains showed the presence of mutations, N294S and R292K, markers of oseltamivir resistance. In conclusion, Lucknow strains have accumulated the significant number of mutations in the antigenic sites of the HA and the NA coding sequences and continue to be evolving from the 2013 vaccine strain [A/Victoria/361/2011], however, mutations specific for oseltamivir resistance were not detected. J. Med. Virol. 87:1268–1275, 2015. © 2015 Wiley Periodicals, Inc.</abstract><note type="funding">Influenza surveillance network</note><note type="funding">Indian Council of Medical Research - No. 5/8/7/14/2009‐ECD‐1(Vol.II); </note><subject lang="en"><genre>keywords</genre><topic>influenza A(H3N2) virus</topic><topic>epidemic; HA1 gene</topic><topic>NA gene</topic><topic>phylogenetic</topic><topic>mutations</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Medical Virology</title></titleInfo><titleInfo type="abbreviated"><title>J. Med. Virol.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic><topic>Research Articles</topic></subject><identifier type="ISSN">0146-6615</identifier><identifier type="eISSN">1096-9071</identifier><identifier type="DOI">10.1002/(ISSN)1096-9071</identifier><identifier type="PublisherID">JMV</identifier><part><date>2015</date><detail type="volume"><caption>vol.</caption><number>87</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>1268</start><end>1275</end><total>8</total></extent></part></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0001"><titleInfo><title>Molecular and antigenic evolution of human influenza A/H3N2 viruses in Quebec, Canada, 2009–2011</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Ann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Papenburg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Bouhy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Rhéaume</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ME</namePart><namePart type="family">Hamelin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Boivin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ann J, Papenburg J, Bouhy X, Rhéaume C, Hamelin ME, Boivin G. 2012. Molecular and antigenic evolution of human influenza A/H3N2 viruses in Quebec, Canada, 2009–2011. J Clin Virol 53:88–92.</note><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>53</number></detail><extent unit="pages"><start>88</start><end>92</end></extent></part><relatedItem type="host"><titleInfo><title>J Clin Virol</title></titleInfo><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>53</number></detail><extent unit="pages"><start>88</start><end>92</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0002"><titleInfo><title>Molecular characterization and Phylogenetic analysis of H1N1 and H3N2 human influenza A viruses among infants and children in Thailand</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Chutinimitkul</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Chieochansin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Payungporn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Samransamruajkit</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Hiranras</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Theamboonlers</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Poovorawan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chutinimitkul S, Chieochansin T, Payungporn S, Samransamruajkit R, Hiranras T, Theamboonlers A, Poovorawan Y. 2008. Molecular characterization and Phylogenetic analysis of H1N1 and H3N2 human influenza A viruses among infants and children in Thailand. Virus Res 132:122–131.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>132</number></detail><extent unit="pages"><start>122</start><end>131</end></extent></part><relatedItem type="host"><titleInfo><title>Virus Res</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>132</number></detail><extent unit="pages"><start>122</start><end>131</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0003"><titleInfo><title>2014. Molecular Characterization of Circulating Pandemic Strains of Influenza A Virus During 2012 to 2013 in Lucknow (India)</title></titleInfo><name type="personal"><namePart type="given">T</namePart><namePart type="family">Dangi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Jain</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AK</namePart><namePart type="family">Singh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JV</namePart><namePart type="family">Singh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Kumar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Dwivedi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AK</namePart><namePart type="family">Verma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MS</namePart><namePart type="family">Chadha</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Jain</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dangi T, Jain B, Singh AK, Singh JV, Kumar R, Dwivedi M, Verma AK, Chadha MS, Jain A. 2014. 2014. Molecular Characterization of Circulating Pandemic Strains of Influenza A Virus During 2012 to 2013 in Lucknow (India). J Med Virol 2014. DOI: 10.1002/jmv.23946</note><part><date>2014</date><extent unit="pages"><start>2014</start></extent></part><relatedItem type="host"><titleInfo><title>J Med Virol</title></titleInfo><part><date>2014</date><extent unit="pages"><start>2014</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0004"><titleInfo><title>European Centre for Disease Prevention and Control (ECDC) Surveillance Report 2013, Stockholm. Influenza virus characterisation, summary Europe, December 2013. Available on: http://www.ecdc.europa.eu/en/publications/Publications/influenza‐virus‐characterisation‐dec‐2013.pdf.</title></titleInfo><genre>other</genre><part><date>2013</date></part></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0005"><titleInfo><title>European Centre for Disease Prevention and Control (ECDC) Surveillance Report 2014, Stockholm. Influenza virus characterization, summary Europe, April 2014. Available on: http://www.ecdc.europa.eu/en/publications/Publications/ERLI‐Net‐report‐April‐2014.pdf.</title></titleInfo><genre>other</genre><part><date>2014</date></part></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0006"><titleInfo><title>Genetic structure of human A/H1N1 and A/H3N2 influenza virus on Corsica Island: Phylogenetic analysis and vaccine strain match 2006–2010</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Falchi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Amoros</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Arena</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Arrighi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Casabianca</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Andreoletti</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Turbelin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AT</namePart><namePart type="family">Flahault Blanchon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Hanslik</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L</namePart><namePart type="family">Varesi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Falchi A, Amoros JP, Arena C, Arrighi J, Casabianca F, Andreoletti L, Turbelin C, Flahault Blanchon AT, Hanslik T, Varesi L. 2011. Genetic structure of human A/H1N1 and A/H3N2 influenza virus on Corsica Island: Phylogenetic analysis and vaccine strain match 2006–2010. PLoS ONE 6:e24471. DOI: 10.1371/journal.pone.0024471</note><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>e24471</start></extent></part><relatedItem type="host"><titleInfo><title>PLoS ONE</title></titleInfo><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>e24471</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0007"><titleInfo><title>A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Guindon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Gascuel</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Guindon S, Gascuel O. 2003. A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol 52:696–704.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>52</number></detail><extent unit="pages"><start>696</start><end>704</end></extent></part><relatedItem type="host"><titleInfo><title>Syst Biol</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>52</number></detail><extent unit="pages"><start>696</start><end>704</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0008"><titleInfo><title>Universal primer set for the full‐length amplification of all influenza A viruses</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Hoffmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Stech</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Guan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RG</namePart><namePart type="family">Webster</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DR</namePart><namePart type="family">Perez</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hoffmann E, Stech J, Guan Y, Webster RG, Perez DR. 2001. Universal primer set for the full‐length amplification of all influenza A viruses. Arch Virol 146:2275–2289.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>146</number></detail><extent unit="pages"><start>2275</start><end>2289</end></extent></part><relatedItem type="host"><titleInfo><title>Arch Virol</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>146</number></detail><extent unit="pages"><start>2275</start><end>2289</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0009"><titleInfo><title>Antiviral activity of antiserum specific for an influenza virus neuraminidase</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Kilbourne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Laver</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Schulman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Webster</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kilbourne E, Laver W, Schulman J, Webster R. 1968. Antiviral activity of antiserum specific for an influenza virus neuraminidase. J Virol 2:281–288.</note><part><date>1968</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>281</start><end>288</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>1968</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>281</start><end>288</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0010"><titleInfo><title>Heterosubtypic immunity to influenza A virus infections in mallards may explain Existence of multiple virus subtypes</title></titleInfo><name type="personal"><namePart type="given">N</namePart><namePart type="family">Latorre‐Margalef</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Grosbois</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Wahlgren</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VJ</namePart><namePart type="family">Munster</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Tolf</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RAM</namePart><namePart type="family">Fouchier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ADME</namePart><namePart type="family">Osterhaus</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Olsen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Waldenström</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Latorre‐Margalef N, Grosbois V, Wahlgren J, Munster VJ, Tolf C, Fouchier RAM, Osterhaus ADME, Olsen B, Waldenström J. 2013. Heterosubtypic immunity to influenza A virus infections in mallards may explain Existence of multiple virus subtypes. PLoS Pathog 9:e1003443. DOI: 10.1371/journal.ppat.1003443</note><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><end>e1003443</end></extent></part><relatedItem type="host"><titleInfo><title>PLoS Pathog</title></titleInfo><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><end>e1003443</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0011"><titleInfo><title>Predicting antigenic variants of influenza A/H3N2 viruses</title></titleInfo><name type="personal"><namePart type="given">MS</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JS</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lee MS, Chen JS. 2004. Predicting antigenic variants of influenza A/H3N2 viruses. Emerg Infect Dis 10:1385–1390.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><start>1385</start><end>1390</end></extent></part><relatedItem type="host"><titleInfo><title>Emerg Infect Dis</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>10</number></detail><extent unit="pages"><start>1385</start><end>1390</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0012"><titleInfo><title>Recent changes among human influenza viruses</title></titleInfo><name type="personal"><namePart type="given">YP</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Gregory</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Bennett</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Hay</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lin YP, Gregory V, Bennett M, Hay A. 2004. Recent changes among human influenza viruses. Virus Res 103:47–52.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>103</number></detail><extent unit="pages"><start>47</start><end>52</end></extent></part><relatedItem type="host"><titleInfo><title>Virus Res</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>103</number></detail><extent unit="pages"><start>47</start><end>52</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0013"><titleInfo><title>Pandemic influenza (H1N1) 2009 is associated with severe disease in India</title></titleInfo><name type="personal"><namePart type="given">AC</namePart><namePart type="family">Mishra</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MS</namePart><namePart type="family">Chadha</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ML</namePart><namePart type="family">Choudhary</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">VA</namePart><namePart type="family">Potdar</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Mishra AC, Chadha MS, Choudhary ML, Potdar VA. 2010. Pandemic influenza (H1N1) 2009 is associated with severe disease in India. PLoS ONE 5:e10540. DOI: 10.1371/journal.pone.0010540</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>e10540</start></extent></part><relatedItem type="host"><titleInfo><title>PLoS ONE</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>e10540</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0014"><titleInfo><title>Genetic drift of influenza A(H3N2) virus hemagglutinin (HA) variants originated during the last pandemic turn out to be predominant in the 2011–2012 season in Northern Italy</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Pariani</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Amendola</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Ebranati</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Ranghiero</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Lai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Anselmi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Zehender</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Zanetti</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Pariani E, Amendola A, Ebranati E, Ranghiero A, Lai A, Anselmi G, Zehender G, Zanetti A. 2013. Genetic drift of influenza A(H3N2) virus hemagglutinin (HA) variants originated during the last pandemic turn out to be predominant in the 2011–2012 season in Northern Italy. Infect Genet Evol 13:252–260.</note><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>252</start><end>260</end></extent></part><relatedItem type="host"><titleInfo><title>Infect Genet Evol</title></titleInfo><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>252</start><end>260</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0015"><titleInfo><title>Codon bias and frequency‐dependent selection on the hemagglutinin epitopes of influenza A virus</title></titleInfo><name type="personal"><namePart type="given">JB</namePart><namePart type="family">Plotkin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Dushoff</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Plotkin JB, Dushoff J. 2003. Codon bias and frequency‐dependent selection on the hemagglutinin epitopes of influenza A virus. Proc Natl Acad Sci USA 100:7152–7157.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>100</number></detail><extent unit="pages"><start>7152</start><end>7157</end></extent></part><relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci USA</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>100</number></detail><extent unit="pages"><start>7152</start><end>7157</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0016"><titleInfo><title>Genetic characterization of the influenza A pandemic (H1N1) 2009 virus isolates from India</title></titleInfo><name type="personal"><namePart type="given">VA</namePart><namePart type="family">Potdar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MS</namePart><namePart type="family">Chadha</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SM</namePart><namePart type="family">Jadhav</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Mullick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SS</namePart><namePart type="family">Cherian</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AC</namePart><namePart type="family">Mishra</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Potdar VA, Chadha MS, Jadhav SM, Mullick J, Cherian SS, Mishra AC. 2010. Genetic characterization of the influenza A pandemic (H1N1) 2009 virus isolates from India. PLoS ONE 5:e9693.DOI: 10.1371/journal.pone.0009693</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>e9693</start></extent></part><relatedItem type="host"><titleInfo><title>PLoS ONE</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>e9693</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0017"><titleInfo><title>Interim estimates of influenza vaccine effectiveness in 2012/13 from Canada's sentinel surveillance network, January 2013</title></titleInfo><name type="personal"><namePart type="given">DM</namePart><namePart type="family">Skowronski</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NZ</namePart><namePart type="family">Janjua</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">De Serres</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Dickinson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Winter</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SM</namePart><namePart type="family">Mahmud</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Skowronski DM, Janjua NZ, De Serres G, Dickinson JA, Winter A, Mahmud SM. 2013. Interim estimates of influenza vaccine effectiveness in 2012/13 from Canada's sentinel surveillance network, January 2013. Euro Surveill 18:pii: 20394. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId = 20394.</note><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>18</number></detail></part><relatedItem type="host"><titleInfo><title>Euro Surveill</title></titleInfo><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>18</number></detail></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0018"><titleInfo><title>Mapping the antigenic and genetic evolution o f influenza virus</title></titleInfo><name type="personal"><namePart type="given">DJ</namePart><namePart type="family">Smith</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AS</namePart><namePart type="family">Lapedes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JC</namePart><namePart type="family">de Jong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TM</namePart><namePart type="family">Bestebroer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GF</namePart><namePart type="family">Rimmelzwaan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ADME</namePart><namePart type="family">Osterhaus</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RAM</namePart><namePart type="family">Fouchier</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Smith DJ, Lapedes AS, de Jong JC, Bestebroer TM, Rimmelzwaan GF, Osterhaus ADME, Fouchier RAM. 2004. Mapping the antigenic and genetic evolution o f influenza virus. Science 305:371–376.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>305</number></detail><extent unit="pages"><start>371</start><end>376</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>305</number></detail><extent unit="pages"><start>371</start><end>376</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0019"><titleInfo><title>Molecular genetic analysis of influenza A/H3N2 virus strains isolated in Western Siberia in the 2010–2011 epidemic seasons</title></titleInfo><name type="personal"><namePart type="given">I</namePart><namePart type="family">Sobolev</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Kurskaya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Susloparov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Ilyicheva</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Shestopalov</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Sobolev I, Kurskaya O, Susloparov I, Ilyicheva T, Shestopalov A. 2012. Molecular genetic analysis of influenza A/H3N2 virus strains isolated in Western Siberia in the 2010–2011 epidemic seasons. Infect Genet Evol 12:1694–1698.</note><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>1694</start><end>1698</end></extent></part><relatedItem type="host"><titleInfo><title>Infect Genet Evol</title></titleInfo><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>1694</start><end>1698</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0020"><titleInfo><title>Influenza‐WHO cares</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Stohr</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Stohr K. 2002. Influenza‐WHO cares. Lancet Infect Dis 2:517.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>517</start></extent></part><relatedItem type="host"><titleInfo><title>Lancet Infect Dis</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>517</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0021"><titleInfo><title>MEGA5: Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Tamura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Peterson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Peterson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Stecher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Nei</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Kumar</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S. 2011. MEGA5: Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol 28:2731–2739.</note><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>2731</start><end>2739</end></extent></part><relatedItem type="host"><titleInfo><title>Mol Biol Evol</title></titleInfo><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>2731</start><end>2739</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0022"><titleInfo><title>Influenza viruses: Breaking all the rules</title></titleInfo><name type="personal"><namePart type="given">JK</namePart><namePart type="family">Taubenberger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DM</namePart><namePart type="family">Morens</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Taubenberger JK, Morens DM. 2013. Influenza viruses: Breaking all the rules. mBio 4:e00365–e00313. DOI: 10.1128/mBio.00365‐13</note><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>e00365</start><end>e00313</end></extent></part><relatedItem type="host"><titleInfo><title>mBio</title></titleInfo><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>e00365</start><end>e00313</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0023"><titleInfo><title>Clustal W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position specific gap penalties and weight matrix choice</title></titleInfo><name type="personal"><namePart type="given">JD</namePart><namePart type="family">Thompson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DG</namePart><namePart type="family">Higgins</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TJ</namePart><namePart type="family">Gibson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Thompson JD, Higgins DG, Gibson TJ. 1994. Clustal W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position specific gap penalties and weight matrix choice. Nucl Acid Res 22:4673–4680.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><extent unit="pages"><start>4673</start><end>4680</end></extent></part><relatedItem type="host"><titleInfo><title>Nucl Acid Res</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><extent unit="pages"><start>4673</start><end>4680</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0024"><titleInfo><title>WHO. 2003. Fact sheet number 211. Influenza. Available on: http://www.who.int/mediacentre/factsheets/fs211.</title></titleInfo><genre>other</genre><part><date>2003</date></part></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0025"><titleInfo><title>World Health Organization (WHO). 2009. CDC protocol of real‐time RTPCR for influenza A (H1N1). Available from: http://www.who.int/csr/resources/publications/swineflu/realtimeptpcr/en/index.htm. (accessed on April 30, 2009).</title></titleInfo><genre>other</genre><part><date>2009</date></part></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0026"><titleInfo><title>WHO 2011. London Influenza Report 2011: Report prepared for the WHO annual consultation on the composition of influenza vaccine for the Northern Hemisphere. 14th–17th February. Available on: http://www.who.cc.imr.mrc.ac.uk.</title></titleInfo><genre>other</genre><part><date>2011</date></part></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0027"><titleInfo><title>WHO Global Influenza Surveillance Network. 2011. Manual for the laboratory diagnosis and virological surveillance of influenza.</title></titleInfo><genre>other</genre><part><date>2011</date></part></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0028"><titleInfo><title>WHO surveillance Report: Summary of the influenza season in the WHO European region. Available on: http://www.who.int/influenza/vaccines/virus/recommendations/2012_13_north/en/.</title></titleInfo><genre>other</genre></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0029"><titleInfo><title>World Health Organization (WHO). CDC protocol of real‐time RTPCR for influenza A (H1N1). Available from:flu/realtimeptpcr/en/index html; http://www.who.int/csr/resources/publications/swine. (accessed on April 30, 2009).</title></titleInfo><genre>other</genre><part><date>2009</date></part></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0030"><titleInfo><title>Structural identification of the antibody‐binding sites of Hong Kong influenza hemagglutinin and their involvement in antigenic variation</title></titleInfo><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Wiley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IA</namePart><namePart type="family">Wilson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JJ</namePart><namePart type="family">Skehel</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wiley DC, Wilson IA, Skehel JJ. 1981. Structural identification of the antibody‐binding sites of Hong Kong influenza hemagglutinin and their involvement in antigenic variation. Nature 289:373–378.</note><part><date>1981</date><detail type="volume"><caption>vol.</caption><number>289</number></detail><extent unit="pages"><start>373</start><end>378</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>1981</date><detail type="volume"><caption>vol.</caption><number>289</number></detail><extent unit="pages"><start>373</start><end>378</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0031"><titleInfo><title>Structural basis of immune recognition of influenza virus hemagglutinin</title></titleInfo><name type="personal"><namePart type="given">IA</namePart><namePart type="family">Wilson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NJ</namePart><namePart type="family">Cox</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wilson IA, Cox NJ. 1990. Structural basis of immune recognition of influenza virus hemagglutinin. Annu Rev Immunol 8:737–771.</note><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>737</start><end>771</end></extent></part><relatedItem type="host"><titleInfo><title>Annu Rev Immunol</title></titleInfo><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>737</start><end>771</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="jmv24096-cit-0032"><titleInfo><title>Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3A resolutions</title></titleInfo><name type="personal"><namePart type="given">IA</namePart><namePart type="family">Wilson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JJ</namePart><namePart type="family">Skehel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Wiley</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wilson IA, Skehel JJ, Wiley DC. 1981. Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3A resolutions. Nature 289:366–373.</note><part><date>1981</date><detail type="volume"><caption>vol.</caption><number>289</number></detail><extent unit="pages"><start>366</start><end>373</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>1981</date><detail type="volume"><caption>vol.</caption><number>289</number></detail><extent unit="pages"><start>366</start><end>373</end></extent></part></relatedItem></relatedItem><identifier type="istex">C8872BDC2688E93C2EFAA7BD623432F7AF8722BD</identifier><identifier type="ark">ark:/67375/WNG-QR1JJF8F-H</identifier><identifier type="DOI">10.1002/jmv.24096</identifier><identifier type="ArticleID">JMV24096</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2015 Wiley Periodicals, Inc.© 2015 Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-15</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-QR1JJF8F-H/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001104 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001104 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:C8872BDC2688E93C2EFAA7BD623432F7AF8722BD
|texte= Genetic changes in influenza A(H3N2) viruses circulating during 2011 to 2013 in northern India (Lucknow)
}}
| This area was generated with Dilib version V0.6.33. |  |