ORIGINAL ARTICLE: H3N2 Influenza A Virus Replicates in Immortalized Human First Trimester Trophoblast Cell Lines and Induces Their Rapid Apoptosis
Identifieur interne : 001103 ( Istex/Corpus ); précédent : 001102; suivant : 001104ORIGINAL ARTICLE: H3N2 Influenza A Virus Replicates in Immortalized Human First Trimester Trophoblast Cell Lines and Induces Their Rapid Apoptosis
Auteurs : Quang Duy Trinh ; Yasuyuki Izumi ; Shihoko Komine-Aizawa ; Toshikatsu Shibata ; Yoshitaka Shimotai ; Kazumichi Kuroda ; Masashi Mizuguchi ; Hiroshi Ushijima ; Gil Mor ; Satoshi HayakawaSource :
- American Journal of Reproductive Immunology [ 1046-7408 ] ; 2009-09.
Abstract
Problem Epidemiological data suggested that pandemic influenza increased the risks of spontaneous abortion and premature labor, while seasonal influenza also increased the risk of schizophrenia in adolescence. However, their pathogenesis is so far unknown. Method of study The first trimester trophoblast cell lines, namely, Swan71 and HTR8 cells were challenged with A/Udorn/72 influenza virus (H3N2). At indicated time points, cells were examined for expression of influenza proteins. Viral replication in culture media, apoptosis and the expression of human leukocyte antigen (HLA)‐G were also examined. Results Intracellular localization of viral proteins was observed. Twenty‐four hours after inoculation, virus was detected in culture media while most cells fell into apoptosis. During apoptosis, expression of HLA‐G was unchanged. Conclusion We revealed replication of low pathogenic influenza virus in the first trimester trophoblast cell lines. Placental damages are likely to be induced by direct cytopathic effects of influenza virus and subsequent apoptosis rather than down regulation of HLA‐G expression and subsequent rejection by maternal immune system.
Url:
DOI: 10.1111/j.1600-0897.2009.00723.x
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">ORIGINAL ARTICLE: H3N2 Influenza A Virus Replicates in Immortalized Human First Trimester Trophoblast Cell Lines and Induces Their Rapid Apoptosis</title><author><name sortKey="Trinh, Quang Duy" sort="Trinh, Quang Duy" uniqKey="Trinh Q" first="Quang Duy" last="Trinh">Quang Duy Trinh</name><affiliation><mods:affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Izumi, Yasuyuki" sort="Izumi, Yasuyuki" uniqKey="Izumi Y" first="Yasuyuki" last="Izumi">Yasuyuki Izumi</name><affiliation><mods:affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Komine Izawa, Shihoko" sort="Komine Izawa, Shihoko" uniqKey="Komine Izawa S" first="Shihoko" last="Komine-Aizawa">Shihoko Komine-Aizawa</name><affiliation><mods:affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Shibata, Toshikatsu" sort="Shibata, Toshikatsu" uniqKey="Shibata T" first="Toshikatsu" last="Shibata">Toshikatsu Shibata</name><affiliation><mods:affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Shimotai, Yoshitaka" sort="Shimotai, Yoshitaka" uniqKey="Shimotai Y" first="Yoshitaka" last="Shimotai">Yoshitaka Shimotai</name><affiliation><mods:affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kuroda, Kazumichi" sort="Kuroda, Kazumichi" uniqKey="Kuroda K" first="Kazumichi" last="Kuroda">Kazumichi Kuroda</name><affiliation><mods:affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Mizuguchi, Masashi" sort="Mizuguchi, Masashi" uniqKey="Mizuguchi M" first="Masashi" last="Mizuguchi">Masashi Mizuguchi</name><affiliation><mods:affiliation>Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Ushijima, Hiroshi" sort="Ushijima, Hiroshi" uniqKey="Ushijima H" first="Hiroshi" last="Ushijima">Hiroshi Ushijima</name><affiliation><mods:affiliation>Aino Health Science Center, Aino University, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Mor, Gil" sort="Mor, Gil" uniqKey="Mor G" first="Gil" last="Mor">Gil Mor</name><affiliation><mods:affiliation>Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, CT, USA</mods:affiliation></affiliation></author><author><name sortKey="Hayakawa, Satoshi" sort="Hayakawa, Satoshi" uniqKey="Hayakawa S" first="Satoshi" last="Hayakawa">Satoshi Hayakawa</name><affiliation><mods:affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3C69A02A52118DA5FE363A2326747E210C5EF372</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1111/j.1600-0897.2009.00723.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-CH4D31R4-H/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001103</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001103</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">ORIGINAL ARTICLE: H3N2 Influenza A Virus Replicates in Immortalized Human First Trimester Trophoblast Cell Lines and Induces Their Rapid Apoptosis</title><author><name sortKey="Trinh, Quang Duy" sort="Trinh, Quang Duy" uniqKey="Trinh Q" first="Quang Duy" last="Trinh">Quang Duy Trinh</name><affiliation><mods:affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Izumi, Yasuyuki" sort="Izumi, Yasuyuki" uniqKey="Izumi Y" first="Yasuyuki" last="Izumi">Yasuyuki Izumi</name><affiliation><mods:affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Komine Izawa, Shihoko" sort="Komine Izawa, Shihoko" uniqKey="Komine Izawa S" first="Shihoko" last="Komine-Aizawa">Shihoko Komine-Aizawa</name><affiliation><mods:affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Shibata, Toshikatsu" sort="Shibata, Toshikatsu" uniqKey="Shibata T" first="Toshikatsu" last="Shibata">Toshikatsu Shibata</name><affiliation><mods:affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Shimotai, Yoshitaka" sort="Shimotai, Yoshitaka" uniqKey="Shimotai Y" first="Yoshitaka" last="Shimotai">Yoshitaka Shimotai</name><affiliation><mods:affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kuroda, Kazumichi" sort="Kuroda, Kazumichi" uniqKey="Kuroda K" first="Kazumichi" last="Kuroda">Kazumichi Kuroda</name><affiliation><mods:affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Mizuguchi, Masashi" sort="Mizuguchi, Masashi" uniqKey="Mizuguchi M" first="Masashi" last="Mizuguchi">Masashi Mizuguchi</name><affiliation><mods:affiliation>Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Ushijima, Hiroshi" sort="Ushijima, Hiroshi" uniqKey="Ushijima H" first="Hiroshi" last="Ushijima">Hiroshi Ushijima</name><affiliation><mods:affiliation>Aino Health Science Center, Aino University, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Mor, Gil" sort="Mor, Gil" uniqKey="Mor G" first="Gil" last="Mor">Gil Mor</name><affiliation><mods:affiliation>Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, CT, USA</mods:affiliation></affiliation></author><author><name sortKey="Hayakawa, Satoshi" sort="Hayakawa, Satoshi" uniqKey="Hayakawa S" first="Satoshi" last="Hayakawa">Satoshi Hayakawa</name><affiliation><mods:affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">American Journal of Reproductive Immunology</title><title level="j" type="alt">AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY</title><idno type="ISSN">1046-7408</idno><idno type="eISSN">1600-0897</idno><imprint><biblScope unit="vol">62</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="139">139</biblScope><biblScope unit="page" to="146">146</biblScope><biblScope unit="page-count">8</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-09">2009-09</date></imprint><idno type="ISSN">1046-7408</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1046-7408</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Problem Epidemiological data suggested that pandemic influenza increased the risks of spontaneous abortion and premature labor, while seasonal influenza also increased the risk of schizophrenia in adolescence. However, their pathogenesis is so far unknown. Method of study The first trimester trophoblast cell lines, namely, Swan71 and HTR8 cells were challenged with A/Udorn/72 influenza virus (H3N2). At indicated time points, cells were examined for expression of influenza proteins. Viral replication in culture media, apoptosis and the expression of human leukocyte antigen (HLA)‐G were also examined. Results Intracellular localization of viral proteins was observed. Twenty‐four hours after inoculation, virus was detected in culture media while most cells fell into apoptosis. During apoptosis, expression of HLA‐G was unchanged. Conclusion We revealed replication of low pathogenic influenza virus in the first trimester trophoblast cell lines. Placental damages are likely to be induced by direct cytopathic effects of influenza virus and subsequent apoptosis rather than down regulation of HLA‐G expression and subsequent rejection by maternal immune system.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>trophoblast</json:string><json:string>viral</json:string><json:string>influenza virus</json:string><json:string>apoptosis</json:string><json:string>influenza</json:string><json:string>udorn</json:string><json:string>placenta</json:string><json:string>cell line</json:string><json:string>immunology</json:string><json:string>fetal</json:string><json:string>schizophrenia</json:string><json:string>reproductive immunology</json:string><json:string>american journal</json:string><json:string>immunofluorescence</json:string><json:string>viremia</json:string><json:string>primer</json:string><json:string>pregnant woman</json:string><json:string>trimester</json:string><json:string>virus 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International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Yasuyuki Izumi</name><affiliations><json:string>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Shihoko Komine‐Aizawa</name><affiliations><json:string>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Toshikatsu Shibata</name><affiliations><json:string>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Yoshitaka Shimotai</name><affiliations><json:string>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Kazumichi Kuroda</name><affiliations><json:string>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Masashi Mizuguchi</name><affiliations><json:string>Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Hiroshi Ushijima</name><affiliations><json:string>Aino Health Science Center, Aino University, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Gil Mor</name><affiliations><json:string>Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, CT, USA</json:string></affiliations></json:item><json:item><name>Satoshi Hayakawa</name><affiliations><json:string>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Apoptosis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>first trimester trophoblast</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>influenza A virus</value></json:item></subject><articleId><json:string>AJI723</json:string></articleId><arkIstex>ark:/67375/WNG-CH4D31R4-H</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Problem Epidemiological data suggested that pandemic influenza increased the risks of spontaneous abortion and premature labor, while seasonal influenza also increased the risk of schizophrenia in adolescence. However, their pathogenesis is so far unknown. Method of study The first trimester trophoblast cell lines, namely, Swan71 and HTR8 cells were challenged with A/Udorn/72 influenza virus (H3N2). At indicated time points, cells were examined for expression of influenza proteins. Viral replication in culture media, apoptosis and the expression of human leukocyte antigen (HLA)‐G were also examined. Results Intracellular localization of viral proteins was observed. Twenty‐four hours after inoculation, virus was detected in culture media while most cells fell into apoptosis. During apoptosis, expression of HLA‐G was unchanged. Conclusion We revealed replication of low pathogenic influenza virus in the first trimester trophoblast cell lines. Placental damages are likely to be induced by direct cytopathic effects of influenza virus and subsequent apoptosis rather than down regulation of HLA‐G expression and subsequent rejection by maternal immune system.</abstract><qualityIndicators><score>7.939</score><pdfWordCount>3995</pdfWordCount><pdfCharCount>25524</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>8</pdfPageCount><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><pdfWordsPerPage>499</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>162</abstractWordCount><abstractCharCount>1172</abstractCharCount><keywordCount>3</keywordCount></qualityIndicators><title>ORIGINAL ARTICLE: H3N2 Influenza A Virus Replicates in Immortalized Human First Trimester Trophoblast Cell Lines and Induces Their Rapid Apoptosis</title><pmid><json:string>19694639</json:string></pmid><genre><json:string>article</json:string></genre><host><title>American Journal of Reproductive Immunology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-0897</json:string></doi><issn><json:string>1046-7408</json:string></issn><eissn><json:string>1600-0897</json:string></eissn><publisherId><json:string>AJI</json:string></publisherId><volume>62</volume><issue>3</issue><pages><first>139</first><last>146</last><total>8</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>2009</json:string><json:string>1968</json:string><json:string>1957</json:string><json:string>In the 20th century</json:string><json:string>1918</json:string></date><geogName></geogName><orgName><json:string>Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan</json:string><json:string>Honjo International Scholarship Foundation</json:string><json:string>Nakarai Tesque, Inc., Kyoto, Japan</json:string><json:string>TaKaRa Bio Inc.</json:string><json:string>Aino Health Science Center</json:string><json:string>Perfect Real Time</json:string><json:string>Nihon University</json:string><json:string>Department of Obstetrics, Gynecology and Reproductive Sciences</json:string><json:string>LINE EDIT Co.</json:string><json:string>Department of Pathology and Microbiology</json:string><json:string>American Journal of Reproductive Immunology</json:string><json:string>Ministry of Heath, Labor and Welfare</json:string><json:string>Ministry of Education, Culture, Sports, Science and Technology, Japan</json:string><json:string>TaKaRa Co.</json:string><json:string>Yale University</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Gil Mor</json:string><json:string>Hong Kong</json:string><json:string>Alexa Fluor</json:string><json:string>John Wiley</json:string><json:string>I. 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TROPHOBLASTS</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><licence>© 2009 John Wiley & Sons A/S</licence></availability><date type="published" when="2009-09"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">ORIGINAL ARTICLE: H3N2 Influenza A Virus Replicates in Immortalized Human First Trimester Trophoblast Cell Lines and Induces Their Rapid Apoptosis</title><title level="a" type="short">INFLUENZA A VIRUS REPLICATES IN TROPHOBLASTS</title><author xml:id="author-0000"><persName><forename type="first">Quang Duy</forename><surname>Trinh</surname></persName><affiliation><orgName type="department">Division of Microbiology</orgName><orgName type="department">Department of Pathology and Microbiology</orgName><orgName type="institution">Nihon University School of Medicine</orgName><address><addrLine>Tokyo</addrLine><addrLine>Japan</addrLine><country key="JP" xml:lang="en">JAPAN</country></address></affiliation><affiliation><orgName type="division">Department of Developmental Medical Sciences</orgName><orgName type="institution">Institute of International Health</orgName><orgName type="department">Graduate School of Medicine</orgName><orgName type="institution">The University of Tokyo</orgName><address><addrLine>Tokyo</addrLine><addrLine>Japan</addrLine><country key="JP" xml:lang="en">JAPAN</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Yasuyuki</forename><surname>Izumi</surname></persName><affiliation><orgName type="department">Division of Microbiology</orgName><orgName type="department">Department of Pathology and Microbiology</orgName><orgName type="institution">Nihon University School of Medicine</orgName><address><addrLine>Tokyo</addrLine><addrLine>Japan</addrLine><country key="JP" xml:lang="en">JAPAN</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Shihoko</forename><surname>Komine‐Aizawa</surname></persName><affiliation><orgName type="department">Division of Microbiology</orgName><orgName type="department">Department of Pathology and Microbiology</orgName><orgName type="institution">Nihon University School of Medicine</orgName><address><addrLine>Tokyo</addrLine><addrLine>Japan</addrLine><country key="JP" xml:lang="en">JAPAN</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Toshikatsu</forename><surname>Shibata</surname></persName><affiliation><orgName type="department">Division of Microbiology</orgName><orgName type="department">Department of Pathology and Microbiology</orgName><orgName type="institution">Nihon University School of Medicine</orgName><address><addrLine>Tokyo</addrLine><addrLine>Japan</addrLine><country key="JP" xml:lang="en">JAPAN</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Yoshitaka</forename><surname>Shimotai</surname></persName><affiliation><orgName type="department">Division of Microbiology</orgName><orgName type="department">Department of Pathology and Microbiology</orgName><orgName type="institution">Nihon University School of Medicine</orgName><address><addrLine>Tokyo</addrLine><addrLine>Japan</addrLine><country key="JP" xml:lang="en">JAPAN</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Kazumichi</forename><surname>Kuroda</surname></persName><affiliation><orgName type="department">Division of Microbiology</orgName><orgName type="department">Department of Pathology and Microbiology</orgName><orgName type="institution">Nihon University School of Medicine</orgName><address><addrLine>Tokyo</addrLine><addrLine>Japan</addrLine><country key="JP" xml:lang="en">JAPAN</country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Masashi</forename><surname>Mizuguchi</surname></persName><affiliation><orgName type="division">Department of Developmental Medical Sciences</orgName><orgName type="institution">Institute of International Health</orgName><orgName type="department">Graduate School of Medicine</orgName><orgName type="institution">The University of Tokyo</orgName><address><addrLine>Tokyo</addrLine><addrLine>Japan</addrLine><country key="JP" xml:lang="en">JAPAN</country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">Hiroshi</forename><surname>Ushijima</surname></persName><affiliation><orgName type="institution">Aino Health Science Center</orgName><orgName type="institution">Aino University</orgName><address><addrLine>Tokyo</addrLine><addrLine>Japan</addrLine><country key="JP" xml:lang="en">JAPAN</country></address></affiliation></author><author xml:id="author-0008"><persName><forename type="first">Gil</forename><surname>Mor</surname></persName><affiliation><orgName type="division">Department of Obstetrics</orgName><address><addrLine>Gynecology and Reproductive Sciences</addrLine><addrLine>Reproductive Immunology Unit, Yale University School of Medicine, New Haven, CT, USA</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0009"><persName><forename type="first">Satoshi</forename><surname>Hayakawa</surname></persName><affiliation><orgName type="department">Division of Microbiology</orgName><orgName type="department">Department of Pathology and Microbiology</orgName><orgName type="institution">Nihon University School of Medicine</orgName><address><addrLine>Tokyo</addrLine><addrLine>Japan</addrLine><country key="JP" xml:lang="en">JAPAN</country></address></affiliation></author><idno type="istex">3C69A02A52118DA5FE363A2326747E210C5EF372</idno><idno type="ark">ark:/67375/WNG-CH4D31R4-H</idno><idno type="DOI">10.1111/j.1600-0897.2009.00723.x</idno><idno type="unit">AJI723</idno><idno type="toTypesetVersion">file:AJI.AJI723.pdf</idno></analytic><monogr><title level="j" type="main">American Journal of Reproductive Immunology</title><title level="j" type="alt">AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY</title><idno type="pISSN">1046-7408</idno><idno type="eISSN">1600-0897</idno><idno type="book-DOI">10.1111/(ISSN)1600-0897</idno><idno type="book-part-DOI">10.1111/aji.2009.62.issue-3</idno><idno type="product">AJI</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">62</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="139">139</biblScope><biblScope unit="page" to="146">146</biblScope><biblScope unit="page-count">8</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-09"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><p><hi rend="bold">Problem </hi> Epidemiological data suggested that pandemic influenza increased the risks of spontaneous abortion and premature labor, while seasonal influenza also increased the risk of schizophrenia in adolescence. However, their pathogenesis is so far unknown.</p><p><hi rend="bold">Method of study </hi> The first trimester trophoblast cell lines, namely, Swan71 and HTR8 cells were challenged with A/Udorn/72 influenza virus (H3N2). At indicated time points, cells were examined for expression of influenza proteins. Viral replication in culture media, apoptosis and the expression of human leukocyte antigen (HLA)‐G were also examined.</p><p><hi rend="bold">Results</hi> Intracellular localization of viral proteins was observed. Twenty‐four hours after inoculation, virus was detected in culture media while most cells fell into apoptosis. During apoptosis, expression of HLA‐G was unchanged.</p><p><hi rend="bold">Conclusion </hi> We revealed replication of low pathogenic influenza virus in the first trimester trophoblast cell lines. Placental damages are likely to be induced by direct cytopathic effects of influenza virus and subsequent apoptosis rather than down regulation of HLA‐G expression and subsequent rejection by maternal immune system.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">Apoptosis</term><term xml:id="k2">first trimester trophoblast</term><term xml:id="k3">influenza A virus</term></keywords><keywords rend="tocHeading1"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-CH4D31R4-H/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0897</doi><issn type="print">1046-7408</issn><issn type="electronic">1600-0897</issn><idGroup><id type="product" value="AJI"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY">American Journal of Reproductive Immunology</title></titleGroup></publicationMeta><publicationMeta level="part" position="09003"><doi origin="wiley">10.1111/aji.2009.62.issue-3</doi><numberingGroup><numbering type="journalVolume" number="62">62</numbering><numbering type="journalIssue" number="3">3</numbering></numberingGroup><coverDate startDate="2009-09">September 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="3" status="forIssue"><doi origin="wiley">10.1111/j.1600-0897.2009.00723.x</doi><idGroup><id type="unit" value="AJI723"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><copyright>© 2009 John Wiley & Sons A/S</copyright><eventGroup><event type="firstOnline" date="2009-08-11"></event><event type="publishedOnlineFinalForm" date="2009-08-11"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.16 mode:FullText" date="2010-08-17"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="139">139</numbering><numbering type="pageLast" number="146">146</numbering></numberingGroup><correspondenceTo>Satoshi Hayakawa, Nihon University School of Medicine, 30‐1 Ohyaguchi Kamimachi, Itabashi‐ku, Tokyo 173‐8610, Japan.
E‐mail: <email normalForm="satoshih@med.nihon-u.ac.jp">satoshih@med.nihon‐u.ac.jp</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:AJI.AJI723.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Submitted April 20, 2009; accepted June 16, 2009.</unparsedEditorialHistory><countGroup><count type="figureTotal" number="5"></count><count type="tableTotal" number="1"></count></countGroup><titleGroup><title type="main">ORIGINAL ARTICLE: H3N2 Influenza A Virus Replicates in Immortalized Human First Trimester Trophoblast Cell Lines and Induces Their Rapid Apoptosis</title><title type="shortAuthors">TRINH ET AL.</title><title type="short">INFLUENZA A VIRUS REPLICATES IN TROPHOBLASTS</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2"><personName><givenNames>Quang Duy</givenNames><familyName>Trinh</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Yasuyuki</givenNames><familyName>Izumi</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>Shihoko</givenNames><familyName>Komine‐Aizawa</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Toshikatsu</givenNames><familyName>Shibata</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>Yoshitaka</givenNames><familyName>Shimotai</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><personName><givenNames>Kazumichi</givenNames><familyName>Kuroda</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a2"><personName><givenNames>Masashi</givenNames><familyName>Mizuguchi</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a3"><personName><givenNames>Hiroshi</givenNames><familyName>Ushijima</familyName></personName></creator><creator creatorRole="author" xml:id="cr9" affiliationRef="#a4"><personName><givenNames>Gil</givenNames><familyName>Mor</familyName></personName></creator><creator creatorRole="author" xml:id="cr10" affiliationRef="#a1"><personName><givenNames>Satoshi</givenNames><familyName>Hayakawa</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="JP"><unparsedAffiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="JP"><unparsedAffiliation>Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="JP"><unparsedAffiliation>Aino Health Science Center, Aino University, Tokyo, Japan</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="US"><unparsedAffiliation>Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, CT, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Apoptosis</keyword><keyword xml:id="k2">first trimester trophoblast</keyword><keyword xml:id="k3">influenza A virus</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Problem </b> Epidemiological data suggested that pandemic influenza increased the risks of spontaneous abortion and premature labor, while seasonal influenza also increased the risk of schizophrenia in adolescence. However, their pathogenesis is so far unknown.</p><p><b>Method of study </b> The first trimester trophoblast cell lines, namely, Swan71 and HTR8 cells were challenged with A/Udorn/72 influenza virus (H3N2). At indicated time points, cells were examined for expression of influenza proteins. Viral replication in culture media, apoptosis and the expression of human leukocyte antigen (HLA)‐G were also examined.</p><p><b>Results</b> Intracellular localization of viral proteins was observed. Twenty‐four hours after inoculation, virus was detected in culture media while most cells fell into apoptosis. During apoptosis, expression of HLA‐G was unchanged.</p><p><b>Conclusion </b> We revealed replication of low pathogenic influenza virus in the first trimester trophoblast cell lines. Placental damages are likely to be induced by direct cytopathic effects of influenza virus and subsequent apoptosis rather than down regulation of HLA‐G expression and subsequent rejection by maternal immune system.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>ORIGINAL ARTICLE: H3N2 Influenza A Virus Replicates in Immortalized Human First Trimester Trophoblast Cell Lines and Induces Their Rapid Apoptosis</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>INFLUENZA A VIRUS REPLICATES IN TROPHOBLASTS</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>ORIGINAL ARTICLE: H3N2 Influenza A Virus Replicates in Immortalized Human First Trimester Trophoblast Cell Lines and Induces Their Rapid Apoptosis</title></titleInfo><name type="personal"><namePart type="given">Quang Duy</namePart><namePart type="family">Trinh</namePart><affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</affiliation><affiliation>Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yasuyuki</namePart><namePart type="family">Izumi</namePart><affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Shihoko</namePart><namePart type="family">Komine‐Aizawa</namePart><affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Toshikatsu</namePart><namePart type="family">Shibata</namePart><affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yoshitaka</namePart><namePart type="family">Shimotai</namePart><affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kazumichi</namePart><namePart type="family">Kuroda</namePart><affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Masashi</namePart><namePart type="family">Mizuguchi</namePart><affiliation>Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hiroshi</namePart><namePart type="family">Ushijima</namePart><affiliation>Aino Health Science Center, Aino University, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gil</namePart><namePart type="family">Mor</namePart><affiliation>Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, CT, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Satoshi</namePart><namePart type="family">Hayakawa</namePart><affiliation>Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2009-09</dateIssued><edition>Submitted April 20, 2009; accepted June 16, 2009.</edition><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">5</extent><extent unit="tables">1</extent></physicalDescription><abstract lang="en">Problem Epidemiological data suggested that pandemic influenza increased the risks of spontaneous abortion and premature labor, while seasonal influenza also increased the risk of schizophrenia in adolescence. However, their pathogenesis is so far unknown. Method of study The first trimester trophoblast cell lines, namely, Swan71 and HTR8 cells were challenged with A/Udorn/72 influenza virus (H3N2). At indicated time points, cells were examined for expression of influenza proteins. Viral replication in culture media, apoptosis and the expression of human leukocyte antigen (HLA)‐G were also examined. Results Intracellular localization of viral proteins was observed. Twenty‐four hours after inoculation, virus was detected in culture media while most cells fell into apoptosis. During apoptosis, expression of HLA‐G was unchanged. Conclusion We revealed replication of low pathogenic influenza virus in the first trimester trophoblast cell lines. Placental damages are likely to be induced by direct cytopathic effects of influenza virus and subsequent apoptosis rather than down regulation of HLA‐G expression and subsequent rejection by maternal immune system.</abstract><subject lang="en"><genre>keywords</genre><topic>Apoptosis</topic><topic>first trimester trophoblast</topic><topic>influenza A virus</topic></subject><relatedItem type="host"><titleInfo><title>American Journal of Reproductive Immunology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">1046-7408</identifier><identifier type="eISSN">1600-0897</identifier><identifier type="DOI">10.1111/(ISSN)1600-0897</identifier><identifier type="PublisherID">AJI</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>62</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>139</start><end>146</end><total>8</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit2"><titleInfo><title>Pandemic influenza and pregnant women</title></titleInfo><name type="personal"><namePart type="given">SA</namePart><namePart type="family">Rasmussen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DJ</namePart><namePart type="family">Jamieson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JS</namePart><namePart type="family">Bresee</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rasmussen SA, Jamieson DJ, Bresee JS: Pandemic influenza and pregnant women. 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