Acute optic neuritis: A virological study in relation to multiple sclerosis
Identifieur interne : 000D93 ( Istex/Corpus ); précédent : 000D92; suivant : 000D94Acute optic neuritis: A virological study in relation to multiple sclerosis
Auteurs : Daniela Santoli ; Zofia Wroblewska ; Natalie E. Cremer ; Florence S. Lief ; Norman SchatzSource :
- Journal of Medical Virology [ 0146-6615 ] ; 1977.
English descriptors
- Teeft :
- Acta neurologica scandinavica, Acute phase, Antibody titers, Body excretions, Brain cells, California state department, Cell cultures, Cell lysates, Cerebrospinal, Cerebrospinal fluid, Control groups, Cytochemical analysis, Diagnostic procedures, Electron microscope, Electron microscopy, England journal, Etiology, Excretion samples, Filament, Fusion technique, Grand island, Health association, Indicator cells, Infectious agents, Infectious virus, Intranuclear, Intranuclear filaments, Koprowski, Lymphocyte, Measles virus, Meulen, Mononuclear, Mononuclear cells, Multiple sclerosis, Negative results, Neuritis, Nikoskelainen, Nuclear changes, Optic, Optic neuritis, Parainfluenza, Parainfluenza type, Peripheral blood, Respiratory syncytial, Rickettsial infections, Room temperature, Santoli, Sclerosis, Serological studies, Serological techniques, Subacute sclerosing panencephalitis, Suitable virological, Systemic lupus erythematosus, Tanaka, Throat swabs, Unusual intranuclear filaments, Viral, Viral agent, Viral antigen, Viral antigens, Viral footprints, Viral origin, Viral particles, Virological, Virological study, Virus antibody levels, Wistar institute.
Abstract
Previous ultrastructural examination of peripheral blood lymphocytes revealed the presence of intranuclear filamentous structures in multiple sclerosis (MS) and in some optic neuritis (ON) patients. The present investigation was undertaken in the attempt to correlate the presence of such structures with the etiology of ON and MS and possibly to demonstrate the viral origin of the filaments. Suitable virological and serological techniques were used to detect and isolate infectious agents from peripheral blood samples and body excretions of 12 monosymptomatic ON patients at their first acute attack. Nevertheless, any efforts to demonstrate the presence of a virus in these patients have been unsuccessful: no evidence of active viral infection was obtained by serological studies of serum and cerebrospinal fluid samples, nor could viral antigens or inclusions be observed by immunofluorescence and cytochemical analysis. Negative results were also obtained from studies performed in parallel on MS patients and various controls. The significance of the failure to isolate infectious agents from either ON and MS patients is discussed.
Url:
DOI: 10.1002/jmv.1890010307
Links to Exploration step
ISTEX:430E89A4B02A2E22A020E6B296C63AD5C873A883Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Acute optic neuritis: A virological study in relation to multiple sclerosis</title><author><name sortKey="Santoli, Daniela" sort="Santoli, Daniela" uniqKey="Santoli D" first="Daniela" last="Santoli">Daniela Santoli</name><affiliation><mods:affiliation>Multiple Sclerosis Research Center of the Wistar Institute and the University of Pennsylvania, Philadelphia</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: The Wistar Institute, 36th Street at Spruce, Philadelphia, PA 19104===</mods:affiliation></affiliation></author><author><name sortKey="Wroblewska, Zofia" sort="Wroblewska, Zofia" uniqKey="Wroblewska Z" first="Zofia" last="Wroblewska">Zofia Wroblewska</name><affiliation><mods:affiliation>Multiple Sclerosis Research Center of the Wistar Institute and the University of Pennsylvania, Philadelphia</mods:affiliation></affiliation></author><author><name sortKey="Cremer, Natalie E" sort="Cremer, Natalie E" uniqKey="Cremer N" first="Natalie E." last="Cremer">Natalie E. Cremer</name><affiliation><mods:affiliation>Viral and Rickettsial Disease Laboratory, California State Department of Health, Berkeley</mods:affiliation></affiliation></author><author><name sortKey="Lief, Florence S" sort="Lief, Florence S" uniqKey="Lief F" first="Florence S." last="Lief">Florence S. Lief</name><affiliation><mods:affiliation>Multiple Sclerosis Research Center of the Wistar Institute and the University of Pennsylvania, Philadelphia</mods:affiliation></affiliation></author><author><name sortKey="Schatz, Norman" sort="Schatz, Norman" uniqKey="Schatz N" first="Norman" last="Schatz">Norman Schatz</name><affiliation><mods:affiliation>Wills Eye Hospital, Philadelphia, Pennsylvania</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:430E89A4B02A2E22A020E6B296C63AD5C873A883</idno><date when="1977" year="1977">1977</date><idno type="doi">10.1002/jmv.1890010307</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-9VJ7ZQLF-B/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000D93</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000D93</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Acute optic neuritis: A virological study in relation to multiple sclerosis</title><author><name sortKey="Santoli, Daniela" sort="Santoli, Daniela" uniqKey="Santoli D" first="Daniela" last="Santoli">Daniela Santoli</name><affiliation><mods:affiliation>Multiple Sclerosis Research Center of the Wistar Institute and the University of Pennsylvania, Philadelphia</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: The Wistar Institute, 36th Street at Spruce, Philadelphia, PA 19104===</mods:affiliation></affiliation></author><author><name sortKey="Wroblewska, Zofia" sort="Wroblewska, Zofia" uniqKey="Wroblewska Z" first="Zofia" last="Wroblewska">Zofia Wroblewska</name><affiliation><mods:affiliation>Multiple Sclerosis Research Center of the Wistar Institute and the University of Pennsylvania, Philadelphia</mods:affiliation></affiliation></author><author><name sortKey="Cremer, Natalie E" sort="Cremer, Natalie E" uniqKey="Cremer N" first="Natalie E." last="Cremer">Natalie E. Cremer</name><affiliation><mods:affiliation>Viral and Rickettsial Disease Laboratory, California State Department of Health, Berkeley</mods:affiliation></affiliation></author><author><name sortKey="Lief, Florence S" sort="Lief, Florence S" uniqKey="Lief F" first="Florence S." last="Lief">Florence S. Lief</name><affiliation><mods:affiliation>Multiple Sclerosis Research Center of the Wistar Institute and the University of Pennsylvania, Philadelphia</mods:affiliation></affiliation></author><author><name sortKey="Schatz, Norman" sort="Schatz, Norman" uniqKey="Schatz N" first="Norman" last="Schatz">Norman Schatz</name><affiliation><mods:affiliation>Wills Eye Hospital, Philadelphia, Pennsylvania</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">1</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="201">201</biblScope><biblScope unit="page" to="208">208</biblScope><biblScope unit="page-count">8</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1977">1977</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acta neurologica scandinavica</term><term>Acute phase</term><term>Antibody titers</term><term>Body excretions</term><term>Brain cells</term><term>California state department</term><term>Cell cultures</term><term>Cell lysates</term><term>Cerebrospinal</term><term>Cerebrospinal fluid</term><term>Control groups</term><term>Cytochemical analysis</term><term>Diagnostic procedures</term><term>Electron microscope</term><term>Electron microscopy</term><term>England journal</term><term>Etiology</term><term>Excretion samples</term><term>Filament</term><term>Fusion technique</term><term>Grand island</term><term>Health association</term><term>Indicator cells</term><term>Infectious agents</term><term>Infectious virus</term><term>Intranuclear</term><term>Intranuclear filaments</term><term>Koprowski</term><term>Lymphocyte</term><term>Measles virus</term><term>Meulen</term><term>Mononuclear</term><term>Mononuclear cells</term><term>Multiple sclerosis</term><term>Negative results</term><term>Neuritis</term><term>Nikoskelainen</term><term>Nuclear changes</term><term>Optic</term><term>Optic neuritis</term><term>Parainfluenza</term><term>Parainfluenza type</term><term>Peripheral blood</term><term>Respiratory syncytial</term><term>Rickettsial infections</term><term>Room temperature</term><term>Santoli</term><term>Sclerosis</term><term>Serological studies</term><term>Serological techniques</term><term>Subacute sclerosing panencephalitis</term><term>Suitable virological</term><term>Systemic lupus erythematosus</term><term>Tanaka</term><term>Throat swabs</term><term>Unusual intranuclear filaments</term><term>Viral</term><term>Viral agent</term><term>Viral antigen</term><term>Viral antigens</term><term>Viral footprints</term><term>Viral origin</term><term>Viral particles</term><term>Virological</term><term>Virological study</term><term>Virus antibody levels</term><term>Wistar institute</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous ultrastructural examination of peripheral blood lymphocytes revealed the presence of intranuclear filamentous structures in multiple sclerosis (MS) and in some optic neuritis (ON) patients. The present investigation was undertaken in the attempt to correlate the presence of such structures with the etiology of ON and MS and possibly to demonstrate the viral origin of the filaments. Suitable virological and serological techniques were used to detect and isolate infectious agents from peripheral blood samples and body excretions of 12 monosymptomatic ON patients at their first acute attack. Nevertheless, any efforts to demonstrate the presence of a virus in these patients have been unsuccessful: no evidence of active viral infection was obtained by serological studies of serum and cerebrospinal fluid samples, nor could viral antigens or inclusions be observed by immunofluorescence and cytochemical analysis. Negative results were also obtained from studies performed in parallel on MS patients and various controls. The significance of the failure to isolate infectious agents from either ON and MS patients is discussed.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>viral</json:string><json:string>koprowski</json:string><json:string>optic</json:string><json:string>santoli</json:string><json:string>optic neuritis</json:string><json:string>intranuclear</json:string><json:string>tanaka</json:string><json:string>multiple sclerosis</json:string><json:string>mononuclear cells</json:string><json:string>neuritis</json:string><json:string>lymphocyte</json:string><json:string>nikoskelainen</json:string><json:string>filament</json:string><json:string>sclerosis</json:string><json:string>cerebrospinal</json:string><json:string>meulen</json:string><json:string>etiology</json:string><json:string>parainfluenza</json:string><json:string>virological</json:string><json:string>viral antigens</json:string><json:string>infectious agents</json:string><json:string>subacute sclerosing panencephalitis</json:string><json:string>mononuclear</json:string><json:string>peripheral blood</json:string><json:string>viral origin</json:string><json:string>intranuclear filaments</json:string><json:string>virological study</json:string><json:string>infectious virus</json:string><json:string>unusual intranuclear filaments</json:string><json:string>cytochemical analysis</json:string><json:string>negative results</json:string><json:string>california state department</json:string><json:string>cell lysates</json:string><json:string>body excretions</json:string><json:string>wistar institute</json:string><json:string>brain cells</json:string><json:string>cerebrospinal fluid</json:string><json:string>nuclear changes</json:string><json:string>diagnostic procedures</json:string><json:string>rickettsial infections</json:string><json:string>health association</json:string><json:string>electron microscopy</json:string><json:string>viral particles</json:string><json:string>throat swabs</json:string><json:string>antibody titers</json:string><json:string>respiratory syncytial</json:string><json:string>room temperature</json:string><json:string>indicator cells</json:string><json:string>grand island</json:string><json:string>cell cultures</json:string><json:string>suitable virological</json:string><json:string>serological studies</json:string><json:string>serological techniques</json:string><json:string>viral antigen</json:string><json:string>parainfluenza type</json:string><json:string>viral agent</json:string><json:string>fusion technique</json:string><json:string>viral footprints</json:string><json:string>acta neurologica scandinavica</json:string><json:string>acute phase</json:string><json:string>control groups</json:string><json:string>systemic lupus erythematosus</json:string><json:string>measles virus</json:string><json:string>england journal</json:string><json:string>virus antibody levels</json:string><json:string>electron microscope</json:string><json:string>excretion samples</json:string></teeft></keywords><author><json:item><name>Dr. Daniela Santoli</name><affiliations><json:string>Multiple Sclerosis Research Center of the Wistar Institute and the University of Pennsylvania, Philadelphia</json:string><json:string>Correspondence address: The Wistar Institute, 36th Street at Spruce, Philadelphia, PA 19104===</json:string></affiliations></json:item><json:item><name>Zofia Wroblewska</name><affiliations><json:string>Multiple Sclerosis Research Center of the Wistar Institute and the University of Pennsylvania, Philadelphia</json:string></affiliations></json:item><json:item><name>Natalie E. Cremer</name><affiliations><json:string>Viral and Rickettsial Disease Laboratory, California State Department of Health, Berkeley</json:string></affiliations></json:item><json:item><name>Florence S. Lief</name><affiliations><json:string>Multiple Sclerosis Research Center of the Wistar Institute and the University of Pennsylvania, Philadelphia</json:string></affiliations></json:item><json:item><name>Norman Schatz</name><affiliations><json:string>Wills Eye Hospital, Philadelphia, Pennsylvania</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>optic neuritis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>monosymptomatic patients</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>intranuclear filaments</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>peripheral blood mononuclear cells</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>rescue of infectious agents</value></json:item></subject><articleId><json:string>JMV1890010307</json:string></articleId><arkIstex>ark:/67375/WNG-9VJ7ZQLF-B</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Previous ultrastructural examination of peripheral blood lymphocytes revealed the presence of intranuclear filamentous structures in multiple sclerosis (MS) and in some optic neuritis (ON) patients. The present investigation was undertaken in the attempt to correlate the presence of such structures with the etiology of ON and MS and possibly to demonstrate the viral origin of the filaments. Suitable virological and serological techniques were used to detect and isolate infectious agents from peripheral blood samples and body excretions of 12 monosymptomatic ON patients at their first acute attack. Nevertheless, any efforts to demonstrate the presence of a virus in these patients have been unsuccessful: no evidence of active viral infection was obtained by serological studies of serum and cerebrospinal fluid samples, nor could viral antigens or inclusions be observed by immunofluorescence and cytochemical analysis. Negative results were also obtained from studies performed in parallel on MS patients and various controls. The significance of the failure to isolate infectious agents from either ON and MS patients is discussed.</abstract><qualityIndicators><score>7.575</score><pdfWordCount>3583</pdfWordCount><pdfCharCount>21919</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>8</pdfPageCount><pdfPageSize>504 x 719.759 pts</pdfPageSize><pdfWordsPerPage>448</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>166</abstractWordCount><abstractCharCount>1141</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Acute optic neuritis: A virological study in relation to multiple sclerosis</title><pmid><json:string>416177</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Medical Virology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1096-9071</json:string></doi><issn><json:string>0146-6615</json:string></issn><eissn><json:string>1096-9071</json:string></eissn><publisherId><json:string>JMV</json:string></publisherId><volume>1</volume><issue>3</issue><pages><first>201</first><last>208</last><total>8</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Article</value></json:item><json:item><value>Articles</value></json:item></subject></host><namedEntities><unitex><date><json:string>1977</json:string></date><geogName></geogName><orgName><json:string>Disease Laboratory, California State Department</json:string><json:string>National Institute of Communicable Diseases and Stroke</json:string><json:string>Wills Eye Hospital, Philadelphia, Pennsylvania Previous</json:string><json:string>Willis Eye Hospital, The Scheie Eye Institute, and the Department of Neurology of the Hospital of the University of Pennsylvania</json:string><json:string>Hartford Foundation</json:string><json:string>University of Pennsylvania</json:string><json:string>California State Department of Health</json:string><json:string>Liss, Inc.</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Mary Devlin</json:string><json:string>R. P. Lisal</json:string><json:string>D. Silberberg</json:string><json:string>H. Scheie</json:string><json:string>Falcon Flasks</json:string><json:string>Viral Antigens</json:string><json:string>Zofia Wroblewska</json:string><json:string>D. H. Gilden</json:string><json:string>Society</json:string><json:string>Norman Schatz</json:string><json:string>Daniela Santoli</json:string><json:string>Viral Isolation</json:string><json:string>Mary Wellish</json:string></persName><placeName><json:string>Philadelphia</json:string><json:string>NY</json:string><json:string>N.C.</json:string><json:string>York</json:string><json:string>Greenville</json:string><json:string>PA</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Duke-Elder and Scott, 1971</json:string><json:string>Goldman, 1969</json:string><json:string>Armstrong, 1956</json:string><json:string>Percy, Nobrega and Kurland, 1972</json:string><json:string>Tanaka, Santoli, and Koprowslu, 1976</json:string><json:string>Lief et al., 1975</json:string><json:string>Tanaka, Santoli, and Koprowski, 1976</json:string><json:string>Katz and Koprowski, 1973</json:string><json:string>Faris and Martinez, 1972</json:string><json:string>Santoli et al.</json:string><json:string>Link, Norrby and Olsson, 1973</json:string><json:string>Meulen et al., 1972</json:string><json:string>McAlpine, Lumsden and Acheson, 1972</json:string><json:string>Norrby and Olsson, 1973</json:string><json:string>Bove and Schwartz, 1973</json:string><json:string>Gardner et al., 1971</json:string><json:string>Nikoskelainen and Riekkinen, 1974</json:string><json:string>and Rucker, 1956</json:string><json:string>Daniels et al., 1974</json:string><json:string>Marshall, 1950</json:string><json:string>Nikoskelainen, Irjala and Salmi, 1975</json:string><json:string>Chanock, 1969</json:string><json:string>Raine et al., 1975</json:string><json:string>Meulen et al., 1975</json:string><json:string>Shaw and Sumi, 1975</json:string><json:string>Payne, Baublis, and Itabashi, 1969</json:string><json:string>Barbanti-Brodano et al., 1970</json:string><json:string>Coblentz and Pleet, 1974</json:string><json:string>Lennette, 1969</json:string><json:string>Prineas, 1972</json:string><json:string>Tanaka, Iwasaki and Koprowski, 1974</json:string><json:string>Horta-Barbosa et al., 1969</json:string><json:string>Koprowski and ter Meulen, 1975</json:string><json:string>Oksala, 1964</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-9VJ7ZQLF-B</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - virology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - virology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Infectious Diseases</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Virology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1977</publicationDate><copyrightDate>1977</copyrightDate><doi><json:string>10.1002/jmv.1890010307</json:string></doi><id>430E89A4B02A2E22A020E6B296C63AD5C873A883</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-9VJ7ZQLF-B/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-9VJ7ZQLF-B/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-9VJ7ZQLF-B/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Acute optic neuritis: A virological study in relation to multiple sclerosis</title><title level="a" type="short" xml:lang="en">Virological Study of Optic Neuritis</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><availability><licence>Copyright © 1977 Wiley‐Liss, Inc., A Wiley Company</licence></availability><date type="published" when="1977"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Acute optic neuritis: A virological study in relation to multiple sclerosis</title><title level="a" type="short" xml:lang="en">Virological Study of Optic Neuritis</title><author xml:id="author-0000" role="corresp"><persName><addName>Dr.</addName><forename type="first">Daniela</forename><surname>Santoli</surname></persName><affiliation><orgName type="institution">Multiple Sclerosis Research Center of the Wistar Institute and the University of Pennsylvania</orgName><address><addrLine>Philadelphia</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Zofia</forename><surname>Wroblewska</surname></persName><affiliation><orgName type="institution">Multiple Sclerosis Research Center of the Wistar Institute and the University of Pennsylvania</orgName><address><addrLine>Philadelphia</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Natalie E.</forename><surname>Cremer</surname></persName><affiliation><orgName type="laboratory">Viral and Rickettsial Disease Laboratory</orgName><orgName type="division">California State Department of Health</orgName><address><addrLine>Berkeley</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Florence S.</forename><surname>Lief</surname></persName><affiliation><orgName type="institution">Multiple Sclerosis Research Center of the Wistar Institute and the University of Pennsylvania</orgName><address><addrLine>Philadelphia</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Norman</forename><surname>Schatz</surname></persName><affiliation><orgName type="institution">Wills Eye Hospital</orgName><address><addrLine>Philadelphia</addrLine><addrLine>Pennsylvania</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><idno type="istex">430E89A4B02A2E22A020E6B296C63AD5C873A883</idno><idno type="ark">ark:/67375/WNG-9VJ7ZQLF-B</idno><idno type="DOI">10.1002/jmv.1890010307</idno><idno type="unit">JMV1890010307</idno><idno type="toTypesetVersion">file:JMV.JMV1890010307.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="pISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><idno type="book-DOI">10.1002/(ISSN)1096-9071</idno><idno type="book-part-DOI">10.1002/jmv.v1:3</idno><idno type="product">JMV</idno><imprint><biblScope unit="vol">1</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="201">201</biblScope><biblScope unit="page" to="208">208</biblScope><biblScope unit="page-count">8</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1977"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>Previous ultrastructural examination of peripheral blood lymphocytes revealed the presence of intranuclear filamentous structures in multiple sclerosis (MS) and in some optic neuritis (ON) patients. The present investigation was undertaken in the attempt to correlate the presence of such structures with the etiology of ON and MS and possibly to demonstrate the viral origin of the filaments. Suitable virological and serological techniques were used to detect and isolate infectious agents from peripheral blood samples and body excretions of 12 monosymptomatic ON patients at their first acute attack. Nevertheless, any efforts to demonstrate the presence of a virus in these patients have been unsuccessful: no evidence of active viral infection was obtained by serological studies of serum and cerebrospinal fluid samples, nor could viral antigens or inclusions be observed by immunofluorescence and cytochemical analysis. Negative results were also obtained from studies performed in parallel on MS patients and various controls. The significance of the failure to isolate infectious agents from either ON and MS patients is discussed.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1">optic neuritis</term><term xml:id="kwd2">monosymptomatic patients</term><term xml:id="kwd3">intranuclear filaments</term><term xml:id="kwd4">peripheral blood mononuclear cells</term><term xml:id="kwd5">rescue of infectious agents</term></keywords><keywords rend="articleCategory"><term>Article</term></keywords><keywords rend="tocHeading1"><term>Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-9VJ7ZQLF-B/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>New York</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1096-9071</doi><issn type="print">0146-6615</issn><issn type="electronic">1096-9071</issn><idGroup><id type="product" value="JMV"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="JOURNAL OF MEDICAL VIROLOGY">Journal of Medical Virology</title><title type="short">J. Med. Virol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="30"><doi origin="wiley" registered="yes">10.1002/jmv.v1:3</doi><numberingGroup><numbering type="journalVolume" number="1">1</numbering><numbering type="journalIssue">3</numbering></numberingGroup><coverDate startDate="1977">1977</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="7" status="forIssue"><doi origin="wiley" registered="yes">10.1002/jmv.1890010307</doi><idGroup><id type="unit" value="JMV1890010307"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Article</title><title type="tocHeading1">Articles</title></titleGroup><copyright ownership="publisher">Copyright © 1977 Wiley‐Liss, Inc., A Wiley Company</copyright><eventGroup><event type="manuscriptReceived" date="1977-01-31"></event><event type="firstOnline" date="2005-12-09"></event><event type="publishedOnlineFinalForm" date="2005-12-09"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-15"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-20"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst">201</numbering><numbering type="pageLast">208</numbering></numberingGroup><correspondenceTo>The Wistar Institute, 36th Street at Spruce, Philadelphia, PA 19104===</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JMV.JMV1890010307.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="0"></count><count type="referenceTotal" number="37"></count></countGroup><titleGroup><title type="main" xml:lang="en">Acute optic neuritis: A virological study in relation to multiple sclerosis</title><title type="short" xml:lang="en">Virological Study of Optic Neuritis</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><honorifics>Dr.</honorifics><givenNames>Daniela</givenNames><familyName>Santoli</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Zofia</givenNames><familyName>Wroblewska</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Natalie E.</givenNames><familyName>Cremer</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Florence S.</givenNames><familyName>Lief</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Norman</givenNames><familyName>Schatz</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Multiple Sclerosis Research Center of the Wistar Institute and the University of Pennsylvania, Philadelphia</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Viral and Rickettsial Disease Laboratory, California State Department of Health, Berkeley</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Wills Eye Hospital, Philadelphia, Pennsylvania</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">optic neuritis</keyword><keyword xml:id="kwd2">monosymptomatic patients</keyword><keyword xml:id="kwd3">intranuclear filaments</keyword><keyword xml:id="kwd4">peripheral blood mononuclear cells</keyword><keyword xml:id="kwd5">rescue of infectious agents</keyword></keywordGroup><fundingInfo><fundingAgency>USPHS Research</fundingAgency><fundingNumber>NS 11036</fundingNumber></fundingInfo><fundingInfo><fundingAgency>The National Institute of Communicable Diseases and Stroke</fundingAgency></fundingInfo><fundingInfo><fundingAgency>The National MS Society and The John A Hartford Foundation</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Previous ultrastructural examination of peripheral blood lymphocytes revealed the presence of intranuclear filamentous structures in multiple sclerosis (MS) and in some optic neuritis (ON) patients. The present investigation was undertaken in the attempt to correlate the presence of such structures with the etiology of ON and MS and possibly to demonstrate the viral origin of the filaments. Suitable virological and serological techniques were used to detect and isolate infectious agents from peripheral blood samples and body excretions of 12 monosymptomatic ON patients at their first acute attack. Nevertheless, any efforts to demonstrate the presence of a virus in these patients have been unsuccessful: no evidence of active viral infection was obtained by serological studies of serum and cerebrospinal fluid samples, nor could viral antigens or inclusions be observed by immunofluorescence and cytochemical analysis. Negative results were also obtained from studies performed in parallel on MS patients and various controls. The significance of the failure to isolate infectious agents from either ON and MS patients is discussed.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Acute optic neuritis: A virological study in relation to multiple sclerosis</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Virological Study of Optic Neuritis</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Acute optic neuritis: A virological study in relation to multiple sclerosis</title></titleInfo><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="given">Daniela</namePart><namePart type="family">Santoli</namePart><affiliation>Multiple Sclerosis Research Center of the Wistar Institute and the University of Pennsylvania, Philadelphia</affiliation><affiliation>Correspondence address: The Wistar Institute, 36th Street at Spruce, Philadelphia, PA 19104===</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Zofia</namePart><namePart type="family">Wroblewska</namePart><affiliation>Multiple Sclerosis Research Center of the Wistar Institute and the University of Pennsylvania, Philadelphia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Natalie E.</namePart><namePart type="family">Cremer</namePart><affiliation>Viral and Rickettsial Disease Laboratory, California State Department of Health, Berkeley</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Florence S.</namePart><namePart type="family">Lief</namePart><affiliation>Multiple Sclerosis Research Center of the Wistar Institute and the University of Pennsylvania, Philadelphia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Norman</namePart><namePart type="family">Schatz</namePart><affiliation>Wills Eye Hospital, Philadelphia, Pennsylvania</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">1977</dateIssued><dateCaptured encoding="w3cdtf">1977-01-31</dateCaptured><copyrightDate encoding="w3cdtf">1977</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">0</extent><extent unit="tables">0</extent><extent unit="references">37</extent></physicalDescription><abstract lang="en">Previous ultrastructural examination of peripheral blood lymphocytes revealed the presence of intranuclear filamentous structures in multiple sclerosis (MS) and in some optic neuritis (ON) patients. The present investigation was undertaken in the attempt to correlate the presence of such structures with the etiology of ON and MS and possibly to demonstrate the viral origin of the filaments. Suitable virological and serological techniques were used to detect and isolate infectious agents from peripheral blood samples and body excretions of 12 monosymptomatic ON patients at their first acute attack. Nevertheless, any efforts to demonstrate the presence of a virus in these patients have been unsuccessful: no evidence of active viral infection was obtained by serological studies of serum and cerebrospinal fluid samples, nor could viral antigens or inclusions be observed by immunofluorescence and cytochemical analysis. Negative results were also obtained from studies performed in parallel on MS patients and various controls. The significance of the failure to isolate infectious agents from either ON and MS patients is discussed.</abstract><note type="funding">USPHS Research - No. NS 11036; </note><note type="funding">The National Institute of Communicable Diseases and Stroke</note><note type="funding">The National MS Society and The John A Hartford Foundation</note><subject lang="en"><genre>keywords</genre><topic>optic neuritis</topic><topic>monosymptomatic patients</topic><topic>intranuclear filaments</topic><topic>peripheral blood mononuclear cells</topic><topic>rescue of infectious agents</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Medical Virology</title></titleInfo><titleInfo type="abbreviated"><title>J. Med. Virol.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Article</topic><topic>Articles</topic></subject><identifier type="ISSN">0146-6615</identifier><identifier type="eISSN">1096-9071</identifier><identifier type="DOI">10.1002/(ISSN)1096-9071</identifier><identifier type="PublisherID">JMV</identifier><part><date>1977</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>201</start><end>208</end><total>8</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Histochemical differentiation of nucleic acids by means of induced fluorescence</title></titleInfo><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Armstrong</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Armstrong JA (1956). Histochemical differentiation of nucleic acids by means of induced fluorescence. Experimental Cell Research 11: 640–643.</note><part><date>1956</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>640</start><end>643</end></extent></part><relatedItem type="host"><titleInfo><title>Experimental Cell Research</title></titleInfo><part><date>1956</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>640</start><end>643</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit2"><titleInfo><title>Presence of two different viral agents in brain cells of patients with subacute sclerosing panencephalitis</title></titleInfo><name type="personal"><namePart type="given">G</namePart><namePart type="family">Barbanti‐Brodano</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Oyanagi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Katz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Koprowski</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Barbanti‐Brodano G, Oyanagi S, Katz M, Koprowski H (1970). Presence of two different viral agents in brain cells of patients with subacute sclerosing panencephalitis. Proceedings of the Society of Experimental Biology 134: 230–236.</note><part><date>1970</date><detail type="volume"><caption>vol.</caption><number>134</number></detail><extent unit="pages"><start>230</start><end>236</end></extent></part><relatedItem type="host"><titleInfo><title>Proceedings of the Society of Experimental Biology</title></titleInfo><part><date>1970</date><detail type="volume"><caption>vol.</caption><number>134</number></detail><extent unit="pages"><start>230</start><end>236</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit3"><titleInfo><title>On so‐called “virus‐like” intranuclear filaments in brain autopsy material: A reappraisal on hand of two fatal cases of tickborne encephalitis</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Blinzinger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AP</namePart><namePart type="family">Anzil</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Jellinger</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Blinzinger K, Anzil AP, Jellinger K (1974). On so‐called “virus‐like” intranuclear filaments in brain autopsy material: A reappraisal on hand of two fatal cases of tickborne encephalitis. Acta Neuropathology 28: 69–73.</note><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>69</start><end>73</end></extent></part><relatedItem type="host"><titleInfo><title>Acta Neuropathology</title></titleInfo><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>69</start><end>73</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit4"><titleInfo><title>Focal lipid cardiomyopathy in an infant with paroxysmal atrial tachycardia</title></titleInfo><name type="personal"><namePart type="given">KE</namePart><namePart type="family">Bove</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Schwartz</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bove KE, Schwartz DC (1973). Focal lipid cardiomyopathy in an infant with paroxysmal atrial tachycardia. Archives of Pathology 95: 26–36.</note><part><date>1973</date><detail type="volume"><caption>vol.</caption><number>95</number></detail><extent unit="pages"><start>26</start><end>36</end></extent></part><relatedItem type="host"><titleInfo><title>Archives of Pathology</title></titleInfo><part><date>1973</date><detail type="volume"><caption>vol.</caption><number>95</number></detail><extent unit="pages"><start>26</start><end>36</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit5"><titleInfo><title>Parainfluenza viruses</title></titleInfo><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Chanock</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book-chapter</genre><relatedItem type="host"><titleInfo><title>Diagnostic Procedures for Viral and Rickettsial Infections</title></titleInfo><originInfo><publisher>American Public Health Association, Inc</publisher><place><placeTerm type="text">New York</placeTerm></place></originInfo><part><date>1969</date><extent unit="pages"><start>434</start><end>456</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit6"><titleInfo><title>Tubuloreticular structures within labial salivary glands in Sjogren's syndrome</title></titleInfo><name type="personal"><namePart type="given">TE</namePart><namePart type="family">Daniels</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RA</namePart><namePart type="family">Sylvester</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Silverman Jr</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Polando</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N</namePart><namePart type="family">Talal</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Daniels TE, Sylvester RA, Silverman S Jr, Polando V, Talal N (1974). Tubuloreticular structures within labial salivary glands in Sjogren's syndrome. Arthritis and Rheumatism 17: 593–597.</note><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>593</start><end>597</end></extent></part><relatedItem type="host"><titleInfo><title>Arthritis and Rheumatism</title></titleInfo><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>593</start><end>597</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit7"><titleInfo><title>Subacute sclerosing panencephalitis: Unusual nuclear inclusions and lenethy clinical course</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Dubois‐Dalcq</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Coblentz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AB</namePart><namePart type="family">Pleet</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dubois‐Dalcq M, Coblentz JM, Pleet AB (1974). Subacute sclerosing panencephalitis: Unusual nuclear inclusions and lenethy clinical course. Archives of Neurology 31: 355–363.</note><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>355</start><end>363</end></extent></part><relatedItem type="host"><titleInfo><title>Archives of Neurology</title></titleInfo><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>31</number></detail><extent unit="pages"><start>355</start><end>363</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit8"><titleInfo><title>Neuro‐ophthalmology</title></titleInfo><name type="personal"><namePart type="given">WS</namePart><namePart type="family">Duke‐Elder</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GI</namePart><namePart type="family">Scott</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book-chapter</genre><relatedItem type="host"><titleInfo><title>System of Ophthalmology</title></titleInfo><originInfo><publisher>Kimpton</publisher><place><placeTerm type="text">London</placeTerm></place></originInfo><part><date>1971</date><detail type="volume"><caption>vol.</caption><number>XII</number></detail><extent unit="pages"><start>969</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit9"><titleInfo><title>Primary progressive multifocal leukoencephalopathy: A central nervous system disease caused by a slow virus</title></titleInfo><name type="personal"><namePart type="given">AA</namePart><namePart type="family">Faris</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AJ</namePart><namePart type="family">Martinez</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Faris AA, Martinez AJ (1972). Primary progressive multifocal leukoencephalopathy: A central nervous system disease caused by a slow virus. Archives of Neurology 27: 357–360, (1972).</note><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>357</start><end>360</end></extent></part><relatedItem type="host"><titleInfo><title>Archives of Neurology</title></titleInfo><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>357</start><end>360</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit10"><titleInfo><title>New human papovirus (B.K.) isolated from urine after renal transplantation</title></titleInfo><name type="personal"><namePart type="given">SD</namePart><namePart type="family">Gardner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AM</namePart><namePart type="family">Field</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DV</namePart><namePart type="family">Coleman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Hulme</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Gardner SD, Field AM, Coleman DV, Hulme B (1971). New human papovirus (B.K.) isolated from urine after renal transplantation. Lancet 1: 1253–1256.</note><part><date>1971</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>1253</start><end>1256</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>1971</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>1253</start><end>1256</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit11"><titleInfo><title>Goldman M(1969).“Fluorescent Antibody Methods.”New York:Academic Press.</title></titleInfo><note type="citation/reference">Goldman M (1969). “Fluorescent Antibody Methods.” New York: Academic Press.</note><name type="personal"><namePart type="given">M</namePart><namePart type="family">Goldman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Academic Press</publisher><place><placeTerm type="text">New York</placeTerm></place></originInfo><part><date>1969</date></part></relatedItem><relatedItem type="references" displayLabel="cit12"><titleInfo><title>Abnormal structures in circulating lymphacytes from patients with systemic lupus erythematosus and related diseases</title></titleInfo><name type="personal"><namePart type="given">PM</namePart><namePart type="family">Grimley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Decker</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HJ</namePart><namePart type="family">Michelitch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MM</namePart><namePart type="family">Frantz</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Grimley PM, Decker JL, Michelitch HJ, Frantz MM (1973). Abnormal structures in circulating lymphacytes from patients with systemic lupus erythematosus and related diseases. Arthritis and Rheumatism 16: 313–323.</note><part><date>1973</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>313</start><end>323</end></extent></part><relatedItem type="host"><titleInfo><title>Arthritis and Rheumatism</title></titleInfo><part><date>1973</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>313</start><end>323</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit13"><titleInfo><title>Subacute sclerosing panencephalitis: Isolation of measles virus from a brain biopsy</title></titleInfo><name type="personal"><namePart type="given">L</namePart><namePart type="family">Horta‐Barbosa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DA</namePart><namePart type="family">Fuccillo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Sever</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Zeman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Horta‐Barbosa L, Fuccillo DA, Sever J, Zeman W (1969). Subacute sclerosing panencephalitis: Isolation of measles virus from a brain biopsy. Nature 221: 974.</note><part><date>1969</date><detail type="volume"><caption>vol.</caption><number>221</number></detail><extent unit="pages"><start>974</start></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>1969</date><detail type="volume"><caption>vol.</caption><number>221</number></detail><extent unit="pages"><start>974</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit14"><titleInfo><title>The significance of failure to isolate infectious virus in cases of subacute sclerosing panencephalitis</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Katz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Koprowski</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Katz M, Koprowski H (1973). The significance of failure to isolate infectious virus in cases of subacute sclerosing panencephalitis. Archiv für die gesamte Virusforschung 41: 390–393.</note><part><date>1973</date><detail type="volume"><caption>vol.</caption><number>41</number></detail><extent unit="pages"><start>390</start><end>393</end></extent></part><relatedItem type="host"><titleInfo><title>Archiv für die gesamte Virusforschung</title></titleInfo><part><date>1973</date><detail type="volume"><caption>vol.</caption><number>41</number></detail><extent unit="pages"><start>390</start><end>393</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit15"><titleInfo><title>Multiple sclerosis and parainfluenza 1 virus</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Koprowski</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">ter Meulen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Koprowski H, ter Meulen V (1975). Multiple sclerosis and parainfluenza 1 virus. Journal of Neurology 208: 175–190.</note><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>208</number></detail><extent unit="pages"><start>175</start><end>190</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of Neurology</title></titleInfo><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>208</number></detail><extent unit="pages"><start>175</start><end>190</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit16"><titleInfo><title>General principles underlying laboratory diagnosis of viral and rickettsial infection</title></titleInfo><name type="personal"><namePart type="given">EH</namePart><namePart type="family">Lennette</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book-chapter</genre><relatedItem type="host"><titleInfo><title>Diagnostic Procedures for Viral and Rickettsial Infections</title></titleInfo><originInfo><publisher>American Public Health Association, Inc</publisher><place><placeTerm type="text">New York</placeTerm></place></originInfo><part><date>1969</date><extent unit="pages"><start>1</start><end>65</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit17"><titleInfo><title>Lennette EH,Schmidt NJ(1969).“Diagnostic Procedures for Viral and Rickettsial Infections.” 4th Ed,New York:American Public Health Association, Inc,pp 52–58.</title></titleInfo><note type="citation/reference">Lennette EH, Schmidt NJ (1969). “Diagnostic Procedures for Viral and Rickettsial Infections.” 4th Ed, New York: American Public Health Association, Inc, pp 52–58.</note><name type="personal"><namePart type="given">EH</namePart><namePart type="family">Lennette</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">NJ</namePart><namePart type="family">Schmidt</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>American Public Health Association, Inc</publisher><place><placeTerm type="text">New York</placeTerm></place></originInfo><part><date>1969</date><extent unit="pages"><start>52</start><end>58</end></extent></part></relatedItem><relatedItem type="references" displayLabel="cit18"><titleInfo><title>Antigenic variations among parainfluenza type 1 (Sendai) viruses: Analysis of 6/94 virus</title></titleInfo><name type="personal"><namePart type="given">FS</namePart><namePart type="family">Lief</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Loh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">ter Meulen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Koprowski</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lief FS, Loh W, ter Meulen V, Koprowski H (1975). Antigenic variations among parainfluenza type 1 (Sendai) viruses: Analysis of 6/94 virus. Intervirology 5: 1–9.</note><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>1</start><end>9</end></extent></part><relatedItem type="host"><titleInfo><title>Intervirology</title></titleInfo><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>1</start><end>9</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit19"><titleInfo><title>Immunoglobulins and measles antibodies in optic neuritis</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Link</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Norrby</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JE</namePart><namePart type="family">Olsson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Link H, Norrby E, Olsson JE (1973). Immunoglobulins and measles antibodies in optic neuritis. New England Journal of Medicine 289: 1103–1107.</note><part><date>1973</date><detail type="volume"><caption>vol.</caption><number>289</number></detail><extent unit="pages"><start>1103</start><end>1107</end></extent></part><relatedItem type="host"><titleInfo><title>New England Journal of Medicine</title></titleInfo><part><date>1973</date><detail type="volume"><caption>vol.</caption><number>289</number></detail><extent unit="pages"><start>1103</start><end>1107</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit20"><titleInfo><title>McAlpine D,Lumsden CE,Acheson ED(1972).“Multiple Sclerosis: A Reappraisal.”2nd Ed,London:Churchill Livingston.</title></titleInfo><note type="citation/reference">McAlpine D, Lumsden CE, Acheson ED (1972). “Multiple Sclerosis: A Reappraisal.” 2nd Ed, London: Churchill Livingston.</note><name type="personal"><namePart type="given">D</namePart><namePart type="family">McAlpine</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CE</namePart><namePart type="family">Lumsden</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ED</namePart><namePart type="family">Acheson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Churchill Livingston</publisher><place><placeTerm type="text">London</placeTerm></place></originInfo><part><date>1972</date></part></relatedItem><relatedItem type="references" displayLabel="cit21"><titleInfo><title>Ocular manifestations of multiple sclerosis and relationship to retr bulbar neuritis</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Marshall</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Marshall D (1950). Ocular manifestations of multiple sclerosis and relationship to retr bulbar neuritis. Transactions of the American Ophthalmological Society 48: 487–525.</note><part><date>1950</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>487</start><end>525</end></extent></part><relatedItem type="host"><titleInfo><title>Transactions of the American Ophthalmological Society</title></titleInfo><part><date>1950</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>487</start><end>525</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit22"><titleInfo><title>Cerebrospinal fluid findings in patients with optic neuritis</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Nikoskelainen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Irjala</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TT</namePart><namePart type="family">Salmi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nikoskelainen E, Irjala K, Salmi TT (1975). Cerebrospinal fluid findings in patients with optic neuritis. Acta Ophthalmologica 53: 105–119.</note><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>53</number></detail><extent unit="pages"><start>105</start><end>119</end></extent></part><relatedItem type="host"><titleInfo><title>Acta Ophthalmologica</title></titleInfo><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>53</number></detail><extent unit="pages"><start>105</start><end>119</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit23"><titleInfo><title>Virus antibody levels in the cerebrospinal fluid from patients with optic neuritis and from matched controls</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Nikoskelainen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Nikoskelainen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AA</namePart><namePart type="family">Salmi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PE</namePart><namePart type="family">Halonen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nikoskelainen E, Nikoskelainen J, Salmi AA, Halonen PE (1975a). Virus antibody levels in the cerebrospinal fluid from patients with optic neuritis and from matched controls. Acta Neurologica Scandinavica 51: 333–346.</note><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>51</number></detail><extent unit="pages"><start>333</start><end>346</end></extent></part><relatedItem type="host"><titleInfo><title>Acta Neurologica Scandinavica</title></titleInfo><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>51</number></detail><extent unit="pages"><start>333</start><end>346</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit24"><titleInfo><title>Virus antibody levels in the cerebrospinal fluid from patients with optic neuritis</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Nikoskelainen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Nikoskelainen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AA</namePart><namePart type="family">Salmi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PE</namePart><namePart type="family">Halonen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nikoskelainen E, Nikoskelainen J, Salmi AA, Halonen PE (1975b). Virus antibody levels in the cerebrospinal fluid from patients with optic neuritis. Acta Neurologica Scandinavica 51: 347–364.</note><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>51</number></detail><extent unit="pages"><start>347</start><end>364</end></extent></part><relatedItem type="host"><titleInfo><title>Acta Neurologica Scandinavica</title></titleInfo><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>51</number></detail><extent unit="pages"><start>347</start><end>364</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit25"><titleInfo><title>Optic neuritis: A sign of multiple sclerosis or other diseases of the central nervous system</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Nikoskelainen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Riekkinen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nikoskelainen E, Riekkinen P (1974). Optic neuritis: A sign of multiple sclerosis or other diseases of the central nervous system. Acta Neurologica Scandinavica 50: 690–718.</note><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>50</number></detail><extent unit="pages"><start>690</start><end>718</end></extent></part><relatedItem type="host"><titleInfo><title>Acta Neurologica Scandinavica</title></titleInfo><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>50</number></detail><extent unit="pages"><start>690</start><end>718</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit26"><titleInfo><title>Measles virus antibodies in multiple sclerosis. Comparison of antibody titers in cerebrospinal fluid and serum</title></titleInfo><name type="personal"><namePart type="given">E</namePart><namePart type="family">Norrby</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Link</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JE</namePart><namePart type="family">Olsson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Norrby E, Link J, Olsson JE (1974). Measles virus antibodies in multiple sclerosis. Comparison of antibody titers in cerebrospinal fluid and serum, Archives of Neurology 30: 285–292.</note><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>30</number></detail><extent unit="pages"><start>285</start><end>292</end></extent></part><relatedItem type="host"><titleInfo><title>Archives of Neurology</title></titleInfo><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>30</number></detail><extent unit="pages"><start>285</start><end>292</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit27"><titleInfo><title>Cortisone therapy in fasciculitis optica</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Oksala</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Oksala A (1964). Cortisone therapy in fasciculitis optica. Ophthalmologica (Basel) 148: 13–24.</note><part><date>1964</date><detail type="volume"><caption>vol.</caption><number>148</number></detail><extent unit="pages"><start>13</start><end>24</end></extent></part><relatedItem type="host"><titleInfo><title>Ophthalmologica (Basel)</title></titleInfo><part><date>1964</date><detail type="volume"><caption>vol.</caption><number>148</number></detail><extent unit="pages"><start>13</start><end>24</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit28"><titleInfo><title>Isolation of measles virus from cell cultures of brain from a patient with subacute sclerosing panencephalitis</title></titleInfo><name type="personal"><namePart type="given">FE</namePart><namePart type="family">Payne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JV</namePart><namePart type="family">Baublis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HH</namePart><namePart type="family">Itabashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Payne FE, Baublis JV, Itabashi HH (1969). Isolation of measles virus from cell cultures of brain from a patient with subacute sclerosing panencephalitis. New England Journal of Medicine 281: 585–589.</note><part><date>1969</date><detail type="volume"><caption>vol.</caption><number>281</number></detail><extent unit="pages"><start>585</start><end>589</end></extent></part><relatedItem type="host"><titleInfo><title>New England Journal of Medicine</title></titleInfo><part><date>1969</date><detail type="volume"><caption>vol.</caption><number>281</number></detail><extent unit="pages"><start>585</start><end>589</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit29"><titleInfo><title>Optic neuritis and multiple sclerosis: an epidemiological study</title></titleInfo><name type="personal"><namePart type="given">AK</namePart><namePart type="family">Percy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FT</namePart><namePart type="family">Nobrega</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LT</namePart><namePart type="family">Kurland</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Percy AK, Nobrega FT, Kurland LT (1972). Optic neuritis and multiple sclerosis: an epidemiological study. Archives of Ophthalmology 87: 135–139.</note><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>87</number></detail><extent unit="pages"><start>135</start><end>139</end></extent></part><relatedItem type="host"><titleInfo><title>Archives of Ophthalmology</title></titleInfo><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>87</number></detail><extent unit="pages"><start>135</start><end>139</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit30"><titleInfo><title>Paramyxovirus‐like particles associated with acute demyelination in chronic relapsing multiple sclerosis</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Prineas</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Prineas J (1972). Paramyxovirus‐like particles associated with acute demyelination in chronic relapsing multiple sclerosis. Science 178: 760–763.</note><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>178</number></detail><extent unit="pages"><start>760</start><end>763</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>178</number></detail><extent unit="pages"><start>760</start><end>763</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit31"><titleInfo><title>Intranuclear “paramyxovirus‐like” material in multiple sclerosis, adrenoleukodystrophy and Kuf's disease</title></titleInfo><name type="personal"><namePart type="given">CS</namePart><namePart type="family">Raine</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HH</namePart><namePart type="family">Schaumburg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DH</namePart><namePart type="family">Snyder</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Suzuki</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Raine CS, Schaumburg HH, Snyder DH, Suzuki K (1975). Intranuclear “paramyxovirus‐like” material in multiple sclerosis, adrenoleukodystrophy and Kuf's disease. Journal of the Neurological Society 25: 29–41.</note><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>29</start><end>41</end></extent></part><relatedItem type="host"><titleInfo><title>Journal of the Neurological Society</title></titleInfo><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><extent unit="pages"><start>29</start><end>41</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit32"><titleInfo><title>Symposium: diseases of the optic nerve. Optic neuritis of unknown etiology</title></titleInfo><name type="personal"><namePart type="given">CW</namePart><namePart type="family">Rucker</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rucker CW (1956). Symposium: diseases of the optic nerve. Optic neuritis of unknown etiology. Transactions of the American Academy of Ophthalmology and Otolaryngology 60: 93–96.</note><part><date>1956</date><detail type="volume"><caption>vol.</caption><number>60</number></detail><extent unit="pages"><start>93</start><end>96</end></extent></part><relatedItem type="host"><titleInfo><title>Transactions of the American Academy of Ophthalmology and Otolaryngology</title></titleInfo><part><date>1956</date><detail type="volume"><caption>vol.</caption><number>60</number></detail><extent unit="pages"><start>93</start><end>96</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit33"><titleInfo><title>Non‐viral intranuclear filamentous inclusions</title></titleInfo><name type="personal"><namePart type="given">CM</namePart><namePart type="family">Shaw</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SM</namePart><namePart type="family">Sumi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Shaw CM, Sumi SM (1975). Non‐viral intranuclear filamentous inclusions. Archives of Neurology 32: 428–432.</note><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>428</start><end>432</end></extent></part><relatedItem type="host"><titleInfo><title>Archives of Neurology</title></titleInfo><part><date>1975</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>428</start><end>432</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit34"><titleInfo><title>A rapidly fatal case of systemic lupus erythematosus: Structures resembling viral nucleoprotein strands in the kidney and activities of lymphocytes in culture</title></titleInfo><name type="personal"><namePart type="given">JG</namePart><namePart type="family">Sinkovics</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Gyorkey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GW</namePart><namePart type="family">Thoma</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Sinkovics JG, Gyorkey F, Thoma GW (1969). A rapidly fatal case of systemic lupus erythematosus: Structures resembling viral nucleoprotein strands in the kidney and activities of lymphocytes in culture. Texas Reports on Biology and Medicine 27: 887–908.</note><part><date>1969</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>887</start><end>908</end></extent></part><relatedItem type="host"><titleInfo><title>Texas Reports on Biology and Medicine</title></titleInfo><part><date>1969</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>887</start><end>908</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit35"><titleInfo><title>Fusion of cultured multiple sclerosis brain cells with indicator cells: presence of nucleocapsids and virions and isolation of parainfluenza‐type virus</title></titleInfo><name type="personal"><namePart type="given">V</namePart><namePart type="family">ter Meulen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Koprowski</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Iwasaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YM</namePart><namePart type="family">Kackell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Muller</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">ter Meulen V, Koprowski H, Iwasaki Y, Kackell YM, Muller D (1972). Fusion of cultured multiple sclerosis brain cells with indicator cells: presence of nucleocapsids and virions and isolation of parainfluenza‐type virus. Lancet 2: 1–5.</note><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>1</start><end>5</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>1</start><end>5</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit36"><titleInfo><title>Unusual intranuclear filaments in multiple sclerosis brain</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Tanaka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Iwasaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Koprowski</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tanaka R, Iwasaki Y, Koprowski H (1974). Unusual intranuclear filaments in multiple sclerosis brain. Lancet 1: 1236–1237.</note><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>1236</start><end>1237</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>1974</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>1236</start><end>1237</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit37"><titleInfo><title>Unusual intranuclear filaments in circulating lymphocytes of patients with multiple sclerosis and optic neuritis</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Tanaka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Santoli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Koprowski</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tanaka R, Santoli D, Koprowski H (1976). Unusual intranuclear filaments in circulating lymphocytes of patients with multiple sclerosis and optic neuritis. American Journal of Pathology 83: 245–254.</note><part><date>1976</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><extent unit="pages"><start>245</start><end>254</end></extent></part><relatedItem type="host"><titleInfo><title>American Journal of Pathology</title></titleInfo><part><date>1976</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><extent unit="pages"><start>245</start><end>254</end></extent></part></relatedItem></relatedItem><identifier type="istex">430E89A4B02A2E22A020E6B296C63AD5C873A883</identifier><identifier type="ark">ark:/67375/WNG-9VJ7ZQLF-B</identifier><identifier type="DOI">10.1002/jmv.1890010307</identifier><identifier type="ArticleID">JMV1890010307</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1977 Wiley‐Liss, Inc., A Wiley Company</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-15</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-9VJ7ZQLF-B/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D93 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000D93 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:430E89A4B02A2E22A020E6B296C63AD5C873A883
|texte= Acute optic neuritis: A virological study in relation to multiple sclerosis
}}
| This area was generated with Dilib version V0.6.33. |  |