Antibody induction by influenza vaccines in the elderly: a review of the literature
Identifieur interne : 000C60 ( Istex/Corpus ); précédent : 000C59; suivant : 000C61Antibody induction by influenza vaccines in the elderly: a review of the literature
Auteurs : Walter E. P. Beyer ; Abraham M. Palache ; Machteld Baljet ; Nic MasurelSource :
- Vaccine [ 0264-410X ] ; 1989.
English descriptors
- Teeft :
- Absolute differences, Active immunization, Admission criteria, Antibody, Antibody production, Antibody response, Antibody responses, Antibody titres, Antigenic drift, Beyer, Biol, Birth date, Bivalent vaccine, Booster vaccination, Cancer chemotherapy, Chlamydial infections, Control group, Control groups, Cystic fibrosis, Diagnostic procedures, Dos, Elderly, Elderly people, Elderly persons, Elderly population, Experimental trials, Field trials, Group composition, Groups vaccinated, Haemagglutinin, Health association, Health state, Heterogeneous picture, High concentrations, Immune, Immune response, Immune response study, Immune system, Immunization, Immunogerontological studies, Influenza, Influenza antigens, Influenza immunization, Influenza infection, Influenza vaccination, Influenza vaccine, Influenza vaccines, Influenza virus vaccine, Influenza viruses, Laboratory tests, Latter strain, Major groups, Medical research council, Natural infection, Neutralization test, October, Original data, Original paper, Original papers, Other papers, Pneumococcal vaccine, Postvaccination sera, Postvaccination titres, Prevaccination, Prevaccination antibody, Prevaccination state, Previous exposure, Previous vaccinations, Protection rate, Protection rates, Protection threshold, Quantitative methods, Response rate, Response rates, Selection biases, Senieur protocol, Serological, Serological response, Serological results, Seroresponse, Seroresponse measures, Seroresponse variables, Serum antibody, Sign stat, Significance level, Significant differences, Slight tendency, Statistical calculations, Stratification, Stratification criteria, Streptococcus pneumoniae, Study design, Study groups, Study populations, Study subjects, Subunit, Subunit vaccines, Tetanus toxoid, Titre, Unprotected subjects, Vaccinated, Vaccination, Vaccination trials, Vaccine, Vaccine component, Vaccine components, Vaccine efficacy, Vaccine strain, Viral, Viral haemagglutinin, Viral infections, Virus vaccines, Whole virus vaccine, World health organization, Young adults, Young group, Young groups, Young study groups, Young subjects, Younger control subjects, Younger groups, Younger subjects.
Abstract
Abstract: Conflicting results have been reported concerning the association between high age and response to influenza vaccines. Some authors have found a reduced response in aged subjects, others have found no difference or even better results as compared with younger control subjects. Seventeen papers were selected from international literature published in the period 1968–1988 for a review of the anti-haemagglutinin-IgG sero-response following vaccination: among 30 cases in which vaccine components could be studied independently, ten revealed a better immune response in young subjects than in the elderly, four found more favourable results in the elderly, and 16 could not detect any significant between-group-differences, the latter most probably because of a high type-2-error. Nine of these 16 cases tended to favour young subjects. These results were relativated by the finding that each paper had at least one of three methodological limitations: (1) the failure to exclude subjects with illnesses or using drugs influencing the immune system, (2) the failure to exclude subjects with previous vaccinations against influenza, (3) the failure to exclude subjects with high prevaccination antibody titres. The direction of these biases is such that failure to address any one issue will lead to an underestimate of the response of aged subjects. In view of the failure to control these biases, it was not surprising that the papers reviewed presented a heterogeneous picture. Thus, the association between high age per se and response to influenza vaccines, if any, has not yet been established. Suggestions are made for future studies in which admission criteria should control health state and previous exposure to influenza antigens.
Url:
DOI: 10.1016/0264-410X(89)90150-3
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ISTEX:5ABFEFFC3E631EDDC93EDF9F98E93D0EE91EFCF8Le document en format XML
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P." last="Beyer">Walter E. P. Beyer</name><affiliation><mods:affiliation>Department of Virology and WHO Influenza Centre, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Palache, Abraham M" sort="Palache, Abraham M" uniqKey="Palache A" first="Abraham M." last="Palache">Abraham M. 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subjects</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Conflicting results have been reported concerning the association between high age and response to influenza vaccines. Some authors have found a reduced response in aged subjects, others have found no difference or even better results as compared with younger control subjects. Seventeen papers were selected from international literature published in the period 1968–1988 for a review of the anti-haemagglutinin-IgG sero-response following vaccination: among 30 cases in which vaccine components could be studied independently, ten revealed a better immune response in young subjects than in the elderly, four found more favourable results in the elderly, and 16 could not detect any significant between-group-differences, the latter most probably because of a high type-2-error. Nine of these 16 cases tended to favour young subjects. These results were relativated by the finding that each paper had at least one of three methodological limitations: (1) the failure to exclude subjects with illnesses or using drugs influencing the immune system, (2) the failure to exclude subjects with previous vaccinations against influenza, (3) the failure to exclude subjects with high prevaccination antibody titres. The direction of these biases is such that failure to address any one issue will lead to an underestimate of the response of aged subjects. In view of the failure to control these biases, it was not surprising that the papers reviewed presented a heterogeneous picture. Thus, the association between high age per se and response to influenza vaccines, if any, has not yet been established. Suggestions are made for future studies in which admission criteria should control health state and previous exposure to influenza antigens.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>vaccine</json:string><json:string>influenza</json:string><json:string>influenza vaccines</json:string><json:string>prevaccination</json:string><json:string>seroresponse</json:string><json:string>immune</json:string><json:string>original paper</json:string><json:string>vaccination</json:string><json:string>young groups</json:string><json:string>october</json:string><json:string>viral</json:string><json:string>young group</json:string><json:string>influenza vaccine</json:string><json:string>haemagglutinin</json:string><json:string>biol</json:string><json:string>subunit</json:string><json:string>vaccine components</json:string><json:string>beyer</json:string><json:string>vaccinated</json:string><json:string>field trials</json:string><json:string>health 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Beyer</name><affiliations><json:string>Department of Virology and WHO Influenza Centre, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands</json:string></affiliations></json:item><json:item><name>Abraham M. Palache</name><affiliations><json:string>Duphar BV, Department of Clinical Research, Weesp, The Netherlands</json:string></affiliations></json:item><json:item><name>Machteld Baljet</name><affiliations><json:string>Duphar BV, Department of Clinical Research, Weesp, The Netherlands</json:string></affiliations></json:item><json:item><name>Nic Masurel</name><affiliations><json:string>Department of Virology and WHO Influenza Centre, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands</json:string></affiliations></json:item></author><arkIstex>ark:/67375/6H6-5RSV617S-R</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Review article</json:string></originalGenre><abstract>Abstract: Conflicting results have been reported concerning the association between high age and response to influenza vaccines. Some authors have found a reduced response in aged subjects, others have found no difference or even better results as compared with younger control subjects. Seventeen papers were selected from international literature published in the period 1968–1988 for a review of the anti-haemagglutinin-IgG sero-response following vaccination: among 30 cases in which vaccine components could be studied independently, ten revealed a better immune response in young subjects than in the elderly, four found more favourable results in the elderly, and 16 could not detect any significant between-group-differences, the latter most probably because of a high type-2-error. Nine of these 16 cases tended to favour young subjects. These results were relativated by the finding that each paper had at least one of three methodological limitations: (1) the failure to exclude subjects with illnesses or using drugs influencing the immune system, (2) the failure to exclude subjects with previous vaccinations against influenza, (3) the failure to exclude subjects with high prevaccination antibody titres. The direction of these biases is such that failure to address any one issue will lead to an underestimate of the response of aged subjects. In view of the failure to control these biases, it was not surprising that the papers reviewed presented a heterogeneous picture. Thus, the association between high age per se and response to influenza vaccines, if any, has not yet been established. Suggestions are made for future studies in which admission criteria should control health state and previous exposure to influenza antigens.</abstract><qualityIndicators><score>10</score><pdfWordCount>7129</pdfWordCount><pdfCharCount>47726</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>576 x 836 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>263</abstractWordCount><abstractCharCount>1750</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Antibody induction by influenza vaccines in the elderly: a review of the literature</title><pmid><json:string>2683459</json:string></pmid><pii><json:string>0264-410X(89)90150-3</json:string></pii><genre><json:string>review-article</json:string></genre><serie><title>Report on a WHO Working Group</title><language><json:string>unknown</json:string></language></serie><host><title>Vaccine</title><language><json:string>unknown</json:string></language><publicationDate>1989</publicationDate><issn><json:string>0264-410X</json:string></issn><pii><json:string>S0264-410X(00)X0229-0</json:string></pii><volume>7</volume><issue>5</issue><pages><first>385</first><last>394</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1968</json:string><json:string>50s</json:string><json:string>1971</json:string><json:string>1040</json:string><json:string>1133</json:string><json:string>60s</json:string><json:string>1889</json:string><json:string>1977</json:string><json:string>1933</json:string><json:string>70s</json:string><json:string>1989</json:string><json:string>1978</json:string><json:string>1980</json:string><json:string>1967</json:string><json:string>40s</json:string></date><geogName></geogName><orgName><json:string>Medical Research Council</json:string><json:string>UK Ruben</json:string><json:string>Department of Clinical Research, Weesp, The Netherlands</json:string><json:string>Erasmus University</json:string><json:string>FR UK USA Feery</json:string><json:string>Medical Research Council Library, National Institute for Medical Research, Mill Hill, London, UK</json:string><json:string>World Health Organization</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Hong Kong</json:string><json:string>Nic Masurei</json:string><json:string>R.S. EngelsBakker</json:string><json:string>Faculty</json:string><json:string>G.J. Ligthart</json:string><json:string>Rotterdam</json:string><json:string>J.M.P. Den</json:string><json:string>N. Hamido</json:string></persName><placeName><json:string>United States of America</json:string><json:string>Chile</json:string><json:string>Port Chalmers</json:string><json:string>Japan</json:string><json:string>Philippines</json:string><json:string>Rotterdam</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Gross et al.</json:string><json:string>Sachs et al.</json:string><json:string>Musher et al.</json:string><json:string>Sabin et al.</json:string><json:string>Strassburg et al.</json:string><json:string>W.E.P. Beyer et al.</json:string><json:string>Ligthart et al.</json:string><json:string>Masurel and Andre (1978)</json:string><json:string>December 1988</json:string><json:string>Ammann et al.</json:string><json:string>Denis et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-5RSV617S-R</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - medicine, research & experimental</json:string><json:string>2 - immunology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - virology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Infectious Diseases</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Public Health, Environmental and Occupational Health</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Veterinary</json:string><json:string>3 - General Veterinary</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - General Immunology and Microbiology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - Molecular Medicine</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1989</publicationDate><copyrightDate>1989</copyrightDate><doi><json:string>10.1016/0264-410X(89)90150-3</json:string></doi><id>5ABFEFFC3E631EDDC93EDF9F98E93D0EE91EFCF8</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-5RSV617S-R/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-5RSV617S-R/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-5RSV617S-R/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Antibody induction by influenza vaccines in the elderly: a review of the literature</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>elsevier</p></licence></availability><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M"></p><date>1989</date></publicationStmt><notesStmt><note type="review-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note type="content">Section title: Review</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Antibody induction by influenza vaccines in the elderly: a review of the literature</title><author xml:id="author-0000"><persName><forename type="first">Walter E.P.</forename><surname>Beyer</surname></persName><affiliation>Department of Virology and WHO Influenza Centre, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Abraham M.</forename><surname>Palache</surname></persName><affiliation>Duphar BV, Department of Clinical Research, Weesp, The Netherlands</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Machteld</forename><surname>Baljet</surname></persName><affiliation>Duphar BV, Department of Clinical Research, Weesp, The Netherlands</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Nic</forename><surname>Masurel</surname></persName><affiliation>Department of Virology and WHO Influenza Centre, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands</affiliation></author><idno type="istex">5ABFEFFC3E631EDDC93EDF9F98E93D0EE91EFCF8</idno><idno type="ark">ark:/67375/6H6-5RSV617S-R</idno><idno type="DOI">10.1016/0264-410X(89)90150-3</idno><idno type="PII">0264-410X(89)90150-3</idno></analytic><monogr><title level="j">Vaccine</title><title level="j" type="abbrev">JVAC</title><idno type="pISSN">0264-410X</idno><idno type="PII">S0264-410X(00)X0229-0</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1989"></date><biblScope unit="volume">7</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="385">385</biblScope><biblScope unit="page" to="394">394</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1989</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Conflicting results have been reported concerning the association between high age and response to influenza vaccines. Some authors have found a reduced response in aged subjects, others have found no difference or even better results as compared with younger control subjects. Seventeen papers were selected from international literature published in the period 1968–1988 for a review of the anti-haemagglutinin-IgG sero-response following vaccination: among 30 cases in which vaccine components could be studied independently, ten revealed a better immune response in young subjects than in the elderly, four found more favourable results in the elderly, and 16 could not detect any significant between-group-differences, the latter most probably because of a high type-2-error. Nine of these 16 cases tended to favour young subjects. These results were relativated by the finding that each paper had at least one of three methodological limitations: (1) the failure to exclude subjects with illnesses or using drugs influencing the immune system, (2) the failure to exclude subjects with previous vaccinations against influenza, (3) the failure to exclude subjects with high prevaccination antibody titres. The direction of these biases is such that failure to address any one issue will lead to an underestimate of the response of aged subjects. In view of the failure to control these biases, it was not surprising that the papers reviewed presented a heterogeneous picture. Thus, the association between high age per se and response to influenza vaccines, if any, has not yet been established. Suggestions are made for future studies in which admission criteria should control health state and previous exposure to influenza antigens.</p></abstract></profileDesc><revisionDesc><change when="1989-04-26">Modified</change><change when="1989">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-5RSV617S-R/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="rev"><item-info><jid>JVAC</jid><aid>89901503</aid><ce:pii>0264-410X(89)90150-3</ce:pii><ce:doi>10.1016/0264-410X(89)90150-3</ce:doi><ce:copyright type="unknown" year="1989"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Review</ce:textfn></ce:dochead><ce:title>Antibody induction by influenza vaccines in the elderly: a review of the literature</ce:title><ce:author-group><ce:author><ce:given-name>Walter E.P.</ce:given-name><ce:surname>Beyer</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Abraham M.</ce:given-name><ce:surname>Palache</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>†</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Machteld</ce:given-name><ce:surname>Baljet</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>†</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Nic</ce:given-name><ce:surname>Masurel</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Department of Virology and WHO Influenza Centre, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Duphar BV, Department of Clinical Research, Weesp, The Netherlands</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="5" month="10" year="1988"></ce:date-received><ce:date-revised day="26" month="4" year="1989"></ce:date-revised><ce:date-accepted day="10" month="5" year="1989"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Conflicting results have been reported concerning the association between high age and response to influenza vaccines. Some authors have found a reduced response in aged subjects, others have found no difference or even better results as compared with younger control subjects. Seventeen papers were selected from international literature published in the period 1968–1988 for a review of the anti-haemagglutinin-IgG sero-response following vaccination: among 30 cases in which vaccine components could be studied independently, ten revealed a better immune response in young subjects than in the elderly, four found more favourable results in the elderly, and 16 could not detect any significant between-group-differences, the latter most probably because of a high type-2-error. Nine of these 16 cases tended to favour young subjects. These results were relativated by the finding that each paper had at least one of three methodological limitations: (1) the failure to exclude subjects with illnesses or using drugs influencing the immune system, (2) the failure to exclude subjects with previous vaccinations against influenza, (3) the failure to exclude subjects with high prevaccination antibody titres. The direction of these biases is such that failure to address any one issue will lead to an underestimate of the response of aged subjects. In view of the failure to control these biases, it was not surprising that the papers reviewed presented a heterogeneous picture. Thus, the association between high age <ce:italic>per se</ce:italic> and response to influenza vaccines, if any, has not yet been established. Suggestions are made for future studies in which admission criteria should control health state and previous exposure to influenza antigens.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Antibody induction by influenza vaccines in the elderly: a review of the literature</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Antibody induction by influenza vaccines in the elderly: a review of the literature</title></titleInfo><name type="personal"><namePart type="given">Walter E.P.</namePart><namePart type="family">Beyer</namePart><affiliation>Department of Virology and WHO Influenza Centre, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Abraham M.</namePart><namePart type="family">Palache</namePart><affiliation>Duphar BV, Department of Clinical Research, Weesp, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Machteld</namePart><namePart type="family">Baljet</namePart><affiliation>Duphar BV, Department of Clinical Research, Weesp, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nic</namePart><namePart type="family">Masurel</namePart><affiliation>Department of Virology and WHO Influenza Centre, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="Review article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1989</dateIssued><dateModified encoding="w3cdtf">1989-04-26</dateModified><copyrightDate encoding="w3cdtf">1989</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Conflicting results have been reported concerning the association between high age and response to influenza vaccines. Some authors have found a reduced response in aged subjects, others have found no difference or even better results as compared with younger control subjects. Seventeen papers were selected from international literature published in the period 1968–1988 for a review of the anti-haemagglutinin-IgG sero-response following vaccination: among 30 cases in which vaccine components could be studied independently, ten revealed a better immune response in young subjects than in the elderly, four found more favourable results in the elderly, and 16 could not detect any significant between-group-differences, the latter most probably because of a high type-2-error. Nine of these 16 cases tended to favour young subjects. These results were relativated by the finding that each paper had at least one of three methodological limitations: (1) the failure to exclude subjects with illnesses or using drugs influencing the immune system, (2) the failure to exclude subjects with previous vaccinations against influenza, (3) the failure to exclude subjects with high prevaccination antibody titres. The direction of these biases is such that failure to address any one issue will lead to an underestimate of the response of aged subjects. In view of the failure to control these biases, it was not surprising that the papers reviewed presented a heterogeneous picture. Thus, the association between high age per se and response to influenza vaccines, if any, has not yet been established. Suggestions are made for future studies in which admission criteria should control health state and previous exposure to influenza antigens.</abstract><note type="content">Section title: Review</note><relatedItem type="host"><titleInfo><title>Vaccine</title></titleInfo><titleInfo type="abbreviated"><title>JVAC</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1989</dateIssued></originInfo><identifier type="ISSN">0264-410X</identifier><identifier type="PII">S0264-410X(00)X0229-0</identifier><part><date>1989</date><detail type="volume"><number>7</number><caption>vol.</caption></detail><detail type="issue"><number>5</number><caption>no.</caption></detail><extent unit="issue-pages"><start>377</start><end>480</end></extent><extent unit="pages"><start>385</start><end>394</end></extent></part></relatedItem><identifier type="istex">5ABFEFFC3E631EDDC93EDF9F98E93D0EE91EFCF8</identifier><identifier type="ark">ark:/67375/6H6-5RSV617S-R</identifier><identifier type="DOI">10.1016/0264-410X(89)90150-3</identifier><identifier type="PII">0264-410X(89)90150-3</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-5RSV617S-R/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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