H2N2V1, Istex, Corpus, bibRecord, 000929

Evaluation of Live Attenuated Cold-Adapted Influenza B/Yamagataj16/88 Reassortant Virus Vaccine in Healthy Adults

Identifieur interne : 000929 ( Istex/Corpus ); précédent : 000928; suivant : 000930

Evaluation of Live Attenuated Cold-Adapted Influenza B/Yamagataj16/88 Reassortant Virus Vaccine in Healthy Adults

Auteurs : John J. Treanor ; Robert F. Betts

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 1993.

RBID : ISTEX:CDAB7B589A09C8AF38CAA4285215C30339434AB7

Abstract

The safety and immunogenicity of a new cold-adapted reassortant influenza B/Yamagata/10/88 virus vaccine was evaluated in healthy young adults with low levels of preinoculation serum antibody to the vaccine virus, and symptoms and viral shedding after vaccination were compared with those following administration of the homologous BjYamagata/88 wild-type virus. Administration of the cold-adapted virus was well tolerated and resulted in a significantly lower frequency of respiratory symptoms and viral shedding than did the wild-type virus. Twelve of 14 subjects who received the cold-adapted virus had an antibody response to the vaccine virus following vaccination. These data suggest that the B/Yamagata/88 virus is safe and immunogenic in seronegative adults and support the concept that the attenuation phenotype can be transferred reliably and reproducibly to successive new influenza B wild-type viruses along with the six internal gene segments of the cold-adapted influenza BjAnn Arbor/l/66 master vaccine virus.

Url:

https://api.istex.fr/ark:/67375/HXZ-Z1XBHJG4-D/fulltext.pdf

DOI: 10.1093/infdis/168.2.455

Links to Exploration step

ISTEX:CDAB7B589A09C8AF38CAA4285215C30339434AB7

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<p>The safety and immunogenicity of a new cold-adapted reassortant influenza B/Yamagata/10/88 virus vaccine was evaluated in healthy young adults with low levels of preinoculation serum antibody to the vaccine virus, and symptoms and viral shedding after vaccination were compared with those following administration of the homologous BjYamagata/88 wild-type virus. Administration of the cold-adapted virus was well tolerated and resulted in a significantly lower frequency of respiratory symptoms and viral shedding than did the wild-type virus. Twelve of 14 subjects who received the cold-adapted virus had an antibody response to the vaccine virus following vaccination. These data suggest that the B/Yamagata/88 virus is safe and immunogenic in seronegative adults and support the concept that the attenuation phenotype can be transferred reliably and reproducibly to successive new influenza B wild-type viruses along with the six internal gene segments of the cold-adapted influenza BjAnn Arbor/l/66 master vaccine virus.</p>

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<affiliation>Infectious Diseases Unit, Department of Medicine, University of Rochester School of Medicine, Rochester, New York</affiliation>
<affiliation>Reprints or correspondence: Dr. John J. Treanor, Infectious Diseases Unit, University of Rochester School of Medicine and Dentistry, Box 649, 601 Elmwood Ave., Rochester, NY 14642.</affiliation>
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<name type="personal"><namePart type="given">Robert F.</namePart>
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<abstract>The safety and immunogenicity of a new cold-adapted reassortant influenza B/Yamagata/10/88 virus vaccine was evaluated in healthy young adults with low levels of preinoculation serum antibody to the vaccine virus, and symptoms and viral shedding after vaccination were compared with those following administration of the homologous BjYamagata/88 wild-type virus. Administration of the cold-adapted virus was well tolerated and resulted in a significantly lower frequency of respiratory symptoms and viral shedding than did the wild-type virus. Twelve of 14 subjects who received the cold-adapted virus had an antibody response to the vaccine virus following vaccination. These data suggest that the B/Yamagata/88 virus is safe and immunogenic in seronegative adults and support the concept that the attenuation phenotype can be transferred reliably and reproducibly to successive new influenza B wild-type viruses along with the six internal gene segments of the cold-adapted influenza BjAnn Arbor/l/66 master vaccine virus.</abstract>
<note type="author-notes">Reprints or correspondence: Dr. John J. Treanor, Infectious Diseases Unit, University of Rochester School of Medicine and Dentistry, Box 649, 601 Elmwood Ave., Rochester, NY 14642.</note>
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Evaluation of Live Attenuated Cold-Adapted Influenza B/Yamagataj16/88 Reassortant Virus Vaccine in Healthy Adults

Evaluation of Live Attenuated Cold-Adapted Influenza B/Yamagataj16/88 Reassortant Virus Vaccine in Healthy Adults

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