Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses
Identifieur interne : 000417 ( Istex/Checkpoint ); précédent : 000416; suivant : 000418Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses
Auteurs : Jayanta Haldar [États-Unis] ; Jianzhu Chen [États-Unis] ; Terrence M. Tumpey [États-Unis] ; Larisa V. Gubareva [États-Unis] ; Alexander M. Klibanov [États-Unis]Source :
- Biotechnology Letters [ 0141-5492 ] ; 2008-03-01.
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Abstract
Abstract: Glass slides painted with the hydrophobic long-chained polycation N,N-dodecyl,methyl-polyethylenimine (N,N-dodecyl,methyl-PEI) are highly lethal to waterborne influenza A viruses, including not only wild-type human and avian strains but also their neuraminidase mutants resistant to currently used anti-influenza drugs.
Url:
DOI: 10.1007/s10529-007-9565-5
Affiliations:
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<front><div type="abstract" xml:lang="en">Abstract: Glass slides painted with the hydrophobic long-chained polycation N,N-dodecyl,methyl-polyethylenimine (N,N-dodecyl,methyl-PEI) are highly lethal to waterborne influenza A viruses, including not only wild-type human and avian strains but also their neuraminidase mutants resistant to currently used anti-influenza drugs.</div>
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