H2N2V1, Hal, Corpus, bibRecord, 000311

Vaccine effectiveness of 2011/12 trivalent seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: evidence of waning intra-seasonal protection

Identifieur interne : 000311 ( Hal/Corpus ); précédent : 000310; suivant : 000312

Vaccine effectiveness of 2011/12 trivalent seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: evidence of waning intra-seasonal protection

Auteurs : R. Pebody ; N. Andrews ; J. Mcmenamin ; H. Durnall ; J. Ellis ; C. I. Thompson ; C. Robertson ; S. Cottrell ; B. Smyth ; M. Zambon ; C. Moore ; D. M. Fleming ; J. M. Watson

Source :

RBID : Hal:hal-01261731

English descriptors

mix :
- DNA Time Factors Treatment Outcome Vaccination/statistics & numerical data, H3N2 Subtype/genetics/immunology/isolation & purification Influenza Vaccines/*administration & dosage/immunology Influenza, Human/diagnosis/*epidemiology/*prevention & control/virology Male Middle Aged Primary Health Care Reverse Transcriptase Polymerase Chain Reaction Seasons Sentinel Surveillance Sequence Analysis, Adolescent Adult Aged Case-Control Studies Child Confidence Intervals Female Great Britain/epidemiology Hemagglutination Inhibition Tests Humans Influenza A Virus.

Abstract

The 2011/12 season was characterised by unusually late influenza A (H3N2) activity in the United Kingdom (UK). We measured vaccine effectiveness (VE) of the 2011/12 trivalent seasonal influenza vaccine (TIV) in a test-negative case-control study in primary care. Overall VE against confirmed influenza A (H3N2) infection, adjusted for age, surveillance scheme and month, was 23% (95% confidence interval (CI): -10 to 47). Stratified analysis by time period gave an adjusted VE of 43% (95% CI: -34 to 75) for October 2011 to January 2012 and 17% (95% CI: -24 to 45) for February 2012 to April 2012. Stratified analysis by time since vaccination gave an adjusted VE of 53% (95% CI: 0 to 78) for those vaccinated less than three months, and 12% (95% CI: -31 to 41) for those vaccinated three months or more before onset of symptoms (test for trend: p=0.02). For confirmed influenza B infection, adjusted VE was 92% (95% CI: 38 to 99). A proportion (20.6%) of UK influenza A(H3N2) viruses circulating in 2011/12 showed reduced reactivity (fourfold difference in haemagglutination inhibition assays) to the A/Perth/16/2009 2011/12 vaccine component, with no significant change in proportion over the season. Overall TIV protection against influenza A(H3N2) infection was low, with significant intraseasonal waning.

Url:

https://hal.archives-ouvertes.fr/hal-01261731

Links to Exploration step

Hal:hal-01261731

Le document en format XML

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<author><name sortKey="Mcmenamin, J" sort="Mcmenamin, J" uniqKey="Mcmenamin J" first="J." last="Mcmenamin">J. Mcmenamin</name>
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<author><name sortKey="Smyth, B" sort="Smyth, B" uniqKey="Smyth B" first="B." last="Smyth">B. Smyth</name>
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<author><name sortKey="Zambon, M" sort="Zambon, M" uniqKey="Zambon M" first="M." last="Zambon">M. Zambon</name>
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<front><div type="abstract" xml:lang="en">              <p>The 2011/12 season was characterised by unusually late influenza A (H3N2) activity in the United Kingdom (UK). We measured vaccine effectiveness (VE) of the 2011/12 trivalent seasonal influenza vaccine (TIV) in a test-negative case-control study in primary care. Overall VE against confirmed influenza A (H3N2) infection, adjusted for age, surveillance scheme and month, was 23% (95% confidence interval (CI): -10 to 47). Stratified analysis by time period gave an adjusted VE of 43% (95% CI: -34 to 75) for October 2011 to January 2012 and 17% (95% CI: -24 to 45) for February 2012 to April 2012. Stratified analysis by time since vaccination gave an adjusted VE of 53% (95% CI: 0 to 78) for those vaccinated less than three months, and 12% (95% CI: -31 to 41) for those vaccinated three months or more before onset of symptoms (test for trend: p=0.02). For confirmed influenza B infection, adjusted VE was 92% (95% CI: 38 to 99). A proportion (20.6%) of UK influenza A(H3N2) viruses circulating in 2011/12 showed reduced reactivity (fourfold difference in haemagglutination inhibition assays) to the A/Perth/16/2009 2011/12 vaccine component, with no significant change in proportion over the season. Overall TIV protection against influenza A(H3N2) infection was low, with significant intraseasonal waning.</p>
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Vaccine effectiveness of 2011/12 trivalent seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: evidence of waning intra-seasonal protection

Vaccine effectiveness of 2011/12 trivalent seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: evidence of waning intra-seasonal protection

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri