Use of neuraminidase inhibitors in primary health care during pandemic and seasonal influenza between 2009 and 2013
Identifieur interne : 000310 ( Hal/Corpus ); précédent : 000309; suivant : 000311Use of neuraminidase inhibitors in primary health care during pandemic and seasonal influenza between 2009 and 2013
Auteurs : Thierry Blanchon ; Félicité Geffrier ; Clément Turbelin ; Isabelle Daviaud ; Cédric Laouénan ; Xavier Duval ; Bruno Lambert ; Thomas Hanslik ; Anne Mosnier ; Catherine LeportSource :
- Antiviral Therapy [ 1359-6535 ] ; 2015-02-17.
English descriptors
- mix :
Abstract
BACKGROUND:In a context of controversy about influenza antiviral treatments, this study assessed primary health-care physicians' prescription of neuraminidase inhibitors (NIs) in France during pandemic and seasonal influenza between 2009 and 2013.METHODS:This observational study, using data recorded in three national databases, estimated the rate of NI prescription among influenza-like illness (ILI) patients seen in GP and paediatrician consultations, and determined factors associated with this prescription according to a multivariate analysis. NI delivery by pharmacists was also evaluated.RESULTS:Rates of NI prescription were estimated to be 61.1% among ILI patients with a severe influenza risk factor seen in GP consultation during the A(H1N1)pdm2009 pandemic versus an average rate of 25.9% during the three following seasonal influenza epidemics. Factors associated with NI prescription were a chronic disease in patients under 65 years (OR 14.85; 95% CI 13.00, 16.97) and in those aged 65 and older (OR 7.54; 5.86, 9.70), an age ≥65 years in patients without chronic disease (OR 1.35; 1.04, 1.74), a pregnancy (OR 10.63; 7.67, 15.76), obesity (OR 4.67; 3.50, 6.22) and a consultation during the pandemic A(H1N1)pdm2009 (OR 3.19; 2.93, 3.48). The number of antiviral treatments delivered by pharmacists during the A(H1N1)pdm2009 pandemic was 835 per 100,000 inhabitants, and an average of 275 per 100,000 inhabitants during the three following seasonal influenza epidemics.CONCLUSIONS:Although physicians seem to follow the recommended indications for NIs in primary health-care practice, this study confirms the low rate of NI prescription to ILI patients with a severe influenza risk factor, especially during seasonal epidemics.
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DOI: 10.3851/IMP2945
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Hal:inserm-01242944Le document en format XML
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Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle active="#struct-303171" type="direct"><org type="regroupinstitution" xml:id="struct-303171" status="VALID"> <orgName>Université Sorbonne Paris Cité</orgName> <orgName type="acronym">USPC</orgName> <date type="start">2010</date> <desc> <address> <addrLine>Université Sorbonne Paris Cité | 100-104, avenue de France | 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-paris-cite.fr/fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Duval, Xavier" sort="Duval, Xavier" uniqKey="Duval X" first="Xavier" last="Duval">Xavier Duval</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-247341" status="OLD"> <idno type="IdRef">235514829</idno> <idno type="RNSR">201420743R</idno> <orgName>Infection, Anti-microbiens, Modélisation, Evolution</orgName> <orgName type="acronym">IAME (UMR_S_1137 / U1137)</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>Faculté de médecine Paris Diderot Paris 7 - 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Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle active="#struct-303171" type="direct"><org type="regroupinstitution" xml:id="struct-303171" status="VALID"> <orgName>Université Sorbonne Paris Cité</orgName> <orgName type="acronym">USPC</orgName> <date type="start">2010</date> <desc> <address> <addrLine>Université Sorbonne Paris Cité | 100-104, avenue de France | 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-paris-cite.fr/fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Lambert, Bruno" sort="Lambert, Bruno" uniqKey="Lambert B" first="Bruno" last="Lambert">Bruno Lambert</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-443862" status="INCOMING"> <orgName>Service d'Etudes de Marché</orgName> <desc> <address> <addrLine>Tour Ariane - 5-7 Voie des Sculpteurs 92800 Puteaux</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-443861" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-443861" type="direct"><org type="institution" xml:id="struct-443861" status="INCOMING"> <orgName>International Metal Service of Health</orgName> <orgName type="acronym">IMS Health</orgName> <desc> <address> <addrLine>Tour Ariane - 5-7 Voie des Sculpteurs 92800 Puteaux</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Hanslik, Thomas" sort="Hanslik, Thomas" uniqKey="Hanslik T" first="Thomas" last="Hanslik">Thomas Hanslik</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-267618" status="OLD"> <idno type="RNSR">201420917E</idno> <orgName>Institut Pierre Louis d'Epidémiologie et de Santé Publique</orgName> <orgName type="acronym">iPLESP</orgName> <desc> <address> <addrLine>56, boulevard Vincent Auriol - CS 81393 - 75646 Paris Cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.iplesp.upmc.fr/</ref> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation name="U1136" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="OLD"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc> </org></tutelle><tutelle name="U1136" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Mosnier, Anne" sort="Mosnier, Anne" uniqKey="Mosnier A" first="Anne" last="Mosnier">Anne Mosnier</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-192803" status="INCOMING"> <orgName>Réseau des Groupes Régionaux d'Observation de la Grippe</orgName> <orgName type="acronym">GROG</orgName> <desc> <address> <addrLine>Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-347863" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-347863" type="direct"><org type="institution" xml:id="struct-347863" status="INCOMING"> <orgName>Coordination nationale</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Leport, Catherine" sort="Leport, Catherine" uniqKey="Leport C" first="Catherine" last="Leport">Catherine Leport</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-192808" status="INCOMING"> <orgName>Unité de Coordination des Risques Epidémiques et Biologiques</orgName> <desc> <address> <addrLine>Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author></analytic><idno type="DOI">10.3851/IMP2945</idno><series><title level="j">Antiviral Therapy</title><idno type="ISSN">1359-6535</idno><imprint><date type="datePub">2015-02-17</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Influenza</term><term>epidemiologic factors</term><term>neuraminidase inhibitors</term><term>primary healthcare</term><term>treatment outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>BACKGROUND:In a context of controversy about influenza antiviral treatments, this study assessed primary health-care physicians' prescription of neuraminidase inhibitors (NIs) in France during pandemic and seasonal influenza between 2009 and 2013.METHODS:This observational study, using data recorded in three national databases, estimated the rate of NI prescription among influenza-like illness (ILI) patients seen in GP and paediatrician consultations, and determined factors associated with this prescription according to a multivariate analysis. NI delivery by pharmacists was also evaluated.RESULTS:Rates of NI prescription were estimated to be 61.1% among ILI patients with a severe influenza risk factor seen in GP consultation during the A(H1N1)pdm2009 pandemic versus an average rate of 25.9% during the three following seasonal influenza epidemics. Factors associated with NI prescription were a chronic disease in patients under 65 years (OR 14.85; 95% CI 13.00, 16.97) and in those aged 65 and older (OR 7.54; 5.86, 9.70), an age ≥65 years in patients without chronic disease (OR 1.35; 1.04, 1.74), a pregnancy (OR 10.63; 7.67, 15.76), obesity (OR 4.67; 3.50, 6.22) and a consultation during the pandemic A(H1N1)pdm2009 (OR 3.19; 2.93, 3.48). The number of antiviral treatments delivered by pharmacists during the A(H1N1)pdm2009 pandemic was 835 per 100,000 inhabitants, and an average of 275 per 100,000 inhabitants during the three following seasonal influenza epidemics.CONCLUSIONS:Although physicians seem to follow the recommended indications for NIs in primary health-care practice, this study confirms the low rate of NI prescription to ILI patients with a severe influenza risk factor, especially during seasonal epidemics.</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Use of neuraminidase inhibitors in primary health care during pandemic and seasonal influenza between 2009 and 2013</title> <title xml:lang="en" type="sub">Outpatient influenza antiviral treatment</title> <author role="crp"> <persName> <forename type="first">Thierry</forename> <surname>Blanchon</surname> </persName> <email type="md5">98c0c4267ed4dd5f8977b4066349c212</email> <email type="domain">upmc.fr</email> <idno type="halauthorid">1260454</idno> <affiliation ref="#struct-267618"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Félicité</forename> <surname>Geffrier</surname> </persName> <idno type="halauthorid">1260455</idno> <affiliation ref="#struct-267618"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Clément</forename> <surname>Turbelin</surname> </persName> <idno type="halauthorid">610637</idno> <affiliation ref="#struct-267618"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Isabelle</forename> <surname>Daviaud</surname> </persName> <idno type="halauthorid">992441</idno> <affiliation ref="#struct-192803"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Cédric</forename> <surname>Laouénan</surname> </persName> <idno type="halauthorid">1012911</idno> <affiliation ref="#struct-247341"></affiliation> <affiliation ref="#struct-443864"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Xavier</forename> <surname>Duval</surname> </persName> <idno type="halauthorid">203676</idno> <affiliation ref="#struct-247341"></affiliation> <affiliation ref="#struct-443854"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Bruno</forename> <surname>Lambert</surname> </persName> <idno type="halauthorid">716651</idno> <affiliation ref="#struct-443862"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Thomas</forename> <surname>Hanslik</surname> </persName> <idno type="halauthorid">647173</idno> <affiliation ref="#struct-267618"></affiliation> <affiliation ref="#struct-443863"></affiliation> <affiliation ref="#struct-413224"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Anne</forename> <surname>Mosnier</surname> </persName> <idno type="halauthorid">727095</idno> <affiliation ref="#struct-192803"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Catherine</forename> <surname>Leport</surname> </persName> <idno type="halauthorid">80110</idno> <affiliation ref="#struct-192808"></affiliation> <affiliation ref="#struct-247341"></affiliation> </author> <editor role="depositor"> <persName> <forename>Thierry</forename> <surname>Blanchon</surname> </persName> <email type="md5">50ca7367b305d37ba16a2ba87a1da493</email> <email type="domain">upmc.fr</email> </editor> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2015-12-14 12:46:23</date> <date type="whenModified">2020-03-27 03:42:43</date> <date type="whenReleased">2015-12-14 15:21:49</date> <date type="whenProduced">2015-02-17</date> <date type="whenEndEmbargoed">2015-12-14</date> <ref type="file" target="https://www.hal.inserm.fr/inserm-01242944/document"> <date notBefore="2015-12-14"></date> </ref> <ref type="file" subtype="author" n="1" target="https://www.hal.inserm.fr/inserm-01242944/file/HAL-Inserm_retroDINA_Antivir-Ther_2015.pdf"> <date notBefore="2015-12-14"></date> </ref> <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325875/pdf"></ref> </edition> <respStmt> <resp>contributor</resp> <name key="328157"> <persName> <forename>Thierry</forename> <surname>Blanchon</surname> </persName> <email type="md5">50ca7367b305d37ba16a2ba87a1da493</email> <email type="domain">upmc.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">inserm-01242944</idno> <idno type="halUri">https://www.hal.inserm.fr/inserm-01242944</idno> <idno type="halBibtex">blanchon:inserm-01242944</idno> <idno type="halRefHtml">Antiviral Therapy, International Medical Press, 2015, 20 (7), pp.753-61. ⟨10.3851/IMP2945⟩</idno> <idno type="halRef">Antiviral Therapy, International Medical Press, 2015, 20 (7), pp.753-61. ⟨10.3851/IMP2945⟩</idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno> <idno type="stamp" n="UNIV-PARIS7" corresp="UNIV-PARIS">Université Denis Diderot - Paris VII</idno> <idno type="stamp" n="UNIV-PARIS13">Université Paris-Nord - Paris XIII </idno> <idno type="stamp" n="UPMC" corresp="SORBONNE-UNIVERSITE">Université Pierre et Marie Curie</idno> <idno type="stamp" n="UVSQ">Université de Versailles Saint-Quentin-en-Yvelines</idno> <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno> <idno type="stamp" n="IPLESP" corresp="SORBONNE-UNIVERSITE">Institut Pierre Louis d'Epidémiologie et de Santé Publique</idno> <idno type="stamp" n="USPC">Université Sorbonne Paris Cité</idno> <idno type="stamp" n="UVSQ-SACLAY" corresp="UNIV-PARIS-SACLAY">UVSQ-SACLAY</idno> <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno> <idno type="stamp" n="UPMC_POLE_4" corresp="UPMC">UPMC Pôle 4</idno> <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno> <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Médecine de Sorbonne Université</idno> <idno type="stamp" n="IAME" corresp="SORBONNE-PARIS-NORD">(Infection, Antimicrobiens, Modélisation, Evolution) - UMR 1137</idno> <idno type="stamp" n="SORBONNE-PARIS-NORD">Université Sorbonne Paris Nord</idno> <idno type="stamp" n="UNIV-PARIS">Université de Paris</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Use of neuraminidase inhibitors in primary health care during pandemic and seasonal influenza between 2009 and 2013</title> <title xml:lang="en" type="sub">Outpatient influenza antiviral treatment</title> <author role="crp"> <persName> <forename type="first">Thierry</forename> <surname>Blanchon</surname> </persName> <email type="md5">98c0c4267ed4dd5f8977b4066349c212</email> <email type="domain">upmc.fr</email> <idno type="halauthorid">1260454</idno> <affiliation ref="#struct-267618"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Félicité</forename> <surname>Geffrier</surname> </persName> <idno type="halauthorid">1260455</idno> <affiliation ref="#struct-267618"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Clément</forename> <surname>Turbelin</surname> </persName> <idno type="halauthorid">610637</idno> <affiliation ref="#struct-267618"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Isabelle</forename> <surname>Daviaud</surname> </persName> <idno type="halauthorid">992441</idno> <affiliation ref="#struct-192803"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Cédric</forename> <surname>Laouénan</surname> </persName> <idno type="halauthorid">1012911</idno> <affiliation ref="#struct-247341"></affiliation> <affiliation ref="#struct-443864"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Xavier</forename> <surname>Duval</surname> </persName> <idno type="halauthorid">203676</idno> <affiliation ref="#struct-247341"></affiliation> <affiliation ref="#struct-443854"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Bruno</forename> <surname>Lambert</surname> </persName> <idno type="halauthorid">716651</idno> <affiliation ref="#struct-443862"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Thomas</forename> <surname>Hanslik</surname> </persName> <idno type="halauthorid">647173</idno> <affiliation ref="#struct-267618"></affiliation> <affiliation ref="#struct-443863"></affiliation> <affiliation ref="#struct-413224"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Anne</forename> <surname>Mosnier</surname> </persName> <idno type="halauthorid">727095</idno> <affiliation ref="#struct-192803"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Catherine</forename> <surname>Leport</surname> </persName> <idno type="halauthorid">80110</idno> <affiliation ref="#struct-192808"></affiliation> <affiliation ref="#struct-247341"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">22685</idno> <idno type="issn">1359-6535</idno> <title level="j">Antiviral Therapy</title> <imprint> <publisher>International Medical Press</publisher> <biblScope unit="volume">20</biblScope> <biblScope unit="issue">7</biblScope> <biblScope unit="pp">753-61</biblScope> <date type="datePub">2015-02-17</date> </imprint> </monogr> <idno type="doi">10.3851/IMP2945</idno> <idno type="pubmed">25687219</idno> <idno type="pubmedcentral">PMC5325875</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <keywords scheme="author"> <term xml:lang="en">treatment outcome</term> <term xml:lang="en">Influenza</term> <term xml:lang="en">neuraminidase inhibitors</term> <term xml:lang="en">epidemiologic factors</term> <term xml:lang="en">primary healthcare</term> </keywords> <classCode scheme="halDomain" n="sdv.mhep.mi">Life Sciences [q-bio]/Human health and pathology/Infectious diseases</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>BACKGROUND:In a context of controversy about influenza antiviral treatments, this study assessed primary health-care physicians' prescription of neuraminidase inhibitors (NIs) in France during pandemic and seasonal influenza between 2009 and 2013.METHODS:This observational study, using data recorded in three national databases, estimated the rate of NI prescription among influenza-like illness (ILI) patients seen in GP and paediatrician consultations, and determined factors associated with this prescription according to a multivariate analysis. NI delivery by pharmacists was also evaluated.RESULTS:Rates of NI prescription were estimated to be 61.1% among ILI patients with a severe influenza risk factor seen in GP consultation during the A(H1N1)pdm2009 pandemic versus an average rate of 25.9% during the three following seasonal influenza epidemics. Factors associated with NI prescription were a chronic disease in patients under 65 years (OR 14.85; 95% CI 13.00, 16.97) and in those aged 65 and older (OR 7.54; 5.86, 9.70), an age ≥65 years in patients without chronic disease (OR 1.35; 1.04, 1.74), a pregnancy (OR 10.63; 7.67, 15.76), obesity (OR 4.67; 3.50, 6.22) and a consultation during the pandemic A(H1N1)pdm2009 (OR 3.19; 2.93, 3.48). The number of antiviral treatments delivered by pharmacists during the A(H1N1)pdm2009 pandemic was 835 per 100,000 inhabitants, and an average of 275 per 100,000 inhabitants during the three following seasonal influenza epidemics.CONCLUSIONS:Although physicians seem to follow the recommended indications for NIs in primary health-care practice, this study confirms the low rate of NI prescription to ILI patients with a severe influenza risk factor, especially during seasonal epidemics.</p> </abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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