Occurrence of temperature-sensitive influenza A viruses in nature.
Identifieur interne : 000188 ( 1957/Analysis ); précédent : 000187; suivant : 000189Occurrence of temperature-sensitive influenza A viruses in nature.
Auteurs : C M Chu ; S F Tian ; G F Ren ; Y M Zhang ; L X Zhang ; G Q LiuSource :
- Journal of Virology [ 0022-538X ] ; 1982.
Abstract
The origin and characteristics of the first naturally occurring temperature-sensitive (ts) strain of influenza A virus identified in 1973, Xia-ts, are described. Natural ts strains were found to occur in the early egg passage material of all influenza A subtypes examined, but the proportion of ts virus varied from 8.3% for old H1N1 virus (1949 to 1957) to 82.4% for recent H3N2 virus (1979 to 1980). A number of strains were found to be composed of a mixture of ts and wild-type (ts+) particles. Six natural ts strains with different shutoff temperatures and one ts+ strain of the H1N1 subtype were tested in antibody-free volunteers. Strains with a shutoff temperature of 38 degrees C or lower caused very mild symptoms, whereas those with a shutoff temperature of 39 degrees C and the ts+ strain were much more reactogenic. By complementation tests against a set of prototype WSN ts mutants with a defined genetic lesion, the ts lesion of two H3N2 viruses (HK/8/68 and Xia-ts) was located on the NP gene and that of two H1N1 viruses (Tianjin/78/77 and Beijing/1/79) was located on the M protein gene. The present study demonstrates the widespread occurrence in nature of influenza viruses of different degrees of temperature sensitivity and presumably of different degrees of virulence.
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PubMed: 7077746
PubMed Central: 256765
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PMC:256765Le document en format XML
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Natural ts strains were found to occur in the early egg passage material of all influenza A subtypes examined, but the proportion of ts virus varied from 8.3% for old H1N1 virus (1949 to 1957) to 82.4% for recent H3N2 virus (1979 to 1980). A number of strains were found to be composed of a mixture of ts and wild-type (ts+) particles. Six natural ts strains with different shutoff temperatures and one ts+ strain of the H1N1 subtype were tested in antibody-free volunteers. Strains with a shutoff temperature of 38 degrees C or lower caused very mild symptoms, whereas those with a shutoff temperature of 39 degrees C and the ts+ strain were much more reactogenic. By complementation tests against a set of prototype WSN ts mutants with a defined genetic lesion, the ts lesion of two H3N2 viruses (HK/8/68 and Xia-ts) was located on the NP gene and that of two H1N1 viruses (Tianjin/78/77 and Beijing/1/79) was located on the M protein gene. The present study demonstrates the widespread occurrence in nature of influenza viruses of different degrees of temperature sensitivity and presumably of different degrees of virulence.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Chu, C M" sort="Chu, C M" uniqKey="Chu C" first="C M" last="Chu">C M Chu</name><name sortKey="Liu, G Q" sort="Liu, G Q" uniqKey="Liu G" first="G Q" last="Liu">G Q Liu</name><name sortKey="Ren, G F" sort="Ren, G F" uniqKey="Ren G" first="G F" last="Ren">G F Ren</name><name sortKey="Tian, S F" sort="Tian, S F" uniqKey="Tian S" first="S F" last="Tian">S F Tian</name><name sortKey="Zhang, L X" sort="Zhang, L X" uniqKey="Zhang L" first="L X" last="Zhang">L X Zhang</name><name sortKey="Zhang, Y M" sort="Zhang, Y M" uniqKey="Zhang Y" first="Y M" last="Zhang">Y M Zhang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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