Occurrence of temperature-sensitive influenza A viruses in nature.
Identifieur interne : 000411 ( Pmc/Corpus ); précédent : 000410; suivant : 000412Occurrence of temperature-sensitive influenza A viruses in nature.
Auteurs : C M Chu ; S F Tian ; G F Ren ; Y M Zhang ; L X Zhang ; G Q LiuSource :
- Journal of Virology [ 0022-538X ] ; 1982.
Abstract
The origin and characteristics of the first naturally occurring temperature-sensitive (ts) strain of influenza A virus identified in 1973, Xia-ts, are described. Natural ts strains were found to occur in the early egg passage material of all influenza A subtypes examined, but the proportion of ts virus varied from 8.3% for old H1N1 virus (1949 to 1957) to 82.4% for recent H3N2 virus (1979 to 1980). A number of strains were found to be composed of a mixture of ts and wild-type (ts+) particles. Six natural ts strains with different shutoff temperatures and one ts+ strain of the H1N1 subtype were tested in antibody-free volunteers. Strains with a shutoff temperature of 38 degrees C or lower caused very mild symptoms, whereas those with a shutoff temperature of 39 degrees C and the ts+ strain were much more reactogenic. By complementation tests against a set of prototype WSN ts mutants with a defined genetic lesion, the ts lesion of two H3N2 viruses (HK/8/68 and Xia-ts) was located on the NP gene and that of two H1N1 viruses (Tianjin/78/77 and Beijing/1/79) was located on the M protein gene. The present study demonstrates the widespread occurrence in nature of influenza viruses of different degrees of temperature sensitivity and presumably of different degrees of virulence.
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PubMed: 7077746
PubMed Central: 256765
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Occurrence of temperature-sensitive influenza A viruses in nature.</title><author><name sortKey="Chu, C M" sort="Chu, C M" uniqKey="Chu C" first="C M" last="Chu">C M Chu</name></author><author><name sortKey="Tian, S F" sort="Tian, S F" uniqKey="Tian S" first="S F" last="Tian">S F Tian</name></author><author><name sortKey="Ren, G F" sort="Ren, G F" uniqKey="Ren G" first="G F" last="Ren">G F Ren</name></author><author><name sortKey="Zhang, Y M" sort="Zhang, Y M" uniqKey="Zhang Y" first="Y M" last="Zhang">Y M Zhang</name></author><author><name sortKey="Zhang, L X" sort="Zhang, L X" uniqKey="Zhang L" first="L X" last="Zhang">L X Zhang</name></author><author><name sortKey="Liu, G Q" sort="Liu, G Q" uniqKey="Liu G" first="G Q" last="Liu">G Q Liu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">7077746</idno><idno type="pmc">256765</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC256765</idno><idno type="RBID">PMC:256765</idno><date when="1982">1982</date><idno type="wicri:Area/Pmc/Corpus">000411</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000411</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Occurrence of temperature-sensitive influenza A viruses in nature.</title><author><name sortKey="Chu, C M" sort="Chu, C M" uniqKey="Chu C" first="C M" last="Chu">C M Chu</name></author><author><name sortKey="Tian, S F" sort="Tian, S F" uniqKey="Tian S" first="S F" last="Tian">S F Tian</name></author><author><name sortKey="Ren, G F" sort="Ren, G F" uniqKey="Ren G" first="G F" last="Ren">G F Ren</name></author><author><name sortKey="Zhang, Y M" sort="Zhang, Y M" uniqKey="Zhang Y" first="Y M" last="Zhang">Y M Zhang</name></author><author><name sortKey="Zhang, L X" sort="Zhang, L X" uniqKey="Zhang L" first="L X" last="Zhang">L X Zhang</name></author><author><name sortKey="Liu, G Q" sort="Liu, G Q" uniqKey="Liu G" first="G Q" last="Liu">G Q Liu</name></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="1982">1982</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The origin and characteristics of the first naturally occurring temperature-sensitive (ts) strain of influenza A virus identified in 1973, Xia-ts, are described. Natural ts strains were found to occur in the early egg passage material of all influenza A subtypes examined, but the proportion of ts virus varied from 8.3% for old H1N1 virus (1949 to 1957) to 82.4% for recent H3N2 virus (1979 to 1980). A number of strains were found to be composed of a mixture of ts and wild-type (ts+) particles. Six natural ts strains with different shutoff temperatures and one ts+ strain of the H1N1 subtype were tested in antibody-free volunteers. Strains with a shutoff temperature of 38 degrees C or lower caused very mild symptoms, whereas those with a shutoff temperature of 39 degrees C and the ts+ strain were much more reactogenic. By complementation tests against a set of prototype WSN ts mutants with a defined genetic lesion, the ts lesion of two H3N2 viruses (HK/8/68 and Xia-ts) was located on the NP gene and that of two H1N1 viruses (Tianjin/78/77 and Beijing/1/79) was located on the M protein gene. The present study demonstrates the widespread occurrence in nature of influenza viruses of different degrees of temperature sensitivity and presumably of different degrees of virulence.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-title>Journal of Virology</journal-title><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn></journal-meta><article-meta><article-id pub-id-type="pmid">7077746</article-id><article-id pub-id-type="pmc">256765</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Occurrence of temperature-sensitive influenza A viruses in nature.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chu</surname><given-names>C M</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tian</surname><given-names>S F</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ren</surname><given-names>G F</given-names></name></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Y M</given-names></name></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>L X</given-names></name></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>G Q</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><month>2</month><year>1982</year></pub-date><volume>41</volume><issue>2</issue><fpage>353</fpage><lpage>359</lpage><abstract><p>The origin and characteristics of the first naturally occurring temperature-sensitive (ts) strain of influenza A virus identified in 1973, Xia-ts, are described. Natural ts strains were found to occur in the early egg passage material of all influenza A subtypes examined, but the proportion of ts virus varied from 8.3% for old H1N1 virus (1949 to 1957) to 82.4% for recent H3N2 virus (1979 to 1980). A number of strains were found to be composed of a mixture of ts and wild-type (ts+) particles. Six natural ts strains with different shutoff temperatures and one ts+ strain of the H1N1 subtype were tested in antibody-free volunteers. Strains with a shutoff temperature of 38 degrees C or lower caused very mild symptoms, whereas those with a shutoff temperature of 39 degrees C and the ts+ strain were much more reactogenic. By complementation tests against a set of prototype WSN ts mutants with a defined genetic lesion, the ts lesion of two H3N2 viruses (HK/8/68 and Xia-ts) was located on the NP gene and that of two H1N1 viruses (Tianjin/78/77 and Beijing/1/79) was located on the M protein gene. The present study demonstrates the widespread occurrence in nature of influenza viruses of different degrees of temperature sensitivity and presumably of different degrees of virulence.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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