Antiviral therapy and outcomes of influenza requiring hospitalization in Ontario, Canada.
Identifieur interne : 000893 ( Main/Exploration ); précédent : 000892; suivant : 000894Antiviral therapy and outcomes of influenza requiring hospitalization in Ontario, Canada.
Auteurs : Allison Mcgeer [Canada] ; Karen A. Green ; Agron Plevneshi ; Altynay Shigayeva ; Nilofar Siddiqi ; Janet Raboud ; Donald E. LowSource :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2007.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Antiviraux (usage thérapeutique), Enfant (MeSH), Femelle (MeSH), Grippe humaine (mortalité), Grippe humaine (traitement médicamenteux), Hospitalisation (MeSH), Humains (MeSH), Mâle (MeSH), Ontario (MeSH), Résultat thérapeutique (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Surveillance de la population (MeSH), Études de cohortes (MeSH), Études prospectives (MeSH).
- MESH :
- mortalité : Grippe humaine.
- traitement médicamenteux : Grippe humaine.
- usage thérapeutique : Antiviraux.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Femelle, Hospitalisation, Humains, Mâle, Ontario, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Surveillance de la population, Études de cohortes, Études prospectives.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Antiviral Agents (therapeutic use), Child (MeSH), Cohort Studies (MeSH), Female (MeSH), Hospitalization (MeSH), Humans (MeSH), Influenza, Human (drug therapy), Influenza, Human (mortality), Male (MeSH), Middle Aged (MeSH), Ontario (MeSH), Population Surveillance (MeSH), Prospective Studies (MeSH), Treatment Outcome (MeSH).
- MESH :
- chemical , therapeutic use : Antiviral Agents.
- geographic : Ontario.
- drug therapy : Influenza, Human.
- mortality : Influenza, Human.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Cohort Studies, Female, Hospitalization, Humans, Male, Middle Aged, Population Surveillance, Prospective Studies, Treatment Outcome.
Abstract
BACKGROUND
We conducted a prospective cohort study to assess the impact of antiviral therapy on outcomes of patients hospitalized with influenza in southern Ontario, Canada.
METHODS
Patients admitted to Toronto Invasive Bacterial Diseases Network hospitals with laboratory-confirmed influenza from 1 January 2005 through 31 May 2006 were enrolled in the study. Demographic and medical data were collected by patient and physician interview and chart review. The main outcome evaluated was death within 15 days after symptom onset.
RESULTS
Data were available for 512 of 541 eligible patients. There were 185 children (<15 years of age), none of whom died and none of whom were treated with antiviral drugs. The median age of the 327 adults was 77 years (range, 15-98 years), 166 (51%) were male, 245 (75%) had a chronic underlying illness, and 216 (71%) had been vaccinated against influenza. Of the 327 adult patients, 184 (59%) presented to the emergency department within 48 h after symptom onset, 52 (16%) required intensive care unit admission, and 27 (8.3%) died within 15 days after symptom onset. Most patients (292 patients; 89%) received antibacterial therapy; 106 (32%) were prescribed antiviral drugs. Treatment with antiviral drugs active against influenza was associated with a significant reduction in mortality (odds ratio, 0.21; 95% confidence interval, 0.06-0.80; n=100, 260). There was no apparent impact of antiviral therapy on length of stay in survivors.
CONCLUSIONS
There is a significant burden of illness attributable to influenza in this highly vaccinated population. Treatment with antiviral drugs was associated with a significant reduction in mortality.
DOI: 10.1086/523584
PubMed: 18190317
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Green</name></author><author><name sortKey="Plevneshi, Agron" sort="Plevneshi, Agron" uniqKey="Plevneshi A" first="Agron" last="Plevneshi">Agron Plevneshi</name></author><author><name sortKey="Shigayeva, Altynay" sort="Shigayeva, Altynay" uniqKey="Shigayeva A" first="Altynay" last="Shigayeva">Altynay Shigayeva</name></author><author><name sortKey="Siddiqi, Nilofar" sort="Siddiqi, Nilofar" uniqKey="Siddiqi N" first="Nilofar" last="Siddiqi">Nilofar Siddiqi</name></author><author><name sortKey="Raboud, Janet" sort="Raboud, Janet" uniqKey="Raboud J" first="Janet" last="Raboud">Janet Raboud</name></author><author><name sortKey="Low, Donald E" sort="Low, Donald E" uniqKey="Low D" first="Donald E" last="Low">Donald E. Low</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:18190317</idno><idno type="pmid">18190317</idno><idno type="doi">10.1086/523584</idno><idno type="wicri:Area/Main/Corpus">000844</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000844</idno><idno type="wicri:Area/Main/Curation">000844</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000844</idno><idno type="wicri:Area/Main/Exploration">000844</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antiviral therapy and outcomes of influenza requiring hospitalization in Ontario, Canada.</title><author><name sortKey="Mcgeer, Allison" sort="Mcgeer, Allison" uniqKey="Mcgeer A" first="Allison" last="Mcgeer">Allison Mcgeer</name><affiliation wicri:level="1"><nlm:affiliation>Toronto Medical Laboratories and Mount Sinai Hospital, Toronto, ON M5G 1X5 Canada. amcgeer@mtsinai.on.ca</nlm:affiliation><country wicri:rule="url">Canada</country></affiliation></author><author><name sortKey="Green, Karen A" sort="Green, Karen A" uniqKey="Green K" first="Karen A" last="Green">Karen A. Green</name></author><author><name sortKey="Plevneshi, Agron" sort="Plevneshi, Agron" uniqKey="Plevneshi A" first="Agron" last="Plevneshi">Agron Plevneshi</name></author><author><name sortKey="Shigayeva, Altynay" sort="Shigayeva, Altynay" uniqKey="Shigayeva A" first="Altynay" last="Shigayeva">Altynay Shigayeva</name></author><author><name sortKey="Siddiqi, Nilofar" sort="Siddiqi, Nilofar" uniqKey="Siddiqi N" first="Nilofar" last="Siddiqi">Nilofar Siddiqi</name></author><author><name sortKey="Raboud, Janet" sort="Raboud, Janet" uniqKey="Raboud J" first="Janet" last="Raboud">Janet Raboud</name></author><author><name sortKey="Low, Donald E" sort="Low, Donald E" uniqKey="Low D" first="Donald E" last="Low">Donald E. Low</name></author></analytic><series><title level="j">Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</title><idno type="eISSN">1537-6591</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Antiviral Agents (therapeutic use)</term><term>Child (MeSH)</term><term>Cohort Studies (MeSH)</term><term>Female (MeSH)</term><term>Hospitalization (MeSH)</term><term>Humans (MeSH)</term><term>Influenza, Human (drug therapy)</term><term>Influenza, Human (mortality)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Ontario (MeSH)</term><term>Population Surveillance (MeSH)</term><term>Prospective Studies (MeSH)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Antiviraux (usage thérapeutique)</term><term>Enfant (MeSH)</term><term>Femelle (MeSH)</term><term>Grippe humaine (mortalité)</term><term>Grippe humaine (traitement médicamenteux)</term><term>Hospitalisation (MeSH)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Ontario (MeSH)</term><term>Résultat thérapeutique (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Surveillance de la population (MeSH)</term><term>Études de cohortes (MeSH)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Ontario</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Cohort Studies</term><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Population Surveillance</term><term>Prospective Studies</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Enfant</term><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Mâle</term><term>Ontario</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Surveillance de la population</term><term>Études de cohortes</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>We conducted a prospective cohort study to assess the impact of antiviral therapy on outcomes of patients hospitalized with influenza in southern Ontario, Canada.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Patients admitted to Toronto Invasive Bacterial Diseases Network hospitals with laboratory-confirmed influenza from 1 January 2005 through 31 May 2006 were enrolled in the study. Demographic and medical data were collected by patient and physician interview and chart review. The main outcome evaluated was death within 15 days after symptom onset.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Data were available for 512 of 541 eligible patients. There were 185 children (<15 years of age), none of whom died and none of whom were treated with antiviral drugs. The median age of the 327 adults was 77 years (range, 15-98 years), 166 (51%) were male, 245 (75%) had a chronic underlying illness, and 216 (71%) had been vaccinated against influenza. Of the 327 adult patients, 184 (59%) presented to the emergency department within 48 h after symptom onset, 52 (16%) required intensive care unit admission, and 27 (8.3%) died within 15 days after symptom onset. Most patients (292 patients; 89%) received antibacterial therapy; 106 (32%) were prescribed antiviral drugs. Treatment with antiviral drugs active against influenza was associated with a significant reduction in mortality (odds ratio, 0.21; 95% confidence interval, 0.06-0.80; n=100, 260). There was no apparent impact of antiviral therapy on length of stay in survivors.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>There is a significant burden of illness attributable to influenza in this highly vaccinated population. Treatment with antiviral drugs was associated with a significant reduction in mortality.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18190317</PMID><DateCompleted><Year>2008</Year><Month>03</Month><Day>11</Day></DateCompleted><DateRevised><Year>2008</Year><Month>05</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1537-6591</ISSN><JournalIssue CitedMedium="Internet"><Volume>45</Volume><Issue>12</Issue><PubDate><Year>2007</Year><Month>Dec</Month><Day>15</Day></PubDate></JournalIssue><Title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</Title><ISOAbbreviation>Clin. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Antiviral therapy and outcomes of influenza requiring hospitalization in Ontario, Canada.</ArticleTitle><Pagination><MedlinePgn>1568-75</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1086/523584</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">We conducted a prospective cohort study to assess the impact of antiviral therapy on outcomes of patients hospitalized with influenza in southern Ontario, Canada.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Patients admitted to Toronto Invasive Bacterial Diseases Network hospitals with laboratory-confirmed influenza from 1 January 2005 through 31 May 2006 were enrolled in the study. Demographic and medical data were collected by patient and physician interview and chart review. The main outcome evaluated was death within 15 days after symptom onset.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Data were available for 512 of 541 eligible patients. There were 185 children (<15 years of age), none of whom died and none of whom were treated with antiviral drugs. The median age of the 327 adults was 77 years (range, 15-98 years), 166 (51%) were male, 245 (75%) had a chronic underlying illness, and 216 (71%) had been vaccinated against influenza. Of the 327 adult patients, 184 (59%) presented to the emergency department within 48 h after symptom onset, 52 (16%) required intensive care unit admission, and 27 (8.3%) died within 15 days after symptom onset. Most patients (292 patients; 89%) received antibacterial therapy; 106 (32%) were prescribed antiviral drugs. Treatment with antiviral drugs active against influenza was associated with a significant reduction in mortality (odds ratio, 0.21; 95% confidence interval, 0.06-0.80; n=100, 260). There was no apparent impact of antiviral therapy on length of stay in survivors.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">There is a significant burden of illness attributable to influenza in this highly vaccinated population. Treatment with antiviral drugs was associated with a significant reduction in mortality.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>McGeer</LastName><ForeName>Allison</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Toronto Medical Laboratories and Mount Sinai Hospital, Toronto, ON M5G 1X5 Canada. amcgeer@mtsinai.on.ca</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Green</LastName><ForeName>Karen A</ForeName><Initials>KA</Initials></Author><Author ValidYN="Y"><LastName>Plevneshi</LastName><ForeName>Agron</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Shigayeva</LastName><ForeName>Altynay</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Siddiqi</LastName><ForeName>Nilofar</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Raboud</LastName><ForeName>Janet</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Low</LastName><ForeName>Donald E</ForeName><Initials>DE</Initials></Author><Author ValidYN="Y"><CollectiveName>Toronto Invasive Bacterial Diseases Network</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Infect Dis</MedlineTA><NlmUniqueID>9203213</NlmUniqueID><ISSNLinking>1058-4838</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Clin Infect Dis. 2008 May 15;46(10):1628-9; author reply 1629-30</RefSource><PMID Version="1">18419504</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Clin Infect Dis. 2008 Apr 15;46(8):1323-4</RefSource><PMID Version="1">18444878</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009864" MajorTopicYN="N" Type="Geographic">Ontario</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011159" MajorTopicYN="N">Population Surveillance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>1</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>3</Month><Day>12</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>1</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18190317</ArticleId><ArticleId IdType="doi">10.1086/523584</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Green, Karen A" sort="Green, Karen A" uniqKey="Green K" first="Karen A" last="Green">Karen A. Green</name><name sortKey="Low, Donald E" sort="Low, Donald E" uniqKey="Low D" first="Donald E" last="Low">Donald E. Low</name><name sortKey="Plevneshi, Agron" sort="Plevneshi, Agron" uniqKey="Plevneshi A" first="Agron" last="Plevneshi">Agron Plevneshi</name><name sortKey="Raboud, Janet" sort="Raboud, Janet" uniqKey="Raboud J" first="Janet" last="Raboud">Janet Raboud</name><name sortKey="Shigayeva, Altynay" sort="Shigayeva, Altynay" uniqKey="Shigayeva A" first="Altynay" last="Shigayeva">Altynay Shigayeva</name><name sortKey="Siddiqi, Nilofar" sort="Siddiqi, Nilofar" uniqKey="Siddiqi N" first="Nilofar" last="Siddiqi">Nilofar Siddiqi</name></noCountry><country name="Canada"><noRegion><name sortKey="Mcgeer, Allison" sort="Mcgeer, Allison" uniqKey="Mcgeer A" first="Allison" last="Mcgeer">Allison Mcgeer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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