Salivary concentration of free LL-37 in edentulism, chronic periodontitis and healthy periodontium.
Identifieur interne : 000B82 ( PubMed/Corpus ); précédent : 000B81; suivant : 000B83Salivary concentration of free LL-37 in edentulism, chronic periodontitis and healthy periodontium.
Auteurs : Sotiria Davidopoulou ; Eudoxia Diza ; Dimitra Sakellari ; George Menexes ; Sotirios KalfasSource :
- Archives of oral biology [ 1879-1506 ] ; 2013.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Antimicrobial Cationic Peptides (analysis), Chronic Periodontitis (metabolism), Female, Humans, Male, Middle Aged, Mouth, Edentulous (metabolism), Multigene Family, Periodontium (metabolism), Saliva (chemistry), Salivary Proteins and Peptides (analysis), Sex Factors, Young Adult.
- MESH :
- chemical , analysis : Antimicrobial Cationic Peptides, Salivary Proteins and Peptides.
- chemistry : Saliva.
- metabolism : Chronic Periodontitis, Mouth, Edentulous, Periodontium.
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Multigene Family, Sex Factors, Young Adult.
Abstract
The antimicrobial peptide LL-37, a component of innate immunity, has an important role in maintaining oral health. This study aimed to investigate the concentration of free LL-37 in whole saliva of periodontally healthy, edentulous and chronic periodontitis subjects.
DOI: 10.1016/j.archoralbio.2013.01.003
PubMed: 23778112
Links to Exploration step
pubmed:23778112Le document en format XML
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<author><name sortKey="Davidopoulou, Sotiria" sort="Davidopoulou, Sotiria" uniqKey="Davidopoulou S" first="Sotiria" last="Davidopoulou">Sotiria Davidopoulou</name>
<affiliation><nlm:affiliation>School of Dentistry, Department of Preventive Dentistry, Periodontology and Implant Biology, Aristotle University of Thessaloniki, Greece. sotiria@davidopoulou.gr</nlm:affiliation>
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<author><name sortKey="Diza, Eudoxia" sort="Diza, Eudoxia" uniqKey="Diza E" first="Eudoxia" last="Diza">Eudoxia Diza</name>
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<author><name sortKey="Sakellari, Dimitra" sort="Sakellari, Dimitra" uniqKey="Sakellari D" first="Dimitra" last="Sakellari">Dimitra Sakellari</name>
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<author><name sortKey="Menexes, George" sort="Menexes, George" uniqKey="Menexes G" first="George" last="Menexes">George Menexes</name>
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<author><name sortKey="Kalfas, Sotirios" sort="Kalfas, Sotirios" uniqKey="Kalfas S" first="Sotirios" last="Kalfas">Sotirios Kalfas</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Salivary concentration of free LL-37 in edentulism, chronic periodontitis and healthy periodontium.</title>
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<affiliation><nlm:affiliation>School of Dentistry, Department of Preventive Dentistry, Periodontology and Implant Biology, Aristotle University of Thessaloniki, Greece. sotiria@davidopoulou.gr</nlm:affiliation>
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<author><name sortKey="Diza, Eudoxia" sort="Diza, Eudoxia" uniqKey="Diza E" first="Eudoxia" last="Diza">Eudoxia Diza</name>
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<author><name sortKey="Sakellari, Dimitra" sort="Sakellari, Dimitra" uniqKey="Sakellari D" first="Dimitra" last="Sakellari">Dimitra Sakellari</name>
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<author><name sortKey="Menexes, George" sort="Menexes, George" uniqKey="Menexes G" first="George" last="Menexes">George Menexes</name>
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<author><name sortKey="Kalfas, Sotirios" sort="Kalfas, Sotirios" uniqKey="Kalfas S" first="Sotirios" last="Kalfas">Sotirios Kalfas</name>
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<series><title level="j">Archives of oral biology</title>
<idno type="eISSN">1879-1506</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antimicrobial Cationic Peptides (analysis)</term>
<term>Chronic Periodontitis (metabolism)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mouth, Edentulous (metabolism)</term>
<term>Multigene Family</term>
<term>Periodontium (metabolism)</term>
<term>Saliva (chemistry)</term>
<term>Salivary Proteins and Peptides (analysis)</term>
<term>Sex Factors</term>
<term>Young Adult</term>
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<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antimicrobial Cationic Peptides</term>
<term>Salivary Proteins and Peptides</term>
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<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Saliva</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Chronic Periodontitis</term>
<term>Mouth, Edentulous</term>
<term>Periodontium</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multigene Family</term>
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<front><div type="abstract" xml:lang="en">The antimicrobial peptide LL-37, a component of innate immunity, has an important role in maintaining oral health. This study aimed to investigate the concentration of free LL-37 in whole saliva of periodontally healthy, edentulous and chronic periodontitis subjects.</div>
</front>
</TEI>
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<DateCompleted><Year>2014</Year>
<Month>02</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>06</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1506</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>58</Volume>
<Issue>8</Issue>
<PubDate><Year>2013</Year>
<Month>Aug</Month>
</PubDate>
</JournalIssue>
<Title>Archives of oral biology</Title>
<ISOAbbreviation>Arch. Oral Biol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Salivary concentration of free LL-37 in edentulism, chronic periodontitis and healthy periodontium.</ArticleTitle>
<Pagination><MedlinePgn>930-4</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.archoralbio.2013.01.003</ELocationID>
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<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The antimicrobial peptide LL-37, a component of innate immunity, has an important role in maintaining oral health. This study aimed to investigate the concentration of free LL-37 in whole saliva of periodontally healthy, edentulous and chronic periodontitis subjects.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">Unstimulated whole saliva was sampled from 154 subjects (76 periodontally healthy, 20 edentulous, and 58 subjects with chronic periodontitis). All participants were in good general health. The salivary LL-37 was determined by ELISA.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The median salivary concentrations of free LL-37 were 30.5, 22.5, and 1.8ng/ml for the healthy, the chronic periodontitis and the edentulous group, respectively. The differences in concentration between the edentulous and the others were statistically significant (Mann-Whitney test, p<0.001). In the healthy subjects, women displayed significantly higher peptide concentrations compared to men (Mann-Whitney test, p<0.05). The intra-subject variation in LL-37 concentration was wider for the healthy (range 0.75-285ng/ml) and chronic periodontitis patients (range 1-207ng/ml) than for the edentulous subjects (range 0.15-4.4ng/ml).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The present findings show that edentulism correlates with a substantial decrease in salivary levels of free LL-37, thus indicating the considerable contribution of the gingival tissues in the secretion of the peptide in the oral environment.</AbstractText>
<CopyrightInformation>Copyright © 2013 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Davidopoulou</LastName>
<ForeName>Sotiria</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>School of Dentistry, Department of Preventive Dentistry, Periodontology and Implant Biology, Aristotle University of Thessaloniki, Greece. sotiria@davidopoulou.gr</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Diza</LastName>
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<Author ValidYN="Y"><LastName>Sakellari</LastName>
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<Author ValidYN="Y"><LastName>Menexes</LastName>
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<Author ValidYN="Y"><LastName>Kalfas</LastName>
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<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
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<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D009066" MajorTopicYN="N">Mouth, Edentulous</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D005810" MajorTopicYN="Y">Multigene Family</DescriptorName>
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<MeshHeading><DescriptorName UI="D012463" MajorTopicYN="N">Saliva</DescriptorName>
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<MeshHeading><DescriptorName UI="D012737" MajorTopicYN="N">Sex Factors</DescriptorName>
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<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
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