A cohort study of the impact of tooth loss and periodontal disease on respiratory events among COPD subjects: modulatory role of systemic biomarkers of inflammation.
Identifieur interne : 000B81 ( PubMed/Corpus ); précédent : 000B80; suivant : 000B82A cohort study of the impact of tooth loss and periodontal disease on respiratory events among COPD subjects: modulatory role of systemic biomarkers of inflammation.
Auteurs : Silvana P. Barros ; Robert Suruki ; Zvi G. Loewy ; James D. Beck ; Steven OffenbacherSource :
- PloS one [ 1932-6203 ] ; 2013.
English descriptors
- KwdEn :
- Biomarkers (blood), Cohort Studies, Female, Humans, Inflammation (blood), Inflammation (complications), Interleukin-6 (blood), Male, Middle Aged, Mouth, Edentulous (complications), Periodontal Diseases (complications), Proportional Hazards Models, Pulmonary Disease, Chronic Obstructive (blood), Pulmonary Disease, Chronic Obstructive (etiology), Pulmonary Disease, Chronic Obstructive (pathology), Tooth Loss (complications).
- MESH :
- chemical , blood : Biomarkers, Interleukin-6.
- blood : Inflammation, Pulmonary Disease, Chronic Obstructive.
- complications : Inflammation, Mouth, Edentulous, Periodontal Diseases, Tooth Loss.
- etiology : Pulmonary Disease, Chronic Obstructive.
- pathology : Pulmonary Disease, Chronic Obstructive.
- Cohort Studies, Female, Humans, Male, Middle Aged, Proportional Hazards Models.
Abstract
In COPD patients, fatal and non-fatal respiratory-related events are influenced by age, severity of respiratory disease, and comorbidities.
DOI: 10.1371/journal.pone.0068592
PubMed: 23950871
Links to Exploration step
pubmed:23950871Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A cohort study of the impact of tooth loss and periodontal disease on respiratory events among COPD subjects: modulatory role of systemic biomarkers of inflammation.</title><author><name sortKey="Barros, Silvana P" sort="Barros, Silvana P" uniqKey="Barros S" first="Silvana P" last="Barros">Silvana P. Barros</name><affiliation><nlm:affiliation>Department of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Suruki, Robert" sort="Suruki, Robert" uniqKey="Suruki R" first="Robert" last="Suruki">Robert Suruki</name></author><author><name sortKey="Loewy, Zvi G" sort="Loewy, Zvi G" uniqKey="Loewy Z" first="Zvi G" last="Loewy">Zvi G. Loewy</name></author><author><name sortKey="Beck, James D" sort="Beck, James D" uniqKey="Beck J" first="James D" last="Beck">James D. Beck</name></author><author><name sortKey="Offenbacher, Steven" sort="Offenbacher, Steven" uniqKey="Offenbacher S" first="Steven" last="Offenbacher">Steven Offenbacher</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23950871</idno><idno type="pmid">23950871</idno><idno type="doi">10.1371/journal.pone.0068592</idno><idno type="wicri:Area/PubMed/Corpus">000B81</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B81</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A cohort study of the impact of tooth loss and periodontal disease on respiratory events among COPD subjects: modulatory role of systemic biomarkers of inflammation.</title><author><name sortKey="Barros, Silvana P" sort="Barros, Silvana P" uniqKey="Barros S" first="Silvana P" last="Barros">Silvana P. Barros</name><affiliation><nlm:affiliation>Department of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Suruki, Robert" sort="Suruki, Robert" uniqKey="Suruki R" first="Robert" last="Suruki">Robert Suruki</name></author><author><name sortKey="Loewy, Zvi G" sort="Loewy, Zvi G" uniqKey="Loewy Z" first="Zvi G" last="Loewy">Zvi G. Loewy</name></author><author><name sortKey="Beck, James D" sort="Beck, James D" uniqKey="Beck J" first="James D" last="Beck">James D. Beck</name></author><author><name sortKey="Offenbacher, Steven" sort="Offenbacher, Steven" uniqKey="Offenbacher S" first="Steven" last="Offenbacher">Steven Offenbacher</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biomarkers (blood)</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Inflammation (blood)</term><term>Inflammation (complications)</term><term>Interleukin-6 (blood)</term><term>Male</term><term>Middle Aged</term><term>Mouth, Edentulous (complications)</term><term>Periodontal Diseases (complications)</term><term>Proportional Hazards Models</term><term>Pulmonary Disease, Chronic Obstructive (blood)</term><term>Pulmonary Disease, Chronic Obstructive (etiology)</term><term>Pulmonary Disease, Chronic Obstructive (pathology)</term><term>Tooth Loss (complications)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Interleukin-6</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Inflammation</term><term>Pulmonary Disease, Chronic Obstructive</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Inflammation</term><term>Mouth, Edentulous</term><term>Periodontal Diseases</term><term>Tooth Loss</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Pulmonary Disease, Chronic Obstructive</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Pulmonary Disease, Chronic Obstructive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Proportional Hazards Models</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In COPD patients, fatal and non-fatal respiratory-related events are influenced by age, severity of respiratory disease, and comorbidities.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23950871</PMID><DateCompleted><Year>2014</Year><Month>04</Month><Day>30</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>8</Issue><PubDate><Year>2013</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>A cohort study of the impact of tooth loss and periodontal disease on respiratory events among COPD subjects: modulatory role of systemic biomarkers of inflammation.</ArticleTitle><Pagination><MedlinePgn>e68592</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0068592</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In COPD patients, fatal and non-fatal respiratory-related events are influenced by age, severity of respiratory disease, and comorbidities.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Analyze the effects of edentulism, periodontal disease and systemic biomarkers of inflammation on the occurrence of serious fatal and non-fatal respiratory-related events among subjects with COPD.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Cases were identified from Dental Atherosclerosis Risk in Communities study. Edentulism was defined as study participants without any natural teeth or implants. Participants with one or more natural teeth (comprising 11,378 subjects) were studied as dentate subjects. Periodontal disease status among dentate individuals was determined using the consensus definitions published by the joint Center for Disease Control/American Association of Periodontology working group). Adjusted Hazard Models are developed to evaluate the relationship between edentulism/periodontal disease and COPD Related Events. Models were then stratified by GOLD Stage I, II and III/IV. Serum biomarkers were also evaluated to explore the effect of systemic inflammation.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A statistically significant association was found between oral health status and COPD-related events, even adjusting for conditions such as hypertension, smoking and diabetes. Edentulous individuals who had been diagnosed with COPD had a higher incidence and were at greater risk of having a COPD related event (hospitalization and death) than individuals who had teeth and whose mouths had healthy periodontal status. However, being edentulous did not convey excess risk for COPD-related events for those study participants who were classified as GOLD III/IV at baseline. Finally, we showed that individuals who had levels of serum IL-6 in the highest two quartiles were at even higher risk for COPD-related events.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These findings suggest that the risk for COPD-related events after adjusting for potential confounders may be attributable to both edentulism and elevated serum IL-6 levels.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Barros</LastName><ForeName>Silvana P</ForeName><Initials>SP</Initials><AffiliationInfo><Affiliation>Department of Periodontology, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Suruki</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Loewy</LastName><ForeName>Zvi G</ForeName><Initials>ZG</Initials></Author><Author ValidYN="Y"><LastName>Beck</LastName><ForeName>James D</ForeName><Initials>JD</Initials></Author><Author ValidYN="Y"><LastName>Offenbacher</LastName><ForeName>Steven</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>08</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance 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RefType="ErratumIn"><RefSource>PLoS One. 2013;8(8). doi:10.1371/annotation/066cd415-327b-41cb-adce-3db7e5cb527d</RefSource></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName><QualifierName 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MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016388" MajorTopicYN="N">Tooth Loss</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3738507</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>03</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>05</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>8</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>8</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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