Postoperative irradiation after implant placement: A pilot study for prosthetic reconstruction
Identifieur interne : 002F16 ( Pmc/Curation ); précédent : 002F15; suivant : 002F17Postoperative irradiation after implant placement: A pilot study for prosthetic reconstruction
Auteurs : Re-Mee Doh [Corée du Sud] ; Sungtae Kim [Corée du Sud] ; Ki Chang Keum [Corée du Sud] ; Jun Won Kim [Corée du Sud] ; June-Sung Shim [Corée du Sud] ; Han-Sung Jung [Corée du Sud] ; Kyeong-Mee Park [Corée du Sud] ; Moon-Kyu Chung [Corée du Sud]Source :
- The Journal of Advanced Prosthodontics [ 2005-7806 ] ; 2016.
Abstract
On maxillofacial tumor patients, oral implant placement prior to postoperative radiotherapy can shorten the period of prosthetic reconstruction. There is still lack of research on effects of post-implant radiotherapy such as healing process or loading time, which is important for prosthodontic treatment planning. Therefore, this study evaluated the effects of post-implant local irradiation on the osseointegration of implants during different healing stages.
Custom-made implants were placed bilaterally on maxillary posterior edentulous area 4 weeks after extraction of the maxillary first molars in Forty-eight Sprague-Dawley rats. Experimental group (exp.) received radiation after implant surgery and the other group (control) didn't. Each group was divided into three sub-groups according to the healing time (2, 4, and 8 week) from implant placement. The exp. group 1, 2 received 15-Gy radiation 1 day after implant placement (immediate irradiation). The exp. group 3 received 15-Gy radiation 4 weeks after implant placement (delayed irradiation).
The bone mineral density (BMD) was significantly lower in the immediate irradiation groups. BMD was similar in the delayed irradiation group and the control group. The irradiated groups exhibited a lower bone-to-implant contact ratio, although the difference was not statistically significant. The irradiated groups also exhibited a significantly lower bone volume and higher empty lacuna count than the control groups. No implant failure due to local irradiation was found in this study.
Within the limits of this study, the timing of local irradiation critically influences the bone healing mechanism, which is related to loading time of prostheses.
Url:
DOI: 10.4047/jap.2016.8.5.363
PubMed: 27826386
PubMed Central: 5099128
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002F16
Links to Exploration step
PMC:5099128Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Postoperative irradiation after implant placement: A pilot study for prosthetic reconstruction</title><author><name sortKey="Doh, Re Mee" sort="Doh, Re Mee" uniqKey="Doh R" first="Re-Mee" last="Doh">Re-Mee Doh</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Advanced General Dentistry, Dankook University College of Dentistry, Cheonan, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Advanced General Dentistry, Dankook University College of Dentistry, Cheonan</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Sungtae" sort="Kim, Sungtae" uniqKey="Kim S" first="Sungtae" last="Kim">Sungtae Kim</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Keum, Ki Chang" sort="Keum, Ki Chang" uniqKey="Keum K" first="Ki Chang" last="Keum">Ki Chang Keum</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Jun Won" sort="Kim, Jun Won" uniqKey="Kim J" first="Jun Won" last="Kim">Jun Won Kim</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Shim, June Sung" sort="Shim, June Sung" uniqKey="Shim J" first="June-Sung" last="Shim">June-Sung Shim</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, Yonsei University College of Dentistry, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Jung, Han Sung" sort="Jung, Han Sung" uniqKey="Jung H" first="Han-Sung" last="Jung">Han-Sung Jung</name><affiliation wicri:level="1"><nlm:aff id="A5">Division in Anatomy and Development Biology, Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Division in Anatomy and Development Biology, Department of Oral Biology, Yonsei University College of Dentistry, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Park, Kyeong Mee" sort="Park, Kyeong Mee" uniqKey="Park K" first="Kyeong-Mee" last="Park">Kyeong-Mee Park</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Advanced General Dentistry, Yonsei University College of Dentistry, Seoul, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Advanced General Dentistry, Yonsei University College of Dentistry, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Chung, Moon Kyu" sort="Chung, Moon Kyu" uniqKey="Chung M" first="Moon-Kyu" last="Chung">Moon-Kyu Chung</name><affiliation wicri:level="1"><nlm:aff id="A5">Division in Anatomy and Development Biology, Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Division in Anatomy and Development Biology, Department of Oral Biology, Yonsei University College of Dentistry, Seoul</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27826386</idno><idno type="pmc">5099128</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099128</idno><idno type="RBID">PMC:5099128</idno><idno type="doi">10.4047/jap.2016.8.5.363</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002F16</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002F16</idno><idno type="wicri:Area/Pmc/Curation">002F16</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002F16</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Postoperative irradiation after implant placement: A pilot study for prosthetic reconstruction</title><author><name sortKey="Doh, Re Mee" sort="Doh, Re Mee" uniqKey="Doh R" first="Re-Mee" last="Doh">Re-Mee Doh</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Advanced General Dentistry, Dankook University College of Dentistry, Cheonan, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Advanced General Dentistry, Dankook University College of Dentistry, Cheonan</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Sungtae" sort="Kim, Sungtae" uniqKey="Kim S" first="Sungtae" last="Kim">Sungtae Kim</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Keum, Ki Chang" sort="Keum, Ki Chang" uniqKey="Keum K" first="Ki Chang" last="Keum">Ki Chang Keum</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Jun Won" sort="Kim, Jun Won" uniqKey="Kim J" first="Jun Won" last="Kim">Jun Won Kim</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, Yonsei University College of Medicine, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Shim, June Sung" sort="Shim, June Sung" uniqKey="Shim J" first="June-Sung" last="Shim">June-Sung Shim</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, Yonsei University College of Dentistry, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Jung, Han Sung" sort="Jung, Han Sung" uniqKey="Jung H" first="Han-Sung" last="Jung">Han-Sung Jung</name><affiliation wicri:level="1"><nlm:aff id="A5">Division in Anatomy and Development Biology, Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Division in Anatomy and Development Biology, Department of Oral Biology, Yonsei University College of Dentistry, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Park, Kyeong Mee" sort="Park, Kyeong Mee" uniqKey="Park K" first="Kyeong-Mee" last="Park">Kyeong-Mee Park</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Advanced General Dentistry, Yonsei University College of Dentistry, Seoul, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Advanced General Dentistry, Yonsei University College of Dentistry, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Chung, Moon Kyu" sort="Chung, Moon Kyu" uniqKey="Chung M" first="Moon-Kyu" last="Chung">Moon-Kyu Chung</name><affiliation wicri:level="1"><nlm:aff id="A5">Division in Anatomy and Development Biology, Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Republic of Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Division in Anatomy and Development Biology, Department of Oral Biology, Yonsei University College of Dentistry, Seoul</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Journal of Advanced Prosthodontics</title><idno type="ISSN">2005-7806</idno><idno type="eISSN">2005-7814</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>PURPOSE</title><p>On maxillofacial tumor patients, oral implant placement prior to postoperative radiotherapy can shorten the period of prosthetic reconstruction. There is still lack of research on effects of post-implant radiotherapy such as healing process or loading time, which is important for prosthodontic treatment planning. Therefore, this study evaluated the effects of post-implant local irradiation on the osseointegration of implants during different healing stages.</p></sec><sec><title>MATERIALS AND METHODS</title><p>Custom-made implants were placed bilaterally on maxillary posterior edentulous area 4 weeks after extraction of the maxillary first molars in Forty-eight Sprague-Dawley rats. Experimental group (exp.) received radiation after implant surgery and the other group (control) didn't. Each group was divided into three sub-groups according to the healing time (2, 4, and 8 week) from implant placement. The exp. group 1, 2 received 15-Gy radiation 1 day after implant placement (immediate irradiation). The exp. group 3 received 15-Gy radiation 4 weeks after implant placement (delayed irradiation).</p></sec><sec><title>RESULTS</title><p>The bone mineral density (BMD) was significantly lower in the immediate irradiation groups. BMD was similar in the delayed irradiation group and the control group. The irradiated groups exhibited a lower bone-to-implant contact ratio, although the difference was not statistically significant. The irradiated groups also exhibited a significantly lower bone volume and higher empty lacuna count than the control groups. No implant failure due to local irradiation was found in this study.</p></sec><sec><title>CONCLUSION</title><p>Within the limits of this study, the timing of local irradiation critically influences the bone healing mechanism, which is related to loading time of prostheses.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Schepers, Rh" uniqKey="Schepers R">RH Schepers</name></author><author><name sortKey="Slagter, Ap" uniqKey="Slagter A">AP Slagter</name></author><author><name sortKey="Kaanders, Jh" uniqKey="Kaanders J">JH Kaanders</name></author><author><name sortKey="Van Den Hoogen, Fj" uniqKey="Van Den Hoogen F">FJ van den Hoogen</name></author><author><name sortKey="Merkx, Ma" uniqKey="Merkx M">MA Merkx</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dreizen, S" uniqKey="Dreizen S">S Dreizen</name></author><author><name sortKey="Daly, Te" uniqKey="Daly T">TE Daly</name></author><author><name sortKey="Drane, Jb" uniqKey="Drane J">JB Drane</name></author><author><name sortKey="Brown, Lr" uniqKey="Brown L">LR Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Granstrom, G" uniqKey="Granstrom G">G Granström</name></author><author><name sortKey="Tjellstrom, A" uniqKey="Tjellstrom A">A Tjellström</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sclaroff, A" uniqKey="Sclaroff A">A Sclaroff</name></author><author><name sortKey="Haughey, B" uniqKey="Haughey B">B Haughey</name></author><author><name sortKey="Gay, Wd" uniqKey="Gay W">WD Gay</name></author><author><name sortKey="Paniello, R" uniqKey="Paniello R">R Paniello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schoen, Pj" uniqKey="Schoen P">PJ Schoen</name></author><author><name sortKey="Reintsema, H" uniqKey="Reintsema H">H Reintsema</name></author><author><name sortKey="Raghoebar, Gm" uniqKey="Raghoebar G">GM Raghoebar</name></author><author><name sortKey="Vissink, A" uniqKey="Vissink A">A Vissink</name></author><author><name sortKey="Roodenburg, Jl" uniqKey="Roodenburg J">JL Roodenburg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kwakman, Jm" uniqKey="Kwakman J">JM Kwakman</name></author><author><name sortKey="Freihofer, Hp" uniqKey="Freihofer H">HP Freihofer</name></author><author><name sortKey="Van Waas, Ma" uniqKey="Van Waas M">MA van Waas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brasseur, M" uniqKey="Brasseur M">M Brasseur</name></author><author><name sortKey="Brogniez, V" uniqKey="Brogniez V">V Brogniez</name></author><author><name sortKey="Gregoire, V" uniqKey="Gregoire V">V Grégoire</name></author><author><name sortKey="Reychler, H" uniqKey="Reychler H">H Reychler</name></author><author><name sortKey="Lengele, B" uniqKey="Lengele B">B Lengelé</name></author><author><name sortKey="D Hoore, W" uniqKey="D Hoore W">W D'Hoore</name></author><author><name sortKey="Nyssen Behets, C" uniqKey="Nyssen Behets C">C Nyssen-Behets</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brogniez, V" uniqKey="Brogniez V">V Brogniez</name></author><author><name sortKey="D Hoore, W" uniqKey="D Hoore W">W D'Hoore</name></author><author><name sortKey="Gregoire, V" uniqKey="Gregoire V">V Grégoire</name></author><author><name sortKey="Munting, E" uniqKey="Munting E">E Munting</name></author><author><name sortKey="Reychler, H" uniqKey="Reychler H">H Reychler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brogniez, V" uniqKey="Brogniez V">V Brogniez</name></author><author><name sortKey="Nyssen Behets, C" uniqKey="Nyssen Behets C">C Nyssen-Behets</name></author><author><name sortKey="Gregoire, V" uniqKey="Gregoire V">V Grégoire</name></author><author><name sortKey="Reychler, H" uniqKey="Reychler H">H Reychler</name></author><author><name sortKey="Lengele, B" uniqKey="Lengele B">B Lengelé</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schon, R" uniqKey="Schon R">R Schön</name></author><author><name sortKey="Ohno, K" uniqKey="Ohno K">K Ohno</name></author><author><name sortKey="Kudo, M" uniqKey="Kudo M">M Kudo</name></author><author><name sortKey="Michi, K" uniqKey="Michi K">K Michi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weinlaender, M" uniqKey="Weinlaender M">M Weinlaender</name></author><author><name sortKey="Beumer, J" uniqKey="Beumer J">J Beumer</name></author><author><name sortKey="Kenney, Eb" uniqKey="Kenney E">EB Kenney</name></author><author><name sortKey="Lekovic, V" uniqKey="Lekovic V">V Lekovic</name></author><author><name sortKey="Holmes, R" uniqKey="Holmes R">R Holmes</name></author><author><name sortKey="Moy, Pk" uniqKey="Moy P">PK Moy</name></author><author><name sortKey="Plenk, H" uniqKey="Plenk H">H Plenk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Futami, T" uniqKey="Futami T">T Futami</name></author><author><name sortKey="Fujii, N" uniqKey="Fujii N">N Fujii</name></author><author><name sortKey="Ohnishi, H" uniqKey="Ohnishi H">H Ohnishi</name></author><author><name sortKey="Taguchi, N" uniqKey="Taguchi N">N Taguchi</name></author><author><name sortKey="Kusakari, H" uniqKey="Kusakari H">H Kusakari</name></author><author><name sortKey="Ohshima, H" uniqKey="Ohshima H">H Ohshima</name></author><author><name sortKey="Maeda, T" uniqKey="Maeda T">T Maeda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Del Signore, A" uniqKey="Del Signore A">A Del Signore</name></author><author><name sortKey="De Sanctis, V" uniqKey="De Sanctis V">V De Sanctis</name></author><author><name sortKey="Di Mauro, E" uniqKey="Di Mauro E">E Di Mauro</name></author><author><name sortKey="Negri, R" uniqKey="Negri R">R Negri</name></author><author><name sortKey="Perrone Capano, C" uniqKey="Perrone Capano C">C Perrone-Capano</name></author><author><name sortKey="Paggi, P" uniqKey="Paggi P">P Paggi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jegoux, F" uniqKey="Jegoux F">F Jegoux</name></author><author><name sortKey="Malard, O" uniqKey="Malard O">O Malard</name></author><author><name sortKey="Goyenvalle, E" uniqKey="Goyenvalle E">E Goyenvalle</name></author><author><name sortKey="Aguado, E" uniqKey="Aguado E">E Aguado</name></author><author><name sortKey="Daculsi, G" uniqKey="Daculsi G">G Daculsi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kenzora, Je" uniqKey="Kenzora J">JE Kenzora</name></author><author><name sortKey="Steele, Re" uniqKey="Steele R">RE Steele</name></author><author><name sortKey="Yosipovitch, Zh" uniqKey="Yosipovitch Z">ZH Yosipovitch</name></author><author><name sortKey="Glimcher, Mj" uniqKey="Glimcher M">MJ Glimcher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name></author><author><name sortKey="Park, Yb" uniqKey="Park Y">YB Park</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author><author><name sortKey="Shim, Js" uniqKey="Shim J">JS Shim</name></author><author><name sortKey="Moon, Hs" uniqKey="Moon H">HS Moon</name></author><author><name sortKey="Jung, Hs" uniqKey="Jung H">HS Jung</name></author><author><name sortKey="Chung, Mk" uniqKey="Chung M">MK Chung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andersson, G" uniqKey="Andersson G">G Andersson</name></author><author><name sortKey="Andreasson, L" uniqKey="Andreasson L">L Andreasson</name></author><author><name sortKey="Bjelkengren, G" uniqKey="Bjelkengren G">G Bjelkengren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="August, M" uniqKey="August M">M August</name></author><author><name sortKey="Bast, B" uniqKey="Bast B">B Bast</name></author><author><name sortKey="Jackson, M" uniqKey="Jackson M">M Jackson</name></author><author><name sortKey="Perrott, D" uniqKey="Perrott D">D Perrott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brogniez, V" uniqKey="Brogniez V">V Brogniez</name></author><author><name sortKey="Lejuste, P" uniqKey="Lejuste P">P Lejuste</name></author><author><name sortKey="Pecheur, A" uniqKey="Pecheur A">A Pecheur</name></author><author><name sortKey="Reychler, H" uniqKey="Reychler H">H Reychler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Costantino, Pd" uniqKey="Costantino P">PD Costantino</name></author><author><name sortKey="Friedman, Cd" uniqKey="Friedman C">CD Friedman</name></author><author><name sortKey="Steinberg, Mj" uniqKey="Steinberg M">MJ Steinberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marx, Re" uniqKey="Marx R">RE Marx</name></author><author><name sortKey="Johnson, Rp" uniqKey="Johnson R">RP Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacobsson, Mg" uniqKey="Jacobsson M">MG Jacobsson</name></author><author><name sortKey="Jonsson, Ak" uniqKey="Jonsson A">AK Jönsson</name></author><author><name sortKey="Albrektsson, To" uniqKey="Albrektsson T">TO Albrektsson</name></author><author><name sortKey="Turesson, Ie" uniqKey="Turesson I">IE Turesson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Granstrom, G" uniqKey="Granstrom G">G Granström</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacobsson, M" uniqKey="Jacobsson M">M Jacobsson</name></author><author><name sortKey="Albrektsson, T" uniqKey="Albrektsson T">T Albrektsson</name></author><author><name sortKey="Turesson, I" uniqKey="Turesson I">I Turesson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rebaudi, A" uniqKey="Rebaudi A">A Rebaudi</name></author><author><name sortKey="Koller, B" uniqKey="Koller B">B Koller</name></author><author><name sortKey="Laib, A" uniqKey="Laib A">A Laib</name></author><author><name sortKey="Trisi, P" uniqKey="Trisi P">P Trisi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stoppie, N" uniqKey="Stoppie N">N Stoppie</name></author><author><name sortKey="Van Der Waerden, Jp" uniqKey="Van Der Waerden J">JP van der Waerden</name></author><author><name sortKey="Jansen, Ja" uniqKey="Jansen J">JA Jansen</name></author><author><name sortKey="Duyck, J" uniqKey="Duyck J">J Duyck</name></author><author><name sortKey="Wevers, M" uniqKey="Wevers M">M Wevers</name></author><author><name sortKey="Naert, Ie" uniqKey="Naert I">IE Naert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Todisco, M" uniqKey="Todisco M">M Todisco</name></author><author><name sortKey="Trisi, P" uniqKey="Trisi P">P Trisi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verdonck, Hw" uniqKey="Verdonck H">HW Verdonck</name></author><author><name sortKey="Meijer, Gj" uniqKey="Meijer G">GJ Meijer</name></author><author><name sortKey="Nieman, Fh" uniqKey="Nieman F">FH Nieman</name></author><author><name sortKey="Stoll, C" uniqKey="Stoll C">C Stoll</name></author><author><name sortKey="Riediger, D" uniqKey="Riediger D">D Riediger</name></author><author><name sortKey="De Baat, C" uniqKey="De Baat C">C de Baat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aitasalo, K" uniqKey="Aitasalo K">K Aitasalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fujii, N" uniqKey="Fujii N">N Fujii</name></author><author><name sortKey="Kusakari, H" uniqKey="Kusakari H">H Kusakari</name></author><author><name sortKey="Maeda, T" uniqKey="Maeda T">T Maeda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haga, M" uniqKey="Haga M">M Haga</name></author><author><name sortKey="Fujii, N" uniqKey="Fujii N">N Fujii</name></author><author><name sortKey="Nozawa Inoue, K" uniqKey="Nozawa Inoue K">K Nozawa-Inoue</name></author><author><name sortKey="Nomura, S" uniqKey="Nomura S">S Nomura</name></author><author><name sortKey="Oda, K" uniqKey="Oda K">K Oda</name></author><author><name sortKey="Uoshima, K" uniqKey="Uoshima K">K Uoshima</name></author><author><name sortKey="Maeda, T" uniqKey="Maeda T">T Maeda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Friedrich, Re" uniqKey="Friedrich R">RE Friedrich</name></author><author><name sortKey="Todorovic, M" uniqKey="Todorovic M">M Todorovic</name></author><author><name sortKey="Krull, A" uniqKey="Krull A">A Krüll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schoen, Pj" uniqKey="Schoen P">PJ Schoen</name></author><author><name sortKey="Raghoebar, Gm" uniqKey="Raghoebar G">GM Raghoebar</name></author><author><name sortKey="Van Oort, Rp" uniqKey="Van Oort R">RP van Oort</name></author><author><name sortKey="Reintsema, H" uniqKey="Reintsema H">H Reintsema</name></author><author><name sortKey="Van Der Laan, Bf" uniqKey="Van Der Laan B">BF van der Laan</name></author><author><name sortKey="Burlage, Fr" uniqKey="Burlage F">FR Burlage</name></author><author><name sortKey="Roodenburg, Jl" uniqKey="Roodenburg J">JL Roodenburg</name></author><author><name sortKey="Vissink, A" uniqKey="Vissink A">A Vissink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Friedrich, Re" uniqKey="Friedrich R">RE Friedrich</name></author><author><name sortKey="Todorovic, M" uniqKey="Todorovic M">M Todorovic</name></author><author><name sortKey="Heiland, M" uniqKey="Heiland M">M Heiland</name></author><author><name sortKey="Scheuer, Ha" uniqKey="Scheuer H">HA Scheuer</name></author><author><name sortKey="Krull, A" uniqKey="Krull A">A Krüll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, R" uniqKey="Wang R">R Wang</name></author><author><name sortKey="Pillai, K" uniqKey="Pillai K">K Pillai</name></author><author><name sortKey="Jones, Pk" uniqKey="Jones P">PK Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stoll, P" uniqKey="Stoll P">P Stoll</name></author><author><name sortKey="W Chter, R" uniqKey="W Chter R">R Wächter</name></author><author><name sortKey="Hodapp, N" uniqKey="Hodapp N">N Hodapp</name></author><author><name sortKey="Schilli, W" uniqKey="Schilli W">W Schilli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pekmezci, M" uniqKey="Pekmezci M">M Pekmezci</name></author><author><name sortKey="Dirican, B" uniqKey="Dirican B">B Dirican</name></author><author><name sortKey="Yapici, B" uniqKey="Yapici B">B Yapici</name></author><author><name sortKey="Yazici, M" uniqKey="Yazici M">M Yazici</name></author><author><name sortKey="Alanay, A" uniqKey="Alanay A">A Alanay</name></author><author><name sortKey="Gurdalli, S" uniqKey="Gurdalli S">S Gürdalli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Granstrom, G" uniqKey="Granstrom G">G Granström</name></author><author><name sortKey="Jacobsson, M" uniqKey="Jacobsson M">M Jacobsson</name></author><author><name sortKey="Tjellstrom, A" uniqKey="Tjellstrom A">A Tjellström</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Adv Prosthodont</journal-id><journal-id journal-id-type="iso-abbrev">J Adv Prosthodont</journal-id><journal-id journal-id-type="publisher-id">JAP</journal-id><journal-title-group><journal-title>The Journal of Advanced Prosthodontics</journal-title></journal-title-group><issn pub-type="ppub">2005-7806</issn><issn pub-type="epub">2005-7814</issn><publisher><publisher-name>The Korean Academy of Prosthodontics</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27826386</article-id><article-id pub-id-type="pmc">5099128</article-id><article-id pub-id-type="doi">10.4047/jap.2016.8.5.363</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Postoperative irradiation after implant placement: A pilot study for prosthetic reconstruction</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0001-8512-9134</contrib-id><name><surname>Doh</surname><given-names>Re-Mee</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Kim</surname><given-names>Sungtae</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Keum</surname><given-names>Ki Chang</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Jun Won</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Shim</surname><given-names>June-Sung</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Jung</surname><given-names>Han-Sung</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Kyeong-Mee</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Chung</surname><given-names>Moon-Kyu</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Advanced General Dentistry, Dankook University College of Dentistry, Cheonan, Republic of Korea.</aff><aff id="A2"><label>2</label>Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, Seoul, Republic of Korea.</aff><aff id="A3"><label>3</label>Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Republic of Korea.</aff><aff id="A4"><label>4</label>Department of Prosthodontics, Yonsei University College of Dentistry, Seoul, Republic of Korea.</aff><aff id="A5"><label>5</label>Division in Anatomy and Development Biology, Department of Oral Biology, Yonsei University College of Dentistry, Seoul, Republic of Korea.</aff><aff id="A6"><label>6</label>Department of Advanced General Dentistry, Yonsei University College of Dentistry, Seoul, Republic of Korea.</aff><author-notes><corresp>Corresponding author: Moon-Kyu Chung. Department of Prosthodontics, Yonsei University College of Dentistry, 250 Seongsan-ro, Seodaemun-gu, Seoul 03722, Republic of Korea. Tel. +82222288162: <email>mkchung@yuhs.ac</email></corresp><corresp>Corresponding author: Sungtae Kim. Department of Periodontology, Dental Research Institute, Seoul National University School of Dentistry, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea. Tel. +82220724712: <email>kst72@snu.ac.kr</email></corresp></author-notes><pub-date pub-type="ppub"><month>10</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>21</day><month>10</month><year>2016</year></pub-date><volume>8</volume><issue>5</issue><fpage>363</fpage><lpage>371</lpage><history><date date-type="received"><day>29</day><month>2</month><year>2016</year></date><date date-type="rev-recd"><day>08</day><month>6</month><year>2016</year></date><date date-type="accepted"><day>08</day><month>8</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 The Korean Academy of Prosthodontics</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec><title>PURPOSE</title><p>On maxillofacial tumor patients, oral implant placement prior to postoperative radiotherapy can shorten the period of prosthetic reconstruction. There is still lack of research on effects of post-implant radiotherapy such as healing process or loading time, which is important for prosthodontic treatment planning. Therefore, this study evaluated the effects of post-implant local irradiation on the osseointegration of implants during different healing stages.</p></sec><sec><title>MATERIALS AND METHODS</title><p>Custom-made implants were placed bilaterally on maxillary posterior edentulous area 4 weeks after extraction of the maxillary first molars in Forty-eight Sprague-Dawley rats. Experimental group (exp.) received radiation after implant surgery and the other group (control) didn't. Each group was divided into three sub-groups according to the healing time (2, 4, and 8 week) from implant placement. The exp. group 1, 2 received 15-Gy radiation 1 day after implant placement (immediate irradiation). The exp. group 3 received 15-Gy radiation 4 weeks after implant placement (delayed irradiation).</p></sec><sec><title>RESULTS</title><p>The bone mineral density (BMD) was significantly lower in the immediate irradiation groups. BMD was similar in the delayed irradiation group and the control group. The irradiated groups exhibited a lower bone-to-implant contact ratio, although the difference was not statistically significant. The irradiated groups also exhibited a significantly lower bone volume and higher empty lacuna count than the control groups. No implant failure due to local irradiation was found in this study.</p></sec><sec><title>CONCLUSION</title><p>Within the limits of this study, the timing of local irradiation critically influences the bone healing mechanism, which is related to loading time of prostheses.</p></sec></abstract><kwd-group><kwd>Postoperative radiotherapy</kwd><kwd>Head and neck cancer</kwd><kwd>Local irradiation</kwd><kwd>Implant</kwd><kwd>Empty lacuna</kwd></kwd-group><funding-group><award-group><funding-source country="KR"><institution-wrap><institution>National Research Foundation of Korea</institution><institution-id institution-id-type="CrossRef">http://dx.doi.org/10.13039/501100003725</institution-id></institution-wrap></funding-source><award-id>NRF-2013R1A1A1008441</award-id></award-group></funding-group></article-meta></front><floats-group><fig id="F1" orientation="portrait" position="float"><label>Fig. 1</label><caption><title>Surgical procedures. (A) Maxillary first molar of the rat (white arrow). (B) Implant was placed in the first molar space after 4-week later (white arrow).</title></caption><graphic xlink:href="jap-8-363-g001"></graphic></fig><fig id="F2" orientation="portrait" position="float"><label>Fig. 2</label><caption><title>Local irradiation procedures. (A, B) Verifying radiation fields using an external beam simulator (Nucletron, Veenendaal, the Netherlands). (C, D) Radiation administration using a 6.0-MV linear accelerator (Elekta, Stockholm, Sweden) to marked position (white arrow). Field size of 2 × 2 cm (see light window).</title></caption><graphic xlink:href="jap-8-363-g002"></graphic></fig><fig id="F3" orientation="portrait" position="float"><label>Fig. 3</label><caption><title>Microcomputed tomography analysis. (A) Three-dimensional (3D) image reconstruction using OnDemand 3D software. (B) Bone mineral density (BMD) in the region of interest (ROI). Red stars indicate a significant difference between the exp. and control groups (<italic>P</italic> < .05); orange stars indicate a significant difference between the control groups (<italic>P</italic> < .05).</title></caption><graphic xlink:href="jap-8-363-g003"></graphic></fig><fig id="F4" orientation="portrait" position="float"><label>Fig. 4</label><caption><title>Histologic images of the implant sites. Upper: Hematoxylin-and-eosin (H&E)-stained images at lower magnification (12.5×). Scale bar = 500 µm. A - C: Exp. groups. D - F: Control groups. A, D: 2 weeks after implant placement. B, E: 4 weeks after implant placement. C, F: 8 weeks after implant placement. Black arrows indicate empty lacunae (H&E, original magnification 100×. Scale bar = 200 µm).</title></caption><graphic xlink:href="jap-8-363-g004"></graphic></fig><fig id="F5" orientation="portrait" position="float"><label>Fig. 5</label><caption><title>Fluorescence microscopic images of the implant sites. (A) H&E-stained image, green and red emitting regions ofexp. group 3. (B) H&E-stained image, green and red emitting regions of control group 3. Injection time of fluorescence expression agents after implant surgery are shown on the upper left (original magnification 50×. Scale bar = 200 µm).</title></caption><graphic xlink:href="jap-8-363-g005"></graphic></fig><table-wrap id="T1" orientation="portrait" position="float"><label>Table 1</label><caption><title>Experimental design protocol</title></caption><alternatives><graphic xlink:href="jap-8-363-i001"></graphic><table frame="hsides" rules="rows"><col width="25%" span="1"></col><col width="25%" span="1"></col><col width="25%" span="1"></col><col width="25%" span="1"></col><thead><tr><th valign="middle" align="center" rowspan="1" colspan="1">Radiation</th><th valign="middle" align="center" rowspan="1" colspan="1">Group</th><th valign="middle" align="center" rowspan="1" colspan="1">Irradiation (after implant surgery)</th><th valign="middle" align="center" rowspan="1" colspan="1">Healing (after Implant surgery)</th></tr></thead><tbody><tr><td valign="top" align="center" rowspan="1" colspan="1">Yes</td><td valign="top" align="left" rowspan="1" colspan="1">Exp. 1 (n = 8)</td><td valign="top" align="left" rowspan="1" colspan="1">1 day</td><td valign="top" align="left" rowspan="1" colspan="1">2 weeks</td></tr><tr><td valign="top" align="center" rowspan="1" colspan="1">Yes</td><td valign="top" align="left" rowspan="1" colspan="1">Exp. 2 (n = 8)</td><td valign="top" align="left" rowspan="1" colspan="1">1 day</td><td valign="top" align="left" rowspan="1" colspan="1">4 weeks</td></tr><tr><td valign="top" align="center" rowspan="1" colspan="1">Yes</td><td valign="top" align="left" rowspan="1" colspan="1">Exp. 3 (n = 8)</td><td valign="top" align="left" rowspan="1" colspan="1">4 weeks</td><td valign="top" align="left" rowspan="1" colspan="1">8 weeks</td></tr><tr><td valign="top" align="center" rowspan="1" colspan="1">No</td><td valign="top" align="left" rowspan="1" colspan="1">Control 1 (n = 8)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">2 weeks</td></tr><tr><td valign="top" align="center" rowspan="1" colspan="1">No</td><td valign="top" align="left" rowspan="1" colspan="1">Control 2 (n = 8)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">4 weeks</td></tr><tr><td valign="top" align="center" rowspan="1" colspan="1">No</td><td valign="top" align="left" rowspan="1" colspan="1">Control 3 (n = 8)</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">8 weeks</td></tr></tbody></table></alternatives></table-wrap><table-wrap id="T2" orientation="portrait" position="float"><label>Table 2</label><caption><title>Radiologic and histometric results for bone mineral density (BMD), bone-to-implant contact (BIC), bone area (bone volume/tissue volume), and empty lacuna count (number of empty lacunae/bone volume). Data are mean ± SD values</title></caption><alternatives><graphic xlink:href="jap-8-363-i002"></graphic><table frame="hsides" rules="rows"><col width="20%" span="1"></col><col width="20%" span="1"></col><col width="20%" span="1"></col><col width="20%" span="1"></col><col width="20%" span="1"></col><thead><tr><th valign="top" align="center" rowspan="2" colspan="1"></th><th valign="top" align="center" rowspan="1" colspan="4">Sacrifice time after implantation</th></tr><tr><th valign="middle" align="center" rowspan="1" colspan="1">Group</th><th valign="middle" align="center" rowspan="1" colspan="1">2 weeks</th><th valign="top" align="center" rowspan="1" colspan="1">4 weeks</th><th valign="middle" align="center" rowspan="1" colspan="1">8 weeks</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="3" colspan="1">BMD</td><td valign="top" align="left" rowspan="1" colspan="1">Exp.</td><td valign="top" align="center" rowspan="1" colspan="1">817.7 ± 825.1<sup>*</sup></td><td valign="top" align="center" rowspan="1" colspan="1">1685.1 ± 1094.5*</td><td valign="top" align="center" rowspan="1" colspan="1">2423.2 ± 997.9</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Control</td><td valign="top" align="center" rowspan="1" colspan="1">1443.1 ± 617.5<sup>*</sup></td><td valign="top" align="center" rowspan="1" colspan="1">2593.7 ± 711.4*</td><td valign="top" align="center" rowspan="1" colspan="1">2692 ± 447.9</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>P</italic> value</td><td valign="top" align="center" rowspan="1" colspan="1">.045<sup>*</sup></td><td valign="top" align="center" rowspan="1" colspan="1">.047<sup>*</sup></td><td valign="top" align="center" rowspan="1" colspan="1">.526</td></tr><tr><td valign="top" align="left" rowspan="3" colspan="1">BIC (%)</td><td valign="top" align="left" rowspan="1" colspan="1">Exp.</td><td valign="top" align="center" rowspan="1" colspan="1">18.46 ± 22.14</td><td valign="top" align="center" rowspan="1" colspan="1">21.90 ± 28.25</td><td valign="top" align="center" rowspan="1" colspan="1">44.69 ± 32.88</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Control</td><td valign="top" align="center" rowspan="1" colspan="1">28.74 ± 36.54</td><td valign="top" align="center" rowspan="1" colspan="1">38.29 ± 42.89</td><td valign="top" align="center" rowspan="1" colspan="1">70.25 ± 31.71</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>P</italic> value</td><td valign="top" align="center" rowspan="1" colspan="1">.420</td><td valign="top" align="center" rowspan="1" colspan="1">.393</td><td valign="top" align="center" rowspan="1" colspan="1">.137</td></tr><tr><td valign="top" align="left" rowspan="3" colspan="1">Bone area (%)</td><td valign="top" align="left" rowspan="1" colspan="1">Exp.</td><td valign="top" align="center" rowspan="1" colspan="1">23.77 ± 16.65</td><td valign="top" align="center" rowspan="1" colspan="1">31.20 ± 31.20*</td><td valign="top" align="center" rowspan="1" colspan="1">66.13 ± 15.16*</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Control</td><td valign="top" align="center" rowspan="1" colspan="1">40.20 ± 24.91</td><td valign="top" align="center" rowspan="1" colspan="1">65.77 ± 25.84*</td><td valign="top" align="center" rowspan="1" colspan="1">82.03 ± 13.77*</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>P</italic> value</td><td valign="top" align="center" rowspan="1" colspan="1">.076<sup>**</sup></td><td valign="top" align="center" rowspan="1" colspan="1">.018<sup>*</sup></td><td valign="top" align="center" rowspan="1" colspan="1">.045<sup>*</sup></td></tr><tr><td valign="top" align="left" rowspan="3" colspan="1">Empty lacuna count (%)</td><td valign="top" align="left" rowspan="1" colspan="1">Exp.</td><td valign="top" align="center" rowspan="1" colspan="1">0.0153 ± 0.0086</td><td valign="top" align="center" rowspan="1" colspan="1">0.0273 ± 0.0221**</td><td valign="top" align="center" rowspan="1" colspan="1">0.0242 ± 0.0093*</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Control</td><td valign="top" align="center" rowspan="1" colspan="1">0.013 ± 0.0112</td><td valign="top" align="center" rowspan="1" colspan="1">0.0071 ± 0.0050**</td><td valign="top" align="center" rowspan="1" colspan="1">0.0091 ± 0.0048*</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1"><italic>P</italic> value</td><td valign="top" align="center" rowspan="1" colspan="1">.353</td><td valign="top" align="center" rowspan="1" colspan="1">.051<sup>**</sup></td><td valign="top" align="center" rowspan="1" colspan="1">.003<sup>*</sup></td></tr></tbody></table></alternatives><table-wrap-foot><fn><p><sup>*</sup>Significantly different at <italic>P</italic> < .05</p><p><sup>**</sup>Significantly different at <italic>P</italic> < .10</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002F16 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 002F16 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:5099128
|texte= Postoperative irradiation after implant placement: A pilot study for prosthetic reconstruction
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:27826386" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |