The Mechanical Properties and Biometrical Effect of 3D Preformed Titanium Membrane for Guided Bone Regeneration on Alveolar Bone Defect
Identifieur interne : 002948 ( Pmc/Curation ); précédent : 002947; suivant : 002949The Mechanical Properties and Biometrical Effect of 3D Preformed Titanium Membrane for Guided Bone Regeneration on Alveolar Bone Defect
Auteurs : So-Hyoun Lee [Corée du Sud] ; Jong-Hoon Moon [Corée du Sud] ; Chang-Mo Jeong [Corée du Sud] ; Eun-Bin Bae [Corée du Sud] ; Chung-Eun Park [Corée du Sud] ; Gye-Rok Jeon [Corée du Sud] ; Jin-Ju Lee [Corée du Sud] ; Young-Chan Jeon [Corée du Sud] ; Jung-Bo Huh [Corée du Sud]Source :
- BioMed Research International [ 2314-6133 ] ; 2017.
Abstract
The purpose of this study is to evaluate the effect of three-dimensional preformed titanium membrane (3D-PFTM) to enhance mechanical properties and ability of bone regeneration on the peri-implant bone defect. 3D-PFTMs by new mechanically compressive molding technology and manually shaped- (MS-) PFTMs by hand manipulation were applied in artificial peri-implant bone defect model for static compressive load test and cyclic fatigue load test. In 12 implants installed in the mandibular of three beagle dogs, six 3D-PFTMs, and six collagen membranes (CM) randomly were applied to 2.5 mm peri-implant buccal bone defect with particulate bone graft materials for guided bone regeneration (GBR). The 3D-PFTM group showed about 7.4 times higher mechanical stiffness and 5 times higher fatigue resistance than the MS-PFTM group. The levels of the new bone area (NBA, %), the bone-to-implant contact (BIC, %), distance from the new bone to the old bone (NB-OB, %), and distance from the osseointegration to the old bone (OI-OB, %) were significantly higher in the 3D-PFTM group than the CM group (
Url:
DOI: 10.1155/2017/7102123
PubMed: 29018818
PubMed Central: 5605874
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Dentistry, Pusan National University, Yangsan 50612</wicri:regionArea></affiliation></author><author><name sortKey="Moon, Jong Hoon" sort="Moon, Jong Hoon" uniqKey="Moon J" first="Jong-Hoon" last="Moon">Jong-Hoon Moon</name><affiliation wicri:level="1"><nlm:aff id="I2">Biomedical Engineering, School of Medicine, Pusan National University, Yangsan, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Biomedical Engineering, School of Medicine, Pusan National University, Yangsan</wicri:regionArea></affiliation></author><author><name sortKey="Jeong, Chang Mo" sort="Jeong, Chang Mo" uniqKey="Jeong C" first="Chang-Mo" last="Jeong">Chang-Mo Jeong</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612</wicri:regionArea></affiliation></author><author><name sortKey="Bae, Eun Bin" sort="Bae, Eun Bin" uniqKey="Bae E" first="Eun-Bin" last="Bae">Eun-Bin Bae</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612</wicri:regionArea></affiliation></author><author><name sortKey="Park, Chung Eun" sort="Park, Chung Eun" uniqKey="Park C" first="Chung-Eun" last="Park">Chung-Eun Park</name><affiliation wicri:level="1"><nlm:aff id="I3">School of Dentistry, Pusan National University, Yangsan, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>School of Dentistry, Pusan National University, Yangsan</wicri:regionArea></affiliation></author><author><name sortKey="Jeon, Gye Rok" sort="Jeon, Gye Rok" uniqKey="Jeon G" first="Gye-Rok" last="Jeon">Gye-Rok Jeon</name><affiliation wicri:level="1"><nlm:aff id="I2">Biomedical Engineering, School of Medicine, Pusan National University, Yangsan, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Biomedical Engineering, School of Medicine, Pusan National University, Yangsan</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Jin Ju" sort="Lee, Jin Ju" uniqKey="Lee J" first="Jin-Ju" last="Lee">Jin-Ju Lee</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612</wicri:regionArea></affiliation></author><author><name sortKey="Jeon, Young Chan" sort="Jeon, Young Chan" uniqKey="Jeon Y" first="Young-Chan" last="Jeon">Young-Chan Jeon</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612</wicri:regionArea></affiliation></author><author><name sortKey="Huh, Jung Bo" sort="Huh, Jung Bo" uniqKey="Huh J" first="Jung-Bo" last="Huh">Jung-Bo Huh</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612</wicri:regionArea></affiliation></author></analytic><series><title level="j">BioMed Research International</title><idno type="ISSN">2314-6133</idno><idno type="eISSN">2314-6141</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The purpose of this study is to evaluate the effect of three-dimensional preformed titanium membrane (3D-PFTM) to enhance mechanical properties and ability of bone regeneration on the peri-implant bone defect. 3D-PFTMs by new mechanically compressive molding technology and manually shaped- (MS-) PFTMs by hand manipulation were applied in artificial peri-implant bone defect model for static compressive load test and cyclic fatigue load test. In 12 implants installed in the mandibular of three beagle dogs, six 3D-PFTMs, and six collagen membranes (CM) randomly were applied to 2.5 mm peri-implant buccal bone defect with particulate bone graft materials for guided bone regeneration (GBR). The 3D-PFTM group showed about 7.4 times higher mechanical stiffness and 5 times higher fatigue resistance than the MS-PFTM group. The levels of the new bone area (NBA, %), the bone-to-implant contact (BIC, %), distance from the new bone to the old bone (NB-OB, %), and distance from the osseointegration to the old bone (OI-OB, %) were significantly higher in the 3D-PFTM group than the CM group (<italic>p</italic> < .001). It was verified that the 3D-PFTM increased mechanical properties which were effective in supporting the space maintenance ability and stabilizing the particulate bone grafts, which led to highly efficient bone regeneration.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Br Nemark, P I" uniqKey="Br Nemark P">P. I. Brånemark</name></author><author><name sortKey="Zarb, G A" uniqKey="Zarb G">G. A. Zarb</name></author><author><name sortKey="Albrektsson, T" uniqKey="Albrektsson T">T. Albrektsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Misch, C M" uniqKey="Misch C">C. M. Misch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Enislidis, G" uniqKey="Enislidis G">G. Enislidis</name></author><author><name sortKey="Wittwer, G" uniqKey="Wittwer G">G. Wittwer</name></author><author><name sortKey="Ewers, R" uniqKey="Ewers R">R. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Biomed Res Int</journal-id><journal-id journal-id-type="iso-abbrev">Biomed Res Int</journal-id><journal-id journal-id-type="publisher-id">BMRI</journal-id><journal-title-group><journal-title>BioMed Research International</journal-title></journal-title-group><issn pub-type="ppub">2314-6133</issn><issn pub-type="epub">2314-6141</issn><publisher><publisher-name>Hindawi</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">29018818</article-id><article-id pub-id-type="pmc">5605874</article-id><article-id pub-id-type="doi">10.1155/2017/7102123</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>The Mechanical Properties and Biometrical Effect of 3D Preformed Titanium Membrane for Guided Bone Regeneration on Alveolar Bone Defect</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lee</surname><given-names>So-Hyoun</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Moon</surname><given-names>Jong-Hoon</given-names></name><xref ref-type="aff" rid="I2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jeong</surname><given-names>Chang-Mo</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bae</surname><given-names>Eun-Bin</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Chung-Eun</given-names></name><xref ref-type="aff" rid="I3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jeon</surname><given-names>Gye-Rok</given-names></name><xref ref-type="aff" rid="I2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Jin-Ju</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jeon</surname><given-names>Young-Chan</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-7578-1989</contrib-id><name><surname>Huh</surname><given-names>Jung-Bo</given-names></name><email>huhjb@pusan.ac.kr</email><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib></contrib-group><aff id="I1"><sup>1</sup>Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea</aff><aff id="I2"><sup>2</sup>Biomedical Engineering, School of Medicine, Pusan National University, Yangsan, Republic of Korea</aff><aff id="I3"><sup>3</sup>School of Dentistry, Pusan National University, Yangsan, Republic of Korea</aff><author-notes><fn fn-type="other"><p>Academic Editor: Despina Deligianni</p></fn></author-notes><pub-date pub-type="ppub"><year>2017</year></pub-date><pub-date pub-type="epub"><day>5</day><month>9</month><year>2017</year></pub-date><volume>2017</volume><elocation-id>7102123</elocation-id><history><date date-type="received"><day>28</day><month>3</month><year>2017</year></date><date date-type="accepted"><day>5</day><month>6</month><year>2017</year></date></history><permissions><copyright-statement>Copyright © 2017 So-Hyoun Lee et al.</copyright-statement><copyright-year>2017</copyright-year><license xlink:href="https://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>The purpose of this study is to evaluate the effect of three-dimensional preformed titanium membrane (3D-PFTM) to enhance mechanical properties and ability of bone regeneration on the peri-implant bone defect. 3D-PFTMs by new mechanically compressive molding technology and manually shaped- (MS-) PFTMs by hand manipulation were applied in artificial peri-implant bone defect model for static compressive load test and cyclic fatigue load test. In 12 implants installed in the mandibular of three beagle dogs, six 3D-PFTMs, and six collagen membranes (CM) randomly were applied to 2.5 mm peri-implant buccal bone defect with particulate bone graft materials for guided bone regeneration (GBR). The 3D-PFTM group showed about 7.4 times higher mechanical stiffness and 5 times higher fatigue resistance than the MS-PFTM group. The levels of the new bone area (NBA, %), the bone-to-implant contact (BIC, %), distance from the new bone to the old bone (NB-OB, %), and distance from the osseointegration to the old bone (OI-OB, %) were significantly higher in the 3D-PFTM group than the CM group (<italic>p</italic> < .001). It was verified that the 3D-PFTM increased mechanical properties which were effective in supporting the space maintenance ability and stabilizing the particulate bone grafts, which led to highly efficient bone regeneration.</p></abstract><funding-group><award-group><funding-source>Dental Research Institute</funding-source><award-id>PNUDH DRI-2016-03</award-id></award-group></funding-group></article-meta></front><floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Designs of Ti-membranes. (a) Preformed Ti-membrane (PFTM) designed for the peri-implant buccal bone defect site. (b) Buccal view of deformed PFTM. (c) Lateral view of deformed PFTM (HW, horizontal width; BH, buccal height; BD, buccal depth). (d) 3D preformed Ti-membranes (3D-PFTMs). (e) Manually shaped Ti-membranes (MS-PFTMs).</p></caption><graphic xlink:href="BMRI2017-7102123.001"></graphic></fig><fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label><caption><p>Schematic diagrams of measurements for mechanical properties. (a) The static compressive load test. (b) Assembly of 3D-PFTM or MS-PFTM consisting of PFTM, anchor, and cover cap. (c) The cyclic fatigue load test.</p></caption><graphic xlink:href="BMRI2017-7102123.002"></graphic></fig><fig id="fig3" orientation="portrait" position="float"><label>Figure 3</label><caption><p>Implant surgery and guided bone regeneration procedures for the in vivo study. (a) The buccal open defects 2.5 mm were formed on the mandible of the experiment animal. (b) The implants were placed on the buccal open defects. (c) All the defects were filled with the particulate bone graft materials. (d) The collagen membrane (CM) and 3D preformed Ti-membranes (3D-PFTMs) were placed randomly on the buccal open defects. The 3D-PFTM connected to implant fixture with anchor and cover cap.</p></caption><graphic xlink:href="BMRI2017-7102123.003"></graphic></fig><fig id="fig4" orientation="portrait" position="float"><label>Figure 4</label><caption><p>Parameters measured in the histologic specimens. Red box, the area of interest (AOI was 1 mm horizontally and vertically a range from the horizontal crest of the first thread of the implant to the horizontal crest of the third thread); blue arrow, the horizontal crest of the first thread of the implant (FT); yellow arrow, the most upper point of the new bone (NB); white arrow, the most upper point of the osseointegration site (OI); green arrow, the most upper point of the old bone of AOI (OB).</p></caption><graphic xlink:href="BMRI2017-7102123.004"></graphic></fig><fig id="fig5" orientation="portrait" position="float"><label>Figure 5</label><caption><p>Deformation photographs and stress-strain graphs after static compressive load test. In the 3D-PFTM group, (a) initial state, (b) compressive loading, and (c) primary plastic deformation occurred. In the MS-PFTM group, (d) initial state, (e) compressive loading, and (f) primary plastic deformation occurred. The red (3D-PFTM) and blue (MS-PFTM) arrows in the graph indicated the load at the primary plastic deformation.</p></caption><graphic xlink:href="BMRI2017-7102123.005"></graphic></fig><fig id="fig6" orientation="portrait" position="float"><label>Figure 6</label><caption><p>Deformation photographs and distance-cycles graphs after cyclic fatigue load test. (a) The initial state of 3D-PFTM covering bone grafts filled with artificial bone defects. (b) The original shape of 3D-PFTM was retained after 252,000-cycle fatigue load test (red arrow in the graph). (c) The initial state of 3D-PFTM covering bone grafts filled with artificial bone defects. (d) The original shape of MS-PFTM severely deformed after 51,700-cycle fatigue load test (blue arrow in the graph).</p></caption><graphic xlink:href="BMRI2017-7102123.006"></graphic></fig><fig id="fig7" orientation="portrait" position="float"><label>Figure 7</label><caption><p>The histological images of collagen membrane (CM) group. No membrane was observed in some specimens and the particulate bone graft materials were scattered to bone defect site in peri-implant. Amount of new bone tissues and osseointegration were less. NB, new bone; BGm, bone grafting material; I, implant (H&E stain; magnification 12.5x [left] and 40x [right]).</p></caption><graphic xlink:href="BMRI2017-7102123.007"></graphic></fig><fig id="fig8" orientation="portrait" position="float"><label>Figure 8</label><caption><p>The histological images of 3D-PFTM group. All membrane and the more amounts of the particulate bone graft materials were observed on the bone defect site in peri-implant. New bone formation and osseointegration occurred. NB, new bone; BGm, bone grafting material; I, implant; TiM, Ti-membrane (H&E stain; magnification 12.5x [left] and 40x [right]).</p></caption><graphic xlink:href="BMRI2017-7102123.008"></graphic></fig><fig id="fig9" orientation="portrait" position="float"><label>Figure 9</label><caption><p>Scatter plot and median (the cross) representing graph of the control group (CM) and experimental group (3D-PFTM): (a) the area of newly formed bone tissues (NBA), (b) the remaining area covered by the bone graft substitutes (RBA), (c) bone-to-implant contact within the defect (BIC), (d) distance from the new bone to the old bone (NB-OB), and (e) distance from the osseointegration to the old bone (OI-OB) (<italic>n</italic> = 6). <sup><italic>∗∗∗</italic></sup>Significantly different (<italic>p</italic> < .001).</p></caption><graphic xlink:href="BMRI2017-7102123.009"></graphic></fig><table-wrap id="tab1" orientation="portrait" position="float"><label>Table 1</label><caption><p>Histometric analysis within the area of interest (<italic>n</italic> = 6; %).</p></caption><table frame="hsides" rules="groups"><thead><tr><th colspan="2" align="center" rowspan="1">Group</th><th align="center" rowspan="1" colspan="1">NBA (%)</th><th align="center" rowspan="1" colspan="1">RBA (%)</th><th align="center" rowspan="1" colspan="1">BIC (%)</th><th align="center" rowspan="1" colspan="1">NB-OB (%)</th><th align="center" rowspan="1" colspan="1">OI-OB (%)</th></tr></thead><tbody><tr><td rowspan="2" align="left" colspan="1">CM</td><td align="center" rowspan="1" colspan="1">Mean ± SD</td><td align="center" rowspan="1" colspan="1">4.75 ± 1.16</td><td align="center" rowspan="1" colspan="1">11.11 ± 5.04</td><td align="center" rowspan="1" colspan="1">19.84 ± 4.26</td><td align="center" rowspan="1" colspan="1">27.52 ± 4.61</td><td align="center" rowspan="1" colspan="1">17.84 ± 4.61</td></tr><tr><td align="center" rowspan="1" colspan="1">Median</td><td align="center" rowspan="1" colspan="1">4.83</td><td align="center" rowspan="1" colspan="1">9.98</td><td align="center" rowspan="1" colspan="1">19.60</td><td align="center" rowspan="1" colspan="1">28.35</td><td align="center" rowspan="1" colspan="1">20.61</td></tr><tr><td rowspan="2" align="left" colspan="1">3D-PRTM</td><td align="center" rowspan="1" colspan="1">Mean ± SD</td><td align="center" rowspan="1" colspan="1">35.86 ± 2.65</td><td align="center" rowspan="1" colspan="1">19.35 ± 4.47</td><td align="center" rowspan="1" colspan="1">61.97 ± 4.03</td><td align="center" rowspan="1" colspan="1">70.33 ± 4.94</td><td align="center" rowspan="1" colspan="1">62.00 ± 4.29</td></tr><tr><td align="center" rowspan="1" colspan="1">Median</td><td align="center" rowspan="1" colspan="1">36.03</td><td align="center" rowspan="1" colspan="1">19.89</td><td align="center" rowspan="1" colspan="1">60.53</td><td align="center" rowspan="1" colspan="1">69.10</td><td align="center" rowspan="1" colspan="1">63.50</td></tr><tr><td colspan="2" align="center" rowspan="1"><sup><italic>∗∗∗</italic></sup><italic>p</italic></td><td align="center" rowspan="1" colspan="1"><.001</td><td align="center" rowspan="1" colspan="1"><.001</td><td align="center" rowspan="1" colspan="1"><.001</td><td align="center" rowspan="1" colspan="1"><.001</td><td align="center" rowspan="1" colspan="1"><.001</td></tr></tbody></table><table-wrap-foot><fn><p>CM, collagen membrane; 3D-PFTM, three-dimensional preformed Ti-membrane; NBA, new bone area; RBA, remaining graft bone area; BIC, bone-to-implant contact; NB-OB, distance from the upper point of new bone to the old bone; OI-OB, distance from the upper point of the osseointegration to the old bone. The symbol “<italic>∗∗∗</italic>” indicates statistical significance between the two groups (<italic>p</italic> < .001).</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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