Vitamin C physiology: the known and the unknown and Goldilocks
Identifieur interne : 002789 ( Pmc/Curation ); précédent : 002788; suivant : 002790Vitamin C physiology: the known and the unknown and Goldilocks
Auteurs : Sebastian J. Padayatty ; Mark LevineSource :
- Oral diseases [ 1354-523X ] ; 2016.
Abstract
Vitamin C (Ascorbic Acid), the antiscorbutic vitamin, cannot be synthesized by humans and other primates, and has to be obtained from diet. Ascorbic acid is an electron donor and acts as a cofactor for fifteen mammalian enzymes. Two sodium-dependent transporters are specific for ascorbic acid, and its oxidation product dehydroascorbic acid is transported by glucose transporters. Ascorbic acid is differentially accumulated by most tissues and body fluids. Plasma and tissue vitamin C concentrations are dependent on amount consumed, bioavailability, renal excretion, and utilization. To be biologically meaningful or to be clinically relevant, in vitro and in vivo studies of vitamin C actions have to take into account physiologic concentrations of the vitamin. In this paper, we review vitamin C physiology; the many phenomena involving vitamin C where new knowledge has accrued or where understanding remains limited; raise questions about the vitamin that remain to be answered; and explore lines of investigations that are likely to be fruitful.
Url:
DOI: 10.1111/odi.12446
PubMed: 26808119
PubMed Central: 4959991
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Vitamin C physiology: the known and the unknown and
Goldilocks</title><author><name sortKey="Padayatty, Sebastian J" sort="Padayatty, Sebastian J" uniqKey="Padayatty S" first="Sebastian J" last="Padayatty">Sebastian J. Padayatty</name></author><author><name sortKey="Levine, Mark" sort="Levine, Mark" uniqKey="Levine M" first="Mark" last="Levine">Mark Levine</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26808119</idno><idno type="pmc">4959991</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959991</idno><idno type="RBID">PMC:4959991</idno><idno type="doi">10.1111/odi.12446</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002789</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002789</idno><idno type="wicri:Area/Pmc/Curation">002789</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002789</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Vitamin C physiology: the known and the unknown and
Goldilocks</title><author><name sortKey="Padayatty, Sebastian J" sort="Padayatty, Sebastian J" uniqKey="Padayatty S" first="Sebastian J" last="Padayatty">Sebastian J. Padayatty</name></author><author><name sortKey="Levine, Mark" sort="Levine, Mark" uniqKey="Levine M" first="Mark" last="Levine">Mark Levine</name></author></analytic><series><title level="j">Oral diseases</title><idno type="ISSN">1354-523X</idno><idno type="eISSN">1601-0825</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Vitamin C (Ascorbic Acid), the antiscorbutic vitamin, cannot be
synthesized by humans and other primates, and has to be obtained from diet.
Ascorbic acid is an electron donor and acts as a cofactor for fifteen mammalian
enzymes. Two sodium-dependent transporters are specific for ascorbic acid, and
its oxidation product dehydroascorbic acid is transported by glucose
transporters. Ascorbic acid is differentially accumulated by most tissues and
body fluids. Plasma and tissue vitamin C concentrations are dependent on amount
consumed, bioavailability, renal excretion, and utilization. To be biologically
meaningful or to be clinically relevant, in vitro and in vivo studies of vitamin
C actions have to take into account physiologic concentrations of the vitamin.
In this paper, we review vitamin C physiology; the many phenomena involving
vitamin C where new knowledge has accrued or where understanding remains
limited; raise questions about the vitamin that remain to be answered; and
explore lines of investigations that are likely to be fruitful.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9508565</journal-id><journal-id journal-id-type="pubmed-jr-id">8783</journal-id><journal-id journal-id-type="nlm-ta">Oral Dis</journal-id><journal-id journal-id-type="iso-abbrev">Oral Dis</journal-id><journal-title-group><journal-title>Oral diseases</journal-title></journal-title-group><issn pub-type="ppub">1354-523X</issn><issn pub-type="epub">1601-0825</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26808119</article-id><article-id pub-id-type="pmc">4959991</article-id><article-id pub-id-type="doi">10.1111/odi.12446</article-id><article-id pub-id-type="manuscript">NIHMS754526</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Vitamin C physiology: the known and the unknown and
Goldilocks</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Padayatty</surname><given-names>Sebastian J</given-names></name><degrees>FFARCS, MRCP, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Levine</surname><given-names>Mark</given-names></name><degrees>MD</degrees></contrib><aff id="A1">Molecular and Clinical Nutrition Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1372, USA</aff></contrib-group><author-notes><corresp id="CR1"><italic>Address for Correspondence:</italic> Sebastian J Padayatty
FFARCS, MRCP, PhD, Bldg. 10, Room 4D52 - MSC 1372, Molecular and Clinical
Nutrition Section, Digestive Diseases Branch, National Institute of Diabetes and
Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland
20892-1372, USA, Phone: (301) 496-1069, Fax: (301) 402-6436,
<email>sebastianp@intra.niddk.nih.gov</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>29</day><month>1</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>14</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>9</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>9</month><year>2017</year></pub-date><volume>22</volume><issue>6</issue><fpage>463</fpage><lpage>493</lpage><pmc-comment>elocation-id from pubmed: 10.1111/odi.12446</pmc-comment>
<abstract><p id="P1">Vitamin C (Ascorbic Acid), the antiscorbutic vitamin, cannot be
synthesized by humans and other primates, and has to be obtained from diet.
Ascorbic acid is an electron donor and acts as a cofactor for fifteen mammalian
enzymes. Two sodium-dependent transporters are specific for ascorbic acid, and
its oxidation product dehydroascorbic acid is transported by glucose
transporters. Ascorbic acid is differentially accumulated by most tissues and
body fluids. Plasma and tissue vitamin C concentrations are dependent on amount
consumed, bioavailability, renal excretion, and utilization. To be biologically
meaningful or to be clinically relevant, in vitro and in vivo studies of vitamin
C actions have to take into account physiologic concentrations of the vitamin.
In this paper, we review vitamin C physiology; the many phenomena involving
vitamin C where new knowledge has accrued or where understanding remains
limited; raise questions about the vitamin that remain to be answered; and
explore lines of investigations that are likely to be fruitful.</p></abstract><kwd-group><kwd>Vitamin C</kwd><kwd>Dehydroascorbic Acid</kwd><kwd>Vitamin C Transport</kwd><kwd>Scurvy</kwd><kwd>Dose Concentration Relationship</kwd><kwd>Recommended Dietary Allowance</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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