Mechanism of drug-induced gingival overgrowth revisited: a unifying hypothesis
Identifieur interne : 002788 ( Pmc/Curation ); précédent : 002787; suivant : 002789Mechanism of drug-induced gingival overgrowth revisited: a unifying hypothesis
Auteurs : Rs Brown [États-Unis] ; Pr Arany [États-Unis]Source :
- Oral diseases [ 1354-523X ] ; 2014.
Abstract
Drug-induced gingival overgrowth (DIGO) is a disfiguring side effect of anti-convulsants, calcineurin inhibitors, and calcium channel blocking agents. A unifying hypothesis has been constructed which begins with cation flux inhibition induced by all three of these drug categories. Decreased cation influx of folic acid active transport within gingival fibroblasts leads to decreased cellular folate uptake, which in turn leads to changes in matrix metalloproteinases metabolism and the failure to activate collagenase. Decreased availability of activated collagenase results in decreased degradation of accumulated connective tissue which presents as DIGO. Studies supporting this hypothesis are discussed.
Url:
DOI: 10.1111/odi.12264
PubMed: 24893951
PubMed Central: 5241888
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<front><div type="abstract" xml:lang="en"><p id="P1">Drug-induced gingival overgrowth (DIGO) is a disfiguring side effect of anti-convulsants, calcineurin inhibitors, and calcium channel blocking agents. A unifying hypothesis has been constructed which begins with cation flux inhibition induced by all three of these drug categories. Decreased cation influx of folic acid active transport within gingival fibroblasts leads to decreased cellular folate uptake, which in turn leads to changes in matrix metalloproteinases metabolism and the failure to activate collagenase. Decreased availability of activated collagenase results in decreased degradation of accumulated connective tissue which presents as DIGO. Studies supporting this hypothesis are discussed.</p>
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<aff id="A1"><label>1</label>
Division of Oral Diagnosis, Department of Comprehensive Dentistry, Howard University College of Dentistry, Washington, DC</aff>
<aff id="A2"><label>2</label>
Department of Otolaryngology, Georgetown University Medical Center, Washington, DC</aff>
<aff id="A3"><label>3</label>
Hematology Branch, NHLBI/NIH, Bethesda, MD</aff>
<aff id="A4"><label>4</label>
NIDCR/NIH, Bethesda, MD, USA</aff>
<author-notes><corresp id="cor1">Correspondence: Ronald S. Brown, DDS, MS, Howard University College of Dentistry, 600 W Street, NW, Room 406, Washington, DC 20059, USA. Tel: +202 806 0020, Fax: +202 806 0354, <email>rbrown@howard.edu</email>
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<pub-date pub-type="nihms-submitted"><day>10</day>
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<fpage>e51</fpage>
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<pmc-comment>elocation-id from pubmed: 10.1111/odi.12264</pmc-comment>
<abstract><p id="P1">Drug-induced gingival overgrowth (DIGO) is a disfiguring side effect of anti-convulsants, calcineurin inhibitors, and calcium channel blocking agents. A unifying hypothesis has been constructed which begins with cation flux inhibition induced by all three of these drug categories. Decreased cation influx of folic acid active transport within gingival fibroblasts leads to decreased cellular folate uptake, which in turn leads to changes in matrix metalloproteinases metabolism and the failure to activate collagenase. Decreased availability of activated collagenase results in decreased degradation of accumulated connective tissue which presents as DIGO. Studies supporting this hypothesis are discussed.</p>
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