Dentate transport discs can be used to reconstruct large segmental mandibular defects
Identifieur interne : 002723 ( Pmc/Curation ); précédent : 002722; suivant : 002724Dentate transport discs can be used to reconstruct large segmental mandibular defects
Auteurs : Mohammed E. Elsalanty [États-Unis] ; Veera Malavia [États-Unis] ; Ibrahim Zakhary [États-Unis] ; Timothy Mulone [États-Unis] ; Elias D. Kontogiorgos [États-Unis] ; Paul C. Dechow [États-Unis] ; Lynne A. Opperman [États-Unis]Source :
- Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons [ 0278-2391 ] ; 2014.
Abstract
This study tests the use of a dentate transport segment for the reconstruction of a large U-shaped defect in the anterior segment of the canine mandible, using a novel curved reconstruction plate. The quality and quantity of bone regenerate formed by dentate versus edentulous transport segments was compared.
In five adult foxhound dogs, a defect of 70–75 mm was created in the canine mandible by excising the mandible anterior to the right and left 4th premolars. Reconstruction was done by trifocal distraction osteogenesis using a bone transport reconstruction plate (BTRP-02™), with two transport units being activated simultaneously, one on either side of the defect, one dentate and one edentulous. Bilateral distraction proceeded at a rate of 1mm/day until the segments docked against each other in midline. After 39–44 days consolidation, the animals were euthanized. The quantity and quality of bone regeneration on both sides were compared using micro-computed tomography.
The defect reconstruction was successful. The amount and quality of bone formed by the transport segments was similar on both sides. There were no significant differences in the bone volume fraction and density of the regenerate bone formed by the two transport segments. The bone volume fraction and density of the regenerate was significantly lower than that of the host bone in the distal segments, likely due to the short consolidation period.
Bone transport remains a viable option in reconstructing anterior segmental defects in the mandible. The use of either dentate or edentulous transport segments for reconstruction provides options for the surgeon in often highly compromised patients requiring these surgeries.
Url:
DOI: 10.1016/j.joms.2014.12.002
PubMed: 25661502
PubMed Central: 4369471
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title>
<p id="P1">This study tests the use of a dentate transport segment for the reconstruction of a large U-shaped defect in the anterior segment of the canine mandible, using a novel curved reconstruction plate. The quality and quantity of bone regenerate formed by dentate versus edentulous transport segments was compared.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">In five adult foxhound dogs, a defect of 70–75 mm was created in the canine mandible by excising the mandible anterior to the right and left 4<sup>th</sup>
premolars. Reconstruction was done by trifocal distraction osteogenesis using a bone transport reconstruction plate (BTRP-02™), with two transport units being activated simultaneously, one on either side of the defect, one dentate and one edentulous. Bilateral distraction proceeded at a rate of 1mm/day until the segments docked against each other in midline. After 39–44 days consolidation, the animals were euthanized. The quantity and quality of bone regeneration on both sides were compared using micro-computed tomography.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">The defect reconstruction was successful. The amount and quality of bone formed by the transport segments was similar on both sides. There were no significant differences in the bone volume fraction and density of the regenerate bone formed by the two transport segments. The bone volume fraction and density of the regenerate was significantly lower than that of the host bone in the distal segments, likely due to the short consolidation period.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Bone transport remains a viable option in reconstructing anterior segmental defects in the mandible. The use of either dentate or edentulous transport segments for reconstruction provides options for the surgeon in often highly compromised patients requiring these surgeries.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8206428</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5090</journal-id>
<journal-id journal-id-type="nlm-ta">J Oral Maxillofac Surg</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Oral Maxillofac. Surg.</journal-id>
<journal-title-group><journal-title>Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons</journal-title>
</journal-title-group>
<issn pub-type="ppub">0278-2391</issn>
<issn pub-type="epub">1531-5053</issn>
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<article-meta><article-id pub-id-type="pmid">25661502</article-id>
<article-id pub-id-type="pmc">4369471</article-id>
<article-id pub-id-type="doi">10.1016/j.joms.2014.12.002</article-id>
<article-id pub-id-type="manuscript">NIHMS652719</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Dentate transport discs can be used to reconstruct large segmental mandibular defects</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Elsalanty</surname>
<given-names>Mohammed E.</given-names>
</name>
<degrees>MBBS, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Malavia</surname>
<given-names>Veera</given-names>
</name>
<degrees>DDS</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zakhary</surname>
<given-names>Ibrahim</given-names>
</name>
<degrees>DDS, MSc</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mulone</surname>
<given-names>Timothy</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kontogiorgos</surname>
<given-names>Elias D.</given-names>
</name>
<degrees>DDS, PhD</degrees>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dechow</surname>
<given-names>Paul C.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Opperman</surname>
<given-names>Lynne A.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Associate Professor, Department of Oral Biology and Oral and Maxillofacial Surgery, College of Dental Medicine, Georgia Regents University, Augusta, GA</aff>
<aff id="A2"><label>2</label>
Graduate Student, Department of Biomedical Sciences, Texas A&M University Baylor College of Dentistry, Dallas, TX; Current address: Nova Southeastern University College of Dental Medicine, Fort-Lauderdale-Davie, FL</aff>
<aff id="A3"><label>3</label>
Senior Research Associate, Department of Oral Biology, College of Dental Medicine, Georgia Regents University, Augusta, GA; Current address: Assistant Professor, Department of Oral and Maxillofacial Surgery, University of Detroit Mercy School of Dentistry, Detroit, MI</aff>
<aff id="A4"><label>4</label>
Owner, Craniotech ACR Devices, LLC, Dallas, TX</aff>
<aff id="A5"><label>5</label>
Associate Professor, Department of Restorative Sciences, Texas A&M University Baylor College of Dentistry, Dallas, TX</aff>
<aff id="A6"><label>6</label>
Professor, Department of Biomedical Sciences, Director, Technology Development, Texas A&M University Baylor College of Dentistry, Dallas, TX</aff>
<author-notes><corresp id="cor1">Corresponding Author: Mohammed E. Elsalanty, Associate Professor, Department of Oral Biology And Oral and Maxillofacial Surgery, College of Dental Medicine, Georgia Regents University, 1120 15<sup>th</sup>
Street, Augusta, GA 30809, 706-721-2585, <email>melsalanty@gru.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>23</day>
<month>1</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>13</day>
<month>12</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><month>4</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>4</month>
<year>2016</year>
</pub-date>
<volume>73</volume>
<issue>4</issue>
<fpage>745</fpage>
<lpage>758</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.joms.2014.12.002</pmc-comment>
<permissions><copyright-statement>© 2014 American Association of Oral and Maxillofacial Surgeons. All rights reserved.</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract><sec id="S1"><title>Purpose</title>
<p id="P1">This study tests the use of a dentate transport segment for the reconstruction of a large U-shaped defect in the anterior segment of the canine mandible, using a novel curved reconstruction plate. The quality and quantity of bone regenerate formed by dentate versus edentulous transport segments was compared.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">In five adult foxhound dogs, a defect of 70–75 mm was created in the canine mandible by excising the mandible anterior to the right and left 4<sup>th</sup>
premolars. Reconstruction was done by trifocal distraction osteogenesis using a bone transport reconstruction plate (BTRP-02™), with two transport units being activated simultaneously, one on either side of the defect, one dentate and one edentulous. Bilateral distraction proceeded at a rate of 1mm/day until the segments docked against each other in midline. After 39–44 days consolidation, the animals were euthanized. The quantity and quality of bone regeneration on both sides were compared using micro-computed tomography.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">The defect reconstruction was successful. The amount and quality of bone formed by the transport segments was similar on both sides. There were no significant differences in the bone volume fraction and density of the regenerate bone formed by the two transport segments. The bone volume fraction and density of the regenerate was significantly lower than that of the host bone in the distal segments, likely due to the short consolidation period.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Bone transport remains a viable option in reconstructing anterior segmental defects in the mandible. The use of either dentate or edentulous transport segments for reconstruction provides options for the surgeon in often highly compromised patients requiring these surgeries.</p>
</sec>
</abstract>
<kwd-group><kwd>Bone transport</kwd>
<kwd>distraction osteogenesis</kwd>
<kwd>micro-computed tomography</kwd>
<kwd>bone volume</kwd>
<kwd>density</kwd>
<kwd>dentate</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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