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Bone Induction by Demineralized Dentin Matrix in Nude Mouse Muscles

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Bone Induction by Demineralized Dentin Matrix in Nude Mouse Muscles

Auteurs : Kyung-Wook Kim

Source :

Maxillofacial Plastic and Reconstructive Surgery [ 2288-8101 ] ; 2014.

RBID : PMC:4281903

Abstract

Purpose:

This study examined the osteoinductive activity of demineralized human dentin matrix for nude mice.

Methods:

Twenty healthy nude mice weighing about 15 to 20 g were used for study. Demineralized human dentin matrix was prepared and implanted into the dorsal portion of nude mice (subcutaneous), which were sacrificed at two, four, and eight weeks after demineralized dentin matrix grafting and evaluated histologically by H&E and Masson trichrome staining. The specimens were also evaluated histomorphometrically.

Results:

The demineralized dentin matrix induced bone and cartilage formation independently in soft tissues. Histological examination showed bone-forming cells such as osteoblasts and fibroblasts at two, four, and eight weeks.

Conclusion:

These results suggest that demineralized human dentin matrix has osteoinductive ability, and is a good alternative to autogenous bone graft materials.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281903

DOI: 10.14402/jkamprs.2014.36.2.50
PubMed: 27489810
PubMed Central: 4281903

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<author><name sortKey="Kim, Kyung Wook" sort="Kim, Kyung Wook" uniqKey="Kim K" first="Kyung-Wook" last="Kim">Kyung-Wook Kim</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bone Induction by Demineralized Dentin Matrix in Nude Mouse Muscles</title>
<author><name sortKey="Kim, Kyung Wook" sort="Kim, Kyung Wook" uniqKey="Kim K" first="Kyung-Wook" last="Kim">Kyung-Wook Kim</name>
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<series><title level="j">Maxillofacial Plastic and Reconstructive Surgery</title>
<idno type="ISSN">2288-8101</idno>
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<front><div type="abstract" xml:lang="en"><sec><title>Purpose:</title>
<p>This study examined the osteoinductive activity of demineralized human dentin matrix for nude mice.</p>
</sec>
<sec><title>Methods:</title>
<p>Twenty healthy nude mice weighing about 15 to 20 g were used for study. Demineralized human dentin matrix was prepared and implanted into the dorsal portion of nude mice (subcutaneous), which were sacrificed at two, four, and eight weeks after demineralized dentin matrix grafting and evaluated histologically by H&E and Masson trichrome staining. The specimens were also evaluated histomorphometrically.</p>
</sec>
<sec><title>Results:</title>
<p>The demineralized dentin matrix induced bone and cartilage formation independently in soft tissues. Histological examination showed bone-forming cells such as osteoblasts and fibroblasts at two, four, and eight weeks.</p>
</sec>
<sec><title>Conclusion:</title>
<p>These results suggest that demineralized human dentin matrix has osteoinductive ability, and is a good alternative to autogenous bone graft materials.</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Maxillofac Plast Reconstr Surg</journal-id>
<journal-id journal-id-type="iso-abbrev">Maxillofac Plast Reconstr Surg</journal-id>
<journal-id journal-id-type="publisher-id">MPRS</journal-id>
<journal-title-group><journal-title>Maxillofacial Plastic and Reconstructive Surgery</journal-title>
</journal-title-group>
<issn pub-type="ppub">2288-8101</issn>
<issn pub-type="epub">2288-8586</issn>
<publisher><publisher-name>The Korean Association of Maxillofacial Plastic and Reconstructive Surgeons</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27489810</article-id>
<article-id pub-id-type="pmc">4281903</article-id>
<article-id pub-id-type="doi">10.14402/jkamprs.2014.36.2.50</article-id>
<article-id pub-id-type="publisher-id">mprs-36-050</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Bone Induction by Demineralized Dentin Matrix in Nude Mouse Muscles</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Kyung-Wook</given-names>
</name>
<xref ref-type="corresp" rid="c1-mprs-36-050"></xref>
</contrib>
<aff id="af1-mprs-36-050">Department of Oral and Maxillofacial Surgery, Dankook University College of Dentistry</aff>
</contrib-group>
<author-notes><corresp id="c1-mprs-36-050">Correspondence to <bold>Kyung-Wook Kim</bold>
, Department of Oral and Maxillofacial Surgery, Dankook University College of Dentistry, 119 Dandae-ro, Dongnam-gu, Cheonan 330-714, Korea, Tel: 82-41-550-1994, Fax: 82-41-551-8988, E-mail: <email>kkwoms@dku.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>30</day>
<month>3</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><month>3</month>
<year>2014</year>
</pub-date>
<volume>36</volume>
<issue>2</issue>
<fpage>50</fpage>
<lpage>56</lpage>
<history><date date-type="received"><day>03</day>
<month>2</month>
<year>2014</year>
</date>
<date date-type="rev-recd"><day>17</day>
<month>2</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>17</day>
<month>2</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2014 by The Korean Association of Maxillofacial Plastic and Reconstructive Surgeons. All rights reserved.</copyright-statement>
<copyright-year>2014</copyright-year>
<license><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0">http://creativecommons.org/licenses/by-nc/3.0</ext-link>
) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><sec><title>Purpose:</title>
<p>This study examined the osteoinductive activity of demineralized human dentin matrix for nude mice.</p>
</sec>
<sec><title>Methods:</title>
<p>Twenty healthy nude mice weighing about 15 to 20 g were used for study. Demineralized human dentin matrix was prepared and implanted into the dorsal portion of nude mice (subcutaneous), which were sacrificed at two, four, and eight weeks after demineralized dentin matrix grafting and evaluated histologically by H&E and Masson trichrome staining. The specimens were also evaluated histomorphometrically.</p>
</sec>
<sec><title>Results:</title>
<p>The demineralized dentin matrix induced bone and cartilage formation independently in soft tissues. Histological examination showed bone-forming cells such as osteoblasts and fibroblasts at two, four, and eight weeks.</p>
</sec>
<sec><title>Conclusion:</title>
<p>These results suggest that demineralized human dentin matrix has osteoinductive ability, and is a good alternative to autogenous bone graft materials.</p>
</sec>
</abstract>
<kwd-group><kwd>Dentin</kwd>
<kwd>Demineralized human dentin</kwd>
<kwd>Bone induction</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group><fig id="f1-mprs-36-050" position="float"><label>Fig. 1.</label>
<caption><p>Morphometry of bone-forming cells.</p>
</caption>
<graphic xlink:href="mprs-36-050f1"></graphic>
</fig>
<fig id="f2-mprs-36-050" position="float"><label>Fig. 2.</label>
<caption><p>(A) Histological finding of demineralized dentin matrix (DDM) after 2 weeks (H&E, ×500): Dense fibrous tissues with moderate blood vessels and newly attached fibroblasts are observed around dentin particles. ① Dentinal tuble. ② Fibroblast. ③ Fibroblast. ④ Blood vessel. (B) Histological finding of DDM after 2 weeks (H&E, ×200): Well-encapsulated dentin particles within cell supplies and cellular activities on the surface of dentin, which seem to be an activation of fibroblasts, are observed. (C) Histological finding of DDM after 2 weeks (Masson trichrome, ×200): Activated cells on the surface of dentin looked like an osteoblast (thick arrow). Also produced newly deposited collagens that we can call ‘osteoid’ (thin arrow).</p>
</caption>
<graphic xlink:href="mprs-36-050f2"></graphic>
</fig>
<fig id="f3-mprs-36-050" position="float"><label>Fig. 3.</label>
<caption><p>(A) Histological finding of demineralized dentin matrix (DDM) after 4 weeks (H&E, ×100). ① Well-encapsulated dentin matrix and well-organized fibrous tissues between the particles. ② Fibrous tissue is a reservoir of angiogenesis as well as stem cell supplies. (B) Histological finding of DDM after 4 weeks (H&E, ×500). ① Newly deposited and produced collagen matrix on dentin particles. ② Still-activated osteoblast-like cells on the surface of dentin. ③ Some vacuoles in the newly formed osteoid seem to be osteocytes. (C) Histological finding of DDM after 4 weeks (H&E, ×200). ① Osteoblastic activity from surrounding fibroblasts is profound. ② Dense fibrous tissues turn into highly vasculated tissues. (D) Histological finding of DDM after 4 weeks (Masson trichrome, ×200). ① Osteoblastic activity from surrounding fibroblasts is profound. ② Dense fibrous tissues turn into highly vasculated tissues.</p>
</caption>
<graphic xlink:href="mprs-36-050f3"></graphic>
</fig>
<fig id="f4-mprs-36-050" position="float"><label>Fig. 4.</label>
<caption><p>(A) Histological finding of demineralized dentin matrix (DDM) after 8 weeks (H&E, ×200): More activated osteoblastic activities are observed. (B) Histological finding of DDM after 8 weeks (Masson trichrome, ×200). ① More activated osteoblastic layers surrounding dentin particles. ② Osteoblastic cell band surrounded by dentin particles.</p>
</caption>
<graphic xlink:href="mprs-36-050f4"></graphic>
</fig>
<fig id="f5-mprs-36-050" position="float"><label>Fig. 5.</label>
<caption><p>Histological finding of DDM after 8 weeks (H&E; A: ×100, B: ×500). Induced cartilage and bone marrow formation by dentin matrix is observed.</p>
</caption>
<graphic xlink:href="mprs-36-050f5"></graphic>
</fig>
</floats-group>
</pmc>
</record>

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Bone Induction by Demineralized Dentin Matrix in Nude Mouse Muscles

Bone Induction by Demineralized Dentin Matrix in Nude Mouse Muscles

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