Clinical and histologic features of botryoid odontogenic cyst: a case report
Identifieur interne : 003231 ( Pmc/Corpus ); précédent : 003230; suivant : 003232Clinical and histologic features of botryoid odontogenic cyst: a case report
Auteurs : Vitor H. Farina ; Adriana Ah Brandão ; Janete D. Almeida ; Luiz Ag CabralSource :
- Journal of Medical Case Reports [ 1752-1947 ] ; 2010.
Abstract
The lateral periodontal cyst, as the name implies, occurs on a lateral periodontal location and is of developmental origin, arising from cystic degeneration of clear cells of the dental lamina. A botryoid odontogenic cyst is considered to be a rare multilocular variant of a lateral periodontal cyst.
We report the clinical and histopathologic features of a rare case of botryoid odontogenic cyst found in an edentulous area corresponding to the right lower canine of a 64-year-old African-American woman. A multilocular radiolucency was observed, and surgical removal of the lesion revealed a nodule of rubber-like consistency measuring about 1.5 cm in diameter. Cross-sectioning of the nodule showed that it consisted of various cystic compartments. Histologically, various voluminous periodic acid-Schiff-negative clear cells randomly distributed throughout the cystic epithelium were observed, as well as cell layers showing thickenings generally formed by oval, sometimes entangled plaques. The capsule consisted of fibrous connective tissue and showed rare and discrete foci of a perivascular mononuclear inflammatory infiltrate and reactive bone-tissue fragments. The final diagnosis was botryoid odontogenic cyst.
We provide data that allow the reader to establish the differences between botryoid odontogenic cyst, glandular odontogenic cyst, and lateral periodontal cyst, helping with the differential diagnosis. The reader will have the opportunity to review botryoid odontogenic cyst clinical and histopathologic features, including treatment.
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DOI: 10.1186/1752-1947-4-260
PubMed: 20698969
PubMed Central: 2930647
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical and histologic features of botryoid odontogenic cyst: a case report</title><author><name sortKey="Farina, Vitor H" sort="Farina, Vitor H" uniqKey="Farina V" first="Vitor H" last="Farina">Vitor H. Farina</name><affiliation><nlm:aff id="I1">Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, São Paulo State University-UNESP, São José dos Campos, São Paulo, Brazil</nlm:aff></affiliation></author><author><name sortKey="Brandao, Adriana Ah" sort="Brandao, Adriana Ah" uniqKey="Brandao A" first="Adriana Ah" last="Brandão">Adriana Ah Brandão</name><affiliation><nlm:aff id="I1">Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, São Paulo State University-UNESP, São José dos Campos, São Paulo, Brazil</nlm:aff></affiliation></author><author><name sortKey="Almeida, Janete D" sort="Almeida, Janete D" uniqKey="Almeida J" first="Janete D" last="Almeida">Janete D. Almeida</name><affiliation><nlm:aff id="I1">Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, São Paulo State University-UNESP, São José dos Campos, São Paulo, Brazil</nlm:aff></affiliation></author><author><name sortKey="Cabral, Luiz Ag" sort="Cabral, Luiz Ag" uniqKey="Cabral L" first="Luiz Ag" last="Cabral">Luiz Ag Cabral</name><affiliation><nlm:aff id="I1">Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, São Paulo State University-UNESP, São José dos Campos, São Paulo, Brazil</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20698969</idno><idno type="pmc">2930647</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930647</idno><idno type="RBID">PMC:2930647</idno><idno type="doi">10.1186/1752-1947-4-260</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">003231</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003231</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical and histologic features of botryoid odontogenic cyst: a case report</title><author><name sortKey="Farina, Vitor H" sort="Farina, Vitor H" uniqKey="Farina V" first="Vitor H" last="Farina">Vitor H. Farina</name><affiliation><nlm:aff id="I1">Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, São Paulo State University-UNESP, São José dos Campos, São Paulo, Brazil</nlm:aff></affiliation></author><author><name sortKey="Brandao, Adriana Ah" sort="Brandao, Adriana Ah" uniqKey="Brandao A" first="Adriana Ah" last="Brandão">Adriana Ah Brandão</name><affiliation><nlm:aff id="I1">Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, São Paulo State University-UNESP, São José dos Campos, São Paulo, Brazil</nlm:aff></affiliation></author><author><name sortKey="Almeida, Janete D" sort="Almeida, Janete D" uniqKey="Almeida J" first="Janete D" last="Almeida">Janete D. Almeida</name><affiliation><nlm:aff id="I1">Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, São Paulo State University-UNESP, São José dos Campos, São Paulo, Brazil</nlm:aff></affiliation></author><author><name sortKey="Cabral, Luiz Ag" sort="Cabral, Luiz Ag" uniqKey="Cabral L" first="Luiz Ag" last="Cabral">Luiz Ag Cabral</name><affiliation><nlm:aff id="I1">Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, São Paulo State University-UNESP, São José dos Campos, São Paulo, Brazil</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Medical Case Reports</title><idno type="eISSN">1752-1947</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>The lateral periodontal cyst, as the name implies, occurs on a lateral periodontal location and is of developmental origin, arising from cystic degeneration of clear cells of the dental lamina. A botryoid odontogenic cyst is considered to be a rare multilocular variant of a lateral periodontal cyst.</p></sec><sec><title>Case presentation</title><p>We report the clinical and histopathologic features of a rare case of botryoid odontogenic cyst found in an edentulous area corresponding to the right lower canine of a 64-year-old African-American woman. A multilocular radiolucency was observed, and surgical removal of the lesion revealed a nodule of rubber-like consistency measuring about 1.5 cm in diameter. Cross-sectioning of the nodule showed that it consisted of various cystic compartments. Histologically, various voluminous periodic acid-Schiff-negative clear cells randomly distributed throughout the cystic epithelium were observed, as well as cell layers showing thickenings generally formed by oval, sometimes entangled plaques. The capsule consisted of fibrous connective tissue and showed rare and discrete foci of a perivascular mononuclear inflammatory infiltrate and reactive bone-tissue fragments. The final diagnosis was botryoid odontogenic cyst.</p></sec><sec><title>Conclusion</title><p>We provide data that allow the reader to establish the differences between botryoid odontogenic cyst, glandular odontogenic cyst, and lateral periodontal cyst, helping with the differential diagnosis. The reader will have the opportunity to review botryoid odontogenic cyst clinical and histopathologic features, including treatment.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Weathers, Dr" uniqKey="Weathers D">DR Weathers</name></author><author><name sortKey="Waldron, Ca" uniqKey="Waldron C">CA Waldron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ucok, O" uniqKey="Ucok O">O Uçok</name></author><author><name sortKey="Yaman, Z" uniqKey="Yaman Z">Z Yaman</name></author><author><name sortKey="Gunhan, O" uniqKey="Gunhan O">O Günhan</name></author><author><name sortKey="Ucok, C" uniqKey="Ucok C">C Uçok</name></author><author><name sortKey="Dogan, N" uniqKey="Dogan N">N Dogan</name></author><author><name sortKey="Baykul, T" uniqKey="Baykul T">T Baykul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greer, Ro" uniqKey="Greer R">RO Greer</name></author><author><name sortKey="Johnson, M" uniqKey="Johnson M">M Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramer, M" uniqKey="Ramer M">M Ramer</name></author><author><name sortKey="Valauri, D" uniqKey="Valauri D">D Valauri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heikinheimo, K" uniqKey="Heikinheimo K">K Heikinheimo</name></author><author><name sortKey="Happonen, Rp" uniqKey="Happonen R">RP Happonen</name></author><author><name sortKey="Forssell, K" uniqKey="Forssell K">K Forssell</name></author><author><name sortKey="Kuusilehto, A" uniqKey="Kuusilehto A">A Kuusilehto</name></author><author><name sortKey="Virtanen, I" uniqKey="Virtanen I">I Virtanen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manor, R" uniqKey="Manor R">R Manor</name></author><author><name sortKey="Anavi, Y" uniqKey="Anavi Y">Y Anavi</name></author><author><name sortKey="Kaplan, I" uniqKey="Kaplan I">I Kaplan</name></author><author><name sortKey="Calderon, S" uniqKey="Calderon S">S Calderon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slater, Lj" uniqKey="Slater L">LJ Slater</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falcone, F" uniqKey="Falcone F">F Falcone</name></author><author><name sortKey="Lazow, Sk" uniqKey="Lazow S">SK Lazow</name></author><author><name sortKey="Solomon, Mp" uniqKey="Solomon M">MP Solomon</name></author><author><name sortKey="Berger, Jr" uniqKey="Berger J">JR Berger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gurol, M" uniqKey="Gurol M">M Gurol</name></author><author><name sortKey="Burkes, Ej" uniqKey="Burkes E">EJ Burkes</name></author><author><name sortKey="Jacoway, J" uniqKey="Jacoway J">J Jacoway</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Souza, So" uniqKey="De Souza S">SO de Souza</name></author><author><name sortKey="Campos, Ac" uniqKey="Campos A">AC Campos</name></author><author><name sortKey="Santiago, Jl" uniqKey="Santiago J">JL Santiago</name></author><author><name sortKey="Jaeger, Rg" uniqKey="Jaeger R">RG Jaeger</name></author><author><name sortKey="De Araujo, Vc" uniqKey="De Araujo V">VC de Araújo</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Med Case Reports</journal-id><journal-title-group><journal-title>Journal of Medical Case Reports</journal-title></journal-title-group><issn pub-type="epub">1752-1947</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20698969</article-id><article-id pub-id-type="pmc">2930647</article-id><article-id pub-id-type="publisher-id">1752-1947-4-260</article-id><article-id pub-id-type="doi">10.1186/1752-1947-4-260</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Clinical and histologic features of botryoid odontogenic cyst: a case report</article-title></title-group><contrib-group><contrib contrib-type="author" id="A1"><name><surname>Farina</surname><given-names>Vitor H</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>odontofarina@uol.com.br</email></contrib><contrib contrib-type="author" id="A2"><name><surname>Brandão</surname><given-names>Adriana AH</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>aigotti@fosjc.unesp.br</email></contrib><contrib contrib-type="author" corresp="yes" id="A3"><name><surname>Almeida</surname><given-names>Janete D</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>janete@fosjc.unesp.br</email></contrib><contrib contrib-type="author" id="A4"><name><surname>Cabral</surname><given-names>Luiz AG</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>cabral@fosjc.unesp.br</email></contrib></contrib-group><aff id="I1"><label>1</label>Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, São Paulo State University-UNESP, São José dos Campos, São Paulo, Brazil</aff><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>10</day><month>8</month><year>2010</year></pub-date><volume>4</volume><fpage>260</fpage><lpage>260</lpage><history><date date-type="received"><day>7</day><month>12</month><year>2009</year></date><date date-type="accepted"><day>10</day><month>8</month><year>2010</year></date></history><permissions><copyright-statement>Copyright ©2010 Farina et al; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2010</copyright-year><copyright-holder>Farina et al; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:href="http://www.jmedicalcasereports.com/content/4/1/260"></self-uri><abstract><sec><title>Introduction</title><p>The lateral periodontal cyst, as the name implies, occurs on a lateral periodontal location and is of developmental origin, arising from cystic degeneration of clear cells of the dental lamina. A botryoid odontogenic cyst is considered to be a rare multilocular variant of a lateral periodontal cyst.</p></sec><sec><title>Case presentation</title><p>We report the clinical and histopathologic features of a rare case of botryoid odontogenic cyst found in an edentulous area corresponding to the right lower canine of a 64-year-old African-American woman. A multilocular radiolucency was observed, and surgical removal of the lesion revealed a nodule of rubber-like consistency measuring about 1.5 cm in diameter. Cross-sectioning of the nodule showed that it consisted of various cystic compartments. Histologically, various voluminous periodic acid-Schiff-negative clear cells randomly distributed throughout the cystic epithelium were observed, as well as cell layers showing thickenings generally formed by oval, sometimes entangled plaques. The capsule consisted of fibrous connective tissue and showed rare and discrete foci of a perivascular mononuclear inflammatory infiltrate and reactive bone-tissue fragments. The final diagnosis was botryoid odontogenic cyst.</p></sec><sec><title>Conclusion</title><p>We provide data that allow the reader to establish the differences between botryoid odontogenic cyst, glandular odontogenic cyst, and lateral periodontal cyst, helping with the differential diagnosis. The reader will have the opportunity to review botryoid odontogenic cyst clinical and histopathologic features, including treatment.</p></sec></abstract></article-meta></front><body><sec><title>Introduction</title><p>Botryoid odontogenic cyst (BOC) was originally described in 1973 by Weathers and Waldron [<xref ref-type="bibr" rid="B1">1</xref>] as an intraosseous lesion characterized by a macroscopic and microscopic multilocular growth pattern, resembling a bunch of grapes (from the Greek word <italic>botrios</italic>). BOC is considered to be a variant of a lateral periodontal cyst [<xref ref-type="bibr" rid="B2">2</xref>]. Greer and Johnson [<xref ref-type="bibr" rid="B3">3</xref>], reviewing 10 cases of BOC, observed that nine of the lesions were located in the mandible, mainly the anterior region, and one in the maxilla, also in the anterior region. Radiologically, eight cases were characterized by unilocular radiolucencies, and two, by multilocular radiolucencies. The mean age of the patients was 46 years. Three cases were recurrences, one occurring eight years, and two, 10 years after treatment. Histologically, non-keratinized squamous epithelium consisting of a few cell layers was observed, which showed plaque-like thickening in seven cases. Zones of clear cells scattered throughout the epithelium and containing periodic acid-Schiff (PAS)-positive material were observed in all 10 cases. In four cases, a discretely hyalinized zone underlying the basal epithelial layer was noted. All 10 lesions were characterized by the presence of multiple cystic compartments.</p><p>In a study evaluating 66 cases of BOC, Ramer and Valuri [<xref ref-type="bibr" rid="B4">4</xref>] found a slight predominance in women (53%) over men (47%), with 70% of the cases occurring in white individuals and 30%, in black individuals. Heikinheimo <italic>et al. </italic>[<xref ref-type="bibr" rid="B5">5</xref>] reported a case of BOC with multiple recurrences that had occurred over a period of nine years, which led the authors to propose more-radical surgical intervention in cases of BOC. Manor <italic>et al. </italic>[<xref ref-type="bibr" rid="B6">6</xref>] stated that BOC frequently shows a lobulated radiographic pattern similar to that of glandular odontogenic cysts and, therefore, the latter should be included in the differential diagnosis. However, these cysts are characterized by the presence of salivary gland-like structures in the lining epithelium, an uncommon histologic finding in BOC [<xref ref-type="bibr" rid="B7">7</xref>].</p></sec><sec><title>Case presentation</title><p>A 64-year-old African-American woman presented at our outpatient clinic with a two-year history of asymptomatic enlargement in the right anterior region of the edentulous mandible.</p><p>Clinical examination revealed an expansion, measuring approximately 2 cm in the major diameter and located in the region corresponding to the right lower canine, which was of firm consistency on palpation, lined with intact mucosa, and presented a multi-lobulated surface (Figure <xref ref-type="fig" rid="F1">1a</xref>). Occlusal radiography showed a well-delimited multilocular radiolucency in the region of expansion (Figure <xref ref-type="fig" rid="F1">1b</xref>). On the basis of these data, the differential diagnosis of a cyst of odontogenic origin was established.</p><fig id="F1" position="float"><label>Figure 1</label><caption><p><bold>Details of the asymptomatic enlargement</bold>. <bold>(a) </bold>Expansion located in the region corresponding to the right lower canine lined with intact mucosa and presenting a multi-lobulated surface. <bold>(b) </bold>Occlusal radiograph showing a well-delimited multilocular radiolucent lesion. <bold>(c) </bold>Nodule measuring about 1.5 cm in diameter; it was removed surgically.</p></caption><graphic xlink:href="1752-1947-4-260-1"></graphic></fig><p>Surgical removal of the lesion, which was easily separated from the surrounding bone, revealed a nodule of rubber-like consistency measuring about 1.5 cm in diameter (Figure <xref ref-type="fig" rid="F1">1c</xref>). Cross-sectioning of the nodule showed that it consisted of various cystic compartments (Figure <xref ref-type="fig" rid="F2">2a</xref>). The surgical specimen was sent for histopathologic analysis, which showed the presence of multiple cystic cavities of variable size and shape and thin walls lined with non-keratinized stratified pavement epithelium of variable thickness; the epithelium either consisted of a few cell layers or showed thickenings generally formed by oval, sometimes entangled, plaques (Figure <xref ref-type="fig" rid="F2">2b</xref> and <xref ref-type="fig" rid="F2">2c</xref>). In addition, various voluminous PAS-negative clear cells randomly distributed throughout the cystic epithelium were observed (Figure <xref ref-type="fig" rid="F2">2d</xref>). The capsule consisted of fibrous connective tissue and rare and discrete foci of a perivascular mononuclear inflammatory infiltrate and reactive bone-tissue fragments. The final diagnosis was BOC.</p><fig id="F2" position="float"><label>Figure 2</label><caption><p><bold>Studies of the cyst</bold>. <bold>(a) </bold>Cross-sectioned nodule showing various cystic compartments. <bold>(b) </bold>Multiple cystic cavities lined with thin pavement epithelium with thickened areas (arrows) (H&E, 200×). <bold>(c) </bold>Plaque-like focal thickening in the epithelial lining of the cyst (arrow) (H&E, 400×). <bold>(d) </bold>Cystic cavity showing PAS-negative voluminous clear cells in the lining epithelium (arrow) (PAS, 400×).</p></caption><graphic xlink:href="1752-1947-4-260-2"></graphic></fig></sec><sec><title>Discussion</title><p>The case of BOC reported in the present study was characterized clinically by an asymptomatic nodule located in the right anterior region of the mandible, and radiographically, by a multilocular radiolucent lesion, reflecting the macroscopic aspect of the surgical specimen, a phenomenon not always observed in BOC because this type of cyst tends to present a unilocular radiographic aspect [<xref ref-type="bibr" rid="B4">4</xref>]. Conversely, the multilocular radiographic aspect is very frequent in cases of glandular odontogenic cysts [<xref ref-type="bibr" rid="B6">6</xref>]; however, these cysts show glandular ductlike structures in the lining epithelium, not observed in this case.</p><p>In the present case, the microscopic observation of multiple cystic cavities lined with non-keratinized stratified pavement epithelium consisting of a few cell layers with focal entangled thickenings, the presence of voluminous clear cells in the epithelium, and a thin connective tissue capsule with a few inflammatory cells, combined with the clinical and radiographic findings, defined the diagnosis of BOC, as also reported by Falcone <italic>et al. </italic>[<xref ref-type="bibr" rid="B8">8</xref>]. The fact that the clear cells present in the epithelium were not stained with PAS indicates that they did not contain glycogen or is just an example of the vagaries of histochemical staining procedures. Negative findings may well be due to tissue handling or other technical details. This finding is in contrast to the results of Greer and Johnson [<xref ref-type="bibr" rid="B3">3</xref>] and Gurol <italic>et al. </italic>[<xref ref-type="bibr" rid="B9">9</xref>], who observed staining of these cells with PAS. Greer and Johnson [<xref ref-type="bibr" rid="B3">3</xref>] reported a similarity between these clear cells rich in glycogen, frequently observed in the epithelium of BOC, and dental lamina cells, suggesting that the dental lamina is one of the possible origins of BOC. However, these cells do not seem to exert any influence on the biologic behavior of the cyst. The diagnosis of BOC should not be discarded in cases of negative PAS staining when all other histologic features are present.</p><p>With respect to the similarity between BOC and lateral periodontal cysts, Machado de Souza <italic>et al. </italic>[<xref ref-type="bibr" rid="B10">10</xref>] stated that BOC are distinguished from the latter by their larger size, which, associated with the multilocular characteristic of BOC, increases the possibility of recurrence because complete surgical removal becomes more difficult.</p><p>Üçok <italic>et al. </italic>[<xref ref-type="bibr" rid="B2">2</xref>] reported that the risk of recurrence of BOC is similar to that of keratocystic odontogenic tumors, but that the former shows less aggressive behavior. According to Ramer and Valuri [<xref ref-type="bibr" rid="B4">4</xref>], BOC is not an aggressive lesion, and recurrences are the result of conservative surgical treatment (enucleation). The authors observed that 10 of 13 recurrences studied presented a multilocular radiographic aspect and suggested more-frequent postoperative follow-up visits in these cases.</p><p>The case reported here has been followed up for eight years. So far, no clinical or radiographic evidence characterizes recurrence of the lesion, indicating that the lesion was removed <italic>in toto</italic>. However, follow-up for a longer period is necessary to ensure the success of surgical treatment in this case of BOC.</p></sec><sec><title>Conclusion</title><p>Recurrences of multilocular radiolucent lesions of BOC are common. A non-conservative surgical removal is the only effective treatment for this kind of lesion.</p></sec><sec><title>Competing interests</title><p>The authors declare that they have no competing interests.</p></sec><sec><title>Authors' contributions</title><p>JDA and LAGC analyzed and interpreted the patient data and performed the surgical procedures. AAHB performed the histologic examination and photographs. VHF was a major contributor in writing the manuscript. All authors read and approved the final manuscript.</p></sec><sec><title>Consent</title><p>Written informed consent was obtained from the patient for publication of this case report and accompanying images. 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